PE24052014A1 - Oxyntomodulin variants long acting and production methods thereof - Google Patents

Oxyntomodulin variants long acting and production methods thereof

Info

Publication number
PE24052014A1
PE24052014A1 PE2014001683A PE0016832014A PE24052014A1 PE 24052014 A1 PE24052014 A1 PE 24052014A1 PE 2014001683 A PE2014001683 A PE 2014001683A PE 0016832014 A PE0016832014 A PE 0016832014A PE 24052014 A1 PE24052014 A1 PE 24052014A1
Authority
PE
Peru
Prior art keywords
production methods
long acting
oxyntomodulin
variants
oxyntomodulin variants
Prior art date
Application number
PE2014001683A
Other languages
Spanish (es)
Inventor
Udil Eyal Fima
Oren Hershkovitz
Original Assignee
Opko Biolog Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201261635483P priority Critical
Application filed by Opko Biolog Ltd filed Critical Opko Biolog Ltd
Publication of PE24052014A1 publication Critical patent/PE24052014A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/24Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/59Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Abstract

SE REFIERE A UN AGONISTA DEL RECEPTOR DE GLP-1/GLUCAGON DUAL MODIFICADO CON PEPTIDO CARBOXI TERMINAL (CTP) DE GONADOTROFINA CORIONICA. Concerns a receptor agonist GLP-1 / glucagon DUAL MODIFIED carboxy terminal peptide (CTP) of chorionic gonadotrophin. DICHO POLIPEPTIDO ES UTIL EN EL TRATAMIENTO DE LA DIABETES TIPO II. Said polypeptide is useful in the treatment of type II diabetes.
PE2014001683A 2012-04-19 2013-04-17 Oxyntomodulin variants long acting and production methods thereof PE24052014A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US201261635483P true 2012-04-19 2012-04-19

Publications (1)

Publication Number Publication Date
PE24052014A1 true PE24052014A1 (en) 2015-01-25

Family

ID=49383021

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014001683A PE24052014A1 (en) 2012-04-19 2013-04-17 Oxyntomodulin variants long acting and production methods thereof

Country Status (18)

Country Link
US (2) US9522945B2 (en)
EP (1) EP2838552A4 (en)
JP (1) JP2015520128A (en)
KR (1) KR20150008137A (en)
CN (1) CN104487082A (en)
AU (1) AU2013250711A1 (en)
BR (1) BR112014025951A2 (en)
CA (1) CA2870650A1 (en)
CL (1) CL2014002791A1 (en)
CO (1) CO7200249A2 (en)
EA (1) EA201491898A1 (en)
HK (1) HK1207564A1 (en)
IL (1) IL235184D0 (en)
MX (1) MX2014012625A (en)
MY (1) MY167814A (en)
PE (1) PE24052014A1 (en)
SG (1) SG11201406671RA (en)
WO (1) WO2013157002A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10221228B2 (en) 2006-02-03 2019-03-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US10166295B2 (en) 2011-06-02 2019-01-01 Opko Biologics Ltd. Pegylated OXM variants
BR112013031794A2 (en) 2011-06-10 2016-12-20 Hanmi Science Co Ltd oxytomodulin derivatives and pharmaceutical composition for the treatment of obesity comprising the same
EP2721062B1 (en) 2011-06-17 2018-11-14 Hanmi Science Co., Ltd. A conjugate comprising oxyntomodulin and an immunoglobulin fragment, and use thereof
AU2013250711A1 (en) 2012-04-19 2014-11-27 Opko Biologics Ltd. Long-acting oxyntomodulin variants and methods of producing same
SG10201702228QA (en) 2012-06-04 2017-04-27 Opko Biolog Ltd Pegylated oxm variants
KR101968344B1 (en) 2012-07-25 2019-04-12 한미약품 주식회사 A composition for treating hyperlipidemia comprising oxyntomodulin analog
TW201919585A (en) 2012-11-06 2019-06-01 南韓商韓美藥品股份有限公司 Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment
SG11201503879QA (en) * 2012-11-20 2015-06-29 Opko Biolog Ltd Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides
TW201625303A (en) 2014-09-16 2016-07-16 Hanmi Pharm Ind Co Ltd Long glp-1 / glucagon receptor agonist treatment of bis nonalcoholic fat liver diseases
US20160122713A1 (en) * 2014-10-14 2016-05-05 Medgenics Medical Israel Ltd. Genetically-modified micro-organ secreting a therapeutic peptide and methods of use thereof

