PE01422008A1 - Enantiomerically pure beta-agonists and their methods of preparation - Google Patents

Enantiomerically pure beta-agonists and their methods of preparation

Info

Publication number
PE01422008A1
PE01422008A1 PE0002712007A PE0002712007A PE01422008A1 PE 01422008 A1 PE01422008 A1 PE 01422008A1 PE 0002712007 A PE0002712007 A PE 0002712007A PE 0002712007 A PE0002712007 A PE 0002712007A PE 01422008 A1 PE01422008 A1 PE 01422008A1
Authority
PE
Peru
Prior art keywords
c6
compounds
agonists
preparation
methods
Prior art date
Application number
PE0002712007A
Other languages
Spanish (es)
Inventor
Uwe Ries
Peter Sieger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP06111191 priority Critical
Priority to EP06111338 priority
Priority to EP06111342 priority
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of PE01422008A1 publication Critical patent/PE01422008A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

SE REFIERE A COMPUESTOS DE FORMULA (1), EN DONDE n ES DE 1 A 4; Refers to compounds of formula (1) wherein n is 1 to 4; X ES CH2, C0, NR2, SUO; X is CH2, C0, NR2, SUO; B ES UN GRUPO DE ENLACE DOBLE: CR3R4-O; B is a double bond: CR3R4-O; R1 ES H, ALQUILO(C1-C6),ALQUENILO(C2-C6), CICLOALQUILO, HALOGENO, OH, ENTRE OTROS; R1 is H, alkyl (C1-C6), alkenyl (C2-C6), cycloalkyl, halogen, OH, among others; Ym- ES UN ANION CARGADO NEGATIVAMENTE m VECES, SIENDO ESTE ANION SELECIONADO DE CLORURO, YODURO, SULFATO, METANSULFONATO, ENTRE OTROS; YM is an anion negatively charged m times and this ANION SELECTED CHLORIDE, iodide, sulfate, methanesulfonate, among others; m ES DE 1 O 2. SON PREFERIDAS LAS SALES MALEINATO, TARTRATO Y HEMI-ETANDISULFONATO DEL COMPUESTO 8-{2-[1,1-DIMETIL-3-(2-OXO-2,3-DIHIDRO-BENZOIMIDAZOL-1-IL)-PROPILAMINO]-1-HIDROXI-4H-BENZO[1,4]OXAZIN-3-ONA CRISTALINAS. m is 1 or 2. salts are preferred maleate, tartrate and hemi-ETANDISULFONATO COMPOUND 8- {2- [1,1-dimethyl-3- (2-Oxo-2,3-dihydro-benzoimidazol-1-yl ) propylamino] -1-hydroxy-4H-benzo [1,4] oxazin-3-one CRYSTALLINE. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA EN FORMA DE POLVOS PARA INHALACION Y AEROSOLES DE SUSPENSION. Also it relates to a process for preparing PHARMACEUTICAL COMPOSITION AND SHAPED inhalable powders and spray cans SUSPENSION. ESTOS COMPUESTOS SON BETAMIMETICOS UTILES EN EL TRATAMIENTO DE ENFERMEDADES DE LAS VIAS RESPIRATORIAS These compounds are useful in the treatment Betamimetics OF RESPIRATORY DISEASES
PE0002712007A 2006-03-15 2007-03-13 Enantiomerically pure beta-agonists and their methods of preparation PE01422008A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06111191 2006-03-15
EP06111338 2006-03-17
EP06111342 2006-03-17

Publications (1)

Publication Number Publication Date
PE01422008A1 true PE01422008A1 (en) 2008-04-14

Family

ID=38006901

Family Applications (1)

Application Number Title Priority Date Filing Date
PE0002712007A PE01422008A1 (en) 2006-03-15 2007-03-13 Enantiomerically pure beta-agonists and their methods of preparation

Country Status (16)

