PE02502005A1 - Antagonists Muscarinic acetylcholine receptors - Google Patents

Antagonists Muscarinic acetylcholine receptors

Info

Publication number
PE02502005A1
PE02502005A1 PE0006742004A PE0006742004A PE02502005A1 PE 02502005 A1 PE02502005 A1 PE 02502005A1 PE 0006742004 A PE0006742004 A PE 0006742004A PE 0006742004 A PE0006742004 A PE 0006742004A PE 02502005 A1 PE02502005 A1 PE 02502005A1
Authority
PE
Peru
Prior art keywords
c6
acetylcholine receptors
muscarinic acetylcholine
azoniabicyclo
endo
Prior art date
Application number
PE0006742004A
Other languages
Spanish (es)
Inventor
Kristen E Belmonte
Jakob Busch-Petersen
Michael R Palovich
Dramane I Laine
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US48798203P priority Critical
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE02502005A1 publication Critical patent/PE02502005A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Abstract

REFERIDA A UN COMPUESTO DE FORMULA I DONDE R2 Y R3 SON CADA UNO ALQUILO C1-C6, CICLOALQUILO C5-C6, CICLOALQUILALQUILO C6-C10, ENTRE OTROS; Referring to a compound of formula I wherein R2 and R3 are each C1-C6, C5-C6, C6-C10 cycloalkylalkyl, among others; X - ES UN ANION CON CARGA POSITIVA DE N, DE MODO QUE EL COMPUESTO ES UNA SAL CUATERNARIA. X - it is an anion positively charged N, SO that the compound is a quaternary salt. TAMBIEN REFERIDA A UNA COMPOSICION FARMACEUTICA QUE INCLUYE ESTOS COMPUESTOS CUYOS PREFERIDOS SON: BROMURO DE (3-ENDO)-3-(2-HIDROXI-2,2-DI-2-TIENILETIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO; Also referred TO A PHARMACEUTICAL COMPOSITION WHICH INCLUDES these compounds preferred are: BROMIDE (3-endo) -3- (2-Hydroxy-2,2-di-2-thienylethyl) -8,8-dimethyl-8-azoniabicyclo [ 3.2.1] OCTANE; 4-METILBENCENOSULFONATO DE (3-ENDO)-3-(2-HIDROXI-2,2-DIFENILETIL)-8,8-DIMETIL-8-AZONIABICICLO[3.2.1]OCTANO; 4-methylbenzenesulfonate (3-endo) -3- (2-Hydroxy-2,2-diphenylethyl) -8,8-dimethyl-8-azoniabicyclo [3.2.1] octane; ENTRE OTROS. AMONG OTHERS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES MEDIADAS POR LOS RECEPTORES MUSCARINICOS DE LA ACETILCOLINA TALES COMO BRONQUITIS CRONICA, ASMA, FIBROSIS PULMONAR, ENTRE OTRAS Such compounds are useful in the treatment of diseases mediated by muscarinic acetylcholine receptors and Chronic Bronchitis TALES, ASTHMA, PULMONARY FIBROSIS AMONG OTHERS
PE0006742004A 2003-07-17 2004-07-15 Antagonists Muscarinic acetylcholine receptors PE02502005A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US48798203P true 2003-07-17 2003-07-17

Publications (1)

Publication Number Publication Date
PE02502005A1 true PE02502005A1 (en) 2005-04-08

Family

ID=34102736

Family Applications (1)

Application Number Title Priority Date Filing Date
PE0006742004A PE02502005A1 (en) 2003-07-17 2004-07-15 Antagonists Muscarinic acetylcholine receptors

Country Status (19)