Family Cites Families (128)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (en) 1970-11-10 1977-09-15 Organon Nv Method for the detection and determination of laagmoleculire compounds and of proteins that can specifically bind these compounds, as well as the test pack.
NL154599B (en) 1970-12-28 1977-09-15 Organon Nv Method for the detection and determination of specific binding proteins and their corresponding bindable substances, as well as the test pack.
NL154600B (en) 1971-02-10 1977-09-15 Organon Nv Method for the detection and determination of specific binding proteins and their corresponding bindable substances.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (en) 1972-05-11 1983-06-01 Akzo Nv Method for the detection and determination of haptens, as well as test packs.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
JPS5781447A (en) 1980-11-11 1982-05-21 Toyo Jozo Co Ltd Human chorionic gonadotropic hormone c-terminal fragment
US4853332A (en) 1982-10-19 1989-08-01 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of biologically active proteins
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
DE3421468A1 (en) 1984-06-08 1985-12-19 Rentschler Arzneimittel Lipid Nano pellets as traegersystem for drug for oral application
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4911691A (en) 1984-09-21 1990-03-27 Menlo Care, Inc. Assembly for adminstering IV solution
US4683202B1 (en) 1985-03-28 1990-11-27 Cetus Corp
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
DE122007000007I2 (en) 1986-04-09 2010-12-30 Genzyme Corp Genetically transformed animals that secrete a desired protein in milk
US5118666A (en) 1986-05-05 1992-06-02 The General Hospital Corporation Insulinotropic hormone
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
DE68917883T2 (en) 1988-05-06 1995-02-23 Toray Industries Stable interferon-beta composition.
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US6737515B2 (en) 1993-11-19 2004-05-18 Washington University Follicle stimulating hormone-glycosylation analogs
BR9506313A (en) 1994-08-12 1997-08-05 Univ Washington single-chain forms of the glycoprotein hormone quartet
US5792460A (en) * 1989-02-21 1998-08-11 Washington University Modified glycoprotein hormones having a CTP at the amino terminus
DE69029799D1 (en) 1989-02-21 1997-03-06 Univ Washington Modified forms of reproductive hormones
US6238890B1 (en) 1994-02-18 2001-05-29 Washington University Single chain forms of the glycoprotein hormone quartet
US5338835A (en) 1989-02-21 1994-08-16 Washington University CTP-extended form of FSH
US5705478A (en) 1989-02-21 1998-01-06 Washington University Covalently linked β subunits of the glycoprotein hormones as antagonists
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US7217689B1 (en) 1989-10-13 2007-05-15 Amgen Inc. Glycosylation analogs of erythropoietin
US5126324A (en) 1990-06-07 1992-06-30 Genentech, Inc. Method of enhancing growth in patients using combination therapy
US6028177A (en) 1991-10-04 2000-02-22 Washington University Methods of detecting single-chain forms of the glycoprotein hormone quartet
US6225449B1 (en) 1991-10-04 2001-05-01 Washington University Hormone analogs with multiple CTP extensions
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
ES2141229T3 (en) 1993-04-20 2000-03-16 Univ Washington protein pharmaceuticals and modified peptides.
US5919455A (en) 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5935924A (en) 1994-04-15 1999-08-10 Genentech, Inc. Treatment of congestive heart failure
US5541110A (en) 1994-05-17 1996-07-30 Bristol-Myers Squibb Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica
US5605976A (en) 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
US20050032211A1 (en) 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
IL122732D0 (en) 1997-01-15 1998-08-16 Akzo Nobel Nv Liquid gonadotropin-containing formulation its preparation and a device containing same
US6310183B1 (en) 1997-09-10 2001-10-30 Novo Nordisk A/S Coagulation factor VIIa composition
US6103501A (en) 1997-11-17 2000-08-15 Washington University Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
ES2265693T3 (en) 1998-10-16 2007-02-16 Biogen Idec Ma Inc. Fusion proteins with interferon-beta and uses.
