PE12282008A1 - heteromonocyclic compound - Google Patents

heteromonocyclic compound

Info

Publication number
PE12282008A1
PE12282008A1 PE0016292007A PE0016292007A PE12282008A1 PE 12282008 A1 PE12282008 A1 PE 12282008A1 PE 0016292007 A PE0016292007 A PE 0016292007A PE 0016292007 A PE0016292007 A PE 0016292007A PE 12282008 A1 PE12282008 A1 PE 12282008A1
Authority
PE
Peru
Prior art keywords
oxo
yl
methyl
diseases
oxadiazol
Prior art date
Application number
PE0016292007A
Other languages
Spanish (es)
Inventor
Takanobu Kuroita
Hiroki Sakamoto
Hideyuki Igawa
Minoru Sasaki
Kouhei Asano
Tsuyoshi Maekawa
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2006317839 priority Critical
Priority to JP2007232106 priority
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE12282008A1 publication Critical patent/PE12282008A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, EN DONDE R1 ES OXO, TIOXO, =NR; It REFERS TO A compound of formula I wherein R1 is oxo, thioxo, = NR; R ES ALQUILO C1-C6 SUSTITUIDO O NO, OH, =N-CO-(ALQUILO C1-C6), ENTRE OTROS; R is C1-C6 substituted or OH, = N-CO- (C1-C6), among others; X, X1 Y X2 SON CADA UNO C, N, OPCIONALMENTE SUSTITUIDOS. X, X1 and X2 are each C, N, optionally substituted. SON COMPUESTOS PREFERIDOS: 3-(4-ISOPROPOXIFENIL)-2-METIL-5-{[2'-(5-OXO-4,5-DIHIDRO-1,2,4-OXADIAZOL-3-IL)BIFENIL-4-IL]METIL}-6-PROPILPIRIMIDIN-4(3H)-ONA; Preferred compounds: 3- (4-isopropoxyphenyl) -2-methyl-5 - {[2 '- (5-OXO-4,5-dihydro-1,2,4-oxadiazol-3-yl) biphenyl-4- yl] methyl} -6-propyl-pyrimidin-4 (3H) -one; 6-BUTIL-2-METOXI-5-{[2'-(5-OXO-4,5-DIHIDRO-1,2,4-OXADIAZOL-3IL)BIFENIL-4-IL]METIL}-3-FENILPIRIMIDIN-4(3H)-ONA, ENTRE OTROS. 6-Butyl-2-methoxy-5 - {[2 '- (5-OXO-4,5-dihydro-1,2,4-oxadiazol-3yl) biphenyl-4-yl] methyl} -3-phenylpyrimidine-4 (3H) -one, among others. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ALSO it REFERS TO A pharmaceutical composition and method of preparation. LOS COMPUESTOS DESCRITOS TIENEN ACTIVIDAD INHIBITORIA DEL RECEPTOR DE ANGIOTENSINA II Y/O UNA ACTIVIDAD AGONISTA DEL RECEPTOR ACTIVADO POR EL PROLIFERADOR DE PEROXISOMAS, UTILES EN EL TRATAMIENTO Y PREVENCION DE ENFERMEDADES CIRCULATORIAS, ENFERMEDADES METABOLICAS Y ENFERMEDADES DEL SITEMA NERVIOSO CENTRAL Described compounds have INHIBITORY ACTIVITY II receptor blockers and / or a receptor agonist ACTIVITY ON peroxisome proliferator useful in the treatment and prevention of circulatory diseases, metabolic diseases and diseases of CENTRAL NERVOUS SYSTEM
PE0016292007A 2006-11-24 2007-11-23 heteromonocyclic compound PE12282008A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2006317839 2006-11-24
JP2007232106 2007-09-06

Publications (1)

Publication Number Publication Date
PE12282008A1 true PE12282008A1 (en) 2008-10-29

Family

ID=39205144

Family Applications (1)

Application Number Title Priority Date Filing Date
PE0016292007A PE12282008A1 (en) 2006-11-24 2007-11-23 heteromonocyclic compound

Country Status (21)

Country Link
US (2) US20100056526A1 (en)
EP (2) EP2074117A2 (en)
JP (1) JP2010510962A (en)
KR (1) KR20090085117A (en)
AR (1) AR063912A1 (en)
AU (1) AU2007322608A1 (en)
BR (1) BRPI0719060A2 (en)
CA (1) CA2670404A1 (en)
CL (1) CL2007003352A1 (en)
CO (1) CO6231035A2 (en)
CR (1) CR10847A (en)
EA (1) EA200970510A1 (en)
EC (1) ECSP099461A (en)
IL (1) IL198819D0 (en)
MA (1) MA30985B1 (en)
MX (1) MX2009005449A (en)
NO (1) NO20092415L (en)
PE (1) PE12282008A1 (en)
TN (1) TN2009000199A1 (en)
TW (1) TW200829581A (en)
WO (1) WO2008062905A2 (en)

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TWI525088B (en) * 2011-03-14 2016-03-11 Kowa Co The phenylpyridine derivative and a novel pharmaceutical comprising the derivative of
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US9056110B2 (en) 2011-12-06 2015-06-16 Confluence Life Sciences, Inc. Substituted pyrimidinone-phenyl-pyrimidinyl compounds
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EP3003039A4 (en) 2013-06-07 2017-04-19 Confluence Life Sciences, Inc. Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds
EP3010893B1 (en) 2013-06-20 2019-10-02 Bayer CropScience Aktiengesellschaft Arylsulfide and arylsulfoxide derivatives as acaricides and insecticides
WO2014202505A1 (en) 2013-06-20 2014-12-24 Bayer Cropscience Ag Aryl sulfide derivatives and aryl sulfoxide derivatives as acaricides and insecticides
US9674563B2 (en) 2013-11-04 2017-06-06 Rovi Guides, Inc. Systems and methods for recommending content
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Also Published As

Publication number Publication date
MX2009005449A (en) 2009-06-02
IL198819D0 (en) 2010-02-17
BRPI0719060A2 (en) 2014-02-04
WO2008062905A2 (en) 2008-05-29
TW200829581A (en) 2008-07-16
AU2007322608A1 (en) 2008-05-29
AU2007322608A2 (en) 2009-07-16
US20100056526A1 (en) 2010-03-04
NO20092415L (en) 2009-08-17
TN2009000199A1 (en) 2010-10-18
CL2007003352A1 (en) 2008-07-04
EA200970510A1 (en) 2009-12-30
AR063912A1 (en) 2009-02-25
ECSP099461A (en) 2009-11-30
EP2074117A2 (en) 2009-07-01
EP2256115A1 (en) 2010-12-01
JP2010510962A (en) 2010-04-08
WO2008062905A3 (en) 2008-12-04
CO6231035A2 (en) 2010-12-20
US20080207654A1 (en) 2008-08-28
CR10847A (en) 2009-07-13
CA2670404A1 (en) 2008-05-29
KR20090085117A (en) 2009-08-06
MA30985B1 (en) 2009-12-01

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