Country Link
US (1) US7495010B2 (en)
EP (1) EP1648461A4 (en)
JP (1) JP2007525478A (en)
KR (1) KR20060054316A (en)
CN (1) CN1822839A (en)
AR (1) AR045914A1 (en)
AU (1) AU2004259238A1 (en)
BR (1) BRPI0412537A (en)
CA (1) CA2532433A1 (en)
IL (1) IL172912D0 (en)
IS (1) IS8296A (en)
MA (1) MA27901A1 (en)
MX (1) MXPA06000663A (en)
NO (1) NO20060777L (en)
PE (1) PE02502005A1 (en)
RU (1) RU2006104851A (en)
TW (1) TW200519108A (en)
WO (1) WO2005009362A2 (en)
ZA (1) ZA200600167B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI409060B (en) * 2003-10-14 2013-09-21 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
CN1897947A (en) * 2003-10-17 2007-01-17 葛兰素集团有限公司 Muscarinic acetylcholine receptor antagonists field of the invention
AR046225A1 (en) 2003-11-04 2005-11-30 Glaxo Group Ltd Compound 8-azoniabicyclo (3.2.1) octane, pharmaceutical composition for the treatment of diseases mediated by muscarinic acetylcholine receptors comprising the same and use of said composition for preparing compound
EP1725236A4 (en) * 2004-03-11 2009-05-13 Glaxo Group Ltd Novel m3 muscarinic acetylcholine receptor antagonists
US7384946B2 (en) * 2004-03-17 2008-06-10 Glaxo Group Limited M3 muscarinic acetylcholine receptor antagonists
JP2007529511A (en) * 2004-03-17 2007-10-25 グラクソ グループ リミテッドGlaxo Group Limited M3 muscarinic acetylcholine receptor antagonist
AU2012202307B2 (en) * 2004-04-27 2015-05-07 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
AR050902A1 (en) 2004-04-27 2006-12-06 Glaxo Group Ltd Quinuclidine compound, pharmaceutical composition comprising it and preparing said composition Usagefor
WO2005112644A2 (en) * 2004-05-13 2005-12-01 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
EP1957075A4 (en) * 2004-11-15 2009-11-18 Glaxo Group Ltd Novel m3 muscarinic acetylcholine receptor antagonists
JP2009503099A (en) * 2005-08-02 2009-01-29 グラクソ グループ リミテッドGlaxo Group Limited M3 muscarinic acetylcholine receptor antagonist
US7767691B2 (en) * 2005-08-18 2010-08-03 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists containing an azoniabiocyclo[2.2.1] heptane ring system
AR070564A1 (en) 2008-02-06 2010-04-21 Glaxo Group Ltd Derivatives of 1H-pyrazolo [3,4-b] pyridin-5-yl, phosphodiesterase inhibitors and PDE4 antagonists muscarinic acetylcholine receptors (mAChR), useful in the treatment and / or prophylaxis of respiratory and allergic diseases, and pharmaceutical compositions that comprise
PE15522009A1 (en) 2008-02-06 2009-10-25 Glaxo Group Ltd dual pharmacophores - muscarinic antagonists PDE4
AR070563A1 (en) 2008-02-06 2010-04-21 Glaxo Group Ltd Bicyclo compound of a condensed pyrazole-pyridin-amine, pharmaceutical composition comprising the same and their use for preparing a medicament useful for the treatment of respiratory diseases.
WO2010094643A1 (en) 2009-02-17 2010-08-26 Glaxo Group Limited Quinoline derivatives and their uses for rhinitis and urticaria
EP3248970A1 (en) 2016-05-27 2017-11-29 Zentiva K.S. Forms of umeclidinium bromide