US6514729B1 (en) 1999-05-12 2003-02-04 Xencor, Inc. Recombinant interferon-beta muteins
JO2291B1 (en) 1999-07-02 2005-09-12 اف . هوفمان لاروش ايه جي Erythopintin derivatives
US20030036181A1 (en) 2000-06-30 2003-02-20 Okkels Jens Sigurd Peptide extended glycosylated polypeptides
WO2001056579A1 (en) 2000-02-04 2001-08-09 Esperion Therapeutics Inc. Methods for treating alzheimer's disease
US20020127652A1 (en) 2000-02-11 2002-09-12 Schambye Hans Thalsgard Follicle stimulating hormones
US7094566B2 (en) 2000-03-16 2006-08-22 Amgen Inc., IL-17 receptor like molecules and uses thereof
US7118737B2 (en) 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
EP1353701B1 (en) 2000-10-31 2011-12-21 PR Pharmaceuticals, Inc. Methods for producing compositions for enhanced delivery of bioactive molecules
BR0115257A (en) 2000-11-10 2003-08-12 Proteopharma Aps Analogs of apolipoprotein
US7090869B2 (en) 2000-12-01 2006-08-15 Takeda Pharmaceutical Company Limited Method for producing preparation containing bioactive substance
KR100942864B1 (en) 2000-12-07 2010-02-17 일라이 릴리 앤드 캄파니 GLP-1 Fusion Proteins
KR101229995B1 (en) 2000-12-11 2013-02-06 씨제이 주식회사 Fusion protein having the enhanced in vivo activity of erythropoietin
DE60117919T2 (en) 2000-12-11 2006-12-14 Cheil Jedang Corp. Fusion protein with improved in vivo erythropoietinwirkung
CA2433037C (en) 2000-12-28 2010-12-21 Takeda Chemical Industries, Ltd. Sustained-release preparation
US6987172B2 (en) 2001-03-05 2006-01-17 Washington University In St. Louis Multifunctional single chain glycoprotein hormones comprising three or more β subunits
US6887462B2 (en) 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
JP2004529147A (en) 2001-04-25 2004-09-24 アセヴェド,ハーナン,エフ.Acevedo,Hernan,F. hCG prescription
US20070298041A1 (en) 2002-06-28 2007-12-27 Tomlinson Ian M Ligands That Enhance Endogenous Compounds
US6824769B2 (en) 2001-08-28 2004-11-30 Vertex Pharmaceuticals Incorporated Optimal compositions and methods thereof for treating HCV infections
GB0121709D0 (en) 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
AU2004236174B2 (en) 2001-10-10 2011-06-02 Novo Nordisk A/S Glycopegylation methods and proteins/peptides produced by the methods
CA2756610C (en) 2001-10-29 2015-08-25 Crucell Holland B.V. Methods for producing proteins having n-linked glycans comprising (sialyl-) lewis x or lacdinac structures
KR100467751B1 (en) 2001-12-03 2005-01-24 씨제이 주식회사 Fusion protein having the enhanced in vivo erythropoietin activity
EP1463751B1 (en) 2001-12-21 2013-05-22 Human Genome Sciences, Inc. Albumin fusion proteins
US7081446B2 (en) 2002-01-31 2006-07-25 The Trustees Of Columbia University In The City Of New York Long-acting follicle stimulating hormone analogues and uses thereof
US7173113B2 (en) 2002-01-31 2007-02-06 The Trustees Of Columbia University In The City Of New York Long-acting hormone and growth factor compositions and uses thereof
GB0206048D0 (en) 2002-03-14 2002-04-24 Croda Int Plc Use
CA2485365A1 (en) 2002-05-13 2003-11-20 Modigenetech Ltd. Ctp-extended erythropoietin
RU2401842C2 (en) 2004-10-08 2010-10-20 Домантис Лимитед Antagonists and method of using said antagonists
PL374914A1 (en) 2002-07-17 2005-11-14 Biogen Idec Ma Inc. Therapies for renal failure using interferon-beta
US7459435B2 (en) 2002-08-29 2008-12-02 Hoffmann-La Roche Inc. Treatment of disturbances of iron distribution
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US7459436B2 (en) 2002-11-22 2008-12-02 Hoffmann-La Roche Inc. Treatment of disturbances of iron distribution
WO2004073749A1 (en) 2003-02-19 2004-09-02 Takeda Pharmaceutical Company Limited Dispersant for sustained release preparations
EP1620118B1 (en) 2003-04-08 2014-06-18 Yeda Research And Development Co., Ltd. Reversible pegylated drugs
WO2005035761A1 (en) * 2003-10-16 2005-04-21 Compugen Ltd. Splice variants of preproglucagon, glucagon-like peptide-1 and oxyntomodulin
US7649084B2 (en) 2003-11-12 2010-01-19 University Of Georgia Research Foundation, Inc. Recombinant glycoproteins related to feline thyrotropin
DK1696947T3 (en) 2003-12-19 2014-03-17 Hoffmann La Roche Application of erythropoietin in the treatment of disorders of the iron distribution in chronic inflammatory intestinal diseases
EP1755652B1 (en) 2004-03-19 2010-11-24 Baxter International Inc. Factor ixa for the treatment of bleeding disorders
