PE20100443A1 - I amino acid derivatives of the carbonyl-phenyl-propanoic acid as antagonists of glucagon - Google Patents

I amino acid derivatives of the carbonyl-phenyl-propanoic acid as antagonists of glucagon


Publication number
PE20100443A1 PE2009001096A PE2009001096A PE20100443A1 PE 20100443 A1 PE20100443 A1 PE 20100443A1 PE 2009001096 A PE2009001096 A PE 2009001096A PE 2009001096 A PE2009001096 A PE 2009001096A PE 20100443 A1 PE20100443 A1 PE 20100443A1
Prior art keywords
Prior art date
Application number
Other languages
Spanish (es)
Yoshihiro Banno
Ryoma Hara
Ryosuke Tokunoh
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2009025511 priority Critical
Priority to PCT/JP2009/054095 priority patent/WO2009110520A1/en
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20100443A1 publication Critical patent/PE20100443A1/en



SE REFIERE A UN COMPUESTO DE FORMULA (IA), DONDE ANILLO AA Y ANILLO AC SON CADA UNO BENCENO OPCIONALMENTE SUSTITUIDO O HETEROCICLO AROMATICO DE 5-6 MIEMBROS OPCIONALMENTE SUSTITUIDO; Concerns a compound of formula (IA), where AA RING RING AND AC are each optionally substituted benzene or heterocyclic 5-6 membered aromatic optionally substituted; ANILLO AB ES HETEROCICLO AROMATICO DE 5 MIEMBROS OPCIONALMENTE SUSTITUIDO; RING AB 5-membered aromatic heterocycle optionally substituted; RA3 ES ALQUILO C1-C6; RA3 is C1-C6; CICLOALQUILO C3-C10; C3-C10 cycloalkyl; ARILO C6-C14 OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; C6-C14 optionally substituted, among others; R14 ES H, ALQUILO C1-C6; R14 is H, alkyl C1-C6; RA5 ES -(CH2)3-COORA11, -NRA6-CRA7RA8-CRA9RA10-COORA11; RA5 is - (CH2) 3-COORA11, -NRA6-CRA7RA8-CRA9RA10-COORA11; RA6, RA7, RA8, RA9 Y RA11 SON CADA UNO H, ALQUILO C1-C6; RA6, RA7, RA8, RA9 and RA11 are each H, C1-C6 alkyl; RA10 ES H, OH O ALQUIILO C1-C6. RA10 is H, OH or C1-C6 ALQUIILO. SON COMPUESTOS SELECCIONADOS: ACIDO 3-{[(4-{[CICLOHEXIL(3-METIL-1-BENZOFURAN-2-IL)METIL]AMINO}FENIL)CARBONIL](METIL)AMINO}PROPANOICO; They ARE SELECTED COMPOUNDS: 3 - {[(4 - {[cyclohexyl (3-methyl-1-benzofuran-2-yl) methyl] amino} phenyl) carbonyl] (methyl) amino} propanoic acid; ACIDO 3-{[(6-{[CICLOHEXIL(5-FLUORO-3-METIL-1-BENZOFURAN-2-IL)METIL]AMINO}PIRIDIN-3-IL)CARBONIL](METIL)AMINO}PROPANOICO; 3 - {[(6 - {[cyclohexyl (5-FLUORO-3-METHYL-1-benzofuran-2-yl) methyl] amino} pyridin-3-yl) carbonyl] (methyl) amino} propanoic acid; 3-{[(4-{[2-ETIL-1-(5-FLUORO-3-METIL-1-BENZOFURAN-2-IL)BUTIL]AMINO}FENIL)CARBONIL](METIL)AMINO}PROPANOICO, ENTRE OTROSTAMBIEN SE REFIERE A UN PROCEDIMIENTO Y UNA COMPOSICION FARMACEUTICA. 3 - {[(4 - {[2-ETHYL-1- (5-FLUORO-3-METHYL-1-benzofuran-2-yl) butyl] amino} phenyl) carbonyl] (methyl) amino} propanoic BETWEEN OTROSTAMBIEN SE relates to a method and pharmaceutical composition. DICHOS COMPUESTOS SON ANTAGONISTAS DE GLUCAGON SIENDO UTILES EN EL TRATAMIENTO DE DIABETES Such compounds are glucagon antagonists to be useful in the treatment of diabetes
PE2009001096A 2008-03-05 2009-09-02 I amino acid derivatives of the carbonyl-phenyl-propanoic acid as antagonists of glucagon PE20100443A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009025511 2009-02-06
PCT/JP2009/054095 WO2009110520A1 (en) 2008-03-05 2009-03-04 Heterocyclic compound

Publications (1)

Publication Number Publication Date
PE20100443A1 true PE20100443A1 (en) 2010-06-25



Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009001096A PE20100443A1 (en) 2008-03-05 2009-09-02 I amino acid derivatives of the carbonyl-phenyl-propanoic acid as antagonists of glucagon

Country Status (5)

Country Link
AR (1) AR073486A1 (en)
CL (1) CL2009001796A1 (en)
PE (1) PE20100443A1 (en)
TW (1) TWI475018B (en)
UY (1) UY32088A (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762318B2 (en) * 2001-12-03 2004-07-13 Novo Nordisk A/S Glucagon antagonists
AU2002365622A1 (en) * 2001-12-03 2003-06-17 Novo Nordisk A/S Novel glucagon antagonists
US6881746B2 (en) * 2001-12-03 2005-04-19 Novo Nordick A/S Glucagon antagonists/inverse agonists
EP1617840A4 (en) * 2003-05-01 2008-08-20 Squibb Bristol Myers Co Pyrazole-amide compounds useful as kinase inhibitors
JP2006528687A (en) * 2003-05-09 2006-12-21 メルク エンド カムパニー インコーポレーテッドMerck & Company Incoporated Benzimidazoles, compositions containing such compounds and methods of use
ES2391109T3 (en) * 2005-11-17 2012-11-21 Eli Lilly And Company Glucagon receptor antagonists, preparation and therapeutic uses

Also Published As

Publication number Publication date
TWI475018B (en) 2015-03-01
AR073486A1 (en) 2010-11-10
TW201029996A (en) 2010-08-16
CL2009001796A1 (en) 2011-09-16
UY32088A (en) 2010-08-31

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