PT3329909T - Fenfluramine for use in the treatment of dravet syndrome - Google Patents

Fenfluramine for use in the treatment of dravet syndrome

Info

Publication number
PT3329909T
PT3329909T PT181524067T PT18152406T PT3329909T PT 3329909 T PT3329909 T PT 3329909T PT 181524067 T PT181524067 T PT 181524067T PT 18152406 T PT18152406 T PT 18152406T PT 3329909 T PT3329909 T PT 3329909T
Authority
PT
Portugal
Prior art keywords
fenfluramine
treatment
dravet syndrome
dravet
syndrome
Prior art date
Application number
PT181524067T
Other languages
Portuguese (pt)
Original Assignee
Katholieke Univ Leuven Ku Leuven Research & Development
Univ Hospital Antwerp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50729472&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3329909(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Katholieke Univ Leuven Ku Leuven Research & Development, Univ Hospital Antwerp filed Critical Katholieke Univ Leuven Ku Leuven Research & Development
Publication of PT3329909T publication Critical patent/PT3329909T/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
PT181524067T 2013-05-03 2014-05-01 Fenfluramine for use in the treatment of dravet syndrome PT3329909T (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13/887,014 US9549909B2 (en) 2013-05-03 2013-05-03 Method for the treatment of dravet syndrome

Publications (1)

Publication Number Publication Date
PT3329909T true PT3329909T (en) 2021-05-14

Family

ID=50729472

Family Applications (2)

Application Number Title Priority Date Filing Date
PT181524067T PT3329909T (en) 2013-05-03 2014-05-01 Fenfluramine for use in the treatment of dravet syndrome
PT147240378T PT2991637T (en) 2013-05-03 2014-05-01 Fenfluramine for use in the treatment of dravet syndrome

Family Applications After (1)

Application Number Title Priority Date Filing Date
PT147240378T PT2991637T (en) 2013-05-03 2014-05-01 Fenfluramine for use in the treatment of dravet syndrome

Country Status (17)

