PE09382009A1 - pharmaceutical composition comprising a benzene derivative substituted glucopyranosyl - Google Patents

pharmaceutical composition comprising a benzene derivative substituted glucopyranosyl

Info

Publication number
PE09382009A1
PE09382009A1 PE0013822008A PE0013822008A PE09382009A1 PE 09382009 A1 PE09382009 A1 PE 09382009A1 PE 0013822008 A PE0013822008 A PE 0013822008A PE 0013822008 A PE0013822008 A PE 0013822008A PE 09382009 A1 PE09382009 A1 PE 09382009A1
Authority
PE
Peru
Prior art keywords
methyl
yl
pharmaceutical composition
amino
formula
Prior art date
Application number
PE0013822008A
Other languages
Spanish (es)
Inventor
Klaus Dugi
Frank Himmelsbach
Michael Mark
Leo Thomas
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to EP07114459 priority Critical
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE09382009A1 publication Critical patent/PE09382009A1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39870130&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE09382009(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • A61K9/1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds

Abstract

REFERIDA A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: a) UN DERIVADO DE BENCENO SUSTITUIDO CON GLUCOPIRANOSILO DE FORMULA (I), DONDE R1 ES CLORO, METILO O CIANO; REFERRED TO A PHARMACEUTICAL COMPOSITION COMPRISING: a) a benzene derivative substituted glucopyranosyl formula (I), wherein R1 is chloro, methyl or cyano; R2 ES H, METILO, METOXI O HIDROXI; R2 is H, methyl, methoxy or hydroxy; R3 ES ETILO, CICLOPROPILO, ETINILO, ETOXI, (R)-TETRAHIDROFURANO-3-ILOXI O (S)-TETRAHIDROFURANO-3-ILOXI Y b) UN INHIBIDOR DE DPP IV DE FORMULA (I), (II), (III) O (IV), DONDE R1 ES ([1,5]NAFTIRIDIN-2-IL)METILO, (QUINAZOLIN-2-IL)METILO, (QUINOXALIN-6-IL)METILO, 2-CIANO-BENCILO, ENTRE OTROS Y R2 ES 3-(R)-AMINO-PIPERIDIN-1-ILO, (2-AMINO-2-METIL-PROPIL)-METILAMINO O (2-(S)-AMINO-PROPIL)-METILAMINO; R3 is ethyl, cyclopropyl, ethynyl, ethoxy, (R) -tetrahydrofuran-3-yloxy O (S) -tetrahydrofuran-3-yloxy and b) a DPP IV of formula (I), (II), (III) O (IV), wherein R1 is ([1,5] naphthyridin-2-yl) methyl, (QUINAZOLIN-2-YL) mETHYL, (quinoxalin-6-yl) methyl, 2-cyano-benzyl, among others R2 It is 3- (R) -amino-piperidin-1-yl, (2-aMINO-2-methylpropyl) methylamino or (2- (S) -amino-propyl) -methylamino; O a) UN DERIVADO DE FORMULA (I) Y b) UN INHIBIDOR DE DPP IV TAL COMO SITAGLIPTINA, VIDAGLIPTINA, SAXAGLIPTINA, ALOGLIPTINA, DENAGLIPTINA, ENTRE OTROS. Or a) a compound of formula (I) and b) a DPP IV AS sitagliptin, vildagliptin, saxagliptin, alogliptin, DENAGLIPTINA, among others. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE LA DIABETES MELLITUS TIPO 1 Y TIPO 2, ALTERACION DE LA TOLERANCIA A LA GLUCOSA E HIPERGLUCEMIA Said composition is useful in treating mellitus type 1 diabetes and type 2, ALTERATION OF GLUCOSE TOLERANCE AND HYPERGLYCEMIA
PE0013822008A 2007-08-16 2008-08-14 pharmaceutical composition comprising a benzene derivative substituted glucopyranosyl PE09382009A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07114459 2007-08-16

Publications (1)

Publication Number Publication Date
PE09382009A1 true PE09382009A1 (en) 2009-08-08

Family

ID=39870130

Family Applications (1)

Application Number Title Priority Date Filing Date
PE0013822008A PE09382009A1 (en) 2007-08-16 2008-08-14 pharmaceutical composition comprising a benzene derivative substituted glucopyranosyl

Country Status (37)

Country Link
US (1) US8551957B2 (en)
EP (3) EP2698152A1 (en)
JP (1) JP5595914B2 (en)
KR (1) KR101491554B1 (en)
CN (3) CN104353077A (en)
AR (2) AR067970A1 (en)
AU (1) AU2008288407B2 (en)
CA (1) CA2696558C (en)
CO (1) CO6251239A2 (en)
CY (1) CY1118308T1 (en)
DK (1) DK2187879T3 (en)
EA (1) EA018608B1 (en)
EC (1) ECSP109977A (en)
ES (1) ES2602748T3 (en)
HK (2) HK1203351A1 (en)
HR (1) HRP20170022T1 (en)
HU (2) HUE030158T2 (en)
IL (1) IL202886A (en)
LT (2) LT2187879T (en)
MA (1) MA31612B1 (en)
ME (1) ME02573B (en)
MX (1) MX2010001696A (en)
MY (1) MY152037A (en)
NL (1) NL300872I2 (en)
NO (1) NO2017020I2 (en)
NZ (1) NZ583242A (en)
PE (1) PE09382009A1 (en)
PL (1) PL2187879T3 (en)
PT (1) PT2187879T (en)
RS (1) RS55205B1 (en)
SI (1) SI2187879T1 (en)
TN (1) TN2010000073A1 (en)
TW (2) TWI472325B (en)
UA (1) UA100384C2 (en)
UY (1) UY31296A1 (en)
WO (1) WO2009022007A1 (en)
ZA (1) ZA200909105B (en)

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