OA5448A - Multipenetrating vaccinating device - Google Patents

Multipenetrating vaccinating device Download PDF

Info

Publication number
OA5448A
OA5448A OA55949A OA55949A OA5448A OA 5448 A OA5448 A OA 5448A OA 55949 A OA55949 A OA 55949A OA 55949 A OA55949 A OA 55949A OA 5448 A OA5448 A OA 5448A
Authority
OA
OAPI
Prior art keywords
sleeves
vaccine
penetration
central
points
Prior art date
Application number
OA55949A
Other languages
French (fr)
Original Assignee
Manufrance Manufacture Francai
Pasteur Institut
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR7532385A priority Critical patent/FR2327754B1/fr
Priority to FR7535241A priority patent/FR2330372B2/fr
Application filed by Manufrance Manufacture Francai, Pasteur Institut filed Critical Manufrance Manufacture Francai
Publication of OA5448A publication Critical patent/OA5448A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices

Abstract

A multi-penetration vaccination apparatus comprising a mounting having on one side a manually engageable portion for the handling of the apparatus and on the other side one or more levels of supports adapted for removable press-fit of one extremity of concentric sleeves, the free extremity of the sleeves and the central support having a plurality of points for penetration into the skin of the subject. Vaccine is supplied to the points so as to penetrate into the skin along with such points. The vaccine can be contained in a reservoir formed at the bottom of a cover which is mounted on the outer-most of the sleeves to form a sealed enclosure for such vaccine, the points being immersed in the vaccine. Alternatively, the central support can be formed with a bore in which a vaccine capsule is inserted so as to supply vaccine to the points at the time of penetration thereof into the skin of the subject.

Description

The object of the invention is a multi-penetrating vaccinating device with adaptable effects according to the vaccinated subjects. The subject of the invention relates to the technical field of devices for introducing agents into the body. proposed means or means of vaccinating with multiple tips or teeth that soak or otherwise immerse the vaccine to be inoculated to the subject to be vaccinated "

However, it is known that therapeutic inoculation is related to the age of the vaccinated subject. The older the subject, the greater the amount of inoculated vaccine must be important. Sometimes, on different parts of the skin, the tips or teeth of the vaccinating organ through the patient's skin. The effect is unpleasant for the vaccinated subject who may have relatively wide scars. convenient for the operator and leads to a loss of time "

According to the invention, it has been sought to overcome these drawbacks and to create a multi-penetrating vaccinating device with adaptable effects according to the vaccinated subjects, acting under a single pressure through the skin. This device is remarkable in that it includes a frame. having a portion cited a gripping portion and thrust, while are formed on the other side of this mount one or stepped spans or equiva-lent provisions for the fitting or removable assembly of a- end concentric sleeves or hollow supports engaged into each other, the free ex-tremité said sleeves or supports and the central bearing having a plurality of points, teeth or other asperities penetration "

According to another embodiment, the support members, sleeves or hollow supports, engaged on stepped bearings, concentric grooves or equivalent provisions of the frame, and the central bearing may be integral with the frame, and the cap when used, presen Both shoulders or bulges, preferably, but not limited to conical contact surfaces, so as to e-trap the vaccine in the end portion of the cap or tip holder members, tip area "or asperities penetration, this by improving the rigidity diaaètreie supports and sleeves and facilitating the> 5. gripping in the various manipulations »

According to another characteristic characteristic, the penetration points or asperities have a sectional profile with several radial branches.

Another feature is that the branch section profile is cruciform.

In another feature, between the branches, the apex of which is preferably a sharp edge of penetration, are provided internal angles, shapes or cavities retaining the vaccinia

According to another embodiment, the mount comprises a single piece having a central end, the free end of which carries at least one and generally several points, around this bearing being adapted and retained in a manner that is easily removable by friction adjustment. or at a thread, at least one sleeve with tips at its free end; the central scope of the frame being axially open from one side to the other to receive an organ containing vaccine which is deposited on the skin of the subject to be vaccinated before or at the same time that, by pressure, the tips perforate the skin and inoculate the vaccine.

These and other features emerged from the description which follows

To fix the object of the addition, without: however, limiting it in the appended drawings

Figure 1 is a perspective view showing the separate elements of the vaccinator device according to the invention.

Figure 2 is a perspective view on a larger scale of the dispositiffermé. -

Figure 3 is a sectional view of the closed device. FIG. 4 is a view along arrow P in FIG. 3, showing only the penetration points positioned on their support.

Figures 5 and 6 are respectively front views, in section and below, showing the device after removal of a series of tips.

Figures 7 and 8 are respectively front and bottom views, showing the device after removal of two sets of tips *

Figure 9 is a sectional view of the device according to another embodiment.

FIG. 10 is a view along the arrow P1 of FIG. 9 representing only the support of the tip-holding elements.

