PE20080210A1 - Suspensiones acuosas de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]-amino]-2-pirimidinil]-amino]-benzonitrilo (tmc278) - Google Patents

Suspensiones acuosas de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]-amino]-2-pirimidinil]-amino]-benzonitrilo (tmc278)

Info

Publication number
PE20080210A1
PE20080210A1 PE2007000800A PE2007000800A PE20080210A1 PE 20080210 A1 PE20080210 A1 PE 20080210A1 PE 2007000800 A PE2007000800 A PE 2007000800A PE 2007000800 A PE2007000800 A PE 2007000800A PE 20080210 A1 PE20080210 A1 PE 20080210A1
Authority
PE
Peru
Prior art keywords
amino
tmc278
cyanoethenyl
benzonitrile
dimethylphenyl
Prior art date
Application number
PE2007000800A
Other languages
English (en)
Inventor
Lieven Elvire Colette Baert
Willy Albert Maria Carlo Dries
Laurent Bruno Schueller
Remoortere Peter Jozef Maria Van
Marc Karel Jozef Francois
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38833797&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20080210(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of PE20080210A1 publication Critical patent/PE20080210A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: A) UN INHIBIDOR DE TRANSCRIPTASA INVERSA NO NUCLEOSIDO TAL COMO EL COMPUESTO 4-[[4-[[4-(2-CIANOETENIL)-2,6-DIMETILFENIL]-AMINO]-2-PIRIMIDINIL]-AMINO]-BENZONITRILO (TMC278) QUE TIENE UN TAMANO DE PARTICULA INFERIOR A 200nm Y SE ENCUENTRA EN UNA CANTIDAD DE 3% A 50% P/V DE LA COMPOSICION; B) UN MODIFICADOR DE SUPERFICIE TAL COMO POLOXAMEROS, SUCCINATOS DE a-TOCOFERIL POLIETILENGLICOL, ENTRE OTROS; C) UN PORTADOR ACUOSO TAL COMO AGUA PARA INYECCION, EN DONDE EL PRINCIPIO ACTIVO SE ENCUENTRA EN SUSPENSION. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION. DICHA COMPOSICION ES DE ADMINISTRACION INTRAMUSCULAR O SUBCUTANEA SIENDO UTIL EN EL TRATAMIENTO DE INFECCION POR EL VIRUS DE INMUNODEFICIENCIA HUMANA (VIH)
PE2007000800A 2006-06-23 2007-06-22 Suspensiones acuosas de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]-amino]-2-pirimidinil]-amino]-benzonitrilo (tmc278) PE20080210A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06115938 2006-06-23

Publications (1)

Publication Number Publication Date
PE20080210A1 true PE20080210A1 (es) 2008-04-11

Family

ID=38833797

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000800A PE20080210A1 (es) 2006-06-23 2007-06-22 Suspensiones acuosas de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]-amino]-2-pirimidinil]-amino]-benzonitrilo (tmc278)

Country Status (32)

