PE20100443A1 - I amino acid derivatives of the carbonyl-phenyl-propanoic acid as antagonists of glucagon - Google Patents

I amino acid derivatives of the carbonyl-phenyl-propanoic acid as antagonists of glucagon

Info

Publication number
PE20100443A1
PE20100443A1 PE2009001096A PE2009001096A PE20100443A1 PE 20100443 A1 PE20100443 A1 PE 20100443A1 PE 2009001096 A PE2009001096 A PE 2009001096A PE 2009001096 A PE2009001096 A PE 2009001096A PE 20100443 A1 PE20100443 A1 PE 20100443A1
Authority
PE
Peru
Prior art keywords
methyl
amino
c6
carbonyl
yl
Prior art date
Application number
PE2009001096A
Other languages
Spanish (es)
Inventor
Yoshihiro Banno
Ryoma Hara
Ryosuke Tokunoh
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2009025511 priority Critical
Priority to PCT/JP2009/054095 priority patent/WO2009110520A1/en
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20100443A1 publication Critical patent/PE20100443A1/en

Links

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (IA), DONDE ANILLO AA Y ANILLO AC SON CADA UNO BENCENO OPCIONALMENTE SUSTITUIDO O HETEROCICLO AROMATICO DE 5-6 MIEMBROS OPCIONALMENTE SUSTITUIDO; Concerns a compound of formula (IA), where AA RING RING AND AC are each optionally substituted benzene or heterocyclic 5-6 membered aromatic optionally substituted; ANILLO AB ES HETEROCICLO AROMATICO DE 5 MIEMBROS OPCIONALMENTE SUSTITUIDO; RING AB 5-membered aromatic heterocycle optionally substituted; RA3 ES ALQUILO C1-C6; RA3 is C1-C6; CICLOALQUILO C3-C10; C3-C10 cycloalkyl; ARILO C6-C14 OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; C6-C14 optionally substituted, among others; R14 ES H, ALQUILO C1-C6; R14 is H, alkyl C1-C6; RA5 ES -(CH2)3-COORA11, -NRA6-CRA7RA8-CRA9RA10-COORA11; RA5 is - (CH2) 3-COORA11, -NRA6-CRA7RA8-CRA9RA10-COORA11; RA6, RA7, RA8, RA9 Y RA11 SON CADA UNO H, ALQUILO C1-C6; RA6, RA7, RA8, RA9 and RA11 are each H, C1-C6 alkyl; RA10 ES H, OH O ALQUIILO C1-C6. RA10 is H, OH or C1-C6 ALQUIILO. SON COMPUESTOS SELECCIONADOS: ACIDO 3-{[(4-{[CICLOHEXIL(3-METIL-1-BENZOFURAN-2-IL)METIL]AMINO}FENIL)CARBONIL](METIL)AMINO}PROPANOICO; They ARE SELECTED COMPOUNDS: 3 - {[(4 - {[cyclohexyl (3-methyl-1-benzofuran-2-yl) methyl] amino} phenyl) carbonyl] (methyl) amino} propanoic acid; ACIDO 3-{[(6-{[CICLOHEXIL(5-FLUORO-3-METIL-1-BENZOFURAN-2-IL)METIL]AMINO}PIRIDIN-3-IL)CARBONIL](METIL)AMINO}PROPANOICO; 3 - {[(6 - {[cyclohexyl (5-FLUORO-3-METHYL-1-benzofuran-2-yl) methyl] amino} pyridin-3-yl) carbonyl] (methyl) amino} propanoic acid; 3-{[(4-{[2-ETIL-1-(5-FLUORO-3-METIL-1-BENZOFURAN-2-IL)BUTIL]AMINO}FENIL)CARBONIL](METIL)AMINO}PROPANOICO, ENTRE OTROSTAMBIEN SE REFIERE A UN PROCEDIMIENTO Y UNA COMPOSICION FARMACEUTICA. 3 - {[(4 - {[2-ETHYL-1- (5-FLUORO-3-METHYL-1-benzofuran-2-yl) butyl] amino} phenyl) carbonyl] (methyl) amino} propanoic BETWEEN OTROSTAMBIEN SE relates to a method and pharmaceutical composition. DICHOS COMPUESTOS SON ANTAGONISTAS DE GLUCAGON SIENDO UTILES EN EL TRATAMIENTO DE DIABETES Such compounds are glucagon antagonists to be useful in the treatment of diabetes
PE2009001096A 2008-03-05 2009-09-02 I amino acid derivatives of the carbonyl-phenyl-propanoic acid as antagonists of glucagon PE20100443A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009025511 2009-02-06
PCT/JP2009/054095 WO2009110520A1 (en) 2008-03-05 2009-03-04 Heterocyclic compound

