PE00582012A1 - Imidazopyrazine derivatives as inhibitors of syk - Google Patents

Imidazopyrazine derivatives as inhibitors of syk

Info

Publication number
PE00582012A1
PE00582012A1 PE2011001178A PE0011782011A PE00582012A1 PE 00582012 A1 PE00582012 A1 PE 00582012A1 PE 2011001178 A PE2011001178 A PE 2011001178A PE 0011782011 A PE0011782011 A PE 0011782011A PE 00582012 A1 PE00582012 A1 PE 00582012A1
Authority
PE
Peru
Prior art keywords
hydrogen
syk
inhibitors
c1
halogen
Prior art date
Application number
PE2011001178A
Other languages
Spanish (es)
Inventor
Scott A Mitchell
Peter A Blomgren
Jeffrey E Kropf
Seung H Lee
Jianjun Xu
Douglas G Stafford
James P Harding
Zhongdong Zhao
Jr Antonio J Barbosa
Kevin S Currie
David M Armistead
Original Assignee
Gilead Connecticut Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US12058708P priority Critical
Priority to US14051408P priority
Priority to US24097909P priority
Application filed by Gilead Connecticut Inc filed Critical Gilead Connecticut Inc
Publication of PE00582012A1 publication Critical patent/PE00582012A1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42242994&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE00582012(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205Phosphotransferases in general

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE IMIDAZOPIRAZINA DE FORMULA (I), DONDE R1 ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, HIDROXILO, CARBOXILO, CIANO, ENTRE OTROS; REFERRED TO COMPOUND DERIVED imidazopyrazine of formula (I), where R1 is phenyl optionally substituted with halogen, hydroxyl, carboxyl, cyano, among others; R2 ES ARILO DE 5 O 6 MIEMBROS TAL COMO BENCENO O HETEROARILO DE 5 A 7 MIEMBROS, ENTRE OTROS; R2 is aryl of 5 or 6 members such as benzene or 5- to 7 members, including; R3 ES HIDROGENO, ALQUILO C1-C4, HALOGENO; R3 is hydrogen, C1-C4 alkyl, halogen; R4 ES HIDROGENO O ALQUILO C1-C4; R4 is hydrogen or C1-C4 alkyl; R5 ES HIDROGENO. R5 is hydrogen. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. ALSO REFERRED TO A PHARMACEUTICAL COMPOSITION. DICHOS COMPUESTOS SON INHIBIDORES DE LA TIROSINA QUINASA DEL BAZO (SYK) Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS ALERGICOS, ENFERMEDADES AUTOINMUNITARIAS, ENFERMEDADES INFLAMATORIAS, ENTRE OTRAS Such compounds are tyrosine-kinase inhibitor of the spleen (SYK) and are useful in the treatment of disorders ALLERGIC, autoimmune diseases, inflammatory diseases, among others
PE2011001178A 2008-12-08 2009-12-07 Imidazopyrazine derivatives as inhibitors of syk PE00582012A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12058708P true 2008-12-08 2008-12-08
US14051408P true 2008-12-23 2008-12-23
US24097909P true 2009-09-09 2009-09-09

Publications (1)

Publication Number Publication Date
PE00582012A1 true PE00582012A1 (en) 2012-02-02

Family

ID=42242994

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2011001178A PE00582012A1 (en) 2008-12-08 2009-12-07 Imidazopyrazine derivatives as inhibitors of syk
PE2014000121A PE09752014A1 (en) 2008-12-08 2009-12-07 Imidazopyrazine derivatives as inhibitors of syk

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2014000121A PE09752014A1 (en) 2008-12-08 2009-12-07 Imidazopyrazine derivatives as inhibitors of syk

Country Status (28)

