PE09102017A1 - anti-interleukin-33 antibodies and their uses - Google Patents

anti-interleukin-33 antibodies and their uses

Info

Publication number
PE09102017A1
PE09102017A1 PE2017000823A PE0008232017A PE09102017A1 PE 09102017 A1 PE09102017 A1 PE 09102017A1 PE 2017000823 A PE2017000823 A PE 2017000823A PE 0008232017 A PE0008232017 A PE 0008232017A PE 09102017 A1 PE09102017 A1 PE 09102017A1
Authority
PE
Peru
Prior art keywords
hvr
seq id
amino acid
acid sequence
whose amino
Prior art date
Application number
PE2017000823A
Other languages
Spanish (es)
Inventor
Philip E Hass
Meredith Hazen
Yi-Chun Hsiao
Rajita Khosla
Gerald R Nakamura
Dhaya Seshasayee
Lookeren-Campagne Menno Van
Hongkang Xi
Wenwu Zhai
Jack Bevers Iii
Nancy Chiang
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201462077876P priority Critical
Priority to US201562165732P priority
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE09102017A1 publication Critical patent/PE09102017A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/53Hinge
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54F(ab')2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

SE REFIERE A UN ANTICUERPO AISLADO QUE SE UNE A INTERLEUCINA-33 HUMANA (IL-33) QUE COMPRENDE UN DOMINIO DE UNION QUE COMPRENDE LAS SIGUIENTES SEIS REGIONES HIPERVARIABLES (HVR): i) UNA HVR-H1 CUYA SECUENCIA DE AMINOACIDOS ES LA SEQ ID NO: 1; CONCERNS an isolated antibody that binds to interleukin-33 HUMANA (IL-33) comprising a binding domain comprising the following six regions hypervariable (HVR): i) an HVR-H1 whose amino acid sequence is SEQ ID NO: 1; ii) UNA HVR-H2 CUYA SECUENCIA DE AMINOACIDOS ES LA SEQ ID NO:2; ii) an HVR-H2 WHOSE amino acid sequence is SEQ ID NO: 2; iii) UNA HVR-H3 CUYA SECUENCIA DE AMINOACIDOS ES LA SEQ ID NO: 3; iii) an HVR-H3 IS whose amino acid sequence SEQ ID NO: 3; iv) UNA HVR-L1 CUYA SECUENCIA DE AMINOACIDOS ES LA SEQ ID NO: 4; iv) an HVR-L1 whose amino acid sequence is SEQ ID NO: 4; v) UNA HVR-L2 CUYA SECUENCIA DE AMINOACIDOS ES LA SEQ ID NO: 5; v) A HVRL2 whose amino acid sequence is SEQ ID NO: 5; Y vi) UNA HVR-L3 CUYA SECUENCIA DE AMINOACIDOS ES LA SEQ ID NO: 6. TAMBIEN SE REFIERE A UN ACIDO NUCLEICO; And vi) an HVR-L3 whose amino acid sequence is SEQ ID NO: 6. ALSO REFERRED TO A NUCLEIC ACID; UN VECTOR DE EXPRESION, UNA CELULA HOSPEDADORA YA UNA COMPOSICION FARMACEUTICA. An expression vector, a cell host and composition pharmaceutics. DICHO ANTICUERPO ES UTIL EN EL TRATAMIENTO DE ASMA, DERMATITIS ATOPICA, RINITIS ALERGICA, ARTRITIS REUMATOIDE Such an antibody is useful in the treatment of asthma, dermatitis Atopic Rhinitis ALLERGIC, RHEUMATOID ARTHRITIS
PE2017000823A 2014-11-10 2015-11-10 anti-interleukin-33 antibodies and their uses PE09102017A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US201462077876P true 2014-11-10 2014-11-10
US201562165732P true 2015-05-22 2015-05-22

Publications (1)

Publication Number Publication Date
PE09102017A1 true PE09102017A1 (en) 2017-07-12

Family

ID=54608970

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2017000823A PE09102017A1 (en) 2014-11-10 2015-11-10 anti-interleukin-33 antibodies and their uses

Country Status (17)

Country Link
US (2) US10093730B2 (en)
EP (1) EP3218403A1 (en)
JP (1) JP2018500883A (en)
KR (1) KR20170080604A (en)
CN (1) CN107172879A (en)
AU (1) AU2015346460A1 (en)
BR (1) BR112017009728A2 (en)
CA (1) CA2960297A1 (en)
CR (1) CR20170240A (en)
EA (1) EA201791029A1 (en)
IL (1) IL251248D0 (en)
MX (1) MX2017006094A (en)
PE (1) PE09102017A1 (en)
PH (1) PH12017500861A1 (en)
SG (1) SG11201703767XA (en)
TW (1) TW201625683A (en)
WO (1) WO2016077381A1 (en)

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RU2016132757A3 (en) 2014-01-10 2018-07-16
US10072075B2 (en) 2015-09-23 2018-09-11 Genentech, Inc. Optimized variants of anti-VEGF antibodies and methods of treatment thereof by reducing or inhibiting angiogenesis
MX2018013038A (en) 2016-04-27 2019-03-28 Pfizer Anti-il-33 antibodies, compositions, methods and uses thereof.
WO2018045210A1 (en) * 2016-09-02 2018-03-08 Therapeutics Lp 180 Method of treating localized fibrotic disorders using an il-33/tnf bispecific antibody
WO2018045213A1 (en) * 2016-09-02 2018-03-08 180 Therapeutics Lp Method of treating systemic fibrotic disorders using an il-33/tnf bispecific antibody
TWI647238B (en) * 2016-10-28 2019-01-11 美商美國禮來大藥廠 Anti-il-33 ANTIBODIES AND USES
TW201827079A (en) 2016-12-01 2018-08-01 美商再生元醫藥公司 Methods of treating inflammation
AR110873A1 (en) 2017-02-10 2019-05-08 Genentech Inc Antibodies against tryptase, these compositions and uses of these
WO2018190990A1 (en) 2017-04-13 2018-10-18 Regeneron Pharmaceuticals, Inc. Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1

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