Figure 11 is a partial sectional view showing the arrangement of the tips according to another embodiment.

Fig. 12 is a view showing the separate elements making up the device according to the alternative embodiment. Figure 13 is a sectional view illustrating the device according to Figure 12 but with its assembled elements.

Figures 14 to 24 illustrate different forms of teeth or spikes 3 'Penetration®'

FIG. 2p is a sectional view illustrating a first embodiment of the device according to the second variant,

Fig. 26 is a plan view corresponding to Fig. 25.

Fig. 27 is a view illustrating a first embodiment of the organ containing the vaccine.

Figure 28 illustrates the vaccinator device placed in a -condition-e

Fig. 29 is a view showing separately the components of the vaccinating device according to Fig. 25;

FIG. 30 is a plan view showing alternative embodiments of gripping means for the removable sleeves,

FIG. 31 is a sectional view illustrating another embodiment of the vaccinator device according to the second variant.

Fig. 32 is a plan view corresponding to Fig. 31 "

FIG. 33 illustrates an alternative embodiment of the organ containing the vaccine, more particularly adapted to the vaccinator device according to FIG. 311

Figure 34 shows a vaccine supply in the form of a ring for serial inoculation or modulated case by case. . .

Figures 35 and 36 show two examples of implementation of the dispo-sitive vaccinator with its organ containing the vaccine®

In order to make the object of the invention more concrete, it is now described in non-limiting embodiments illustrated in the figures of the drawings.

The device according to FIGS. 1 to 8 consists of a frame made of a gripping part 1a forming a pallet, connected to a circular plate lb, for example.This plate, opposite the pallet, has cylindrical staggered bearing surfaces for example, 1o, 1d, the, If, ...

The first seat (1b) is intended to receive under pressure and in a sealed manner the open end of a protective cap forming a lower reservoir for the vaccine to be inoculated. Note nr.-i the cap is conical to facilitate gripping. It is also possible, at the limit, not to provide a cap or only a protective sheath, the vaccine being taken in an independent container.

The last reach (if) has on its end face tips, teeth or sharp edges 1q, in a determined number, for example five (Figure 4) "

Intermediate bearing surfaces 1d, 1c, n0 are in any number (1,2,3 ") and are intended to receive by force-fitting elements 4 or hollow supports such as sleeves 3, 4> . which when enga-gés in abutment against the upper shoulders, are in the same alignment at their free end which also has points, teeth or roughnesses 3a, 4a, ··· in a determined number, for example nine on the sleeve 3 and · eighteen on the sleeve _4 (Figure 4) o

These sleeves have a cylindrical bore and are conical to their periphery with the large diameter on the tips side. This arrangement makes it possible, in combination with the dimensioning of the staggered spans, to provide the lower part with a small space E between the sleeves and between the sleeve 3 and the bearing surface 1f, which space is used to retain a certain quantity. On the other hand, the conicity or counter-slope of the sleeves facilitates manipulation to engage or disengage them from their reach, because of the weakest wall at this location.

As can be seen in FIGS. 5 to 8, the number of penetration spikes can be varied rapidly and conveniently as a function of the subject being vaccinated, by removing a sleeve (FIGS. 5 and 6) two sleeves (FIGS. 7 and 8) or more If it's happened.

Thus *, the complete device, that is to say with all these tips, allows the maximum requested vaccination, with a single pressure on the skin. If we want to inoculate less vaccine, we remove one or more 'sleeves'. For a minimum vaccination, the terminal reach 1f is sufficient »

Sleeves and circular bearings have been provided for reasons of simplicity, manufacturing and concentration of the tips, in order to obtain maximum inoculation on a minimum skin surface. But it is easy to pre-see other forms bringing as much concentration. than. sleeves and sleeves of polygonal shape in section (square ^ hexagonal .. "o) o

According to an alternative embodiment illustrated in FIGS. 9 and 10, the liner J only has a bearing surface 5a intended to receive the cap 6. On the end face of the bearing surface are formed: a bore or axial recess 5b which is engaged by force a solid support 7. equipped with teeth 7e and concen-trically to this bore, circular grooves I - 5ά .oo "" receiving the sleeves 8j J>? »<, ♦«, equipped with teeth 8a, 9a »» »».

It is also possible to form a central bearing directly in the mass instead and in place of the support 6. It should also be noted that the teeth or tips may all be of the same length or of different lengths, as shown in FIG. 11 where it can be seen that the The shortest teeth are at the center and the longest at the periphery, the teeth 12 and others being intermediate. To obtain the same effect, it is possible to provide tips of the same length but of different lengths (in the case of FIG. 9) or not at the same level (in the case of FIG. 3, especially). .

This different penetration of the tips makes it possible to adapt the depth of inoculation to the subject in the presence.

