RO117794B1 - Derivati indolici tetraciclici, procedeu de preparare si compozitie farmaceutica - Google Patents

Derivati indolici tetraciclici, procedeu de preparare si compozitie farmaceutica Download PDF

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Publication number
RO117794B1
RO117794B1 RO96-01454A RO9601454A RO117794B1 RO 117794 B1 RO117794 B1 RO 117794B1 RO 9601454 A RO9601454 A RO 9601454A RO 117794 B1 RO117794 B1 RO 117794B1
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RO
Romania
Prior art keywords
carbon atoms
indole
pyrido
dione
hexahydro
Prior art date
Application number
RO96-01454A
Other languages
English (en)
Romanian (ro)
Inventor
Alain Claude-Marie Daugan
Original Assignee
Glaxo Lab Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10749089&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RO117794(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Lab Sa filed Critical Glaxo Lab Sa
Publication of RO117794B1 publication Critical patent/RO117794B1/ro

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RO96-01454A 1994-01-21 1995-01-19 Derivati indolici tetraciclici, procedeu de preparare si compozitie farmaceutica RO117794B1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9401090A GB9401090D0 (en) 1994-01-21 1994-01-21 Chemical compounds
PCT/EP1995/000183 WO1995019978A1 (en) 1994-01-21 1995-01-19 Tetracyclic derivatives, process of preparation and use

Publications (1)

Publication Number Publication Date
RO117794B1 true RO117794B1 (ro) 2002-07-30

Family

ID=10749089

Family Applications (1)

Application Number Title Priority Date Filing Date
RO96-01454A RO117794B1 (ro) 1994-01-21 1995-01-19 Derivati indolici tetraciclici, procedeu de preparare si compozitie farmaceutica

Country Status (48)

Country Link
US (5) US5859006A (enEXAMPLES)
EP (1) EP0740668B1 (enEXAMPLES)
JP (3) JP3808095B2 (enEXAMPLES)
KR (1) KR100357411B1 (enEXAMPLES)
CN (2) CN1045777C (enEXAMPLES)
AP (1) AP556A (enEXAMPLES)
AT (1) ATE169018T1 (enEXAMPLES)
AU (2) AU689205B2 (enEXAMPLES)
BG (1) BG62733B1 (enEXAMPLES)
BR (1) BR9506559C8 (enEXAMPLES)
CA (1) CA2181377C (enEXAMPLES)
CO (1) CO4340684A1 (enEXAMPLES)
CZ (1) CZ286566B6 (enEXAMPLES)
DE (2) DE69503753T2 (enEXAMPLES)
DK (1) DK0740668T3 (enEXAMPLES)
EE (1) EE03231B1 (enEXAMPLES)
EG (1) EG25852A (enEXAMPLES)
ES (1) ES2122543T3 (enEXAMPLES)
FI (1) FI113176B (enEXAMPLES)
GB (1) GB9401090D0 (enEXAMPLES)
HR (1) HRP950023B1 (enEXAMPLES)
HU (1) HU222494B1 (enEXAMPLES)
IL (1) IL112384A (enEXAMPLES)
IN (1) IN183942B (enEXAMPLES)
IS (1) IS1888B (enEXAMPLES)
LU (1) LU91017I2 (enEXAMPLES)
LV (1) LV11690B (enEXAMPLES)
MA (1) MA23433A1 (enEXAMPLES)
MX (1) MX9602904A (enEXAMPLES)
MY (1) MY114663A (enEXAMPLES)
NL (1) NL300124I2 (enEXAMPLES)
NO (2) NO306465B1 (enEXAMPLES)
NZ (1) NZ279199A (enEXAMPLES)
OA (1) OA10584A (enEXAMPLES)
PE (1) PE49495A1 (enEXAMPLES)
PL (1) PL179744B1 (enEXAMPLES)
RO (1) RO117794B1 (enEXAMPLES)
RU (1) RU2142463C1 (enEXAMPLES)
SA (1) SA95150475B1 (enEXAMPLES)
SG (1) SG49184A1 (enEXAMPLES)
SI (1) SI0740668T1 (enEXAMPLES)
SK (1) SK280879B6 (enEXAMPLES)
SV (1) SV1995000002A (enEXAMPLES)
TN (1) TNSN95004A1 (enEXAMPLES)
TW (1) TW378210B (enEXAMPLES)
UY (1) UY23893A1 (enEXAMPLES)
WO (1) WO1995019978A1 (enEXAMPLES)
ZA (1) ZA95424B (enEXAMPLES)

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US6025494A (en) 2000-02-15
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HRP950023A2 (en) 1998-04-30
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SG49184A1 (en) 1998-05-18
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EG25852A (en) 2012-09-10
BR9506559C8 (pt) 2020-07-07
NO2003002I1 (no) 2003-01-22
SA95150475B1 (ar) 2005-07-31
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DK0740668T3 (da) 1999-05-03
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IL112384A (en) 1998-08-16
DE10399006I1 (de) 2003-07-31
CA2181377A1 (en) 1995-07-27
OA10584A (en) 2002-08-26
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EE03231B1 (et) 1999-10-15
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NL300124I2 (nl) 2003-11-03
TNSN95004A1 (fr) 1996-02-06
CO4340684A1 (es) 1996-07-30
AU707055B2 (en) 1999-07-01
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HU9601982D0 (en) 1996-09-30
ATE169018T1 (de) 1998-08-15
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IN183942B (enEXAMPLES) 2000-05-20
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CN1070492C (zh) 2001-09-05

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