PE20221271A1 - Moleculas de fusion del ecd de siglec-9 y metodos de uso de estas - Google Patents
Moleculas de fusion del ecd de siglec-9 y metodos de uso de estasInfo
- Publication number
- PE20221271A1 PE20221271A1 PE2022000710A PE2022000710A PE20221271A1 PE 20221271 A1 PE20221271 A1 PE 20221271A1 PE 2022000710 A PE2022000710 A PE 2022000710A PE 2022000710 A PE2022000710 A PE 2022000710A PE 20221271 A1 PE20221271 A1 PE 20221271A1
- Authority
- PE
- Peru
- Prior art keywords
- siglec
- domain
- methods
- fusion molecules
- ecd fusion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4726—Lectins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Recrystallisation Techniques (AREA)
- External Artificial Organs (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE REFIERE A UN POLIPEPTIDO QUE COMPRENDE UN DOMINIO EXTRACELULAR (ECD) SIGLEC-9 QUE COMPRENDE EL DOMINIO SIGLEC-9 IGV QUE COMPRENDE UNA SECUENCIA DE AMINOACIDOS SELECCIONADA DE LAS SEQ ID NO: 109-137 Y 214-226, UN DOMINIO C2 TIPO 1 (C2T1) Y UN DOMINIO C2 TIPO 2 (C2T2); DONDE EL POLIPEPTIDO COMPRENDE UNA SECUENCIA DE AMINOACIDOS SELECCIONADA DE LAS SEQ ID NO: 79-107 Y 194-206. DICHO POLIPEPTIDO BLOQUEA LA UNION CELULAR DE UNO O MAS MIEMBROS DE LA FAMILIA SIGLEC SELECCIONADOS DE SIGLEC-3, SIGLEC-5, SIGLEC-7, SIGLEC-9, SIGLEC-10 Y SIGLEC-15. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA UTIL EN EL TRATAMIENTO DE CANCER.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962930227P | 2019-11-04 | 2019-11-04 | |
US202063014940P | 2020-04-24 | 2020-04-24 | |
US202063092753P | 2020-10-16 | 2020-10-16 | |
PCT/US2020/058687 WO2021091885A2 (en) | 2019-11-04 | 2020-11-03 | Siglec-9 ecd fusion molecules and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20221271A1 true PE20221271A1 (es) | 2022-09-01 |
Family
ID=73598983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2022000710A PE20221271A1 (es) | 2019-11-04 | 2020-11-03 | Moleculas de fusion del ecd de siglec-9 y metodos de uso de estas |
Country Status (17)
Country | Link |
---|---|
US (2) | US11987612B2 (es) |
EP (1) | EP4055031A2 (es) |
JP (1) | JP2022553571A (es) |
KR (1) | KR20220092918A (es) |
CN (1) | CN114667298A (es) |
AU (1) | AU2020378251A1 (es) |
BR (1) | BR112022008321A2 (es) |
CA (1) | CA3155345A1 (es) |
CL (1) | CL2022001130A1 (es) |
CO (1) | CO2022005587A2 (es) |
CR (1) | CR20220244A (es) |
EC (1) | ECSP22044316A (es) |
IL (1) | IL292499A (es) |
MX (1) | MX2022005376A (es) |
PE (1) | PE20221271A1 (es) |
TW (1) | TW202132329A (es) |
WO (1) | WO2021091885A2 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2021261524A1 (en) | 2020-04-24 | 2022-11-24 | Bayer Aktiengesellschaft | Substituted aminothiazoles as dgkzeta inhibitors for immune activation |
WO2024102635A1 (en) * | 2022-11-07 | 2024-05-16 | Alector Llc | Uses of siglec-9 ecd fusion molecules in cancer treatment |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
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US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
US6133426A (en) | 1997-02-21 | 2000-10-17 | Genentech, Inc. | Humanized anti-IL-8 monoclonal antibodies |
AU2003301882A1 (en) | 2002-11-01 | 2004-06-07 | The Regents Of The University Of Colorado, A Body Corporate | Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry |
CA3018525C (en) | 2005-07-01 | 2023-08-01 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
GB0521991D0 (en) | 2005-10-28 | 2005-12-07 | Univ Dundee | Siglec-9 binding agents |
US20070244038A1 (en) | 2006-04-12 | 2007-10-18 | The Regents Of The University Of California | Methods for treating lymphocyte-associated disorders by modulation of siglec activity |
WO2012145493A1 (en) | 2011-04-20 | 2012-10-26 | Amplimmune, Inc. | Antibodies and other molecules that bind b7-h1 and pd-1 |
CN103987405B (zh) | 2011-11-28 | 2017-03-29 | 默克专利股份公司 | 抗pd‑l1抗体及其用途 |
EA032985B1 (ru) | 2011-12-21 | 2019-08-30 | Амген Инк. | Варианты полипептидов fc-pol с улучшенным связыванием неонатального рецептора fc |
EP2937088B1 (en) | 2012-12-21 | 2020-11-18 | Tokushima University | Composition having tissue repairing activity and utilization thereof |
