PE03522015A1 - Modulators of glucocorticoid receptor fused heteroaryl ketone azadecalin - Google Patents

Modulators of glucocorticoid receptor fused heteroaryl ketone azadecalin

Info

Publication number
PE03522015A1
PE03522015A1 PE0020542014A PE0020542014A PE03522015A1 PE 03522015 A1 PE03522015 A1 PE 03522015A1 PE 0020542014 A PE0020542014 A PE 0020542014A PE 0020542014 A PE0020542014 A PE 0020542014A PE 03522015 A1 PE03522015 A1 PE 03522015A1
Authority
PE
Peru
Prior art keywords
modulators
yl
glucocorticoid receptor
azadecalin
fused heteroaryl
Prior art date
Application number
PE0020542014A
Other languages
Spanish (es)
Inventor
Hazel Hunt
Tony Johnson
Nicholas Ray
Iain Walters
Original Assignee
Corcept Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201261651669P priority Critical
Priority to US201261691083P priority
Priority to US201261715907P priority
Priority to US201361759520P priority
Priority to US201361781629P priority
Application filed by Corcept Therapeutics Inc filed Critical Corcept Therapeutics Inc
Publication of PE03522015A1 publication Critical patent/PE03522015A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53831,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I), DONDE R1 ES UN ANILLO DE HETEROARILO; MEANS a compound of formula (I), wherein R1 is a heteroaryl ring; R2 SE SELECCIONA DE H, ALQUILO C1-C6, ENTRE OTROS; R2 is selected from H, C1-C6 alkyl, among others; R3 SE SELCCIONA DE FENILO Y PIRIDILO, n ES 0-3; R3 SELCCIONA Phenyl and pyridyl, n is 0-3; J ES UN ANILLO CICLOALQUILO, ANILLO DE ARILO, ENTRE OTROS. J is a ring cycloalkyl, aryl, among others. SON COMPUESTOS PREFERIDOS (R)-(6-((6-CLOROPIRIDIN-3-IL)SULFONIL)-1-(4-FLUOROFENIL)-4,4 a, 5,6,7,8-HEXAHIDRO-1H-PIRAZOLO[3,4-g]ISOQUINOLIN-4 a- IL)(PIRIDIN-2-IL)METANONA; Preferred compounds (R) - (6 - ((6-chloropyridin-3-yl) sulfonyl) -1- (4-fluorophenyl) -4,4 a, 5,6,7,8-hexahydro-1H-pyrazolo [ 3,4-g] isoquinolin-4 a- IL) (pyridin-2-yl) methanone; (R)-(6-((6-CLOROPIRIDIN-3-IL)SULFONIL)-1-(4-FLUOROFENIL)-4,4 a, 5,6,7,8-HEXAHIDRO-1H-PIRAZOLO[3,4-g]ISOQUINOLIN-4 a- IL)(TIAZOL-2-IL)METANONA, ENTRE OTROS. (R) - (6 - ((6-chloropyridin-3-yl) sulfonyl) -1- (4-fluorophenyl) -4,4 a, 5,6,7,8-hexahydro-1H-pyrazolo [3,4 -g] isoquinolin-4 a- IL) (thiazol-2-yl) methanone, among others. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. SE also relates to a pharmaceutical composition. DICHOS COMPUESTOS SON UTILES COMO MODULADORES DEL RECEPTOR DE GLUCOCORTICOIDE. Such compounds are useful as modulators of the glucocorticoid receptor.
PE0020542014A 2012-05-25 2013-05-24 Modulators of glucocorticoid receptor fused heteroaryl ketone azadecalin PE03522015A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US201261651669P true 2012-05-25 2012-05-25
US201261691083P true 2012-08-20 2012-08-20
US201261715907P true 2012-10-19 2012-10-19
US201361759520P true 2013-02-01 2013-02-01
US201361781629P true 2013-03-14 2013-03-14

Publications (1)

Publication Number Publication Date
PE03522015A1 true PE03522015A1 (en) 2015-03-16

Family

ID=49624542

Family Applications (1)

Application Number Title Priority Date Filing Date
PE0020542014A PE03522015A1 (en) 2012-05-25 2013-05-24 Modulators of glucocorticoid receptor fused heteroaryl ketone azadecalin

Country Status (21)

