PE18892008A1 - Indole carboxamides as inhibitors of IKK2 - Google Patents

Indole carboxamides as inhibitors of IKK2

Info

Publication number
PE18892008A1
PE18892008A1 PE0005072008A PE0005072008A PE18892008A1 PE 18892008 A1 PE18892008 A1 PE 18892008A1 PE 0005072008 A PE0005072008 A PE 0005072008A PE 0005072008 A PE0005072008 A PE 0005072008A PE 18892008 A1 PE18892008 A1 PE 18892008A1
Authority
PE
Peru
Prior art keywords
c6
indole
dioxidotetrahydro
thiopyran
carboxamide
Prior art date
Application number
PE0005072008A
Other languages
Spanish (es)
Inventor
Jeffrey Charles Boehm
Jakob Busch-Petersen
Wei Fu
Qi Jin
Jeffrey K Kerns
Guoliang Ling
Huijie Li
Xichen Lin
Christopher E Neipp
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US89655807P priority Critical
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of PE18892008A1 publication Critical patent/PE18892008A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE INDOL CARBOXAMIDAS DE FORMULA (I) DONDE R1 ES -YZ, EN DONDE Y ES UN ENLACE, ALQUILENO(C1-C6), ALQUENILENO(C2-C6) O ALQUINILENO(C2-C6); Refers to compounds carboxamides indole derivatives of formula (I) wherein R1 is -YZ, wherein Y is a bond, (C1-C6) -alkylene, (C2-C6) alkynylene O (C2-C6); Z ES ARILO O HETEROARILO OPCIONALMENTE SUSTITUIDOS CON HALO, CN, ALQUILO(C1-C6), ENTRE OTROS SUSTITUYENTES; Z is aryl or heteroaryl optionally substituted with halo, CN, (C1-C6), among other substituents; R2 ES UN HETEROCICLOALQUILO DE 4 A 10 MIEMBROS OPCIONALMENTE SUSTITUIDO CON OH, ALQUILO(C1-C6) O FENILO, ENTRE OTROS; R2 is a heterocycloalkyl of 4 to 10 membered optionally substituted with OH, (C1-C6) or phenyl, among others; R3 Y R4 SON CADA UNO HOF; R3 and R4 are each HOF; m ES 0 O 1. SON COMPUESTOS PREFERIDOS: 3-(1,1-DIOXIDOTETRAHIDRO-2H-TIOPIRAN-4-IL)-5-[5-(3-HIDROXI-3-METILBUTIL)-2-TIENIL]-1H-INDOLO-7-CARBOXAMIDA, 5-[6-(DIMETILAMINO)-3-PIRIDINIL]-3-(1,1-DIOXIDOTETRAHIDRO-2H-TIOPIRAN-4-IL)-1H-INDOLO-7-CARBOXAMIDA, 3-(1,1-DIOXIDOTETRAHIDRO-2H-TIOPIRAN-4-IL)-5-[5-({METIL[2-(METILOXI)ETIL]AMINO}METIL)-3-TIENIL]-1H-INDOLO-7-CARBOXAMIDA, ENTRE OTROS. m is 0 or 1. Preferred compounds are: 3- (1,1-dioxidotetrahydro-2H-thiopyran-4-yl) -5- [5- (3-hydroxy-3-methylbutyl) -2-thienyl] -1H- indole-7-carboxamide, 5- [6- (dimethylamino) -3-pyridinyl] -3- (1,1-dioxidotetrahydro-2H-thiopyran-4-yl) -1H-indole-7-carboxamide, 3- (1 , 1-dioxidotetrahydro-2H-thiopyran-4-yl) -5- [5 - ({methyl [2- (methyloxy) ethyl] amino} methyl) -3-thienyl] -1H-indole-7-carboxamide, LIMITED . SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. ALSO it REFERS TO A pharmaceutical composition. DICHOS COMPUESTOS SON INHIBIDORES DE LA QUINASA IKK2 SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, ASMA, RINITIS, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA Such compounds are IKK2 kinase inhibitors to be useful in the treatment of rheumatoid arthritis, asthma, rhinitis, obstructive pulmonary disease CHRONICLE
PE0005072008A 2007-03-23 2008-03-19 Indole carboxamides as inhibitors of IKK2 PE18892008A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US89655807P true 2007-03-23 2007-03-23

Publications (1)

Publication Number Publication Date
PE18892008A1 true PE18892008A1 (en) 2009-03-05

Family

ID=39788926

Family Applications (1)

Application Number Title Priority Date Filing Date
PE0005072008A PE18892008A1 (en) 2007-03-23 2008-03-19 Indole carboxamides as inhibitors of IKK2

Country Status (14)

Country Link
US (2) US8071584B2 (en)
EP (1) EP2139322A4 (en)
JP (1) JP2010522238A (en)
KR (1) KR20100015797A (en)
CN (1) CN101677547A (en)
AR (1) AR065804A1 (en)
AU (1) AU2008231105B2 (en)
CA (1) CA2681821A1 (en)
CL (1) CL2008000829A1 (en)
EA (1) EA019030B1 (en)
MX (1) MX2009010270A (en)
PE (1) PE18892008A1 (en)
TW (1) TW200901970A (en)
WO (1) WO2008118724A1 (en)

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