Publications (1)

Publication Number Publication Date
PE20100443A1 true PE20100443A1 (en) 2010-06-25

Family

ID=42561095

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009001096A PE20100443A1 (en) 2008-03-05 2009-09-02 I amino acid derivatives of the carbonyl-phenyl-propanoic acid as antagonists of glucagon

Country Status (5)

Country Link
AR (1) AR073486A1 (en)
CL (1) CL2009001796A1 (en)
PE (1) PE20100443A1 (en)
TW (1) TWI475018B (en)
UY (1) UY32088A (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762318B2 (en) * 2001-12-03 2004-07-13 Novo Nordisk A/S Glucagon antagonists
AU2002365622A1 (en) * 2001-12-03 2003-06-17 Novo Nordisk A/S Novel glucagon antagonists
US6881746B2 (en) * 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
EP1617840A4 (en) * 2003-05-01 2008-08-20 Squibb Bristol Myers Co Pyrazole-amide compounds useful as kinase inhibitors
JP2006528687A (en) * 2003-05-09 2006-12-21 メルク エンド カムパニー インコーポレーテッドMerck & Company Incoporated Benzimidazoles, compositions containing such compounds and methods of use
ES2391109T3 (en) * 2005-11-17 2012-11-21 Eli Lilly And Company Glucagon receptor antagonists, preparation and therapeutic uses

Also Published As

Publication number Publication date
TWI475018B (en) 2015-03-01
AR073486A1 (en) 2010-11-10
TW201029996A (en) 2010-08-16
CL2009001796A1 (en) 2011-09-16
UY32088A (en) 2010-08-31

Similar Documents

Publication Publication Date Title
UY33476A (en) SGC stimulators
AR056109A1 (en) Thiazolopyridine derivatives as activators of glucokinase activity
CL2012001971A1 (en) Compounds derived from 1-piperazinyl-3-pyridine-carboxylate, as blockers of sodium channels voltage dependent; pharmaceutical composition; and their use for the treatment of respiratory diseases or the respiratory tract such as asthma, COPD, cough, silicosis, among others.
AR096246A1 (en) Benzimidazole derivatives as inhibitors bromodomain
GEP20156266B (en) Spiroheterocyclic n-oxypiperidines as pesticides
CU24097B1 (en) pyridyloxy-substituted compounds Indoles as inhibitors of the VEGF-R2 useful for the treatment of proliferative diseases
TW201129546A (en) Aromatic amine derivative, and organic electroluminescent element comprising same
NZ603876A (en) Nitrogen heterocyclic compounds useful as pde10 inhibitors
CO6351724A2 (en) CMet inhibitors
DOP2012000225A (en) Pyrrolo-pyrimidine as inhibitors of CDK4 / 6
CO6541606A2 (en) Espiroindolinona- pyrrolidines
PE20040960A1 (en) Acylated piperazine derivatives as agonists of the melanocortin receptor-4
CL2011002697A1 (en) Compounds derived from 3- [4- (oxo-dihydropyridin) benzyl] -1,3-oxazin-one hydrated 11beta-HSD1 inhibitors; pharmaceutical composition which comprises; and their use in the treatment of diabetes
CL2011002706A1 (en) Compounds derived from 4- (1,3-oxazol-2-yl) -1H-indazole; pharmaceutical composition which comprises; and their uses in treating diseases such as COPD, autoimmune, asthma, among others.
UY32096A (en) 2-carboxamide derivatives - cycloamino - Specific urea, pharmaceutically acceptable salts thereof, compositions containing them, prodrugs thereof, processes for their production methods and applications
CU20120107A7 (en) Device
RU2011139132A (en) Nitrogen-containing condensed heterocyclic compounds and their application as beta-amyloid product inhibitors
MX2007011526A (en) 2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl-piperidines used as cgrp antagonists.
BR112012007442A2 (en) n- (1,2,5-oxadiazol-3-yl) benzamides and their use as herbicides
MX2012012189A (en) Certain amino-pyrimidines, compositions thereof, and methods for their use.
AR064735A1 (en) GPCR agonists and pharmaceutical composition based on the compound
DOP2013000062A (en) Protease inhibitors of HCV serine macrocyclic derivatives prolines
GT201400181A (en) Composition for pest control comprising a novel derivative iminopyridine
PE20142335A1 (en) Synthesis of heterocyclic compounds
MX2010011437A (en) Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring.

Legal Events

Date Code Title Description
FG Grant, registration