Country Link
US (13) US9549909B2 (en)
EP (2) EP2991637B1 (en)
JP (3) JP6441313B2 (en)
AU (4) AU2014261329B2 (en)
BR (1) BR112015027282A8 (en)
CA (1) CA2909335C (en)
CY (1) CY1124298T1 (en)
DK (2) DK3329909T3 (en)
ES (2) ES2666657T3 (en)
HR (1) HRP20210819T1 (en)
HU (1) HUE054577T2 (en)
LT (1) LT3329909T (en)
NO (1) NO3092234T3 (en)
PL (2) PL3329909T3 (en)
PT (2) PT3329909T (en)
SI (1) SI3329909T1 (en)
WO (1) WO2014177676A1 (en)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2514054A (en) 2011-09-29 2014-11-12 Gw Pharma Ltd A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD)
US9549909B2 (en) 2013-05-03 2017-01-24 The Katholieke Universiteit Leuven Method for the treatment of dravet syndrome
GB2530001B (en) 2014-06-17 2019-01-16 Gw Pharma Ltd Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy
NZ762886A (en) 2014-09-29 2022-02-25 Zogenix International Ltd Control system for control of distribution of medication
GB2531282A (en) 2014-10-14 2016-04-20 Gw Pharma Ltd Use of cannabinoids in the treatment of epilepsy
GB2531281A (en) 2014-10-14 2016-04-20 Gw Pharma Ltd Use of cannabidiol in the treatment of intractable epilepsy
GB2531278A (en) 2014-10-14 2016-04-20 Gw Pharma Ltd Use of cannabidiol in the treatment of intractable epilepsy
EA201992474A3 (en) * 2015-02-25 2020-05-31 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорниа 5HT AGONISTS FOR TREATMENT OF DISORDERS
JP6668045B2 (en) * 2015-05-15 2020-03-18 ゾゲニクス インターナショナル リミテッド Selective 5-HT receptor agonists and antagonists for treating Dravet syndrome
GB2539472A (en) 2015-06-17 2016-12-21 Gw Res Ltd Use of cannabinoids in the treatment of epilepsy
GB2541191A (en) 2015-08-10 2017-02-15 Gw Pharma Ltd Use of cannabinoids in the treatment of epilepsy
KR102615486B1 (en) * 2015-08-24 2023-12-19 조게닉스 인터내셔널 리미티드 Methods of treating lennox-gastaut syndrome using fenfluramine
SG11201802870RA (en) 2015-10-09 2018-05-30 Univ Southampton Modulation of gene expression and screening for deregulated protein expression
WO2017106377A1 (en) 2015-12-14 2017-06-22 Cold Spring Harbor Laboratory Antisense oligomers for treatment of autosomal dominant mental retardation-5 and dravet syndrome
ES2861774T3 (en) 2015-12-22 2021-10-06 Zogenix International Ltd Fenfluramine Compositions and Procedures for Making Them
US20170174614A1 (en) 2015-12-22 2017-06-22 Zogenix International Limited Metabolism resistant fenfluramine analogs and methods of using the same
GB2548873B (en) 2016-03-31 2020-12-02 Gw Res Ltd Use of Cannabidiol in the Treatment of SturgeWeber Syndrome
GB2551987A (en) 2016-07-01 2018-01-10 Gw Res Ltd Oral cannabinoid formulations
GB2551986A (en) 2016-07-01 2018-01-10 Gw Res Ltd Parenteral formulations
CN109689103A (en) * 2016-08-24 2019-04-26 周格尼克斯国际有限公司 For inhibiting 5-HT2BThe preparation and its application method of the formation of agonist
GB2553139A (en) 2016-08-25 2018-02-28 Gw Res Ltd Use of cannabinoids in the treatment of multiple myeloma
US20180092864A1 (en) * 2016-09-30 2018-04-05 Zogenix International Limited Compositions and methods for treating seizure disorders
MX2019005779A (en) * 2016-11-22 2019-08-22 Ovid Therapeutics Inc Methods of treating developmental disorders and/or seizure disorders with flupirtine.
GB2557921A (en) 2016-12-16 2018-07-04 Gw Res Ltd Use of cannabinoids in the treatment of angelman syndrome
GB2559774B (en) 2017-02-17 2021-09-29 Gw Res Ltd Oral cannabinoid formulations
MX2019012285A (en) 2017-04-13 2020-11-06 Ovid Therapeutics Inc Methods of treating developmental encephalopathies.
CA3062247A1 (en) * 2017-05-09 2018-11-15 Zogenix International Limited Methods of treating doose syndrome using fenfluramine
GB2599884B (en) 2017-08-25 2022-08-31 Stoke Therapeutics Inc Antisense oligomers for treatment of conditions and diseases
WO2019067413A1 (en) * 2017-09-26 2019-04-04 Zogenix International Limited Use of fenfluramine formulation in reducing number and frequencies of convulsive seizures in patient populations
US20190091174A1 (en) * 2017-09-26 2019-03-28 Zogenix International Limited Method of reducing seizure type experienced by a dravet patient
US20190091179A1 (en) * 2017-09-26 2019-03-28 Zogenix International Limited Congnitive function with fenfluramine
US10682317B2 (en) 2017-09-26 2020-06-16 Zogenix International Limited Ketogenic diet compatible fenfluramine formulation
GB201715919D0 (en) 2017-09-29 2017-11-15 Gw Res Ltd use of cannabinoids in the treatment of epilepsy
GB2569961B (en) 2018-01-03 2021-12-22 Gw Res Ltd Pharmaceutical
GB201806953D0 (en) 2018-04-27 2018-06-13 Gw Res Ltd Cannabidiol Preparations
CA3097335A1 (en) * 2018-05-11 2019-11-14 Zogenix International Limited Compositions and methods for treating seizure-induced sudden death
EP3806835A1 (en) 2018-06-14 2021-04-21 Zogenix International Limited Compositions and methods for treating respiratory depression with fenfluramine
US20210113495A1 (en) * 2018-07-10 2021-04-22 Zogenix International Limited Method of treating epilepsy or epileptic encephalopathy with fenfluramine in patients without pulmonary hypertension
AU2019310600A1 (en) * 2018-07-27 2021-02-11 Xenon Pharmaceuticals Inc. Method for treating epilepsy
EP3930841A4 (en) * 2019-02-25 2022-11-30 Zogenix International Limited A formulation for improving seizure control
CN111944835B (en) * 2019-05-14 2022-03-29 南通大学 Construction method and application of mutant GABRG2 transgenic zebra fish epilepsy model
US20220280561A1 (en) * 2019-08-30 2022-09-08 Research Institute At Nationwide Children's Hospital Copper-atsm for treating neurodegenerative disorders associted with mitochondrial dysfunction
KR20220101610A (en) * 2019-09-17 2022-07-19 조게닉스 인터내셔널 리미티드 How to use fenfluramine to treat people with epilepsy
US20210299064A1 (en) 2020-02-05 2021-09-30 Zogenix International Limited Method of treating patients with lennox-gastaut syndrome
GB202002754D0 (en) 2020-02-27 2020-04-15 Gw Res Ltd Methods of treating tuberous sclerosis complex with cannabidiol and everolimus
US20230287410A1 (en) 2020-05-11 2023-09-14 Stoke Therapeutics, Inc. Opa1 antisense oligomers for treatment of conditions and diseases
US11612574B2 (en) 2020-07-17 2023-03-28 Zogenix International Limited Method of treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
US11160757B1 (en) 2020-10-12 2021-11-02 GW Research Limited pH dependent release coated microparticle cannabinoid formulations

