PE20100443A1 - DERIVATIVES OF PHENYL-CARBONYL-AMINO-PROPANOIC ACID AS ANTAGONISTS OF GLUCAGON - Google Patents

DERIVATIVES OF PHENYL-CARBONYL-AMINO-PROPANOIC ACID AS ANTAGONISTS OF GLUCAGON

Info

Publication number
PE20100443A1
PE20100443A1 PE2009001096A PE2009001096A PE20100443A1 PE 20100443 A1 PE20100443 A1 PE 20100443A1 PE 2009001096 A PE2009001096 A PE 2009001096A PE 2009001096 A PE2009001096 A PE 2009001096A PE 20100443 A1 PE20100443 A1 PE 20100443A1
Authority
PE
Peru
Prior art keywords
amino
methyl
carbonyl
phenyl
propanoic acid
Prior art date
Application number
PE2009001096A
Other languages
Spanish (es)
Inventor
Yoshihiro Banno
Ryoma Hara
Ryosuke Tokunoh
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2009/054095 external-priority patent/WO2009110520A1/en
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20100443A1 publication Critical patent/PE20100443A1/en

Links

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (IA), DONDE ANILLO AA Y ANILLO AC SON CADA UNO BENCENO OPCIONALMENTE SUSTITUIDO O HETEROCICLO AROMATICO DE 5-6 MIEMBROS OPCIONALMENTE SUSTITUIDO; ANILLO AB ES HETEROCICLO AROMATICO DE 5 MIEMBROS OPCIONALMENTE SUSTITUIDO; RA3 ES ALQUILO C1-C6; CICLOALQUILO C3-C10; ARILO C6-C14 OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; R14 ES H, ALQUILO C1-C6; RA5 ES -(CH2)3-COORA11, -NRA6-CRA7RA8-CRA9RA10-COORA11; RA6, RA7, RA8, RA9 Y RA11 SON CADA UNO H, ALQUILO C1-C6; RA10 ES H, OH O ALQUIILO C1-C6. SON COMPUESTOS SELECCIONADOS: ACIDO 3-{[(4-{[CICLOHEXIL(3-METIL-1-BENZOFURAN-2-IL)METIL]AMINO}FENIL)CARBONIL](METIL)AMINO}PROPANOICO; ACIDO 3-{[(6-{[CICLOHEXIL(5-FLUORO-3-METIL-1-BENZOFURAN-2-IL)METIL]AMINO}PIRIDIN-3-IL)CARBONIL](METIL)AMINO}PROPANOICO; 3-{[(4-{[2-ETIL-1-(5-FLUORO-3-METIL-1-BENZOFURAN-2-IL)BUTIL]AMINO}FENIL)CARBONIL](METIL)AMINO}PROPANOICO, ENTRE OTROSTAMBIEN SE REFIERE A UN PROCEDIMIENTO Y UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE GLUCAGON SIENDO UTILES EN EL TRATAMIENTO DE DIABETESIT REFERS TO A COMPOUND OF FORMULA (IA), WHERE AA RING AND AC RING ARE EACH ONE OPTIONALLY REPLACED BENZENE OR OPTIONALLY REPLACED 5-6 MEMBER AROMATIC HETEROCYCLE; RING AB IS OPTIONALLY REPLACED 5-MEMBER AROMATIC HETEROCYCLE; RA3 IS C1-C6 ALKYL; C3-C10 CYCLOALKYL; ARILO C6-C14 OPTIONALLY SUBSTITUTED, AMONG OTHERS; R14 IS H, C1-C6 ALKYL; RA5 ES - (CH2) 3-COORA11, -NRA6-CRA7RA8-CRA9RA10-COORA11; RA6, RA7, RA8, RA9 AND RA11 ARE EACH H, C1-C6 ALKYL; RA10 IS H, OH OR C1-C6 ALKYYL. SELECTED COMPOUNDS ARE: 3 - {[(4 - {[CYCLOHEXIL (3-METHYL-1-BENZOFURAN-2-IL) METHYL] AMINO} PHENYL) CARBONYL] (METHYL) AMINO} PROPANOIC ACID; 3 - {[(6 - {[CYCLOHEXIL (5-FLUORO-3-METHYL-1-BENZOFURAN-2-IL) METHYL] AMINO} PYRIDIN-3-IL) CARBONYL] (METHYL) AMINO} PROPANOIC ACID; 3 - {[(4 - {[2-ETHYL-1- (5-FLUORO-3-METHYL-1-BENZOFURAN-2-IL) BUTYL] AMINO} PHENYL) CARBONYL] (METHYL) AMINO} PROPANOIC, BETWEEN OTHERS ALSO SE REFERS TO A PROCEDURE AND A PHARMACEUTICAL COMPOSITION. SAID COMPOUNDS ARE ANTAGONISTS OF GLUCAGON BEING USEFUL IN THE TREATMENT OF DIABETES

PE2009001096A 2009-02-06 2009-09-02 DERIVATIVES OF PHENYL-CARBONYL-AMINO-PROPANOIC ACID AS ANTAGONISTS OF GLUCAGON PE20100443A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009025511 2009-02-06
PCT/JP2009/054095 WO2009110520A1 (en) 2008-03-05 2009-03-04 Heterocyclic compound

Publications (1)

Publication Number Publication Date
PE20100443A1 true PE20100443A1 (en) 2010-06-25

Family

ID=42561095

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009001096A PE20100443A1 (en) 2009-02-06 2009-09-02 DERIVATIVES OF PHENYL-CARBONYL-AMINO-PROPANOIC ACID AS ANTAGONISTS OF GLUCAGON

Country Status (5)

Country Link
AR (1) AR073486A1 (en)
CL (1) CL2009001796A1 (en)
PE (1) PE20100443A1 (en)
TW (1) TWI475018B (en)
UY (1) UY32088A (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1463715A1 (en) * 2001-12-03 2004-10-06 Novo Nordisk A/S Novel glucagon antagonists
US6881746B2 (en) * 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
US6762318B2 (en) * 2001-12-03 2004-07-13 Novo Nordisk A/S Glucagon antagonists
JP4601611B2 (en) * 2003-05-01 2010-12-22 ブリストル−マイヤーズ スクイブ カンパニー Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
EP1626717A4 (en) * 2003-05-09 2009-09-09 Merck & Co Inc Benzimidazoles, compositions containing such compounds and methods of use
PT1951661E (en) * 2005-11-17 2012-09-19 Lilly Co Eli Glucagon receptor antagonists, preparation and therapeutic uses

Also Published As

Publication number Publication date
CL2009001796A1 (en) 2011-09-16
TW201029996A (en) 2010-08-16
TWI475018B (en) 2015-03-01
UY32088A (en) 2010-08-31
AR073486A1 (en) 2010-11-10

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