Country Link
US (7) US8455493B2 (en)
EP (3) EP3123864A1 (en)
JP (4) JP5567587B2 (en)
KR (4) KR20170013414A (en)
CN (2) CN102307474B (en)
AU (1) AU2009325132B2 (en)
CA (1) CA2746023C (en)
CO (1) CO6390078A2 (en)
CY (1) CY1118377T1 (en)
DK (1) DK2716157T3 (en)
EA (3) EA201690111A1 (en)
ES (2) ES2545610T3 (en)
HK (3) HK1162250A1 (en)
HR (1) HRP20161036T1 (en)
HU (1) HUE030427T2 (en)
IL (2) IL213365A (en)
LT (1) LT2716157T (en)
MX (1) MX2011006091A (en)
NZ (1) NZ593459A (en)
PE (2) PE00582012A1 (en)
PL (1) PL2716157T3 (en)
PT (2) PT2716157T (en)
RS (1) RS55055B1 (en)
SG (1) SG171991A1 (en)
SM (1) SMT201600267B (en)
TW (2) TWI529172B (en)
VN (1) VN28228A1 (en)
WO (1) WO2010068257A1 (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5496915B2 (en) 2008-02-13 2014-05-21 シージーアイ ファーマシューティカルズ,インコーポレーテッド 6-aryl - imidazo [1,2-a] pyrazine derivatives, process for their preparation, and their use
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
PE00582012A1 (en) 2008-12-08 2012-02-02 Gilead Connecticut Inc Imidazopyrazine derivatives as inhibitors of syk
PE01212012A1 (en) 2008-12-08 2012-02-20 Gilead Connecticut Inc Imidazopyrazine derivatives as inhibitors of syk
CA2771532A1 (en) * 2009-08-17 2011-02-24 Intellikine, Inc. Heterocyclic compounds and uses thereof
JP5938352B2 (en) 2010-03-11 2016-06-22 ギリアード コネチカット, インコーポレイテッド Imidazopyridine syk inhibitor
US9127000B2 (en) 2011-02-23 2015-09-08 Intellikine, LLC. Heterocyclic compounds and uses thereof
EP2706852B1 (en) 2011-05-10 2018-08-22 Merck Sharp & Dohme Corp. Bipyridylaminopyridines as syk inhibitors
AU2012253886A1 (en) 2011-05-10 2013-10-31 Merck Sharp & Dohme Corp. Pyridyl aminopyridines as Syk inhibitors
WO2012154519A1 (en) 2011-05-10 2012-11-15 Merck Sharp & Dohme Corp. Aminopyrimidines as syk inhibitors
US9006444B2 (en) 2011-10-05 2015-04-14 Merck Sharp & Dohme Corp. Phenyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors
US9216173B2 (en) 2011-10-05 2015-12-22 Merck Sharp & Dohme Corp. 2-Pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors
US8987456B2 (en) 2011-10-05 2015-03-24 Merck Sharp & Dohme Corp. 3-pyridyl carboxamide-containing spleen tyrosine kinase (SYK) inhibitors
AR090650A1 (en) 2012-04-12 2014-11-26 Alcon Res Ltd Treatment microbes induced inflammatory responses in the eye
WO2013188856A1 (en) * 2012-06-14 2013-12-19 Gilead Connecticut, Inc. Imidazopyrazine syk inhibitors
WO2013192125A1 (en) 2012-06-20 2013-12-27 Merck Sharp & Dohme Corp. Pyrazolyl derivatives as syk inhibitors
WO2013192128A1 (en) 2012-06-20 2013-12-27 Merck Sharp & Dohme Corp. Imidazolyl analogs as syk inhibitors
WO2013192098A1 (en) 2012-06-22 2013-12-27 Merck Sharp & Dohme Corp. SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS
US9416111B2 (en) 2012-06-22 2016-08-16 Merck Sharp & Dohme Corp. Substituted diazine and triazine spleen tyrosine kinease (Syk) inhibitors