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1413078A (en) 1973-07-27 1975-11-05 Beecham Group Ltd Process for the production of plus-norfenfluramine and plus-fenfluramine and salts thereof
GB1413070A (en) 1973-07-27 1975-11-05 Beecham Group Ltd Process for the production of - norfenfluramine and - fenfluramine and salts thereof
US4452815A (en) 1980-06-16 1984-06-05 Massachusetts Institute Of Technology Method of utilizing d,l-fenfluramine for modifying feeding behavior
IT1238686B (en) 1990-02-09 1993-09-01 Lab Mag Spa PROCEDURE FOR THE PREPARATION OF LEVO AND RIGHT FENFLURAMINA
FR2684552B1 (en) 1991-12-06 1995-04-28 Adir USE OF D-FENFLURAMINE AND FENFLURAMINE DERIVATIVES IN THE TREATMENT OF HYPERTENSION IN INSULIN RESISTANT SUBJECTS.
US5985880A (en) 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
US5834477A (en) 1993-12-08 1998-11-10 The United States Of America As Represented By The Secretary Of The Army Opiate analgesic formulation with improved safety
AU2002324579B2 (en) 2001-07-31 2007-11-15 Wyeth Sucralose formulations to mask unpleasant tastes
US6599901B1 (en) 2001-11-19 2003-07-29 Hoffman-La Roche Inc. Pyridone substituted benzothiazole derivatives
US7101572B2 (en) 2001-12-07 2006-09-05 Unilab Pharmatech, Ltd. Taste masked aqueous liquid pharmaceutical composition
MX2007014713A (en) 2005-05-25 2008-02-14 Janssen Pharmaceutica Nv Pediatric formulation of topiramate.
GB0515090D0 (en) 2005-07-22 2005-08-31 Birmingham Res & Dev Ltd Novel epilepsy treatment
EP1937255A4 (en) 2005-09-14 2013-06-26 Univ Witwatersrand Jhb Pharmaceutical composition
EP2061471A4 (en) 2006-08-31 2012-02-01 Univ Alberta Method of inhibition of respiratory depression using positive allosteric ampa receptor modulators
WO2009082039A1 (en) 2007-12-26 2009-07-02 Eisai R & D Management Co., Ltd. Ampa receptor antagonists for epilepsy, mental disorders or deficits in sensory organ
EP2240022B1 (en) 2008-01-09 2016-12-28 Charleston Laboratories, Inc. Bilayered tablets comprising oxycodone and promethazine
BRPI0919796A2 (en) 2008-10-09 2015-12-15 Acraf sugar free liquid pharmaceutical formulation, and pharmaceutically acceptable sugar free liquid excipient
CA2758774C (en) 2009-04-15 2015-02-03 Research Triangle Institute Monoamine reuptake inhibitors
US9453027B2 (en) 2009-07-27 2016-09-27 Daljit Singh Dhanoa Deuterium-enriched pyridinonecarboxamides and derivatives
TW201127375A (en) 2010-01-08 2011-08-16 Eurand Inc Taste masked topiramate composition and an orally disintegrating tablet comprising the same
WO2012015712A1 (en) 2010-07-30 2012-02-02 Schering Corporation Inhibition of cyp3a drug metabolism
US20120270848A1 (en) 2010-10-22 2012-10-25 Galleon Pharmaceuticals, Inc. Novel Compositions and Therapeutic Methods Using Same
MX2013003832A (en) 2010-10-26 2013-10-01 Alpharma Pharmaceuticals Llc Formulations and methods for attenuating respiratory depression induced by opioid overdose.
GB2487712B (en) 2011-01-04 2015-10-28 Otsuka Pharma Co Ltd Use of the phytocannabinoid cannabidiol (CBD) in combination with a standard anti-epileptic drug (SAED) in the treatment of epilepsy
SG11201503505QA (en) 2012-11-15 2015-06-29 Galleon Pharmaceuticals Inc Novel orally bioavailable breathing control modulating compounds, and methods of using same
US9549909B2 (en) 2013-05-03 2017-01-24 The Katholieke Universiteit Leuven Method for the treatment of dravet syndrome
HUE053282T2 (en) 2013-08-19 2021-06-28 Univ California Compounds and methods for treating an epileptic disorder
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
GB2530001B (en) 2014-06-17 2019-01-16 Gw Pharma Ltd Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy
EA201992474A3 (en) 2015-02-25 2020-05-31 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорниа 5HT AGONISTS FOR TREATMENT OF DISORDERS
KR102207539B1 (en) 2015-06-30 2021-01-26 네우라드 리미티드 Novel respiratory control modulating compounds, and methods of making and using the same
ES2925951T3 (en) 2015-07-22 2022-10-20 John Hsu Composition comprising a therapeutic agent and a respiratory stimulant and methods for its use
KR102615486B1 (en) 2015-08-24 2023-12-19 조게닉스 인터내셔널 리미티드 Methods of treating lennox-gastaut syndrome using fenfluramine
US20170071949A1 (en) 2015-09-14 2017-03-16 Zogenix International Limited Combination treatment of specific forms of epilepsy
ES2861774T3 (en) 2015-12-22 2021-10-06 Zogenix International Ltd Fenfluramine Compositions and Procedures for Making Them
CN109689103A (en) 2016-08-24 2019-04-26 周格尼克斯国际有限公司 For inhibiting 5-HT2BThe preparation and its application method of the formation of agonist
US20180092864A1 (en) 2016-09-30 2018-04-05 Zogenix International Limited Compositions and methods for treating seizure disorders
CA3062247A1 (en) 2017-05-09 2018-11-15 Zogenix International Limited Methods of treating doose syndrome using fenfluramine

