PT772627E - Producao de proteina neurotrofica recombinante biologicamente activa - Google Patents
Producao de proteina neurotrofica recombinante biologicamente activaInfo
- Publication number
- PT772627E PT772627E PT95918354T PT95918354T PT772627E PT 772627 E PT772627 E PT 772627E PT 95918354 T PT95918354 T PT 95918354T PT 95918354 T PT95918354 T PT 95918354T PT 772627 E PT772627 E PT 772627E
- Authority
- PT
- Portugal
- Prior art keywords
- neurotrophic factor
- biologically active
- production
- neurotherapic
- protein
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 108010025020 Nerve Growth Factor Proteins 0.000 abstract 7
- 102000007072 Nerve Growth Factors Human genes 0.000 abstract 4
- 239000003900 neurotrophic factor Substances 0.000 abstract 4
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 abstract 1
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24012294A | 1994-05-09 | 1994-05-09 | |
| US08/266,080 US5606031A (en) | 1990-04-06 | 1994-06-27 | Production and purification of biologically active recombinant neurotrophic protein in bacteria |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT772627E true PT772627E (pt) | 2005-01-31 |
Family
ID=26933155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95918354T PT772627E (pt) | 1994-05-09 | 1995-05-02 | Producao de proteina neurotrofica recombinante biologicamente activa |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5606031A (pt) |
| EP (1) | EP0772627B1 (pt) |
| JP (1) | JP3673278B2 (pt) |
| AT (1) | ATE275152T1 (pt) |
| AU (1) | AU697891B2 (pt) |
| CA (1) | CA2189659C (pt) |
| DE (1) | DE69533443T2 (pt) |
| DK (1) | DK0772627T3 (pt) |
| ES (1) | ES2230549T3 (pt) |
| PT (1) | PT772627E (pt) |
| WO (1) | WO1995030686A1 (pt) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69330809T2 (de) * | 1992-06-08 | 2002-05-16 | Takeda Chemical Industries, Ltd. | Therapeutisches Agens für Neutropenie |
| US6299895B1 (en) | 1997-03-24 | 2001-10-09 | Neurotech S.A. | Device and method for treating ophthalmic diseases |
| TR199901734T2 (xx) | 1996-11-15 | 2000-01-21 | Genentech, Inc. | N�rotrofinlerin ar�t�lmas�. |
| ES2230851T5 (es) * | 1998-04-17 | 2009-06-25 | N.V. Innogenetics S.A. | Ensayos de inmunodiagnostico mejorados que usan agentes reductores. |
| ATE257514T1 (de) * | 1998-10-09 | 2004-01-15 | Scil Proteins Gmbh | Verfahren zur gewinnung von aktivem beta-ngf |
| US6444788B1 (en) * | 1999-03-15 | 2002-09-03 | Novo Nordisk A/S | Ion exchange chromatography of GLP-1, analogs and derivatives thereof |
| US6451987B1 (en) * | 1999-03-15 | 2002-09-17 | Novo Nordisk A/S | Ion exchange chromatography of proteins and peptides |
| EP1206578A2 (en) | 1999-08-11 | 2002-05-22 | Whitehead Institute For Biomedical Research | Bdnf polymorphism and association with bipolar disorder |
| US6852685B1 (en) | 1999-08-17 | 2005-02-08 | Board Of Regents, The University Of Texas System | Use of colostrinin, constituent peptides thereof, and analogs thereof to promote neuronal cell differentiation |
| WO2001012650A2 (en) | 1999-08-17 | 2001-02-22 | The University Of Texas System | Use of colostrinin, constituent peptides thereof, and analogs thereof as oxidative stress regulators |
| US7119064B2 (en) | 1999-08-17 | 2006-10-10 | Board Of Regents, The University Of Texas System | Use of colostrinin, constituent peptides thereof, and analogs thereof as modulators of intracellular signaling molecules |
| US6903068B1 (en) | 1999-08-17 | 2005-06-07 | Board Of Regents, The University Of Texas System | Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines |
| WO2002004512A2 (en) * | 2000-07-10 | 2002-01-17 | Diosynth Rtp, Inc. | Purification of human troponin i |
| AU2000269179A1 (en) * | 2000-08-17 | 2002-02-25 | The University Of Texas System | Use of colostrinin, constituent peptides thereof, and analogs thereof to promoteneural cell differentiation |
| DE10105912A1 (de) * | 2001-02-09 | 2002-08-14 | Roche Diagnostics Gmbh | Rekombinante Proteinase K |
| US20030232365A1 (en) * | 2001-02-15 | 2003-12-18 | Whitehead Institute For Biomedical Research | BDNF polymorphisms and association with bipolar disorder |
| EP1233075A3 (en) * | 2001-02-15 | 2003-01-08 | Whitehead Institute For Biomedical Research | BDNF polymorphism and association with bipolar disorder |