CA2882134A1 (en) * 2012-08-14 2014-02-20 Gilead Calistoga Llc Combination therapies for treating cancer
EP2884982B1 (en) 2012-08-20 2017-09-20 Merck Sharp & Dohme Corp. SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS
US9586931B2 (en) 2012-09-28 2017-03-07 Merck Sharp & Dohme Corp. Triazolyl derivatives as Syk inhibitors
WO2014093191A1 (en) 2012-12-12 2014-06-19 Merck Sharp & Dohme Corp. AMINO-PYRIMIDINE-CONTAINING SPLEEN TYROSINE KINASE (Syk) INHIBITORS
EP2934525A4 (en) 2012-12-21 2016-06-08 Merck Sharp & Dohme Thiazole-substituted aminopyridines as spleen tyrosine kinase inhibitors
WO2014176216A1 (en) 2013-04-26 2014-10-30 Merck Sharp & Dohme Corp. Thiazole-substituted aminopyrimidines as spleen tyrosine kinase inhibitors
US9745295B2 (en) 2013-04-26 2017-08-29 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
CA2919661A1 (en) * 2013-07-30 2015-02-05 Gilead Connecticut, Inc. Polymorph of syk inhibitors
PE06052016A1 (en) * 2013-07-30 2016-07-20 Gilead Connecticut Inc Formulations syk inhibitors
JP6159028B2 (en) 2013-07-31 2017-07-05 ギリアード サイエンシーズ, インコーポレイテッド Syk inhibitors
SG11201603050TA (en) 2013-12-04 2016-05-30 Gilead Sciences Inc Methods for treating cancers
US9670196B2 (en) 2013-12-20 2017-06-06 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as Spleen Tyrosine Kinase inhibitors
US9783531B2 (en) 2013-12-20 2017-10-10 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
US9822107B2 (en) 2013-12-20 2017-11-21 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
UY35898A (en) 2013-12-23 2015-07-31 Gilead Sciences Inc ? Syk inhibitory compounds and compositions comprising ?.
US9775839B2 (en) 2014-03-13 2017-10-03 Merck Sharp & Dohme Corp. 2-pyrazine carboxamides as spleen tyrosine kinase inhibitors
US9796733B2 (en) 2014-06-04 2017-10-24 Merck Sharp & Dohme Corp. Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators
TW201617074A (en) 2014-07-14 2016-05-16 Gilead Sciences Inc Syk inhibitors
CA2955180A1 (en) 2014-07-14 2016-01-21 Gilead Sciences, Inc. Combinations comprising entospletinib and a vinca-alkaloid for treating cancers
TW201639573A (en) * 2015-02-03 2016-11-16 Gilead Sciences Inc Combination therapies for treating cancers
AU2016252387A1 (en) 2015-04-21 2017-10-19 Gilead Sciences, Inc. Treatment of chronic graft versus host disease with Syk inhibitors
WO2016197987A1 (en) * 2015-06-12 2016-12-15 杭州英创医药科技有限公司 Heterocyclic compound serving as syk inhibitor and/or syk-hdac dual inhibitor
US20170173034A1 (en) 2015-12-17 2017-06-22 Gilead Sciences, Inc. Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders
TW201822764A (en) 2016-09-14 2018-07-01 美商基利科學股份有限公司 Syk inhibitors
WO2018053190A1 (en) 2016-09-14 2018-03-22 Gilead Sciences, Inc. Syk inhibitors
WO2018195471A1 (en) 2017-04-21 2018-10-25 Gilead Sciences, Inc. Syk inhibitors in combination with hypomethylating agents
WO2019040298A1 (en) 2017-08-25 2019-02-28 Gilead Sciences, Inc. Polymorphs of syk inhibitors