Also Published As

Publication number Publication date
US20170151213A1 (en) 2017-06-01
PL3329909T3 (en) 2021-10-11
JP2020063309A (en) 2020-04-23
EP3329909A1 (en) 2018-06-06
US20170151257A1 (en) 2017-06-01
US20200030341A1 (en) 2020-01-30
EP2991637A1 (en) 2016-03-09
US10478441B2 (en) 2019-11-19
SI3329909T1 (en) 2021-08-31
HUE054577T2 (en) 2021-09-28
NO3092234T3 (en) 2018-07-14
US9603814B2 (en) 2017-03-28
CA2909335A1 (en) 2014-11-06
DK2991637T3 (en) 2018-05-07
US20220160727A1 (en) 2022-05-26
US9549909B2 (en) 2017-01-24
AU2019203448B2 (en) 2020-08-06
WO2014177676A1 (en) 2014-11-06
PL2991637T3 (en) 2018-07-31
US20140343044A1 (en) 2014-11-20
BR112015027282A8 (en) 2019-12-24
US9610260B2 (en) 2017-04-04
AU2019203832A1 (en) 2019-06-20
US9603815B2 (en) 2017-03-28
AU2020267264A1 (en) 2020-12-17
CA2909335C (en) 2021-05-18
HRP20210819T1 (en) 2021-08-20
EP2991637B1 (en) 2018-03-07
US20160136114A1 (en) 2016-05-19
JP2016518387A (en) 2016-06-23
AU2019203448A1 (en) 2019-06-06
US20170151194A1 (en) 2017-06-01
PT2991637T (en) 2018-04-24
EP3329909B1 (en) 2021-03-17
US20210121479A1 (en) 2021-04-29
US20140343161A1 (en) 2014-11-20
US10478442B2 (en) 2019-11-19
BR112015027282A2 (en) 2017-07-25
US20170151214A1 (en) 2017-06-01
JP6966584B2 (en) 2021-11-17
ES2666657T3 (en) 2018-05-07
US20170151259A1 (en) 2017-06-01
AU2019203832B2 (en) 2020-10-15
JP6441313B2 (en) 2018-12-19
JP6655156B2 (en) 2020-02-26
AU2014261329A1 (en) 2015-11-05
US20140329908A1 (en) 2014-11-06
LT3329909T (en) 2021-07-12
AU2014261329B2 (en) 2019-02-21
CY1124298T1 (en) 2022-07-22
ES2863929T3 (en) 2021-10-13
DK3329909T3 (en) 2021-04-19
JP2019048862A (en) 2019-03-28
US20140343162A1 (en) 2014-11-20

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