RU2396347C2 (en) 2004-08-17 2010-08-10 Ксл Бехринг Гмбх Modified vitamin k dependent polypeptides
US7563612B2 (en) 2004-09-27 2009-07-21 Cornell Research Foundation, Inc. Recombinant bifunctional protein of human lutropin receptor and human chorionic gonadotropin B-subunit and uses thereof
EP1728798A1 (en) 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
EP2351776A1 (en) 2005-06-13 2011-08-03 Imperial Innovations Limited Oxyntomodulin analogues and their effects on feeding behaviour
WO2007047834A2 (en) 2005-10-18 2007-04-26 Biocon Limited Oral peptide conjugates for metabolic diseases
GB0521621D0 (en) 2005-10-24 2005-11-30 Domantis Ltd Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases
US20150038413A1 (en) 2006-02-03 2015-02-05 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8476234B2 (en) 2006-02-03 2013-07-02 Prolor Biotech Inc. Long-acting coagulation factors and methods of producing same
US20140113860A1 (en) 2006-02-03 2014-04-24 Prolor Biotech Ltd. Long-acting polypeptides and methods of producing and administering same
US8304386B2 (en) 2006-02-03 2012-11-06 Prolor Biotech, Inc. Long-acting growth hormone and methods of producing same
WO2007092252A2 (en) 2006-02-03 2007-08-16 Modigene Inc Long-acting polypeptides and methods of producing same
US8048849B2 (en) 2006-02-03 2011-11-01 Modigene, Inc. Long-acting polypeptides and methods of producing same
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
US8048848B2 (en) 2006-02-03 2011-11-01 Prolor Biotech Ltd. Long-acting interferons and derivatives thereof and methods thereof
US9663778B2 (en) 2009-07-09 2017-05-30 OPKO Biologies Ltd. Long-acting coagulation factors and methods of producing same
US8946155B2 (en) 2006-02-03 2015-02-03 Opko Biologics Ltd. Long-acting polypeptides and methods of producing and administering same
US8759292B2 (en) 2006-02-03 2014-06-24 Prolor Biotech, Llc Long-acting coagulation factors and methods of producing same
US9458444B2 (en) 2006-02-03 2016-10-04 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US10351615B2 (en) 2006-02-03 2019-07-16 Opko Biologics Ltd. Methods of treatment with long-acting growth hormone
US8450269B2 (en) 2006-02-03 2013-05-28 Prolor Biotech Ltd. Long-acting growth hormone and methods of producing same
US7928058B2 (en) 2006-02-22 2011-04-19 Merck Sharp & Dohme Corp. Pharmaceutical composition comprising oxyntomodulin derivatives and a method for reducing body weight using the composition
TW200806317A (en) 2006-03-20 2008-02-01 Wyeth Corp Methods for reducing protein aggregation
AT505262A1 (en) 2007-06-12 2008-12-15 Apeiron Biolog Forschungs Und New recombinant angiotensin I converting enzyme 2 polypeptide comprising specific amount of glycosylated and sugar portion, useful for enzyme substitution therapy for treating acute respiratory distress syndrome or acute lung injury
EP2225372A2 (en) 2007-12-05 2010-09-08 Novozymes A/S Polypeptides having endoglucanase activity and polynucleotides encoding same
WO2010015668A1 (en) 2008-08-06 2010-02-11 Novo Nordisk A/S Conjugated proteins with prolonged in vivo efficacy
US8680263B2 (en) 2008-09-19 2014-03-25 Nektar Therapeutics Carbohydrate-based drug delivery polymers and conjugates thereof
DE102010000595A1 (en) 2009-02-27 2010-09-02 Gühring Ohg Modular Machine Tool
US8828953B2 (en) 2009-04-20 2014-09-09 NaZura BioHealth, Inc. Chemosensory receptor ligand-based therapies
DE102009031992A1 (en) 2009-07-06 2011-01-13 Paul Hartmann Ag Device for negative pressure therapy of wounds
JO2976B1 (en) 2009-12-22 2016-03-15 ايلي ليلي اند كومباني Oxyntomodulin peptide analogue ‎
KR101382593B1 (en) 2010-07-21 2014-04-10 한미사이언스 주식회사 Novel long-acting glucagon conjugate and pharmaceutical composition comprising the same for the prevention and treatment of obesity
US20140349922A1 (en) 2011-06-02 2014-11-27 Udi Eyal Fima Long-acting glp-1/glucagon receptor agonists
AU2013250711A1 (en) 2012-04-19 2014-11-27 Opko Biologics Ltd. Long-acting oxyntomodulin variants and methods of producing same
SG10201702228QA (en) 2012-06-04 2017-04-27 Opko Biolog Ltd Pegylated oxm variants
SG11201503879QA (en) 2012-11-20 2015-06-29 Opko Biolog Ltd Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides