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2607813B1 (en) 1986-12-05 1989-03-31 Montpellier I Universite 8 alkylamino-imidazo (1,2-a) pyrazines and derivatives, their preparation and their application in therapeutic
US5137876A (en) 1990-10-12 1992-08-11 Merck & Co., Inc. Nucleoside antiviral and anti-inflammatory compounds and compositions and methods for using same
DE4327027A1 (en) * 1993-02-15 1994-08-18 Bayer Ag imidazoazines
DE4337611A1 (en) * 1993-11-04 1995-05-11 Boehringer Ingelheim Kg New benzoylguanidines, their preparation and their use in medicaments
DE4337609A1 (en) 1993-11-04 1995-05-11 Boehringer Ingelheim Kg New Pyrazincarboxamidderivate, their preparation and their use in medicaments
FR2711993B1 (en) 1993-11-05 1995-12-01 Rhone Poulenc Rorer Sa Medicaments containing 7H-imidazol [1,2-a] pyrazine-8-one, the novel compounds and their preparation.
US6334997B1 (en) * 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
DE69535592D1 (en) * 1994-03-25 2007-10-25 Isotechnika Inc Improving the effectiveness of medicines duren deuteration
FR2723373B1 (en) 1994-08-02 1996-09-13 Rhone Poulenc Rorer Sa purified form of streptogramins, its preparation and pharmaceutical compositions containing it
WO1996034866A1 (en) 1995-05-01 1996-11-07 Fujisawa Pharmaceutical Co., Ltd. Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivatives and their use as bone resorption inhibitors
US5593997A (en) * 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
US6249495B1 (en) 1997-02-27 2001-06-19 Matsushita Electric Industrial Co., Ltd. Stepping motor control method and disk drive apparatus
SE9704404D0 (en) 1997-11-28 1997-11-28 Astra Ab New compounds
DE19948434A1 (en) 1999-10-08 2001-06-07 Gruenenthal Gmbh Substance library containing bicyclic imidazo-5-amines and / or bicyclic imidazo-3-amine
JP2001302667A (en) * 2000-04-28 2001-10-31 Bayer Ag Imidazopyrimidine derivative and triazolopyrimidine derivative
US6953413B2 (en) 2000-06-19 2005-10-11 Tay Armin S Axial position changing transmission mechanism
GB0018473D0 (en) 2000-07-27 2000-09-13 Merck Sharp & Dohme Therapeutic agents
DE10050663A1 (en) 2000-10-13 2002-04-18 Gruenenthal Gmbh Use of amino-substituted imidazo(1,2-a)pyridine, imidazo(1,2-a)pyrimidine and imidazo(1,2-a)pyrazine derivatives as NO synthase inhibitors, e.g. in treatment of migraine and neurodegenerative diseases
WO2002101221A2 (en) 2000-11-20 2002-12-19 Cryoco, Inc. A method and apparatus for the preparation and usage of a cryogenic propellant or explosive system
DK174233B1 (en) 2000-12-27 2002-10-07 Dss Danish Separation Systems Sanitary spiral filter plant
EP1363702A4 (en) 2001-01-30 2007-08-22 Cytopia Pty Ltd Methods of inhibiting kinases
GB0103926D0 (en) 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
WO2002076985A1 (en) 2001-03-23 2002-10-03 Smithkline Beecham Corporation Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
US7003125B2 (en) 2001-09-12 2006-02-21 Seung-Hwan Yi Micromachined piezoelectric microspeaker and fabricating method thereof