Country Link
US (4) US20090176813A1 (es)
EP (2) EP2040671B1 (es)
JP (1) JP5292288B2 (es)
KR (1) KR101406879B1 (es)
CN (1) CN101478950B (es)
AP (1) AP2618A (es)
AR (1) AR061620A1 (es)
AU (1) AU2007262941B2 (es)
BR (2) BR122020011487B1 (es)
CA (1) CA2654115C (es)
CL (1) CL2007001847A1 (es)
CY (1) CY1120564T1 (es)
DK (1) DK2040671T3 (es)
EA (1) EA021700B1 (es)
ES (1) ES2662068T3 (es)
HR (1) HRP20180629T1 (es)
HU (1) HUE038797T2 (es)
IL (1) IL195491A (es)
JO (1) JOP20200160A1 (es)
LT (1) LT2040671T (es)
MX (1) MX2009000158A (es)
NZ (1) NZ573291A (es)
PE (1) PE20080210A1 (es)
PL (1) PL2040671T3 (es)
PT (1) PT2040671T (es)
RS (1) RS57111B1 (es)
SG (1) SG173315A1 (es)
SI (1) SI2040671T1 (es)
TW (1) TWI413521B (es)
UA (1) UA97641C2 (es)
UY (1) UY30431A1 (es)
WO (1) WO2007147882A2 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
TWI457136B (zh) * 2005-04-04 2014-10-21 Tibotec Pharm Ltd Ｈｉｖ-感染之預防
AR065720A1 (es) 2007-03-14 2009-06-24 Tibotec Pharm Ltd Polvos para reconstitucion que comprenden rilpivirina dispersos en ciertos polimeros. uso. proceso.
EP2306980A2 (en) * 2008-06-30 2011-04-13 Tibotec Pharmaceuticals Powders for reconstitution
SG172398A1 (en) * 2008-12-24 2011-07-28 Tibotec Pharm Ltd Implantable devices for treating hiv
DK2696848T3 (da) 2011-04-15 2020-10-12 Janssen Pharmaceutica Nv Frysetørrede nanosuspensioner af lægemiddel
JO3387B1 (ar) 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين
WO2014093941A1 (en) 2012-12-14 2014-06-19 Glaxosmithkline Llc Pharmaceutical compositions
JP2017528497A (ja) * 2014-09-26 2017-09-28 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ 長時間作用型医薬組成物
WO2017209732A1 (en) * 2016-05-31 2017-12-07 Taimed Biologics, Inc. A long acting pharmaceutical composition of protease inhibitor
TWI678203B (zh) * 2016-05-31 2019-12-01 中裕新藥股份有限公司 蛋白酶抑制劑之長效醫藥組合物
US10369129B2 (en) * 2016-05-31 2019-08-06 Taimed Biologics, Inc. Long acting pharmaceutical composition of protease inhibitor
HRP20240118T1 (hr) 2016-10-24 2024-04-12 Janssen Sciences Ireland Unlimited Company Disperzivni pripravci
PE20200336A1 (es) 2017-07-14 2020-02-14 Janssen Pharmaceutica Nv Formulaciones a largo plazo
CN113440529B (zh) * 2020-03-25 2023-11-14 江苏恒瑞医药股份有限公司 一种可注射的药物组合物及其制备方法
WO2022008644A1 (en) 2020-07-09 2022-01-13 Janssen Pharmaceutica Nv Long-acting formulations
CA3182854A1 (en) 2020-07-09 2022-01-13 Rene Holm Long-acting formulations
CN115867259A (zh) 2020-07-09 2023-03-28 詹森药业有限公司 长效配制品
WO2022109555A1 (en) 2020-11-17 2022-05-27 Janssen Sciences Ireland Unlimited Company Treatment or prevention of hiv infection
MX2023005760A (es) * 2020-11-17 2023-07-31 Janssen Sciences Ireland Unlimited Co Tratamiento o prevención de una enfermedad o trastorno.
WO2023088964A1 (en) 2021-11-17 2023-05-25 Janssen Sciences Ireland Unlimited Company Dissolution test
TW202408516A (zh) 2022-04-22 2024-03-01 愛爾蘭商健生科學愛爾蘭無限公司 液體組成物
TW202406551A (zh) 2022-04-22 2024-02-16 愛爾蘭商健生科學愛爾蘭無限公司 冷凍乾燥組成物(一)
WO2023222754A1 (en) 2022-05-17 2023-11-23 Janssen Sciences Ireland Unlimited Company Rilpivirine for use in the treatment or prevention of hiv infection
TW202408527A (zh) 2022-05-17 2024-03-01 愛爾蘭商健生科學愛爾蘭無限公司 治療或預防hiv感染(二)
WO2024068699A1 (en) 2022-09-28 2024-04-04 Janssen Pharmaceutica Nv Long-acting formulations
WO2024068693A1 (en) 2022-09-28 2024-04-04 Janssen Pharmaceutica Nv Long-acting formulations

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4102124A (en) * 1976-07-12 1978-07-25 Swager William E Locking clevis or the like
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
US5046881A (en) * 1991-02-01 1991-09-10 Swager William E Lockable pin and clevis
US5114260A (en) * 1991-05-13 1992-05-19 Hart Judy L Clevis and screw pin type shackle with pin lock
US5272824A (en) * 1993-05-10 1993-12-28 Caterpillar Inc. Tooth assembly with leaf spring retainer
US5423138A (en) * 1994-04-04 1995-06-13 Caterpillar, Inc. Tip to adapter interface
US6045829A (en) * 1997-02-13 2000-04-04 Elan Pharma International Limited Nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers
UA72189C2 (uk) * 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
CN1174741C (zh) * 1999-09-21 2004-11-10 Rtp药品公司 生物活性物质的表面改性微粒组合物
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
JO3429B1 (ar) * 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
WO2003043586A2 (en) 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Compositions for sustained action product delivery
US7101576B2 (en) * 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
JP5324098B2 (ja) * 2004-11-16 2013-10-23 アルケルメス ファーマ アイルランド リミテッド 注射可能なナノ粒子のオランザピン製剤
TWI457136B (zh) * 2005-04-04 2014-10-21 Tibotec Pharm Ltd Ｈｉｖ-感染之預防
EA014914B1 (ru) * 2006-01-20 2011-02-28 Тиботек Фармасьютикалз Лтд. Долговременное лечение вич-инфекции

