PE01212012A1 - Imidazopyrazine derivatives as inhibitors of syk - Google Patents

Imidazopyrazine derivatives as inhibitors of syk

Info

Publication number
PE01212012A1
PE01212012A1 PE2011001185A PE0011852011A PE01212012A1 PE 01212012 A1 PE01212012 A1 PE 01212012A1 PE 2011001185 A PE2011001185 A PE 2011001185A PE 0011852011 A PE0011852011 A PE 0011852011A PE 01212012 A1 PE01212012 A1 PE 01212012A1
Authority
PE
Peru
Prior art keywords
yl
1h
indazol
pyrazin
imidazo
Prior art date
Application number
PE2011001185A
Other languages
Spanish (es)
Inventor
Kevin S Currie
Peter A Blomgren
Jeffrey E Kropf
Seung H Lee
Jianjun Xu
Douglas G Stafford
Scott A Mitchell
Original Assignee
Gilead Connecticut Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US12059008P priority Critical
Priority to US14053508P priority
Priority to US24098309P priority
Application filed by Gilead Connecticut Inc filed Critical Gilead Connecticut Inc
Publication of PE01212012A1 publication Critical patent/PE01212012A1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42241250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE01212012(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205Phosphotransferases in general
    • G01N2333/9121Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE R1 ES PIRIDINILO, PIRIDAZINILO, PIRAZOLILO SUSTITUIDO O NO, ENTRE OTROS; Concerns a compound of formula (I) wherein R1 is pyridinyl, pyridazinyl, pyrazolyl unsubstituted or, among others; R2 ES 2,3-DIMETIL-2H-INDAZOL-6-ILO, 1H-INDAZOLIL-6-ILO, 1-METIL-1H-INDAZOL-6-ILO, 3-AMINOQUINILIN-6-ILO, ENTRE OTROS; R2 is 2,3-dimethyl-2H-indazol-6-yl, 1H-indazolyl-6-yl, 1-methyl-1H-indazol-6-yl, 3-AMINOQUINILIN-6-yl, among others; R3 ES H, R4 ES H; R3 is H, R4 is H; R5 ES H. SON COMPUESTOS PREFERIDOS: N-[6-(1H-INDAZOL-6-IL)IMIDAZO[1,2-a]PIRAZIN-8-IL]-1H-1,3-BENZODIAZOL-6-AMINA; R5 is H. Preferred compounds are: N- [6- (1H-indazol-6-yl) -imidazo [1,2-a] pyrazin-8-yl] -1H-1,3-BENZODIAZOL-6-amine; 3-CICLOPROPIL-N-[6-(1H-INDAZOL-6-IL)IMIDAZO[1,2-a]PIRAZIN-8-IL]-1H-PIRAZOL-5-AMINA; 3-cyclopropyl-N- [6- (1H-indazol-6-yl) -imidazo [1,2-a] pyrazin-8-yl] -1H-pyrazol-5-amine; 7-(8-{[1-(2-HIDROXIETIL)-1H-PIRAZOL-4-IL]AMINO}IMIDAZO[1,2a]PIRAZIN-6-IL)-1H, 2H,3H-PIRIDO[2,3-b][1,4]OXAZIN-2-ONA; 7- (8 - {[1- (2-hydroxyethyl) -1H-pyrazol-4-yl] amino} imidazo [1,2- a] pyrazin-6-yl) -1H, 2H, 3H-pyrido [2,3- b] [1,4] oxazin-2-one; ENTRE OTROS. AMONG OTHERS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. ALSO REFERRED TO pharmaceutical composition. DICHO COMPUESTO ES INHIBIDOR DE LA TIROSINA CINASA DEL BAZO (SYK) UTIL EN EL TRATAMIENTO DE TRANSTORNOS ALERGICOS, ENFERMEDADES AUTOINMUNITARIAS Y ENFERMEDADES INFLAMATORIAS Said compound is INHIBITOR Tyrosine Kinase BAZO (SYK) useful in the treatment of disorders allergies, autoimmune and inflammatory diseases
PE2011001185A 2008-12-08 2009-12-07 Imidazopyrazine derivatives as inhibitors of syk PE01212012A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12059008P true 2008-12-08 2008-12-08
US14053508P true 2008-12-23 2008-12-23
US24098309P true 2009-09-09 2009-09-09

Publications (1)

Publication Number Publication Date
PE01212012A1 true PE01212012A1 (en) 2012-02-20

Family

ID=42241250

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001185A PE01212012A1 (en) 2008-12-08 2009-12-07 Imidazopyrazine derivatives as inhibitors of syk

Country Status (17)

Country Link
US (5) US8440667B2 (en)
EP (1) EP2373318B1 (en)
JP (2) JP5696052B2 (en)
KR (1) KR101743784B1 (en)
CN (2) CN102307581B (en)
AU (2) AU2009325133B2 (en)
BR (1) BRPI0922226A2 (en)
CA (1) CA2745871C (en)
CL (1) CL2011001361A1 (en)
CO (1) CO6390109A2 (en)
EA (1) EA021293B1 (en)
IL (2) IL213405D0 (en)
MX (1) MX2011006094A (en)
NZ (1) NZ593460A (en)
PE (1) PE01212012A1 (en)
SG (2) SG171993A1 (en)
WO (1) WO2010068258A1 (en)

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