PE02492005A1 - New cyanopyrrolidides and process for their preparation as drugs - Google Patents

New cyanopyrrolidides and process for their preparation as drugs

Info

Publication number
PE02492005A1
PE02492005A1 PE0006652004A PE0006652004A PE02492005A1 PE 02492005 A1 PE02492005 A1 PE 02492005A1 PE 0006652004 A PE0006652004 A PE 0006652004A PE 0006652004 A PE0006652004 A PE 0006652004A PE 02492005 A1 PE02492005 A1 PE 02492005A1
Authority
PE
Peru
Prior art keywords
cyanopyrrolidides
drugs
preparation
new
process
Prior art date
Application number
PE0006652004A
Other languages
Spanish (es)
Inventor
Karl Schoenafinger
Holger Wagner
Gerhard Jaehne
Holger Gaul
Christian Buning
Georg Tschank
Ulrich Werner
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE2003133935 priority Critical patent/DE10333935A1/en
Priority to DE200410019276 priority patent/DE102004019276A1/en
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of PE02492005A1 publication Critical patent/PE02492005A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Abstract

REFERIDA A CIANO PIRROLIDIDAS SUSTITUIDAS DE FORMULA IYA SUS SALES, DONDE R1 ES H, ALQUILO C1-C10, CICLOALQUILO C3-C10, ENTRE OTROS; REFERRED TO SUBSTITUTED CIANO PIRROLIDIDAS FORMULA IYA their salts, wherein R1 is H, C1-C10 alkyl, C3-C10, among others; R2 ES H, ALQUILO C1-C10, ALQUENILO C2-C6, ENTRE OTROS. R2 is H, C1-C10 alkyl, C2-C6, among others. EL MEDICAMENTO RESULTANTE TAMBIEN COMPRENDE OTROS COMPONENTES COMO UNO O MAS ANTIDIABETICOS, INDUCTORES DE RECEPTORES DE LDL, AGONISTAS DE PPAR GAMMA, ENTRE OTROS. DRUG RESULTING also includes other components such as one or more antidiabetic, LDL receptor inducers, PPAR GAMMA, among others. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL METABOLISMO COMO DIABETES TIPO 2, EN MANIFESTACIONES ARTERIOESCLEROTICAS, EN RESISTENCIA A INSULINA, ENTRE OTROS Such compounds are useful in the treatment of DISORDERS METABOLISM AS TYPE 2 DIABETES IN arteriosclerotic DEMONSTRATIONS IN INSULIN RESISTANCE AMONG OTHERS
PE0006652004A 2003-07-25 2004-07-13 New cyanopyrrolidides and process for their preparation as drugs PE02492005A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE2003133935 DE10333935A1 (en) 2003-07-25 2003-07-25 New bicyclic cyano-heterocycles, process for their preparation and their use as pharmaceuticals
DE200410019276 DE102004019276A1 (en) 2004-04-21 2004-04-21 New cyanopyrrolizine derivatives, used e.g. for lowering blood sugar, treating type 2 diabetes, treating disorders of lipid and carbohydrate metabolism, treating arteriosclerotic symptoms

Publications (1)

Publication Number Publication Date
PE02492005A1 true PE02492005A1 (en) 2005-06-01

Family

ID=34117368

Family Applications (1)

Application Number Title Priority Date Filing Date
PE0006652004A PE02492005A1 (en) 2003-07-25 2004-07-13 New cyanopyrrolidides and process for their preparation as drugs

Country Status (13)

Country Link
EP (1) EP1651649B1 (en)
JP (1) JP2006528601A (en)
AR (1) AR045080A1 (en)
AT (1) AT490256T (en)
AU (1) AU2004261364A1 (en)
BR (1) BRPI0412900A (en)
CA (1) CA2534267A1 (en)
DE (1) DE502004011957D1 (en)
IL (1) IL173204D0 (en)
MX (1) MXPA06000634A (en)
PE (1) PE02492005A1 (en)
TW (1) TW200524936A (en)
WO (1) WO2005012308A1 (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DOP2006000008A (en) 2005-01-10 2006-08-31 Arena Pharm Inc combined treatment of diabetes and related conditions therapy and for the treatment of conditions ameliorated by an increase in the blood concentration of glp-1
GB0526291D0 (en) 2005-12-23 2006-02-01 Prosidion Ltd Therapeutic method
PE12212007A1 (en) 2006-04-11 2007-12-14 Arena Pharm Inc GPR119 receptor agonists in methods for increasing bone mass and to treat osteoporosis and other conditions characterized by low bone mass, or the combined therapy related to these agonists
BRPI0715160A2 (en) 2006-08-08 2013-06-11 Sanofi Aventis arylamimoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, drugs comprising these compounds, and their use
DE102007005045B4 (en) 2007-01-26 2008-12-18 Sanofi-Aventis Phenothiazine derivatives, process for their preparation and their use as medicines
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
EP2108960A1 (en) 2008-04-07 2009-10-14 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
AR077642A1 (en) 2009-07-09 2011-09-14 Arena Pharm Inc Modulating metabolism and treatment of disorders related thereto
SG178880A1 (en) 2009-08-26 2012-04-27 Sanofi Sa Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
JP2013523819A (en) 2010-04-06 2013-06-17 アリーナ ファーマシューティカルズ, インコーポレイテッド GPR119 receptor modulators and treatment of disorders related thereto
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
BR112013008100A2 (en) 2010-09-22 2016-08-09 Arena Pharm Inc "gpr19 receptor modulators and the treatment of disorders related thereto."
US8846666B2 (en) 2011-03-08 2014-09-30 Sanofi Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683705B1 (en) 2011-03-08 2015-04-22 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2766349B1 (en) 2011-03-08 2016-06-01 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8895547B2 (en) 2011-03-08 2014-11-25 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
EP2683702B1 (en) 2011-03-08 2014-12-24 Sanofi New substituted phenyl oxathiazine derivatives, method for their manufacture, medicines containing these compounds and their application
WO2012120051A1 (en) 2011-03-08 2012-09-13 Sanofi Benzyl-oxathiazine derivates substituted with adamantane or noradamantane, medicaments containing said compounds and use thereof
EP2683700B1 (en) 2011-03-08 2015-02-18 Sanofi Tetra-substituted oxathiazine derivatives, method for their preparation, their usage as medicament and medicament containing same and its use
US20140018371A1 (en) 2011-04-01 2014-01-16 Arena Pharmaceuticals, Inc. Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
EA201391264A1 (en) 2011-04-13 2014-03-31 Джилид Сайэнс, Инк. 1'-substituted pyrimidine n-nucleoside analogues for anti-virus treatment
WO2012145361A1 (en) 2011-04-19 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145604A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145603A1 (en) 2011-04-22 2012-10-26 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012170702A1 (en) 2011-06-08 2012-12-13 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013055910A1 (en) 2011-10-12 2013-04-18 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
EP2911655A1 (en) 2012-10-24 2015-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Tpl2 kinase inhibitors for preventing or treating diabetes and for promoting -cell survival
WO2014074668A1 (en) 2012-11-08 2014-05-15 Arena Pharmaceuticals, Inc. Modulators of gpr119 and the treatment of disorders related thereto
US10426818B2 (en) 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2997894B2 (en) * 1990-11-07 2000-01-11 株式会社三和化学研究所 Prophylactic and therapeutic agent for circulatory diseases
AU1910299A (en) * 1997-12-18 1999-07-05 Eli Lilly And Company Peptidomimetic template-based combinatorial libraries

