PL3190177T3 - Bioaktywne komórki nerkowe - Google Patents
Bioaktywne komórki nerkoweInfo
- Publication number
- PL3190177T3 PL3190177T3 PL16196757T PL16196757T PL3190177T3 PL 3190177 T3 PL3190177 T3 PL 3190177T3 PL 16196757 T PL16196757 T PL 16196757T PL 16196757 T PL16196757 T PL 16196757T PL 3190177 T3 PL3190177 T3 PL 3190177T3
- Authority
- PL
- Poland
- Prior art keywords
- kidney cells
- bioactive kidney
- bioactive
- cells
- kidney
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0686—Kidney cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33403210P | 2010-05-12 | 2010-05-12 | |
| US35389510P | 2010-06-11 | 2010-06-11 | |
| US37207710P | 2010-08-09 | 2010-08-09 | |
| US37188810P | 2010-08-09 | 2010-08-09 | |
| US37658610P | 2010-08-24 | 2010-08-24 | |
| US38876510P | 2010-10-01 | 2010-10-01 | |
| US41293310P | 2010-11-12 | 2010-11-12 | |
| US41338210P | 2010-11-12 | 2010-11-12 | |
| US201161441423P | 2011-02-10 | 2011-02-10 | |
| US201161473111P | 2011-04-07 | 2011-04-07 | |
| PCT/US2011/036347 WO2011143499A1 (en) | 2010-05-12 | 2011-05-12 | Bioactive renal cells |
| EP16196757.5A EP3190177B8 (en) | 2010-05-12 | 2011-05-12 | Bioactive renal cells |
| EP11722663.9A EP2569418B1 (en) | 2010-05-12 | 2011-05-12 | Bioactive renal cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3190177T3 true PL3190177T3 (pl) | 2022-06-06 |
Family
ID=44121234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16196757T PL3190177T3 (pl) | 2010-05-12 | 2011-05-12 | Bioaktywne komórki nerkowe |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10077442B2 (https=) |
| EP (3) | EP3190177B8 (https=) |
| JP (6) | JP5974215B2 (https=) |
| KR (5) | KR102539589B1 (https=) |
| CN (2) | CN103154236B (https=) |
| AU (5) | AU2011252915B2 (https=) |
| CA (1) | CA2798900C (https=) |
| DK (1) | DK3190177T3 (https=) |
| ES (1) | ES2906750T3 (https=) |
| HU (1) | HUE058155T2 (https=) |
| NZ (1) | NZ603482A (https=) |
| PL (1) | PL3190177T3 (https=) |
| TW (6) | TWI762890B (https=) |
| WO (1) | WO2011143499A1 (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030376A1 (it) | 2003-07-31 | 2005-02-01 | Univ Roma | Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia. |
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US20090104649A1 (en) | 2007-06-11 | 2009-04-23 | Garovic Vesna D | Markers for preeclampsia |
| US20130034861A1 (en) | 2009-12-21 | 2013-02-07 | Mayo Foundation For Medical Education And Research | Early marker of proteinuria in patients treated with an anti-vegf treatment |
| US9845457B2 (en) | 2010-04-30 | 2017-12-19 | Cedars-Sinai Medical Center | Maintenance of genomic stability in cultured stem cells |
| US9249392B2 (en) | 2010-04-30 | 2016-02-02 | Cedars-Sinai Medical Center | Methods and compositions for maintaining genomic stability in cultured stem cells |
| TWI762890B (zh) | 2010-05-12 | 2022-05-01 | 開曼群島商英瑞金公司 | 生物活性腎細胞 |
| CA3065694A1 (en) | 2010-11-10 | 2012-05-18 | Inregen | Methods of forming injectable formulations for providing regenerative effects to an organ such as a kidney |
| WO2013170146A1 (en) | 2012-05-10 | 2013-11-14 | Uab Research Foundation | Methods and compositions for modulating mir-204 activity |
| WO2013184527A1 (en) | 2012-06-05 | 2013-12-12 | Capricor, Inc. | Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy |
| AU2013302799B2 (en) | 2012-08-13 | 2018-03-01 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| RU2702721C2 (ru) * | 2012-10-24 | 2019-10-09 | инРиджен | Популяции клеток почек и их применение |
| EP4299721A3 (en) * | 2013-05-08 | 2024-04-24 | ProKidney | Organoids comprising isolated renal cells and uses thereof |
| US20170003299A1 (en) * | 2013-11-27 | 2017-01-05 | Mayo Foundation For Medical Education And Research | Detecting podocyte injury in diabetic nephropathy and glomerulonephritis |
| CN109207580B (zh) | 2014-03-12 | 2022-03-11 | 西奈山伊坎医学院 | 鉴定处于慢性损伤风险的肾异体移植物接受者的方法 |
| US10308985B2 (en) | 2014-06-26 | 2019-06-04 | Icahn School Of Medicine At Mount Sinai | Methods for diagnosing risk of renal allograft fibrosis and rejection |
| WO2015200887A2 (en) | 2014-06-26 | 2015-12-30 | Icahn School Of Medicine At Mount Sinai | Method for diagnosing subclinical and clinical acute rejection by analysis of predictive gene sets |