Also Published As

Publication number Publication date
CL2014002791A1 (en) 2015-06-05
WO2013157002A1 (en) 2013-10-24
SG11201406671RA (en) 2014-11-27
BR112014025951A2 (en) 2017-07-11
IL235184D0 (en) 2014-12-31
EP2838552A4 (en) 2016-05-18
CN104487082A (en) 2015-04-01
US20170088598A1 (en) 2017-03-30
JP2015520128A (en) 2015-07-16
EP2838552A1 (en) 2015-02-25
US9522945B2 (en) 2016-12-20
MX2014012625A (en) 2015-05-15
CA2870650A1 (en) 2013-10-24
CO7200249A2 (en) 2015-02-27
MY167814A (en) 2018-09-26
US20150072924A1 (en) 2015-03-12
HK1207564A1 (en) 2016-02-05
KR20150008137A (en) 2015-01-21
EA201491898A1 (en) 2015-08-31
AU2013250711A1 (en) 2014-11-27

Similar Documents

Publication Publication Date Title
MX2009008241A (en) Glucagon/glp-1 receptor co-agonists.
PE02322014A1 (en) Antigen binding proteins capable of binding lymphopoietin thymic stromal
AR079344A1 (en) Of oxyntomodulin peptide analog, pharmaceutical composition comprising the same and use for preparing a medicament useful for treating non-insulin dependent diabetes and / or obesity
ECSP045094A (en) Peptides which act as receptor agonists as GLP-1 and glucagon receptor antagonists and their use methods pharmacological
WO2009155258A3 (en) Glucagon/glp-1 receptor co-agonists
JP2014512343A5 (en)
CL2015002522A1 (en) Compositions and methods for activating "stimulator interferon gene" - dependent signaling.
PE15512014A1 (en) Fusion proteins for metabolic disorders
PE07632009A1 (en) Polypeptides, antibody variable domains and antagonists
CL2008002159A1 (en) Compounds derived from n - (((1r, 4r) -4-aminocyclohexyl) methyl) sulfonaminas substituted heterocycles, NPY receptor antagonists y5; pharmaceutical composition comprising a such, useful to treat anorexia and obesity compounds.
CL2011002379A1 (en) A method for implementing a user interface without graphics elements in a mobile device; and the mobile device.
DOP2006000162A (en) New anti-madcan
PE24512014A1 (en) Xten compositions conjugates and methods for making the same
UY34306A (en) Substituted fused pyrimidines and their use
AR092862A1 (en) Liquid formulation of long-acting insulin and an insulinotropic peptide and preparation method
RU2014101697A (en) Glucagon receptor coagonists / GLP-1
MX2014005108A (en) Polypeptide constructs and uses thereof.
CR20130234A (en) Methods of treating disorders associated with FGF21
AR081459A1 (en) Serum albumin binding molecules
EA201000399A1 (en) Compositions and methods of using pro-island peptides and their analogues
AR069136A1 (en) Compounds exhibiting antagonistic activity and glucagon agonist glp-1 (glucagon peptide Somilar type 1) and uses thereof
SG191252A1 (en) Methods for treating metabolic disorders and obesity with gip and glp-1 receptor-active glucagon-based peptides
EA201270713A1 (en) Proteins based on fibronectin with framed domains that bind il-23
PE09542015A1 (en) Domain proteins fibronectin-based support that bind myostatin
DOP2015000156A (en) Exendin-4 derivatives functionalised

Legal Events

Date Code Title Description
FC Refusal