PH24502A - Indene analogs of mevalonolactone and derivatives thereof - Google Patents

Indene analogs of mevalonolactone and derivatives thereof

Info

Publication number
PH24502A
PH24502A PH33123A PH33123A PH24502A PH 24502 A PH24502 A PH 24502A PH 33123 A PH33123 A PH 33123A PH 33123 A PH33123 A PH 33123A PH 24502 A PH24502 A PH 24502A
Authority
PH
Philippines
Prior art keywords
6alkyl
hydrogen
3alkyl
benzyloxy
phenoxy
Prior art date
Application number
PH33123A
Other languages
English (en)
Inventor
Faizulla G Kathawala
Sompong Wattanasin
Original Assignee
Sandoz Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Pharmaceuticals Corp filed Critical Sandoz Pharmaceuticals Corp
Publication of PH24502A publication Critical patent/PH24502A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2632—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/24—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/57—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
PH33123A 1984-12-04 1985-12-03 Indene analogs of mevalonolactone and derivatives thereof PH24502A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67791784A 1984-12-04 1984-12-04

Publications (1)

Publication Number Publication Date
PH24502A true PH24502A (en) 1990-07-18

Family

ID=24720627

Family Applications (1)

Application Number Title Priority Date Filing Date
PH33123A PH24502A (en) 1984-12-04 1985-12-03 Indene analogs of mevalonolactone and derivatives thereof

Country Status (19)

Country Link
EP (1) EP0216785B1 (el)
JP (1) JPS62501009A (el)
KR (1) KR910003427B1 (el)
AT (1) ATE60571T1 (el)
AU (1) AU599580B2 (el)
DE (1) DE3581638D1 (el)
DK (1) DK369086A (el)
ES (1) ES8800888A1 (el)
FI (1) FI863121A0 (el)
GR (1) GR852895B (el)
HU (1) HU198005B (el)
IL (1) IL77199A (el)
MY (1) MY100972A (el)
NZ (1) NZ214402A (el)
PH (1) PH24502A (el)
PL (1) PL147645B1 (el)
PT (1) PT81603B (el)
WO (1) WO1986003488A1 (el)
ZA (1) ZA859303B (el)

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US4904691A (en) * 1987-12-21 1990-02-27 Rorer Pharmaceutical Corporation Novel HMG-CoA reductase inhibitors
US4822799A (en) * 1988-01-27 1989-04-18 Sandoz Pharm. Corp. Pyrazolopyridine analogs of mevalonolactone and derivatives thereof useful for inhibiting cholesterol biosynthesis in mammals
US4876280A (en) * 1988-03-10 1989-10-24 Sandoz Pharm. Corp. Arylcyclohexane and arylcyclohexene analogs of mevalonolactone derivatives and their use
US5506219A (en) * 1988-08-29 1996-04-09 E. R. Squibb & Sons, Inc. Pyridine anchors for HMG-CoA reductase inhibitors
EP0562643A3 (en) * 1988-10-13 1994-05-18 Sandoz Ag 7-substituted-hept-6-enoic and -heptanoic acids and derivatives thereof
FR2642065B1 (fr) * 1989-01-24 1991-05-24 Lipha Derives d'acides benzocycloalcenyl dihydroxy alcanoiques, procede de preparation et medicaments les contenant
US5025017A (en) * 1989-09-28 1991-06-18 E. R. Squibb & Sons, Inc. Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates
US5189180A (en) * 1989-09-28 1993-02-23 E. R. Squibb & Sons, Inc. Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates
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US5256692A (en) * 1992-01-07 1993-10-26 E. R. Squibb & Sons, Inc. Sulfur-containing HMG-COA reductase inhibitors
US20010006644A1 (en) 1997-07-31 2001-07-05 David J. Bova Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
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JP2022509965A (ja) 2018-12-03 2022-01-25 ハー・ルンドベック・アクチエゼルスカベット ４－（（１Ｒ，３Ｓ）－６－クロロ－３－フェニル－２，３－ジヒドロ－１Ｈ－インデン－１－イル）－１，２，２－トリメチルピペラジン及び４－（（１Ｒ，３Ｓ）－６－クロロ－３－（フェニル－ｄ５）－２，３－ジヒドロ－１Ｈ－インデン－１－イル）－２，２－ジメチル－１－（メチル－ｄ３）ピペラジンのプロドラッグ

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Also Published As

Publication number Publication date
PT81603B (pt) 1988-04-21
JPS62501009A (ja) 1987-04-23
DE3581638D1 (de) 1991-03-07
EP0216785B1 (en) 1991-01-30
NZ214402A (en) 1989-01-27
DK369086D0 (da) 1986-08-01
IL77199A (en) 1990-02-09
PL256608A1 (en) 1988-01-07
GR852895B (el) 1986-04-01
DK369086A (da) 1986-08-01
ATE60571T1 (de) 1991-02-15
WO1986003488A1 (en) 1986-06-19
EP0216785A1 (en) 1987-04-08
HU198005B (en) 1989-07-28
AU5230686A (en) 1986-07-01
HUT40398A (en) 1986-12-28
ES549546A0 (es) 1987-12-01
KR870700063A (ko) 1987-02-28
ZA859303B (en) 1987-07-29
FI863121A (fi) 1986-07-30
AU599580B2 (en) 1990-07-26
KR910003427B1 (ko) 1991-05-31
FI863121A0 (fi) 1986-07-30
PL147645B1 (en) 1989-07-31
MY100972A (en) 1991-06-15
PT81603A (en) 1986-01-01
ES8800888A1 (es) 1987-12-01

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