WO2014120642A1 (en) | 2013-01-30 | 2014-08-07 | The General Hospital Corporation | Diagnosis and treatment of hepatorenal syndrome |
AU2015314316B2 (en) | 2014-09-10 | 2020-12-10 | Innate Pharma | Cross reactive Siglec antibodies |
WO2016178996A1 (en) | 2015-05-01 | 2016-11-10 | The Regents Of The University Of California | Glycan-dependent immunotherapeutic molecules |
WO2017075432A2 (en) * | 2015-10-29 | 2017-05-04 | Alector Llc | Anti-siglec-9 antibodies and methods of use thereof |
WO2017075342A1 (en) | 2015-10-30 | 2017-05-04 | Hach Company | Storage stable standards for aqueous chlorine analysis |
AU2016354924A1 (en) | 2015-11-17 | 2018-06-21 | Innate Pharma | Siglec-10 antibodies |
CA3011092A1 (en) | 2016-01-12 | 2017-07-20 | Palleon Pharmaceuticals Inc. | Use of siglec-7 or siglec-9 antibodies for the treatment of cancer |
AU2017230850B2 (en) | 2016-03-08 | 2024-04-18 | Innate Pharma | Siglec neutralizing antibodies |
WO2018006066A1 (en) | 2016-07-01 | 2018-01-04 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibitory immune receptor inhibition methods and compositions |
GB201611535D0 (en) | 2016-07-01 | 2016-08-17 | King S College London | Methods and compositions for treating cancer with siglec-9 activity modulators |
JP2020527144A (ja) | 2017-07-10 | 2020-09-03 | イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. | 癌を処置するためのヒトsiglec−9に対する抗体およびヒトnkg2aに対する抗体を使用する組み合わせ療法 |
JP7293188B2 (ja) | 2017-07-10 | 2023-06-19 | イナート・ファルマ・ソシエテ・アノニム | Siglec-9中和抗体 |
US20210395333A1 (en) | 2018-06-07 | 2021-12-23 | Palleon Pharmaceuticals Inc. | Multimeric proteins for detecting a carbohydrate and/or treating a siglec-mediated disorder |
BR112020026386A2 (pt) | 2018-06-29 | 2021-03-30 | Verseau Therapeutics, Inc. | Composições e métodos para modulação de fenótipos inflamatórios com monócitos e macrófagos e usos de imunoterapia dos mesmos |
CN112805032A (zh) | 2018-10-02 | 2021-05-14 | 台湾浩鼎生技股份有限公司 | 与治疗性肿瘤学药剂组合使用抗ssea-4抗体的组合疗法 |
US20220211831A1 (en) | 2019-04-17 | 2022-07-07 | Bar-Ilan University | Siglec-based chimeric polypeptides and uses thereof |
TW202110890A (zh) | 2019-06-04 | 2021-03-16 | 美商維西歐製藥公司 | 抗siglec-9組合物及其用於調節骨髓細胞發炎表型之方法及用途 |
WO2021011377A2 (en) | 2019-07-12 | 2021-01-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of enhancing immunogenicity of cancers |
-
2020
- 2020-11-03 CR CR20220244A patent/CR20220244A/es unknown
- 2020-11-03 PE PE2022000710A patent/PE20221271A1/es unknown
- 2020-11-03 CA CA3155345A patent/CA3155345A1/en active Pending
- 2020-11-03 MX MX2022005376A patent/MX2022005376A/es unknown
- 2020-11-03 TW TW109138156A patent/TW202132329A/zh unknown
- 2020-11-03 CN CN202080076354.8A patent/CN114667298A/zh active Pending
- 2020-11-03 US US17/088,149 patent/US11987612B2/en active Active
- 2020-11-03 EP EP20816024.2A patent/EP4055031A2/en active Pending
- 2020-11-03 JP JP2022524955A patent/JP2022553571A/ja active Pending
- 2020-11-03 BR BR112022008321A patent/BR112022008321A2/pt unknown
- 2020-11-03 AU AU2020378251A patent/AU2020378251A1/en active Pending
- 2020-11-03 KR KR1020227017802A patent/KR20220092918A/ko unknown
- 2020-11-03 WO PCT/US2020/058687 patent/WO2021091885A2/en unknown
-
2022
- 2022-04-25 IL IL292499A patent/IL292499A/en unknown
- 2022-04-29 CO CONC2022/0005587A patent/CO2022005587A2/es unknown
- 2022-05-02 CL CL2022001130A patent/CL2022001130A1/es unknown
- 2022-06-02 EC ECSENADI202244316A patent/ECSP22044316A/es unknown
-
2024
- 2024-04-17 US US18/637,627 patent/US20240279305A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2021091885A3 (en) | 2021-06-17 |
JP2022553571A (ja) | 2022-12-23 |
CR20220244A (es) | 2022-06-28 |
CL2022001130A1 (es) | 2023-02-24 |
WO2021091885A2 (en) | 2021-05-14 |
EP4055031A2 (en) | 2022-09-14 |
TW202132329A (zh) | 2021-09-01 |
CA3155345A1 (en) | 2021-05-14 |
CO2022005587A2 (es) | 2022-07-29 |
AU2020378251A1 (en) | 2022-05-26 |
CN114667298A (zh) | 2022-06-24 |
KR20220092918A (ko) | 2022-07-04 |
ECSP22044316A (es) | 2022-07-29 |
US20240279305A1 (en) | 2024-08-22 |
BR112022008321A2 (pt) | 2022-07-26 |
US20210284710A1 (en) | 2021-09-16 |
IL292499A (en) | 2022-06-01 |
MX2022005376A (es) | 2022-05-19 |
US11987612B2 (en) | 2024-05-21 |
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