PE13422001A1 - Process for coating medical devices with a thin polymer film and a therapeutic agent - Google Patents

Process for coating medical devices with a thin polymer film and a therapeutic agent

Info

Publication number
PE13422001A1
PE13422001A1 PE0004322001A PE0004322001A PE13422001A1 PE 13422001 A1 PE13422001 A1 PE 13422001A1 PE 0004322001 A PE0004322001 A PE 0004322001A PE 0004322001 A PE0004322001 A PE 0004322001A PE 13422001 A1 PE13422001 A1 PE 13422001A1
Authority
PE
Peru
Prior art keywords
therapeutic agent
polymer
medical devices
process
supercritical
Prior art date
Application number
PE0004322001A
Other languages
Spanish (es)
Inventor
Deepak B Mehta
Michael Corbo
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US20499100P priority Critical
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of PE13422001A1 publication Critical patent/PE13422001A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • A61L31/10Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08Materials for coatings
    • A61L29/085Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L29/00Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606Coatings

Abstract

SE REFIERE A UN PROCESO PARA RECUBRIR DISPOSITIVOS MEDICOS, TALES COMO STENTS, CON UN POLIMERO DE PELICULA DELGADA QUE OPCIONALMENTE CONTIENE UN AGENTE TERAPEUTICO Y COMPRENDE: a) PONER EL STENT U OTRO DISPOSITIVO EN CONTACTO CON UNA SOLUCION DE RECUBRIMIENTO LIQUIDA QUE CONTIENE UN POLIMERO BIOCOMPATIBLE QUE FORMA UNA PELICULA Y UN AGENTE TERAPEUTICO OPCIONAL EN UN SOLVENTE SUPERCRITICO, TAL COMO DIOXIDO DE CARBONO, ETANOL, AMONIACO, ISOPROPANOL EN CONDICIONES DE TEMPERATURA Y PRESION SUPERCRITICAS DE MANERA QUE EL POLIMERO Y EL AGENTE TERAPEUTICO SE SOLUBILICEN EN CONDICIONES SUPERCRITICAS PERO SEAN INSOLUBLES EN CONDICIONES SUBCRITICAS; It REFERS TO A RECOATABILITY medical devices, such as stents PROCESS WITH A POLYMER THIN FILM optionally containing a therapeutic agent and comprises: a) placing the stent or other device in contact with a coating solution containing liquid A biocompatible polymer FORMING A FILM AND AN AGENT THERAPEUTIC OPTION IN A supercritical solvent, AS CARBON DIOXIDE, ethanol, ammonia, isopropanol in temperature and supercritical pressure so that the polymer and therapeutic agent solubilized in supercritical conditions, but insoluble in subcritical conditions; Y, b) REDUCIR LAS CONDICIONES DE PRESION Y/O TEMPERATURA A NIVELES SUBCRITICOS PARA DEPOSITAR UN RECUBRIMIENTO DE PELICULA DELGADO DE DICHO POLIMERO Y AGENTE TERAPEUTICO OPCIONAL SOBRE EL DISPOSITIVO MEDICO. And b) reducing conditions of pressure and / or temperature A LEVELS subcritical to deposit a film coating of said polymer DELGADO AND THERAPEUTIC AGENT OPTION ON MEDICAL DEVICE. SIENDO LOS STENTS ESTRUCTURAS TUBULARES ABIERTAS QUE SE UTILIZAN EN LOS PROCEDIMIENTOS TRANSLUMINALES, COMO ANGIOPLASTIA, PARA RESTAURAR UN FLUJO SANGUINEO ADECUADO AL CORAZON Stents STRUCTURES REMAIN OPEN TUBES USED IN transluminal procedures, such as angioplasty, to restore a PROPER BLOOD FLOW TO THE HEART
PE0004322001A 2000-05-16 2001-05-14 Process for coating medical devices with a thin polymer film and a therapeutic agent PE13422001A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US20499100P true 2000-05-16 2000-05-16

Publications (1)

Publication Number Publication Date
PE13422001A1 true PE13422001A1 (en) 2002-01-28

Family

ID=22760326

Family Applications (1)

Application Number Title Priority Date Filing Date
PE0004322001A PE13422001A1 (en) 2000-05-16 2001-05-14 Process for coating medical devices with a thin polymer film and a therapeutic agent

Country Status (16)

Country Link
US (1) US6627246B2 (en)
EP (1) EP1301221B1 (en)
JP (1) JP4786113B2 (en)
AR (1) AR032456A1 (en)
AT (1) AT317709T (en)
AU (2) AU2001255438B2 (en)
CA (1) CA2409003C (en)
CY (1) CY1107325T1 (en)
DE (1) DE60117251T2 (en)
DK (1) DK1301221T3 (en)
ES (1) ES2257407T3 (en)
MX (1) MXPA02011427A (en)
MY (1) MY129015A (en)
PE (1) PE13422001A1 (en)
TW (1) TWI288006B (en)
WO (1) WO2001087368A1 (en)

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CA2409003A1 (en) 2001-11-22
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MXPA02011427A (en) 2004-09-10
JP4786113B2 (en) 2011-10-05
AU5543801A (en) 2001-11-26
WO2001087368A1 (en) 2001-11-22
TWI288006B (en) 2007-10-11
AR032456A1 (en) 2003-11-12
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DK1301221T3 (en) 2006-07-03
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US6627246B2 (en) 2003-09-30

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