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2800482A (en) * 1955-07-01 1957-07-23 Smith Kline French Lab Olefinic derivatives of 8-alkylnortropanes and the acid and quaternary ammonium salts thereof
US2800478A (en) * 1955-07-01 1957-07-23 Smith Kline French Lab 3-substituted-8-alkylnortropanes and the acid and quaternary ammonium salts thereof
US2800481A (en) * 1955-07-01 1957-07-23 Smith Kline French Lab Tertiary alcohol derivatives of 8-alkylnortropanes and the acid and quaternary ammonium salts thereof
AT298118B (en) 1967-06-08 1972-04-25 Siemens Ag A process for conversion of voltages to digital values ​​and device for carrying out the method
GB2064336B (en) 1979-12-06 1984-03-14 Glaxo Group Ltd Device for dispensing medicaments
EP0069715B1 (en) 1981-07-08 1986-11-05 Aktiebolaget Draco Powder inhalator
GB2169265B (en) 1982-10-08 1987-08-12 Glaxo Group Ltd Pack for medicament
PT77471B (en) 1982-10-08 1986-08-19 Glaxo Group Ltd Devices for administering medicaments to patients
NL8601949A (en) 1985-07-30 1987-02-16 Glaxo Group Ltd Devices for administering medicaments to patients.
IT1204826B (en) 1986-03-04 1989-03-10 Chiesi Farma Spa Pharmaceutical compositions for inhalation
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
US5780466A (en) 1995-01-30 1998-07-14 Sanofi Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present
AU5790598A (en) 1996-12-02 1998-06-29 Georgetown University Tropane derivatives and method for their synthesis
US6248752B1 (en) 1998-02-27 2001-06-19 Charles Duane Smith Azabicyclooctane compositions and methods for enhancing chemotherapy
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
ES2165768B1 (en) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa New quinuclidine derivatives and pharmaceutical compositions containing them.
EP1302458A4 (en) * 2000-07-11 2005-10-19 Banyu Pharma Co Ltd Ester derivatives
EP1438309A1 (en) 2001-10-17 2004-07-21 Ucb, S.A. Quinuclidine derivatives, processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
TW200410951A (en) 2002-08-06 2004-07-01 Glaxo Group Ltd M3 muscarinic acetylcholine receptor antagonists
WO2004091482A2 (en) 2003-04-07 2004-10-28 Glaxo Group Limited M3 muscarinic acetylcholine receptor antagonists
PE07112005A1 (en) 2003-07-17 2005-09-10 Glaxo Group Ltd Compounds 8-azoniabicyclo [3.2.1] octane as antagonists of muscarinic acetylcholine receptors
TW200523261A (en) 2003-07-17 2005-07-16 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
TWI409060B (en) 2003-10-14 2013-09-21 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
CN1897947A (en) 2003-10-17 2007-01-17 葛兰素集团有限公司 Muscarinic acetylcholine receptor antagonists field of the invention
AR046225A1 (en) 2003-11-04 2005-11-30 Glaxo Group Ltd Compound 8-azoniabicyclo (3.2.1) octane, pharmaceutical composition for the treatment of diseases mediated by muscarinic acetylcholine receptors comprising the same and use of said composition for preparing compound
US7345060B2 (en) 2003-11-21 2008-03-18 Theravance, Inc. Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity
AR046784A1 (en) 2003-12-03 2005-12-21 Glaxo Group Ltd Cyclic amine compound pharmaceutical composition comprising the same and their use for preparing latter
TW200530226A (en) 2003-12-03 2005-09-16 Glaxo Group Ltd Novel M3 muscarinic acetylcholine receptor antagonists
JP2007529511A (en) 2004-03-17 2007-10-25 グラクソ グループ リミテッドGlaxo Group Limited M3 muscarinic acetylcholine receptor antagonist
US20070185088A1 (en) 2004-03-17 2007-08-09 Jakob Busch-Petersen M3 muscarinic acetylchoine receptor antagonists
US7384946B2 (en) 2004-03-17 2008-06-10 Glaxo Group Limited M3 muscarinic acetylcholine receptor antagonists
EP1725240A4 (en) 2004-03-17 2009-03-25 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
AR050902A1 (en) 2004-04-27 2006-12-06 Glaxo Group Ltd Quinuclidine compound, pharmaceutical composition comprising it and preparing said composition Usagefor
WO2005112644A2 (en) 2004-05-13 2005-12-01 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
JP2008501020A (en) 2004-05-28 2008-01-17 グラクソ グループ リミテッドGlaxo Group Limited Muscarinic acetylcholine receptor antagonist
US20090258858A1 (en) 2004-10-29 2009-10-15 Jakob Busch-Petersen Muscarinic acetylcholine receptor antagonists
EP1957075A4 (en) 2004-11-15 2009-11-18 Glaxo Group Ltd Novel m3 muscarinic acetylcholine receptor antagonists
WO2006055503A2 (en) 2004-11-15 2006-05-26 Glaxo Group Limited Novel m3 muscarinic acetylcholine receptor antagonists
PE11622006A1 (en) 2004-12-06 2006-10-14 Smithkline Beecham Corp derived olefinic compounds 8-azoniabicyclo [3.2.1] octane
PE08262006A1 (en) 2004-12-06 2006-10-08 Smithkline Beecham Corp Olefinic derivative of 8-azoniabicyclo [3.2.1] octane and pharmaceutical combination understands
WO2006065755A2 (en) 2004-12-13 2006-06-22 Glaxo Group Limited Quaternary ammonium salts of fused hetearomatic amines as novel muscarinic acetylcholine receptor antagonists
WO2006065788A2 (en) 2004-12-13 2006-06-22 Glaxo Group Limited Novel muscarinic acetylcholine receptor antagonists
WO2007018508A1 (en) 2005-07-28 2007-02-15 Glaxo Group Limited Novel m3 muscarinic acetycholine receptor antagonists
WO2007018514A1 (en) 2005-07-28 2007-02-15 Glaxo Group Limited Novel m3 muscarinic acetylcholine receptor antagonists
WO2007016650A2 (en) 2005-08-02 2007-02-08 Glaxo Group Limited M3 muscarinic acetylcholine receptor antagonists
JP2009503099A (en) 2005-08-02 2009-01-29 グラクソ グループ リミテッドGlaxo Group Limited M3 muscarinic acetylcholine receptor antagonist
US7767691B2 (en) 2005-08-18 2010-08-03 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists containing an azoniabiocyclo[2.2.1] heptane ring system

Also Published As

Publication number Publication date
RU2006104851A (en) 2006-06-27
IS8296A (en) 2006-02-13
WO2005009362A2 (en) 2005-02-03
MXPA06000663A (en) 2006-03-30
EP1648461A4 (en) 2009-04-01
EP1648461A2 (en) 2006-04-26
CA2532433A1 (en) 2005-02-03
AU2004259238A1 (en) 2005-02-03
ZA200600167B (en) 2007-01-31
TW200519108A (en) 2005-06-16
CN1822839A (en) 2006-08-23
AR045914A1 (en) 2005-11-16
JP2007525478A (en) 2007-09-06
NO20060777L (en) 2006-04-11
US7495010B2 (en) 2009-02-24
MA27901A1 (en) 2006-05-02
US20060178396A1 (en) 2006-08-10
KR20060054316A (en) 2006-05-22
BRPI0412537A (en) 2006-09-19
WO2005009362A3 (en) 2005-04-07
IL172912D0 (en) 2006-06-11

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