Also Published As

Publication number Publication date
TW200524936A (en) 2005-08-01
CA2534267A1 (en) 2005-02-10
MXPA06000634A (en) 2006-08-23
WO2005012308A1 (en) 2005-02-10
DE502004011957D1 (en) 2011-01-13
BRPI0412900A (en) 2006-10-31
EP1651649A1 (en) 2006-05-03
AU2004261364A1 (en) 2005-02-10
IL173204D0 (en) 2006-06-11
AT490256T (en) 2010-12-15
JP2006528601A (en) 2006-12-21
EP1651649B1 (en) 2010-12-01
AR045080A1 (en) 2005-10-12

Similar Documents

Publication Publication Date Title
ES2111973T3 (en) Diagnosis, evaluation, and treatment of disease of the coronary artery by simulation exercise by the use of the administration of drugs in a closed beta agonist exercise simulating agent cycle.
DOP2011000040A (en) combined treatment of diabetes and related conditions therapy and for the treatment of conditions ameliorated by an increase in the blood concentration of glp-1
CY1108736T1 (en) Phenyl-and-derivatives pyridylpiperidino AS REGULATORS metabolism GLUCOSE
ECSP11010824A (en) Treatment for diabetes in patients unsuitable for therapy with metformin.
AR071385A1 (en) Compounds 2-imino-3-methyl pirrolopirimidinona substituted thiophenyl, pharmaceutical compositions containing them, and use thereof for the treatment of conditions associated with beta amyloid protein such as Alzheimer's and other forms of dementia.
CR10564A (en) Fused cyclic compounds
NO20051161L (en) Azulenderivater and salts thereof
CY1107871T1 (en) Pyrimidinis derivatives and their use as a setting cb2
CL2004000849A1 (en) Compounds derived benzamides-2-hydroxy-3-diaminoalkanes, useful for the treatment or prevention of Alzheimer's disease, Down's syndrome, hereditary cerebral hemorrhage, and other degenerative dementias.
AR077333A1 (en) human high affinity antibodies to human angiopoietin -2
AR054593A1 (en) Methods for preventing and treating metabolic disorders and novel pyrazole derivatives-o-glucoside
PE06802015A1 (en) Variants iib activin receptor polypeptides and applications of these
PE10142009A1 (en) Spiro compounds and pharmaceutical use thereof
PE14362006A1 (en) Substituted amide derivatives as inhibitors of protein kinase
BR112012029026A2 (en) heretocíclicos nitrogen compound useful as inbidores PDE10
UY28489A1 (en) Glucopyranosyloxy-pyrazoles, medicaments containing these compounds, their use and process for their preparation
UY26291A1 (en) chemicals xxii
PE07222002A1 (en) Glucopyranosyloxypyrazole derivatives as human SGLT2 inhibitor
UY31169A1 (en) Sirtuin modulating compounds
CR10621A (en) Adenosine derivatives as agonists of A2A receptor
UY25180A1 (en) Carboxamidotiazoles derivatives, their preparation, pharmaceutical compositions containing them.
CL2009001203A1 (en) indazole derivatives and pyrazole compounds substituted; pharmaceutical composition of these compounds; farmaceutico kit; and their use as glucokinase activators for treating metabolic diseases such as hyperglycemia, diabetes, dyslipidemia, obesity, metabolic syndrome x cardiovascular disease.
HRP20070189A2 (en) Use of erythropoietin
AR023719A1 (en) N- (glicilsustituidas) -2-cyano-pyrrolidines, a pharmaceutical composition and the use thereof for the manufacture of a medicament
UY27736A1 (en) Mimetics glucocorticoids, processes for their preparation, pharmaceutical compositions and use thereof.

Legal Events

Date Code Title Description
FC Refusal