PE06962009A1 - Crystalline forms of saxagliptin and processes for preparing the same - Google Patents

Crystalline forms of saxagliptin and processes for preparing the same

Info

Publication number
PE06962009A1
PE06962009A1 PE0006702008A PE0006702008A PE06962009A1 PE 06962009 A1 PE06962009 A1 PE 06962009A1 PE 0006702008 A PE0006702008 A PE 0006702008A PE 0006702008 A PE0006702008 A PE 0006702008A PE 06962009 A1 PE06962009 A1 PE 06962009A1
Authority
PE
Peru
Prior art keywords
form
saxagliptin
crystalline forms
preparing
processes
Prior art date
Application number
PE0006702008A
Other languages
Spanish (es)
Inventor
Jack Z Gougoutas
Mary F Malley
John D Dimarco
Chenkou Wei
Jurong Yu
Truc Chi Vu
Gregory Scott Jones
Scott A Savage
Xiaotian S Yin
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US91295007P priority Critical
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of PE06962009A1 publication Critical patent/PE06962009A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

REFERIDA A UNA FORMA CRISTALINA DE SAXAGLIPTINA (FORMULA I): FORMA DE UN MONOHIDRATO DE LA BASE LIBRE (FORMA H-1), FORMA DE UN SEMIHIDRATO DE LA BASE LIBRE (FORMA H.5-2) O UNA BASE LIBRE PURA (FORMA N-3), DONDE LA FORMA H-1 TIENE UN PATRON DE DIFRACCION DE POLVO DE RAYOS X QUE POSEE LOS VALORES 2 THETA: 12.4 + 1, 13.3 + 1, 13,6 + 1, 1.47+ 1, 16.2 + 1, 18.2 + 1, 19.9 + 1, 20.9 + 1, 21.9 + 1 Y 22.4 + 1 A UNA TEMPERATURA AMBIENTE. Referring to a crystalline form of saxagliptin (FORMULA I): FORM OF A Monohydrate freebase (Form H-1), hemihydrate A FORM OF freebase (Form H.5-2) OR pure free base (FORMA N-3), where the form H-1 has a diffraction pattern X-ray powder whose property values ​​2 theta: 12.4 + 1 13.3 + 1 13.6 + 1 1.47+ 1 + 1 02.16, 18.2 + 1 + 1 19.9 20.9 + 1, 21.9, and 22.4 + 1 + 1 TO ROOM TEMPERATURE. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA YA UN PROCEDIMIENTO DE PREPARACION. ALSO REFERRED TO A pharmaceutical composition and method of preparation. DICHAS FORMAS CRISTALINAS DEL COMPUESTO SAXAGLIPTINA SON INHIBIDORAS DE LA DIPEPTIDILPEPTIDASA 4 (DPP4) Y SON UTILES EN EL TRATAMIENTO DE LA DIABETES MELLITUS TIPO 2, OBESIDAD, ENTRE OTRAS COMPOUND said crystalline forms saxagliptin are inhibitors of the dipeptidyl peptidase 4 (DPP4) and are useful in the treatment of diabetes mellitus type 2, obesity, AMONG OTHERS
PE0006702008A 2007-04-20 2008-04-17 Crystalline forms of saxagliptin and processes for preparing the same PE06962009A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US91295007P true 2007-04-20 2007-04-20

Publications (1)

Publication Number Publication Date
PE06962009A1 true PE06962009A1 (en) 2009-06-20

Family

ID=39831852

Family Applications (1)

Application Number Title Priority Date Filing Date
PE0006702008A PE06962009A1 (en) 2007-04-20 2008-04-17 Crystalline forms of saxagliptin and processes for preparing the same

Country Status (10)

Country Link
US (4) US7943656B2 (en)
EP (2) EP2481726A3 (en)
JP (2) JP2010524966A (en)
CN (3) CN102924363A (en)
AR (1) AR066130A1 (en)
CL (1) CL2008001127A1 (en)
PE (1) PE06962009A1 (en)
TW (1) TW200906391A (en)
UA (2) UA107174C2 (en)
WO (1) WO2008131149A2 (en)

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