PE13542006A1 - Compounds 2-amino-4-oxobutyl as inhibitors of dipeptidyl peptide-iv - Google Patents

Compounds 2-amino-4-oxobutyl as inhibitors of dipeptidyl peptide-iv

Info

Publication number
PE13542006A1
PE13542006A1 PE0003512006A PE0003512006A PE13542006A1 PE 13542006 A1 PE13542006 A1 PE 13542006A1 PE 0003512006 A PE0003512006 A PE 0003512006A PE 0003512006 A PE0003512006 A PE 0003512006A PE 13542006 A1 PE13542006 A1 PE 13542006A1
Authority
PE
Peru
Prior art keywords
nil
amino
iv
dihydro
compounds
Prior art date
Application number
PE0003512006A
Other languages
Spanish (es)
Inventor
Chang-Seok Lee
Jong Sung Koh
Geun Tae Kim
Sang Yong Hong
Min-Jung Kim
Dongchul Lim
Hee Oon Han
Oh Kwan Kwon
Dong-Jun Yeo
Zi-Ho Yeom
Ji Young Kim
Gwong-Cheung Hur
Sung Ho Kim
Seong Cheol Bu
Hye Jin Kim
Hyen Joo Yim
Sungsub Kim
Kyoung-Hee Kim
Ki Dong Koo
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to KR20050027756 priority Critical
Priority to KR20050053761 priority
Priority to KR20050085980 priority
Priority to KR20050122361 priority
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of PE13542006A1 publication Critical patent/PE13542006A1/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Abstract

SE REFIERE A COMPUESTOS 2-AMINO-4-OXOBUTIL DE FORMULA (I), EN DONDE A ES i) EN DONDE R1 ES HO ALQUILO(C1-C4) OPCIONALMENTE SUSTITUIDO; It refers to compounds 2-amino-4-oxobutyl of formula (I), wherein A is i) wherein R1 is HO (C1-C4) alkyl; X ES CON; X is; ii) 3-(R2)-4,5-DIHIDRO-7H-ISOOXAZOL[3,4-c]PIRIDI-6-NIL; ii) 3- (R2) -4,5-dihydro-7H-isooxazol [3,4-c] pyridinyl-6-NIL; iii) 3,4-DIHIDRO-1H-ISOQUINOLI-1-NIL; iii) 3,4-dihydro-1H-ISOQUINOLI-1-NIL; iv) 2-(R3)-4-(R3')-5,8-DIHIDROPIRIDO[3,4-d]-PIRIMIDI-7-NIL; iv) 2- (R3) -4- (R3 ') - 5,8-dihydropyrido [3,4-d] -PIRIMIDI-7-NIL; v) 2-()-6,7-DIHIDRO[1,3]TIAZOLO[4,5-C]PIRIDI-5(4H)-NIL; v) 2 - () - 6,7-dihydro [1,3] thiazolo [4,5-c] pyridinyl-5 (4H) -nil; ENTRE OTROS y B ES UN GRUPO DE FORMULA 8); LIMITED and B is a group of formula 8); 9); 9); 10) O 11). 10) O 11). SON COMPUESTOS PREFERIDOS: 3-[2S-AMINO-4-OXO-4-(3-TRIFLUOROMETIL-5,6-DIHIDRO-8H-[1,2,4]TRIAZOLO[4,3-a]PIRAZI-7-NIL)-BUTIL]-OXAZOLIDI-2-NONA, 1-[2S-AMINO-4-OXO-4-(3-TRIFLUOROMETIL-5,6-DIHIDRO-8H-[1,2,4]TRIAZOLO[4,3-a]PIRAZI-7-NIL)-BUTIL]-PIPERIDI-2-NONA, 1-{(2S)-2-AMINO-4-OXO-4-[2-FENIL-4-(TRIFLUOROMETIL)-5,8-DIHIDROPIRIDO[3,4-d]PIRIMIDI-7(6H)-NIL]BUTIL}-5,5-DIFLUOROPIPERIDI-2-NONA, ENTRE OTROS. Preferred compounds: 3- [2S-amino-4-OXO-4- (3-trifluoromethyl-5,6-dihydro-8 H- [1,2,4] triazolo [4,3-a] PIRAZI-7-NIL ) -butyl] -OXAZOLIDI-2-NONA, 1- [2S-amino-4-OXO-4- (3-trifluoromethyl-5,6-dihydro-8 H- [1,2,4] triazolo [4,3- a] PIRAZI-7-NIL) -butyl] -PIPERIDI-2-NONA, 1 - {(2S) -2-amino-4-oxo-4- [2-phenyl-4- (trifluoromethyl) -5,8- dihydropyrido [3,4-d] PIRIMIDI-7 (6H) -nil] butyl} -5,5-DIFLUOROPIPERIDI-2-NONA, among others. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ALSO it REFERS TO A PHARMACEUTICAL COMPOSITION. ESTOS COMPUESTOS SON INHIBIDORES DE LA DIPEPTIDIL PEPTIDASA-IV (DPP-IV), POR LO QUE SON UTILES EN EL TRATAMIENTO DE DIABETES MELLITUS O LA OBESIDAD These compounds are peptidase dipeptidyl-IV (DPP-IV), so they are useful in the treatment of diabetes mellitus or obesity
PE0003512006A 2005-04-01 2006-03-30 Compounds 2-amino-4-oxobutyl as inhibitors of dipeptidyl peptide-iv PE13542006A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR20050027756 2005-04-01
KR20050053761 2005-06-22
KR20050085980 2005-09-15
KR20050122361 2005-12-13

