PE10672012A1 - Form of controlled release dosage extruded by hot melt - Google Patents

Form of controlled release dosage extruded by hot melt

Info

Publication number
PE10672012A1
PE10672012A1 PE2012000082A PE0000822012A PE10672012A1 PE 10672012 A1 PE10672012 A1 PE 10672012A1 PE 2012000082 A PE2012000082 A PE 2012000082A PE 0000822012 A PE0000822012 A PE 0000822012A PE 10672012 A1 PE10672012 A1 PE 10672012A1
Authority
PE
Peru
Prior art keywords
controlled release
opioid
extruded
referred
form
Prior art date
Application number
PE2012000082A
Other languages
Spanish (es)
Inventor
Lutz Barnscheid
Eric Galia
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to EP09009499 priority Critical
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42332474&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE10672012(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Publication of PE10672012A1 publication Critical patent/PE10672012A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Abstract

REFERIDA A UNA FORMA DE DOSIFICACION ORAL DE EXTRUSION POR FUSION EN CALIENTE DE LIBERACION CONTROLADA QUE COMPRENDE: A) UN INGREDIENTE FARMACOLOGICAMENTE ACTIVO TAL COMO UN OPIOIDE INCLUIDO EN UNA MATRIZ QUE CONTIENE B) UN POLIMEROTAL COMO UN OXIDO DE POLIALQUILENO QUE PRESENTA UN PESO MOLECULAR DE POR LO MENOS 200.000g/mol. REFERRED TO oral dosage form Extrusion hotmelt controlled release comprising: a) a pharmacologically active agent such as an opioid ingredient included in a matrix containing B) A POLIMEROTAL AS A polyalkyleneoxide having a weight MOLECULAR AT LEAST 200.000g / mol. REFERIDA ADEMAS A UN PROCESO DE PREPARACION QUE COMPRENDE: A) EXTRUSION EN CALIENTE DE UNA MASA QUE COMPRENDE EL OPIOIDE Y EL POLIMERO; ALSO REFERRED TO AN PROCESS preparation comprising: A) A hot extrusion mass comprising the opioid and polymer; B) CORTE DE DICHO EXTRUIDO EN SECCIONES QUE PRESENTAN 2 SUPERFICIES CORTADAS OPUESTAS DE FORMA OBLONGA; B) cutting said extruded sections presenting two opposite cut surfaces oblong shape; C) COLOCAR EN UNA TABLETEADORA QUE COMPRENDE UN PUNZON SUPERIOR Y UN PUNZON INFERIOR, DE UNA MANERA EN QUE LAS SUPERFICIES OPUESTAS DE FORMA OBLONGA SE ENCUENTRAN ENFRENTADAS A DICHOS PUNZONES SUPERIOR E INFERIOR RESPECTIVAMENTE; C) placed in a tableting comprising an upper punch and lower punch, in a way that opposing surfaces oblong ARE FACING A TOP AND BOTTOM PUNCHES SUCH respectively; D) OPCIONALMENTE APLICAR UN RECUBRIMIENTO DE PELICULA. D) optionally applying a film coating. DICHA DOSIFICACION SE CARACTERIZA POR UN PERFIL DE LIBERACION MODIFICADO DEL COMPUESTO DOSAGE IS DEFINED BY THIS PROFILE COMPOUND MODIFIED RELEASE
PE2012000082A 2009-07-22 2010-07-21 Form of controlled release dosage extruded by hot melt PE10672012A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09009499 2009-07-22

Publications (1)

Publication Number Publication Date
PE10672012A1 true PE10672012A1 (en) 2012-09-05

Family

ID=42332474

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012000082A PE10672012A1 (en) 2009-07-22 2010-07-21 Form of controlled release dosage extruded by hot melt

Country Status (21)

Country Link
US (1) US10080721B2 (en)
EP (1) EP2456427B1 (en)
JP (1) JP5667183B2 (en)
KR (1) KR101738369B1 (en)
CN (1) CN102573805A (en)
AR (1) AR077493A1 (en)
AU (1) AU2010275753B2 (en)
BR (1) BR112012001547A2 (en)
CA (1) CA2765971C (en)
CO (1) CO6470796A2 (en)
EC (1) ECSP12011597A (en)
ES (1) ES2534908T3 (en)
HK (1) HK1167811A1 (en)
IL (1) IL216526A (en)
MX (1) MX2012000317A (en)
NZ (1) NZ596667A (en)
PE (1) PE10672012A1 (en)
RU (1) RU2547555C2 (en)
TW (1) TW201105316A (en)
WO (1) WO2011009602A1 (en)
ZA (1) ZA201109445B (en)

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