Country Link
US (2) US7534789B2 (en)
EP (1) EP1996581A1 (en)
JP (1) JP2009530245A (en)
KR (1) KR20080106973A (en)
AR (1) AR059836A1 (en)
AU (1) AU2007224420A1 (en)
BR (1) BRPI0709601A2 (en)
CA (1) CA2643026A1 (en)
EA (1) EA200801894A1 (en)
EC (1) ECSP088723A (en)
MX (1) MX2008011700A (en)
NO (1) NO20083508L (en)
PE (1) PE01422008A1 (en)
TW (1) TW200804360A (en)
UY (1) UY30207A1 (en)
WO (1) WO2007104772A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
PE01422008A1 (en) * 2006-03-15 2008-04-14 Boehringer Ingelheim Int Enantiomerically pure beta-agonists and their methods of preparation
AU2014342017A1 (en) 2013-10-31 2016-06-02 Allergan, Inc. Prostamide-containing intraocular implants and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2609645A1 (en) * 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
DE10253282A1 (en) * 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Treatment of chronic obstructive pulmonary disease, using new or known N-substituted 2-amino-1-(benz-(1,4)-oxazin-3-on-8-yl)-ethanol derivative beta-mimetic agents, suitable for once-daily administration
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US20080176744A1 (en) 2005-03-10 2008-07-24 Basf Aktiengesellschaft Use of 4-Aminopyrimidines for Controlling Harmful Fungi, Novel 4-Aminopyrimidines, Processes for Their Preparation and Compositions Comprising Them
DE102004003428A1 (en) 2004-01-23 2005-08-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg New long-acting beta-2 agonists, and their use as medicaments
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024454A1 (en) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg New Enantiomerically pure beta-agonists, to processes for their preparation and their use as medicaments
DE102004045648A1 (en) * 2004-09-21 2006-03-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg New betamimetics for the treatment of respiratory diseases
CA2642239A1 (en) * 2006-02-16 2007-08-23 Boehringer Ingelheim International Gmbh Drug combinations for the treatment of respiratory tract diseases
PE01422008A1 (en) 2006-03-15 2008-04-14 Boehringer Ingelheim Int Enantiomerically pure beta-agonists and their methods of preparation

Also Published As

Publication number Publication date
WO2007104772A1 (en) 2007-09-20
ECSP088723A (en) 2008-10-31
KR20080106973A (en) 2008-12-09
NO20083508L (en) 2008-09-30
WO2007104772A9 (en) 2007-11-22
AU2007224420A1 (en) 2007-09-20
EA200801894A1 (en) 2009-02-27
US20070249595A1 (en) 2007-10-25
MX2008011700A (en) 2008-09-24
US20090306068A1 (en) 2009-12-10
JP2009530245A (en) 2009-08-27
US7939658B2 (en) 2011-05-10
BRPI0709601A2 (en) 2011-07-19
AR059836A1 (en) 2008-04-30
US7534789B2 (en) 2009-05-19
EP1996581A1 (en) 2008-12-03
UY30207A1 (en) 2007-10-31
TW200804360A (en) 2008-01-16
CA2643026A1 (en) 2007-09-20

Similar Documents

Publication Publication Date Title
ES2581765T3 (en) Substituted acylanilides and methods of use thereof
EP2101759B1 (en) Methods of using mek inhibitors
AU748621B2 (en) Integrin receptor antagonists
KR101569260B1 (en) Novel heterocyclic derivatives and their use in the treatment of neurological disorders
ES2241192T3 (en) Integrin receptor antagonists.
ES2288861T3 (en) Receptor antagonists of integrins alpha v.
MX2007011483A (en) Acetylenyl-pyrazolo-pvrimidine derivatives as mglur2 antagonists.
IL206704D0 (en) Fused heterocyclic derivatives and methods of use as c-met inhibitors
IL184427A (en) Thiazole-4-carboxamide derivatives, process for their preparation and use thereof in the preparation of medicaments for therapy
AR077280A1 (en) Pyrimidinones as PI3K inhibitors, and pharmaceutical compositions comprising
TW200635599A (en) Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
GEP20125566B (en) Aryl-and heteroaryl-substituded tetrahydro-benzazepines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
AR037996A1 (en) Nicotinate amino derivative compound, pharmaceutical composition; process for their preparation and their use as a medicine
WO2010084160A1 (en) Phenylcyclopropylamine derivatives and their medical use
TW200817408A (en) Amine derivatives useful as anticancer agents
CN1660110A (en) Highly selective norepinephrine reuptake inhibitors and methods of using the same
JP5954486B2 (en) Trk-inhibiting compound
PE09652005A1 (en) Process for the preparation of compounds of aminocrotonilo
EA200900178A1 (en) Fused heterocyclic derivatives and their use
EP1858516A1 (en) Pharmaceutical compositions for the treatment and/or prevention of depression
JP5767393B2 (en) New bicyclic pyridinone
RS20080533A (en) Triazolopyrazine derivatives useful as anticancer agents
UY29406A1 (en) gamma crystalline form of ivabradine hydrochloride, its preparation process and pharmaceutical compositions containing it.
AR068840A1 (en) GPR40 modulators substituted biphenyl and pharmaceutical compositions containing them
NZ544989A (en) Tricyclic PARP inhibitors

Legal Events

Date Code Title Description
FD Application declared void or lapsed