Publications (1)

Publication Number Publication Date
PE13542006A1 true PE13542006A1 (en) 2007-01-02

Family

ID=37053586

Family Applications (1)

Application Number Title Priority Date Filing Date
PE0003512006A PE13542006A1 (en) 2005-04-01 2006-03-30 Compounds 2-amino-4-oxobutyl as inhibitors of dipeptidyl peptide-iv

Country Status (27)

Country Link
US (1) US7879848B2 (en)
EP (1) EP1863812B1 (en)
JP (1) JP4977685B2 (en)
KR (3) KR100776623B1 (en)
CN (1) CN101151265B (en)
AR (1) AR053195A1 (en)
AT (1) AT473976T (en)
AU (1) AU2006229520B2 (en)
BR (1) BRPI0609424A2 (en)
CA (1) CA2602248C (en)
DE (1) DE602006015443D1 (en)
DK (1) DK1863812T3 (en)
EA (1) EA012591B1 (en)
ES (1) ES2349178T3 (en)
IL (1) IL185479A (en)
MA (1) MA29586B1 (en)
MX (1) MX2007012175A (en)
MY (1) MY150102A (en)
NZ (1) NZ560789A (en)
PE (1) PE13542006A1 (en)
PT (1) PT1863812E (en)
SI (1) SI1863812T1 (en)
TW (1) TWI357902B (en)
UA (1) UA89396C2 (en)
UY (1) UY29448A1 (en)
WO (1) WO2006104356A1 (en)
ZA (1) ZA200708304B (en)

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Also Published As

Publication number Publication date
ZA200708304B (en) 2008-11-26
CN101151265A (en) 2008-03-26
PT1863812E (en) 2010-08-04
KR100830902B1 (en) 2008-05-22
IL185479A (en) 2013-08-29
AU2006229520A1 (en) 2006-10-05
MX2007012175A (en) 2007-11-21
TW200724542A (en) 2007-07-01
BRPI0609424A2 (en) 2010-03-30
KR100794184B1 (en) 2008-01-11
EA012591B1 (en) 2009-10-30
JP2008534581A (en) 2008-08-28
KR20070094714A (en) 2007-09-21
EA200701854A1 (en) 2008-02-28
DE602006015443D1 (en) 2010-08-26
DK1863812T3 (en) 2010-10-18
NZ560789A (en) 2009-11-27
AR053195A1 (en) 2007-04-25
UA89396C2 (en) 2010-01-25
JP4977685B2 (en) 2012-07-18
AT473976T (en) 2010-07-15
AU2006229520B2 (en) 2010-07-29
EP1863812A4 (en) 2009-06-24
CA2602248C (en) 2011-06-28
IL185479D0 (en) 2008-01-06
KR100776623B1 (en) 2007-11-15
UY29448A1 (en) 2006-10-31
ES2349178T3 (en) 2010-12-28
US7879848B2 (en) 2011-02-01
US20080188471A1 (en) 2008-08-07
MY150102A (en) 2013-11-29
WO2006104356A1 (en) 2006-10-05
SI1863812T1 (en) 2010-11-30
MA29586B1 (en) 2008-07-01
EP1863812A1 (en) 2007-12-12
CA2602248A1 (en) 2006-10-05
CN101151265B (en) 2012-11-28
EP1863812B1 (en) 2010-07-14
KR20060105609A (en) 2006-10-11
TWI357902B (en) 2012-02-11
KR20070098774A (en) 2007-10-05

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