CA2476681A1 (en) 2002-02-19 2003-08-28 Bruce N. Rogers Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
AU2003221731B2 (en) * 2002-04-19 2010-04-15 Cgi Pharmaceuticals, Inc. Imidazo[1,2-a]pyrazin-8-ylamines method of making and method of use thereof
KR20040012451A (en) 2002-05-14 2004-02-11 어플라이드 머티어리얼스, 인코포레이티드 Methods for etching photolithographic reticles
US7288075B2 (en) 2002-06-27 2007-10-30 Ethicon, Inc. Methods and devices utilizing rheological materials
JP2004053714A (en) 2002-07-17 2004-02-19 Fuji Xerox Co Ltd Image fixing device and image fixing method
US20040026867A1 (en) 2002-08-09 2004-02-12 Adams David J. Bearing seal
US6761361B2 (en) 2002-08-09 2004-07-13 Credo Technology Corporation Drill and drive apparatus with improved tool holder
US7312341B2 (en) * 2002-09-09 2007-12-25 Cgi Pharmaceuticals, Inc. 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof
JP4845379B2 (en) 2002-09-19 2011-12-28 シェーリング コーポレイションSchering Corporation Imidazopyridine as cyclin-dependent kinase inhibitor
KR20050057520A (en) * 2002-09-23 2005-06-16 쉐링 코포레이션 Imidazopyrazines as cyclin dependent kinase inhibitors
TW200412967A (en) 2002-09-23 2004-08-01 Schering Corp Novel imidazopyrazines as cyclin dependent kinase inhibitors
JP4056346B2 (en) 2002-09-30 2008-03-05 三洋電機株式会社 Non-aqueous electrolyte secondary battery
CA2504317C (en) 2002-10-29 2012-05-22 Transave, Inc. Sustained release of antiinfectives
WO2004072080A1 (en) 2003-02-10 2004-08-26 Cellular Genomics, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of hsp90 complex activity
AR043002A1 (en) * 2003-02-18 2005-07-13 Altana Pharma Ag 6-substituted imidazopyrazines
US7157460B2 (en) * 2003-02-20 2007-01-02 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
US7186832B2 (en) * 2003-02-20 2007-03-06 Sugen Inc. Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
US7456393B2 (en) 2003-04-10 2008-11-25 Ge Homeland Protection, Inc. Device for testing surfaces of articles for traces of explosives and/or drugs
US7405295B2 (en) * 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US20060183746A1 (en) * 2003-06-04 2006-08-17 Currie Kevin S Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
WO2005005429A1 (en) 2003-06-30 2005-01-20 Cellular Genomics, Inc. Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds
US7259164B2 (en) * 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
US7236749B2 (en) 2003-10-15 2007-06-26 Honeywell International Inc. Stuck microphone deselection system and method
CN101124227A (en) * 2004-11-10 2008-02-13 Cgi制药有限公司 Imidazo[1,2-a]pyrazin-8-ylamines useful as modulators of kinase activity
US20050288295A1 (en) * 2003-11-11 2005-12-29 Currie Kevin S Certain imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof
RU2007121508A (en) * 2004-11-10 2008-12-20 Сги Фармасьютиклз Certain imidazo [1, 2-a] pyrazin-8-ylamine, methods for their preparation and their use methods
WO2005085252A1 (en) * 2004-03-04 2005-09-15 Biofocus Discovery Limited Imidazo ‘1,2-a’ pyrazine compounds which interact with protein kinases
