PT99911A - Processo para a preparacao de 11beta-aril-4-estrenos modificados em posicao 6,7 e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de 11beta-aril-4-estrenos modificados em posicao 6,7 e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT99911A PT99911A PT99911A PT9991191A PT99911A PT 99911 A PT99911 A PT 99911A PT 99911 A PT99911 A PT 99911A PT 9991191 A PT9991191 A PT 9991191A PT 99911 A PT99911 A PT 99911A
- Authority
- PT
- Portugal
- Prior art keywords
- pct
- preparation
- hydrogen atom
- strenos
- 11beta
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 229940083712 aldosterone antagonist Drugs 0.000 abstract 1
- 230000002280 anti-androgenic effect Effects 0.000 abstract 1
- 230000000380 anti-gestagenic effect Effects 0.000 abstract 1
- 230000001327 anti-mineralocorticoid effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- -1 hydroxyimino Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
- 239000002394 mineralocorticoid antagonist Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0092—Alkenyl derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Luminescent Compositions (AREA)
- Internal Circuitry In Semiconductor Integrated Circuit Devices (AREA)
- Photovoltaic Devices (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Photoreceptors In Electrophotography (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Holo Graphy (AREA)
- Semiconductor Memories (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4042007A DE4042007A1 (de) | 1990-12-22 | 1990-12-22 | 6,7-modifizierte-11(beta)-aryl-4-estrene |
Publications (2)
Publication Number | Publication Date |
---|---|
PT99911A true PT99911A (pt) | 1992-12-31 |
PT99911B PT99911B (pt) | 1999-06-30 |
Family
ID=6421578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT99911A PT99911B (pt) | 1990-12-22 | 1991-12-20 | Processo para a preparacao de 11beta-aril-4-estrenos modificados em posicao 6,7 e de composicoes farmaceuticas que os contem |
Country Status (16)
Country | Link |
---|---|
US (1) | US5843931A (pt) |
EP (1) | EP0565553B1 (pt) |
JP (1) | JP3181589B2 (pt) |
CN (1) | CN1065070A (pt) |
AT (1) | ATE182334T1 (pt) |
AU (2) | AU9098191A (pt) |
CA (1) | CA2099018A1 (pt) |
DE (2) | DE4042007A1 (pt) |
FI (1) | FI932874A0 (pt) |
HU (1) | HUT67311A (pt) |
IE (1) | IE914529A1 (pt) |
IL (1) | IL100465A (pt) |
NO (1) | NO932277L (pt) |
PT (1) | PT99911B (pt) |
WO (1) | WO1992011277A1 (pt) |
ZA (1) | ZA9110144B (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3263112T3 (da) | 2006-10-24 | 2020-08-17 | Allergan Pharmaceuticals Int Ltd | Sammensætninger og fremgangsmåder til undertrykkelse af endometriproliferationer |
TWI539953B (zh) | 2008-04-28 | 2016-07-01 | 瑞波若斯治療學公司 | 用於治療乳癌之組成物和方法 |
HUP0900487A2 (hu) * | 2009-08-05 | 2011-03-28 | Richter Gedeon Nyrt | 17-acetoxi-11ß-[4-(dimetil-amino)-fenil]-21-metoxi-19-norpregna-4,9-dién-3,20-dion új kristályos polimorf módosulata és eljárás elõállítására |
EP2550288A1 (en) | 2010-03-22 | 2013-01-30 | Repros Therapeutics Inc. | Compositions and methods for non-toxic delivery of antiprogestins |
US11110103B2 (en) | 2015-12-23 | 2021-09-07 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
US11208432B2 (en) | 2015-12-23 | 2021-12-28 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
US11124537B2 (en) | 2015-12-23 | 2021-09-21 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
