PE03212009A1 - Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica - Google Patents

Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica

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Publication number
PE03212009A1
PE03212009A1 PE2008000929A PE0009292008A PE03212009A1 PE 03212009 A1 PE03212009 A1 PE 03212009A1 PE 2008000929 A PE2008000929 A PE 2008000929A PE 0009292008 A PE0009292008 A PE 0009292008A PE 03212009 A1 PE03212009 A1 PE 03212009A1
Authority
PE
Peru
Prior art keywords
seq id
hvr
notch1 nrr
pharmaceutical composition
sequence
Prior art date
Application number
PE2008000929A
Other languages
English (en)
Inventor
Yan Wu
Christian Siebel
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US93307207P priority Critical
Priority to US99464607P priority
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE03212009A1 publication Critical patent/PE03212009A1/es
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735560&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE03212009(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015Breast
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material Not used, see subgroups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
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    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C12N5/10Cells modified by introduction of foreign genetic material Not used, see subgroups
    • C12N5/12Fused cells, e.g. hybridomas

Abstract

REFERIDA A ANTICUERPOS HUMANIZADOS anti-NOTCH1 NRR (REGION REGULADORA NEGATIVA), QUE SE CARACTERIZA POR SER INICIALMENTE AISLADO DE HUMANO O RATON; UNIRSE A UN RECEPTOR NOTCH1 NRR CON UN Kd DE 1X10-7 A MAS; Y QUE COMPRENDE: a)AL MENOS 1 A 5 SECUENCIAS DE LA REGION HIPERVARIABLE (HVR) SELECCIONADA DE; HVR-L1 QUE ES LA SECUENCIA RASQDVSTAVA (SEQ ID NO:7), HVR-L2 QUE ES LA SECUENCIA SASFLYS (SEQ ID NO:8), HVR-H3 QUE ES LA SECUENCIA ARGSGFRWVMDY (SEQ ID NO:6), ENTRE OTRAS; b)AL MENOS UNA VARIANTE DE HVR, DE ALMENOS UN RESIDUO DE LA SEQ ID NOS: 1 A 12. SE REFIERE TAMBIEN A UN POLINUCLEOTIDO CODIFICADOR, UN VECTOR DE EXPRESION, CELULAS HUESPED, UN METODO DE PREPARACION DEL INMUNOCONJUGADO Y COMPOSICION FARMACEUTICA. DICHOS ANTICUERPOS SON INICIALMENTE AISLADOS DE HUMANO O RATON Y DISMINUYEN LA SENALIZACION DE NOTCH1 LA CUAL ES IMPORTANTE EN EL CRECIMIENTO TUMORAL
PE2008000929A 2007-06-04 2008-06-02 Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica PE03212009A1 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US93307207P true 2007-06-04 2007-06-04
US99464607P true 2007-09-20 2007-09-20

Publications (1)

Publication Number Publication Date
PE03212009A1 true PE03212009A1 (es) 2009-04-20

Family

ID=39735560

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000929A PE03212009A1 (es) 2007-06-04 2008-06-02 Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica

Country Status (27)

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US (5) US8846871B2 (es)
EP (1) EP2152748B1 (es)
JP (4) JP5623272B2 (es)
KR (2) KR20100021581A (es)
CN (1) CN101796074B (es)
AR (1) AR066846A1 (es)
BR (1) BRPI0811382A2 (es)
CA (1) CA2687866C (es)
CO (1) CO6150200A2 (es)
CR (2) CR11139A (es)
CY (1) CY1114690T1 (es)
DK (1) DK2152748T3 (es)
EC (1) ECSP099785A (es)
ES (1) ES2432798T3 (es)
HK (1) HK1141040A1 (es)
HR (1) HRP20131107T1 (es)
IL (3) IL202183D0 (es)
MA (1) MA31502B1 (es)
MX (1) MX2009013199A (es)
NZ (1) NZ581303A (es)
PE (1) PE03212009A1 (es)
PH (1) PH12015500550A1 (es)
PT (1) PT2152748E (es)
RU (1) RU2476443C2 (es)
SI (1) SI2152748T1 (es)
TW (1) TWI458737B (es)
WO (1) WO2008150525A1 (es)

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US8226943B2 (en) 2008-07-08 2012-07-24 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
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RU2573994C2 (ru) 2010-02-10 2016-01-27 Иммьюноджен, Инк Антитела против cd20 и их применение
WO2012080891A1 (en) * 2010-12-15 2012-06-21 Rinat Neuroscience Corp. Anti-notch-1 antibodies
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