Also Published As

Publication number Publication date
CL2007001847A1 (es) 2008-02-08
EA200970047A1 (ru) 2009-04-28
CN101478950B (zh) 2013-02-06
MX2009000158A (es) 2009-01-23
US20220273653A1 (en) 2022-09-01
JP2009541271A (ja) 2009-11-26
JOP20200160A1 (ar) 2022-10-30
EP2040671B1 (en) 2018-01-24
UA97641C2 (en) 2012-03-12
SG173315A1 (en) 2011-08-29
AU2007262941B2 (en) 2013-11-21
EA021700B1 (ru) 2015-08-31
AU2007262941A1 (en) 2007-12-27
SI2040671T1 (en) 2018-05-31
BRPI0713334B1 (pt) 2024-02-20
EP3366278B1 (en) 2024-08-07
AR061620A1 (es) 2008-09-10
NZ573291A (en) 2011-11-25
IL195491A (en) 2014-11-30
RS57111B1 (sr) 2018-06-29
US20150010637A1 (en) 2015-01-08
EP3366278A1 (en) 2018-08-29
IL195491A0 (en) 2009-09-01
UY30431A1 (es) 2008-01-31
HUE038797T2 (hu) 2018-11-28
PL2040671T3 (pl) 2018-08-31
BRPI0713334A8 (pt) 2018-01-02
BRPI0713334A2 (pt) 2012-03-06
CA2654115C (en) 2015-12-22
US11389447B2 (en) 2022-07-19
EP2040671A2 (en) 2009-04-01
US20090176813A1 (en) 2009-07-09
BR122020011487B1 (pt) 2024-02-20
US20160089369A1 (en) 2016-03-31
CA2654115A1 (en) 2007-12-27
TW200817008A (en) 2008-04-16
TWI413521B (zh) 2013-11-01
JP5292288B2 (ja) 2013-09-18
AP2008004682A0 (en) 2008-12-31
CY1120564T1 (el) 2019-07-10
HRP20180629T1 (hr) 2018-06-01
PT2040671T (pt) 2018-03-14
WO2007147882A3 (en) 2008-06-19
WO2007147882A2 (en) 2007-12-27
LT2040671T (lt) 2018-05-10
AP2618A (en) 2013-03-18
ES2662068T3 (es) 2018-04-05
KR20090023703A (ko) 2009-03-05
DK2040671T3 (en) 2018-05-07
CN101478950A (zh) 2009-07-08
KR101406879B1 (ko) 2014-06-13

Similar Documents

Publication Publication Date Title
PE20080210A1 (es) Suspensiones acuosas de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]-amino]-2-pirimidinil]-amino]-benzonitrilo (tmc278)
FI3989972T3 (fi) Glukakonin kaltainen peptidi 1 reseptorin agonistit
AR097455A1 (es) Composición farmacéutica que contiene compuesto de pirimidina como un ingrediente activo
PE20130198A1 (es) Composiciones solidas
CL2011000244A1 (es) Formulacion farmaceutica intra-arterial que comprende particulas esfericas que contienen un factor de crecimiento y un excipiente biodegradable, en donde el diametro medio de dichas particulas es de 15-20 micrometros, con una desviacion estandar de (+/-) 1 micrometro en al menos 99% de las particulas; y su uso en el tratamiento de infarto al miocardio, trastorno cardiaco isquemico, entre otros.
AR095451A1 (es) Formulación de anticuerpos
RU2013150803A (ru) Лиофилизированные лекарственные наносуспензии
ATE471144T1 (de) Intranasale verabreichung von schnell wirkendem insulin
AR110249A1 (es) Hemihidrato de la base libre de n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamida, métodos de fabricación y usos del mismo
PE20081885A1 (es) Administracion semanal de inhibidores de la dipeptidilpeptidasa
AR059097A1 (es) Tratamiento a largo plazo de la infeccion por vih
CL2004000930A1 (es) Compuesto derivado de dihidroquinazolina de formula definida, util para el tratamiento y/o profilaxis de infecciones virales; composicion farmaceutica que comprende al compuesto y uso del compuesto en la preparacion de medicamentos.
UY33525A (es) Nuevo polietilenglicol, estable conjugado de interferón alfa, representado por un isómero de posición
CR10166A (es) Uso de derivados de sulfamida heterociclo benzo-fusionado para el tratamiento del trastorno bipolar y mania
CL2020002252A1 (es) Formulación oftálmica.
AR077139A1 (es) Composiciones farmaceuticas utiles para tratar el vch
IN2014MN01470A (es)
CO2017008426A2 (es) Ácido (2r,4r)-5-(5'-cloro-2'-fluorobifenil-4-il)-2-hidroxi-4- [(5-metiloxazol-2-carbonil)amino]pentanoico
CO2017008115A2 (es) Ácido (2s,4r)-5-(5'-cloro-2'-fluorobifenil-4-il)-4-(etoxioxalilamino)-2-hidroximetil-2-metilpentanoico
DOP2013000308A (es) N-(6-((2r,3s)-3,4-dihidroxibutan-2-iloxi)-2-(4-fluorobenciltio)pirimidin-4-il)-3-metilacetidina-1-sulfonamida como modulador del receptor de quimiocina
BRPI0607811B8 (pt) derivados de óxido de pirimidina de 2-(4-cianofenilamino) inibidores de hiv, composição farmacêutica compreendendo os mesmos, processo para preparar a referida composição e uso
MA43686A (fr) Formulation liquide stable de gonadotrophines
UY38982A (es) Composiciones farmacéuticas
CO2019014516A2 (es) Una nanosuspensión farmacéutica para el tratamiento de la infección por vih
RU2013147449A (ru) Фармацевтическая композиция для профилактики или лечения макулярной дегенерации

Legal Events

Date Code Title Description
FC Refusal