Country Link
EP (2) EP2854814B1 (en)
JP (1) JP6172871B2 (en)
KR (1) KR20150021955A (en)
CN (1) CN104619328B (en)
AU (1) AU2013266110C1 (en)
CA (1) CA2872260A1 (en)
CL (1) CL2014003173A1 (en)
DK (1) DK2854814T3 (en)
ES (1) ES2665338T3 (en)
HK (1) HK1208818A1 (en)
IL (1) IL235868A (en)
MX (1) MX365423B (en)
NZ (1) NZ701469A (en)
PE (1) PE03522015A1 (en)
PH (1) PH12014502584B1 (en)
PL (1) PL2854814T3 (en)
PT (1) PT2854814T (en)
RU (1) RU2639867C2 (en)
SG (1) SG11201407682TA (en)
WO (1) WO2013177559A2 (en)
ZA (1) ZA201408182B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
CA2931302A1 (en) * 2013-11-25 2015-05-28 Corcept Therapeutics, Inc. Octahydro fused azadecalin glucocorticoid receptor modulators
CA2977591A1 (en) * 2015-03-02 2016-09-09 Corcept Therapeutics, Inc. Use of glucocorticoid receptor antagonist and somatostatin analogues to treat acth-secreting tumors
US20180291451A1 (en) * 2015-05-18 2018-10-11 Corcept Therapeutics, Inc. Methods for diagnosing and assessing treatment for cushing's syndrome
KR20180052120A (en) * 2015-08-13 2018-05-17 코어셉트 쎄라퓨틱스, 잉크. Differential diagnosis of ACTH-dependent Cushing's syndrome
CA3015218A1 (en) * 2016-03-01 2017-09-08 Corcept Therapeutics, Inc. The use of glucocorticoid receptor modulators to potentiate checkpoint inhibitors
US9943505B2 (en) 2016-09-09 2018-04-17 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat pancreatic cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
GB8828669D0 (en) * 1988-12-08 1989-01-11 Lilly Industries Ltd Organic compounds
US7928237B2 (en) * 2004-03-09 2011-04-19 Corcept Therapeutics, Inc. Fused ring azadecalin glucocorticoid receptor modulators
US7640389B2 (en) * 2006-02-28 2009-12-29 Freescale Semiconductor, Inc. Non-volatile memory having a multiple block erase mode and method therefor
EP1932843A1 (en) * 2006-12-14 2008-06-18 sanofi-aventis Sulfonyl-phenyl-2H-(1,2,4) oxadiazole-5-one derivatives, processes for their preparation and their use as pharmaceuticals
BR112013004322A2 (en) * 2010-08-27 2016-06-21 Corcept Therapeutics Inc pyridyl amine fused azadecalin modulators

Also Published As

Publication number Publication date
NZ701469A (en) 2017-06-30
CN104619328B (en) 2018-10-02
MX365423B (en) 2019-06-03
WO2013177559A2 (en) 2013-11-28
IL235868D0 (en) 2015-01-29
PH12014502584A1 (en) 2015-01-21
PH12014502584B1 (en) 2015-01-21
RU2639867C2 (en) 2017-12-25
EP3338781A1 (en) 2018-06-27
PL2854814T3 (en) 2018-07-31
CA2872260A1 (en) 2013-11-28
PT2854814T (en) 2018-03-15
CL2014003173A1 (en) 2015-02-27
EP3338781B1 (en) 2019-09-11
IL235868A (en) 2017-12-31
EP2854814B1 (en) 2018-01-31
AU2013266110B2 (en) 2017-04-20
SG11201407682TA (en) 2014-12-30
AU2013266110C1 (en) 2018-07-12
CN104619328A (en) 2015-05-13
ES2665338T3 (en) 2018-04-25
EP2854814A4 (en) 2016-01-27
JP2015517580A (en) 2015-06-22
MX2014014239A (en) 2015-08-05
JP6172871B2 (en) 2017-08-02
AU2013266110A1 (en) 2014-11-20
WO2013177559A3 (en) 2014-01-16
ZA201408182B (en) 2017-09-27
RU2014152625A (en) 2016-07-20
KR20150021955A (en) 2015-03-03
DK2854814T3 (en) 2018-03-12
HK1208818A1 (en) 2016-03-18
EP2854814A2 (en) 2015-04-08

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