CN111690031B (zh) * | 2016-10-07 | 2021-06-01 | 欧瑞克制药公司 | 糖皮质激素受体抑制剂 |
AU2019252561A1 (en) * | 2018-04-11 | 2020-11-26 | Oric Pharmaceuticals, Inc. | Solid forms and formulations comprising a glucocorticoid receptor antagonist and uses thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ214998A (en) * | 1985-02-07 | 1989-06-28 | Schering Ag | 13-(methyl or ethyl)-11-beta-phenyl-gonane derivatives; preparatory processes and pharmaceutical compositions |
DE3702383A1 (de) * | 1987-01-23 | 1988-08-04 | Schering Ag | 11ss-alkinylestrene und -estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
DE3921059A1 (de) * | 1989-06-23 | 1991-01-10 | Schering Ag | 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
DE4018167A1 (de) * | 1990-06-01 | 1991-12-05 | Schering Ag | Verfahren zur herstellung von 10(beta)-h-steroiden |
DE4018168A1 (de) * | 1990-06-01 | 1991-12-05 | Schering Ag | Ausgangsverbindungen fuer die herstellung von 10ss-h-steroiden und ein verfahren zur herstellung dieser ausgangsverbindungen |
-
1990
- 1990-12-22 DE DE4042007A patent/DE4042007A1/de not_active Withdrawn
-
1991
- 1991-12-20 PT PT99911A patent/PT99911B/pt not_active IP Right Cessation
- 1991-12-21 EP EP92901410A patent/EP0565553B1/de not_active Expired - Lifetime
- 1991-12-21 AT AT92901410T patent/ATE182334T1/de not_active IP Right Cessation
- 1991-12-21 AU AU90981/91A patent/AU9098191A/en not_active Abandoned
- 1991-12-21 HU HU9301815A patent/HUT67311A/hu unknown
- 1991-12-21 CA CA002099018A patent/CA2099018A1/en not_active Abandoned
- 1991-12-21 JP JP50140592A patent/JP3181589B2/ja not_active Expired - Fee Related
- 1991-12-21 US US08/078,290 patent/US5843931A/en not_active Expired - Fee Related
- 1991-12-21 WO PCT/EP1991/002493 patent/WO1992011277A1/de active IP Right Grant
- 1991-12-21 DE DE59109142T patent/DE59109142D1/de not_active Expired - Fee Related
- 1991-12-21 CN CN91112835A patent/CN1065070A/zh active Pending
- 1991-12-22 IL IL100465A patent/IL100465A/xx not_active IP Right Cessation
- 1991-12-23 IE IE452991A patent/IE914529A1/en not_active Application Discontinuation
- 1991-12-23 ZA ZA9110144A patent/ZA9110144B/xx unknown
-
1993
- 1993-06-21 FI FI932874A patent/FI932874A0/fi not_active Application Discontinuation
- 1993-06-21 NO NO93932277A patent/NO932277L/no unknown
-
1995
- 1995-11-08 AU AU37733/95A patent/AU3773395A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IE914529A1 (en) | 1992-07-01 |
NO932277D0 (no) | 1993-06-21 |
CA2099018A1 (en) | 1992-06-23 |
EP0565553B1 (de) | 1999-07-21 |
ZA9110144B (en) | 1992-10-28 |
PT99911B (pt) | 1999-06-30 |
ATE182334T1 (de) | 1999-08-15 |
AU3773395A (en) | 1996-01-11 |
WO1992011277A1 (de) | 1992-07-09 |
HUT67311A (en) | 1995-03-28 |
JPH06505707A (ja) | 1994-06-30 |
FI932874A (fi) | 1993-06-21 |
NO932277L (no) | 1993-08-20 |
AU9098191A (en) | 1992-07-22 |
US5843931A (en) | 1998-12-01 |
EP0565553A1 (de) | 1993-10-20 |
IL100465A (en) | 1997-03-18 |
FI932874A0 (fi) | 1993-06-21 |
HU9301815D0 (en) | 1993-09-28 |
JP3181589B2 (ja) | 2001-07-03 |
DE59109142D1 (de) | 1999-08-26 |
CN1065070A (zh) | 1992-10-07 |
DE4042007A1 (de) | 1992-06-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB1A | Laying open of patent application |
Effective date: 19920814 |
|
FG3A | Patent granted, date of granting |
Effective date: 19990302 |
|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20000930 |