JP2006099930A (en) 2004-09-01 2006-04-13 Tdk Corp Information recording medium, recording/reproducing apparatus, and stamper
US8145601B2 (en) 2004-09-09 2012-03-27 Microsoft Corporation Method, system, and apparatus for providing resilient data transfer in a data protection system
DE602005023333D1 (en) 2004-10-15 2010-10-14 Takeda Pharmaceutical kinase inhibitors
JP4883959B2 (en) 2005-08-17 2012-02-22 Ntn株式会社 Rotation detection device and a rotation detector equipped bearing
GB0520838D0 (en) * 2005-10-13 2005-11-23 Glaxo Group Ltd Novel compounds
EP1945644A2 (en) * 2005-11-10 2008-07-23 Schering Corporation Imidazopyrazines as protein kinase inhibitors
JP4837378B2 (en) 2006-01-04 2011-12-14 株式会社日立製作所 Storage device for preventing the falsification of data
US7446352B2 (en) 2006-03-09 2008-11-04 Tela Innovations, Inc. Dynamic array architecture
DE102006032495A1 (en) 2006-07-13 2008-02-07 Nokia Siemens Networks Gmbh & Co.Kg Method and apparatus for avoiding interference in a cellular radio communication system
US20080025821A1 (en) 2006-07-25 2008-01-31 Applied Materials, Inc. Octagon transfer chamber
CA2662074A1 (en) 2006-08-30 2008-03-06 Cellzome Limited Triazole derivatives as kinase inhibitors
ES2307402B1 (en) 2006-10-30 2009-09-30 Archivel Farma, S.L. prophylactic vaccine against tuberculosis.
US8133895B2 (en) * 2007-05-10 2012-03-13 Janssen Pharmaceutica N.V. Fused pyrazine compounds useful for the treatment of degenerative and inflammatory diseases
CA2708361C (en) 2007-12-14 2016-06-07 F. Hoffmann-La Roche Ag Novel imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine derivatives
JP5496915B2 (en) 2008-02-13 2014-05-21 シージーアイ ファーマシューティカルズ,インコーポレーテッド 6-aryl - imidazo [1,2-a] pyrazine derivatives, process for their preparation, and their use
JP5529852B2 (en) * 2008-05-06 2014-06-25 ジリード コネティカット,インコーポレイティド Substituted amides, their use as preparation and Btk inhibitor
CA2726460C (en) 2008-07-15 2017-02-21 F. Hoffmann-La Roche Ag Novel phenyl-imidazopyridines and pyridazines
TWI453207B (en) 2008-09-08 2014-09-21 Signal Pharm Llc Aminotriazolopyridines, compositions thereof, and methods of treatment therewith
PE01212012A1 (en) 2008-12-08 2012-02-20 Gilead Connecticut Inc Imidazopyrazine derivatives as inhibitors of syk
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
PE00582012A1 (en) 2008-12-08 2012-02-02 Gilead Connecticut Inc Imidazopyrazine derivatives as inhibitors of syk
US20110112995A1 (en) 2009-10-28 2011-05-12 Industrial Technology Research Institute Systems and methods for organizing collective social intelligence information using an organic object data model
JP5938352B2 (en) 2010-03-11 2016-06-22 ギリアード コネチカット, インコーポレイテッド Imidazopyridine syk inhibitor
JP5554746B2 (en) 2011-05-06 2014-07-23 株式会社日立製作所 Foreign matter removal method for a gas insulated bus and a gas insulated bus
US20140148430A1 (en) 2012-11-26 2014-05-29 Gilead Connecticut, Inc. Imidazopyridines syk inhibitors