For example, and not limitation, provides the following dimensions: - length of the closed device: 39 millimeters, -Outer diameter or circumscribed diameter: about 12 millimeters, - length of the pallet ± 17 millimeters, - length of the tips About 3 millimeters, or 3, 2, 8 and 2.5 millimeters, they are of different lengths. - taper of the sleeves about 2 degrees, - space between the sleeves about 0.5 millimeters?

According to these provisions, the rapid adaptation to the vaccinated subject of the quantity of vaccine to be inoculated by the mobility of the spike-carrying elements is emphasized, thus ensuring a precise vaccination according to the subject, in particular according to his age; this in one pressure on the skin. - The concentration of inoculation tips by the arrangement of the tips, allowing maximum inoculation on a minimum skin area, which avoids oibatrices too important, - the intervals between the sleeves ensuring the retention of the vaccine.

According to FIGS. 12 and 13 there is illustrated alternatively a booster device whose mounting has removable adaptation arrangements for sleeves or hollow supports, of the cylindrical bearing-staggered type of the mount, but it is obvious that these sleeves or removable supports can be mounted in using equivalent arrangements such as the centric grooves described above.

The mount 13 has as in the first embodiment, a pallet gripping portion 13a, connected to a circular tray 13b or other sectionA opposite the pallet, the plate is extended by cylindrical stepped bearings 13o, 13d, 13e, 13f, 13%, .... The first range 13c receives in pressure the open end of a cap $ 4 <The bottom receives the vaccine to be inoculated

The last span (13q) has on its end face penetration asperities (teeth or spikes 15 for example) in a suitably-determined number, 6

Intermediate bearing surfaces 13d, 13c, &quot; serve in any number, and are forcibly fitted with sleeves or hollow supports 16, 17, bearing at their end opposite to the insertion of penetration asperities. (Teeth or spikes 18-19 for example) in number - suitably determined "" ".

The sleeves 16, 17 preferably have near their endportant the tips, parts, bulges or shoulders 16a, 17a: having tapered contact faces for example. The same conical arrangement is found in the form of shoulder or chamfer 13h between the bearing surfaces 13 f- and 13 q, and 10 inside the cap 14 (surface or chamfer 14a) .It is not excluded in the frame Of the invention, the bulged portions or shoulders have contact faces perpendicular to the general axis of the device.

These contact surfaces provide an effective seal for mounting, to prevent the vaccine from rising, during handling, along. 15 sleeves. Indeed, the sleeve 16, fitted on the bearing 13e, is in support on the surface 13h the sleeve 17, fitted on the bearing surface 13 d taking .support on the surface of the shoulder 16a of the sleeve 16, and the cap, emman 13c is resting on the surface of the shoulder 17a of the sleeve 17 °. It should be further noted that to facilitate the insertion and disengagement of the sleeves, on the periphery of said sleeves, asperities are provided. such as grooves 16b - 17b, grooves, grooves, grid, ... In a manner improved with respect to the previous embodiment, the conicitê more important of the sleeves or supports increases the rigidity and facilitates the. grasping and manipulations. '

The asperities of penetration into the skin are preferably desdents or tapered tips. FIGS. 14 to 24 show different shapes of tips or teeth which may be of equal or unequal lengths.

For example, FIGS. 14, 15 and 22 show tips 20 whose section is three or four branches with a convex or concave flat surface. not- "

In Figures 16 and 17, the tips 21 are cruciform section thin branches; In Figures 38 and 19, the spikes 22 are of thick-section form with thick branches, and in Figures 20 and 21 the spikes 23 are spindle-shaped with thick branches and curved faces (concave or convex). spikes 2p -> ort with polygonal section with concave surfaces.

In these various forms, the surfaces between the edges of the branches constitute reserves of vaccine. 7 '0 5 448

Finally, in FIGS. 23 and 24, there is illustrated the conformation of a cylindrical tip 24 having a chamfered end 24a and presenting one or more cavities or concave bow-shaped shapes 24b.