| CA2681952A1 (en) * | 2001-04-25 | 2002-10-31 | Eidgenoessische Technische Hochschule Zurich | Drug delivery matrices to enhance wound healing |
| EP2322229B1 (en) | 2001-10-10 | 2016-12-21 | Novo Nordisk A/S | Remodeling and glycoconjugation of Factor IX |
| WO2004099231A2 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US7416858B2 (en) | 2001-10-10 | 2008-08-26 | Neose Technologies, Inc. | Pharmaceutical compositions of glycoconjugates |
| CA2532340A1 (en) * | 2003-08-21 | 2005-03-03 | Novo Nordisk A/S | Separation of polypeptides comprising a racemized amino acid |
| JP2012512812A (ja) * | 2007-12-28 | 2012-06-07 | クロス・バイオサージェリー・アクチェンゲゼルシャフト | フィブリンフォームに組込まれたｐｄｇｆ融合タンパク質 |
| KR20140091651A (ko) | 2010-12-02 | 2014-07-22 | 뉴로테크 유에스에이, 인코포레이티드. | 항-혈관 신생 항체-스캐폴드 및 가용성 수용체를 분비하는 세포주 및 이의 용도 |
| EP3302524B1 (en) | 2015-05-27 | 2020-09-23 | Neurotech USA, Inc. | Use of encapsulated cell therapy for treatment of glaucoma |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4223967A (en) * | 1978-05-10 | 1980-09-23 | Antonio Royer | Telescopic structural element for making modular closets, partition walls, door supports and the like |
| US4421685A (en) * | 1980-03-27 | 1983-12-20 | Eli Lilly And Company | Process for producing an insulin |
| US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4620948A (en) * | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4518526A (en) * | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4599197A (en) * | 1982-12-22 | 1986-07-08 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| DK161152C (da) * | 1983-03-03 | 1991-11-11 | Genentech Inc | Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat |
| US5169762A (en) * | 1983-03-03 | 1992-12-08 | Genentech, Inc. | Human nerve growth factor by recombinant technology |
| US4451396A (en) * | 1983-08-01 | 1984-05-29 | Eli Lilly And Company | Process for inhibiting undesired thiol reactions during cyanogen bromide cleavage of peptides |
| JPH01257491A (ja) * | 1988-04-08 | 1989-10-13 | Tosoh Corp | 不溶性融合異種蛋白質の処理方法 |
| US4923967A (en) * | 1988-09-26 | 1990-05-08 | Eli Lilly And Company | Purification and refolding of recombinant proteins |
| US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
| IL95511A (en) * | 1989-08-30 | 2000-10-31 | Max Planck Gesellschaft | Neurotrophin-3 a novel neurotrophic factor related to nerve growth and brain derived neurotrophic factor |
| US5235043A (en) * | 1990-04-06 | 1993-08-10 | Synergen, Inc. | Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins |
| US5169764A (en) * | 1990-08-08 | 1992-12-08 | Regeneron Pharmaceuticals, Inc. | Multitrophic and multifunctional chimeric neurotrophic factors, and nucleic acids and plasmids encoding the chimeras |
| DE4139000A1 (de) * | 1991-11-27 | 1993-06-03 | Boehringer Mannheim Gmbh | Verfahren zur gentechnologischen herstellung von biologisch aktivem ss-ngf |
-
1994
- 1994-06-27 US US08/266,080 patent/US5606031A/en not_active Expired - Lifetime
-
1995
- 1995-05-02 CA CA002189659A patent/CA2189659C/en not_active Expired - Fee Related
- 1995-05-02 DE DE69533443T patent/DE69533443T2/de not_active Expired - Lifetime
- 1995-05-02 PT PT95918354T patent/PT772627E/pt unknown
- 1995-05-02 EP EP95918354A patent/EP0772627B1/en not_active Expired - Lifetime
- 1995-05-02 DK DK95918354T patent/DK0772627T3/da active
- 1995-05-02 AT AT95918354T patent/ATE275152T1/de active
- 1995-05-02 ES ES95918354T patent/ES2230549T3/es not_active Expired - Lifetime
- 1995-05-02 JP JP52904395A patent/JP3673278B2/ja not_active Expired - Fee Related
- 1995-05-02 AU AU24320/95A patent/AU697891B2/en not_active Ceased
- 1995-05-02 WO PCT/US1995/005423 patent/WO1995030686A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10502804A (ja) | 1998-03-17 |
| ES2230549T3 (es) | 2005-05-01 |
| AU2432095A (en) | 1995-11-29 |
| CA2189659A1 (en) | 1995-11-16 |
| DE69533443D1 (de) | 2004-10-07 |
| US5606031A (en) | 1997-02-25 |
| DE69533443T2 (de) | 2005-01-20 |
| EP0772627B1 (en) | 2004-09-01 |
| ATE275152T1 (de) | 2004-09-15 |
| EP0772627A1 (en) | 1997-05-14 |
| EP0772627A4 (pt) | 1997-06-11 |
| AU697891B2 (en) | 1998-10-22 |
| JP3673278B2 (ja) | 2005-07-20 |
| DK0772627T3 (da) | 2004-11-29 |
| CA2189659C (en) | 2006-12-12 |
| WO1995030686A1 (en) | 1995-11-16 |
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