| CN107641614B (zh) * | 2014-06-30 | 2020-11-20 | 中国人民解放军军事医学科学院野战输血研究所 | 微囊泡在诱导干细胞巨核分化中的用途 |
| CA2962444C (en) | 2014-10-03 | 2023-09-05 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy |
| WO2017058938A1 (en) | 2015-09-29 | 2017-04-06 | Research Institute At Nationwide Children's Hospital | Methods for detecting hepatic fibrosis and responsiveness to therapy |
| EP3402543B1 (en) | 2016-01-11 | 2021-09-08 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| KR102467150B1 (ko) | 2016-05-06 | 2022-11-14 | 유니사이트 이브이 에이지 | 고혈당으로 인해 유발되는 섬유성 질환의 치료에 사용하기 위한 miRNA를 함유하는 약제학적 담체 |
| WO2017210652A1 (en) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Cdc-derived exosomes for treatment of ventricular tachyarrythmias |
| US11123372B2 (en) | 2016-07-29 | 2021-09-21 | Prokidney | Bioactive renal cells for the treatment of chronic kidney disease |
| US11541078B2 (en) | 2016-09-20 | 2023-01-03 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders |
| KR101725025B1 (ko) * | 2016-11-25 | 2017-04-10 | 서울대학교산학협력단 | 무형성골질환 진단용 miRNA 마커 |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| EP4699658A2 (en) | 2017-04-19 | 2026-02-25 | Cedars-Sinai Medical Center | Methods and compositions for treating skeletal muscular dystrophy |
| CN107236799B (zh) * | 2017-06-15 | 2020-06-09 | 昆明医科大学第六附属医院 | 一种肾纤维化miRNA标记物 |
| CA3067558A1 (en) | 2017-06-16 | 2018-12-20 | Avery Therapeutics, Inc. | Three dimensional tissue compositions and methods of use |
| BR112019027086A2 (pt) * | 2017-06-21 | 2020-07-07 | Timothy A. Bertram | células renais bioativas imunoprivilegiadas para o tratamento de doença renal |
| US11395832B2 (en) * | 2017-12-14 | 2022-07-26 | Unicyte Ev Ag | Pharmaceutical carriers containing miRNAs for use in the treatment of renal cancer |
| US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| US12146137B2 (en) | 2018-02-05 | 2024-11-19 | Cedars-Sinai Medical Center | Methods for therapeutic use of exosomes and Y-RNAS |
| ES3037279T3 (en) | 2018-04-16 | 2025-09-30 | Icahn School Med Mount Sinai | Method and kits for prediction of acute rejection and renal allograft loss using pre-transplant transcriptomic signatures in recipient blood |
| TWI698640B (zh) * | 2018-04-23 | 2020-07-11 | 長庚醫療財團法人高雄長庚紀念醫院 | 用於檢測狼瘡性腎炎或評估狼瘡性腎炎風險的方法及其應用 |
| EP3843760A4 (en) * | 2018-08-31 | 2022-11-09 | Timothy Bertram | COMPOSITIONS WITH CELL-DERIVED VESICLES AND THEIR USES |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US20210393853A1 (en) * | 2018-10-29 | 2021-12-23 | Avery Therapeutics, Inc. | Compositions and methods for cryopreservation and reconstitution of engineered tissues |
| CN111733234A (zh) * | 2019-03-25 | 2020-10-02 | 深圳大学 | 一种食管癌分子标志物及其应用 |
| KR20220042117A (ko) * | 2019-08-09 | 2022-04-04 | 우베 고산 가부시키가이샤 | 엑소좀의 생성 방법 |
| EP4015635A4 (en) * | 2019-08-16 | 2023-10-25 | Public University Corporation Nagoya City University | Colorectal cancer diagnostic marker, method for assisting diagnosis of colorectal cancer, method for collecting data for diagnosis of colorectal cancer, colorectal cancer diagnostic kit, therapeutic agent for colorectal cancer, method for treating colorectal cancer, and method for diagnosing colorectal cancer |
| CN110734972B (zh) * | 2019-11-28 | 2023-06-16 | 河北仁博科技有限公司 | miR-181c-3p作为肾纤维化标志物的应用 |
| WO2021177387A1 (ja) * | 2020-03-04 | 2021-09-10 | 株式会社メトセラ | エリスロポエチン産生能が亢進された線維芽細胞 |
| US20230212492A1 (en) * | 2020-06-08 | 2023-07-06 | National University Corporation Tokyo Medical And Dental University | Cell culture method |
| CN112263587B (zh) * | 2020-10-23 | 2022-08-30 | 河北仁博科技有限公司 | miR-3065-5p在制备预防和/或治疗肾纤维化的药物中的应用 |
| CN112760376B (zh) * | 2020-12-30 | 2021-12-07 | 陈晓熠 | miRNA-3918在非小细胞肺癌检测中的应用 |
| WO2023107698A1 (en) * | 2021-12-09 | 2023-06-15 | Encellin, Inc. | Methods and devices for pre-vascularization of implantation sites and/or cell encapsulation devices |
| CN115976211A (zh) * | 2022-12-09 | 2023-04-18 | 深圳市科芮达健康科技有限公司 | 血液microRNA作为尿路上皮癌筛查或诊断标志物的用途、检测引物和试剂盒 |
| CN116240161B (zh) * | 2023-02-27 | 2024-05-10 | 四川大学华西医院 | 具有肾脏损伤修复作用的细胞外囊泡制备方法及应用 |
| CN117853729B (zh) * | 2024-01-10 | 2025-09-30 | 清华大学深圳国际研究生院 | 一种基于深度学习的多切面层次肾小球识别和匹配方法 |
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