Also Published As

Publication number Publication date
CN102307474B (en) 2015-04-01
VN28228A1 (en) 2011-12-26
TWI478922B (en) 2015-04-01
DK2716157T3 (en) 2016-08-15
EP2373169A1 (en) 2011-10-12
EA201190042A1 (en) 2012-02-28
CO6390078A2 (en) 2012-02-29
US20100222323A1 (en) 2010-09-02
PT2716157T (en) 2016-08-23
JP2014139251A (en) 2014-07-31
EA020461B1 (en) 2014-11-28
US20140357627A1 (en) 2014-12-04
SMT201600267B (en) 2016-08-31
IL234326A (en) 2017-09-28
PL2716157T3 (en) 2017-06-30
AU2009325132B2 (en) 2016-03-17
IL213365D0 (en) 2011-07-31
HK1211939A1 (en) 2016-06-03
US20180086769A1 (en) 2018-03-29
EP3123864A1 (en) 2017-02-01
PT2373169E (en) 2015-10-05
EP2716157B1 (en) 2016-05-18
HK1196037A1 (en) 2017-07-21
TW201033212A (en) 2010-09-16
US8748607B2 (en) 2014-06-10
JP5567587B2 (en) 2014-08-06
SG171991A1 (en) 2011-07-28
EA201400197A1 (en) 2014-09-30
RS55055B1 (en) 2016-12-30
US20140336169A1 (en) 2014-11-13
JP6132445B2 (en) 2017-05-24
US8765761B2 (en) 2014-07-01
US20130237521A1 (en) 2013-09-12
CN104744476B (en) 2017-04-12
US8455493B2 (en) 2013-06-04
EP2716157A1 (en) 2014-04-09
SI2716157T1 (en) 2016-10-28
LT2716157T (en) 2016-09-12
HUE030427T2 (en) 2017-05-29
SI2373169T1 (en) 2015-10-30
US20160031894A1 (en) 2016-02-04
MX2011006091A (en) 2011-11-29
EA201690111A1 (en) 2017-01-30
JP2012510997A (en) 2012-05-17
WO2010068257A1 (en) 2010-06-17
TWI529172B (en) 2016-04-11
CN102307474A (en) 2012-01-04
NZ593459A (en) 2013-09-27
JP2017101090A (en) 2017-06-08
PE09752014A1 (en) 2014-08-25
US20130237520A1 (en) 2013-09-12
US9796718B2 (en) 2017-10-24
JP2015205935A (en) 2015-11-19
US9120811B2 (en) 2015-09-01
ES2590804T3 (en) 2016-11-23
HRP20161036T1 (en) 2017-06-16
EP2373169B1 (en) 2015-05-20
US9212191B2 (en) 2015-12-15
TW201529576A (en) 2015-08-01
CA2746023C (en) 2018-03-27
CN104744476A (en) 2015-07-01
CY1118377T1 (en) 2017-06-28
JP5832586B2 (en) 2015-12-16
EA024140B1 (en) 2016-08-31
IL213365A (en) 2014-11-30
KR20110098795A (en) 2011-09-01
AU2009325132A1 (en) 2011-06-30
KR101745732B1 (en) 2017-06-12
KR20170013414A (en) 2017-02-06
KR101748925B1 (en) 2017-06-19
KR20150004436A (en) 2015-01-12
EP2373169A4 (en) 2012-08-29
HK1162250A1 (en) 2016-02-19
ES2545610T3 (en) 2015-09-14
CA2746023A1 (en) 2010-06-17
KR20170066685A (en) 2017-06-14

Similar Documents

Publication Publication Date Title
JO2870B1 (en) Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
TWI403513B (en) Pyrrolopyrazinyl urea kinase inhibitors
CY1119784T1 (en) Aketyliomenes salikylikes COMPOUNDS FATTY ACID AND USES these
CY1116578T1 (en) INHIBITORS AND USES bromodomain these
EA018863B1 (en) Organic compounds
SG10201805844QA (en) 1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
CY1112200T1 (en) Combination for the treatment diseases involving cell proliferation
UA107445C2 (en) LibreOfficeDERIVATIVES AS FUNGICIDES
UA96936C2 (en) Multicyclic amino acid derivatives and methods of their use
TW201033208A (en) Salt forms of organic compound
NZ547481A (en) Heterocyclic inhibitors of mek and methods of use thereof
PE13712014A1 (en) Heterocyclic compounds and uses thereof
AR072952A1 (en) March 2-imino-phenyl-metilpirrolopirimidinona-substituted compounds as inhibitors of BACE-1, compositions and their use
PE08052007A1 (en) Imidazopyrazines as protein kinase inhibitors
CY1115844T1 (en) Macrocyclic INHIBITORS PROTEASE SERINE HEPATITIS c
AR067090A1 (en) Espiriciclos as inhibitors of 11- beta hydroxysteroid dehydrogenase type 1
CO6450621A2 (en) sulfonamides nematicides
PE13032006A1 (en) pharmaceutical composition comprising oxaprozin
CY1109183T1 (en) Syntigmenes HETEROCYCLIC COMPOUNDS and use these as a hcv POLYMERASE INHIBITOR
EA201201648A1 (en) stimulants sgc
CR20110092A (en) Novel compounds useful for treating degenerative and inflammatory diseases
MXPA06012831A (en) Novel compounds of proline and morpholine derivatives.
MX2007015216A (en) Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors.
MXPA05000962A (en) Novel benzodioxoles.
CY1118879T1 (en) Triazinis COMPOUNDS AS KINASE INHIBITORS p13 and mtor

Legal Events

Date Code Title Description
FG Grant, registration