According to this embodiment, the following is particularly emphasized: the sealing of the device at the level of the shoulders. and contact surfaces 13h - 16a - 17a - 14a preventing the vaccine from flowing and unnecessarily depositing along the sleeves. the shoulders or the bulges of the sleeves increase the rigidity, noticeably diametrically transverse. The placement of each sleeve or support helps to perfect the mounting of the sleeve or support previously engaged, and, consequently, the tightness of the assembly. The arrangement of the shoulders, as provided, has the effect of thus moving the pre-tensioning part away from the tips when handling the sleeves, which avoids having the fingers in contact with the vaccine and the tips. . - The teeth or tips of different lengths (the least long in the center of preference) ensure easier progressive penetration under a reduced pressure, eliminating or reducing as much painful perception of the patient. . - Section profiles with several radial branches, cruciform, bevelled, 20 faceted, or cavities or cuvettes allow better retention of the vac-cin in the corners, or internal shapes or cavities on the straight or curved faces, this in particular by the surface tension effect. These points of roughness, for a surface or section of equivalent penetration have a larger sur- face carrier, which allows to reduce the number of points without 2 resort to the effect of capillarity extreme approximation points. - better penetration of the vaccine by the effect of the radial branches of the tips that open the skin in a corresponding way without the lips of the skin do not return or wipe the vaccine, especially the vaccine deposited in the angles or internal advantages entered the branches FIGS. 25, 20, 28, 2, 36 and 36 show a vaccinator device according to a first embodiment of the invention. second variant in. wherein the device comprises a mount 26 consisting of a central two-stage central cylinder 26a whose free end carries at least one and generally several penetration points 26b. In the upper part the frame has a cylindrical shoulder 26c extending partially and for example by fins 26d diametrically opposite.

Axially, the mount has a tapered bore 26e tapered at the narrower bottom portion by a throat 26f opening at the free end.

On the first stage of the bearing surface 26a is engaged with friction the bore 2 "a of a sleeve 27, having an upper flange 27b bearing on the shoulder 26c of the frame and points 27c at the free end annulai-re Other sleeves may be friction fit on the outer diameter of the first sleeve 27. In the illustrated example, there is only one sleeve, the outer diameter 27d of the sleeve 27 receives friction a cap 2o for protecting the tips on a mechanical level (to avoid 1'emous-wise shock or friction) and medical uv vlan (to ensure sterilization s being understood that this sterilization is also performed in the upperparts opened in 26th by conditioning the device in a package Z (FIG. 23). It should be noted that the tips 26b and 27c are of different lengths, so that the tips 26b closest to the axis of the frame are the longest. and the s the shortest points on the largest diameter, constituting together a fictitious surface (Figure 25) convex with respect to the axis and the direction of penetration of the tips. In FIG. 27, there is illustrated a member intended to contain the vaccine to be inoculated, according to a first embodiment constituted by a flexible flexible cap-sule 2g comprising a reservoir portion 29a followed by an end-cone 29b fitting into the 26th bore of the frame and a 29c-breakable pellet. The tip 29b and the bore 26e have a suitable conicity and for example conform to the French standard S 9OOII.

According to another embodiment illustrated in FIGS. 31 and 32, the vaccinator device always has the sleeve or sleeves 27 and the capu-chon 28, while the frame 30 has the central bearing 30a with the tips 30b> the cylindrical shoulder 30c, the fins 30d and the bore 30e with lower throttle 30f «

The upper part of the shoulder 30s has a 30g boss vertically extending by at least two uprights or 30h ribs, connected to the upper part to a crown or bearing 30i · The nervuressess are located outside a diameter delimited by a bore 30j of the bearing 30i and by a chamber 3CSc of the boss 30g opening in the conical bore 30e »

This particular form of the frame allows the engagement and guidance of a vaccine container (FIG. 33) in the form of a flexible tube 31 comprising a reservoir portion 31a followed by a corresponding conical tip 31b. 9 to 10 20 25

U at the 30th bore of the mount, and a breakable pellet 31c * In Figure 34 on &amp; illustrated another form of vaccine container type syringe 32 comprising a body or tank 32a terminated by a ferrule 32b corresponding to the conical bore of the frame and a piston 32c.

This provision allows a controlled distribution and dosed at the will of the vaccine, case by case, by the practitioner. Note that the flexible tube 31 and the syringe 32 can also be used with the vaccinator device according to the first embodiment.

Specific arrangements have also been made to facilitate handling, in particular the fins 26d or 30d of the frame allowing the easy removal of the removable sleeve or sleeves 27 whose upper support flanges 27b project beyond the cylindrical bearing surfaces 26c or 30c of the cylinder. ture (Figures 26 and 32). It is also possible to provide on the sleeves further blades 27θ> 27f,. <> ·., (FIG. 30) offset angularly with respect to the wings 26d of the frame

According to another variant, it is possible to provide different colors for the frame and the sleeve or sleeves, in order to facilitate handling.

This color differentiation can be performed on all elements or only on the fins or flanges.

The implementation of the vaccinator device is now described by referring to FIGS. 31 and 36 of the drawings. FIG. 35 shows a complete vaccinating device, that is to say comprising a maximum of penetration points, in which a vaccine capsule is engaged by friction. The practitioner holds the capsule between the thumb and the index finger and press the vaccinator on the patient's skin while pressing on the faces of the capsule (arrows f1, f2); the end of the presser fingers being in contact with the fins of the frame, the vaccine is then, by the strangulation 26f, in the space between the tips and some quantity enters the epidermis.

According to another practice, the practitioner tie ^ t the capsule engaged in the firing in the bore 26e, between the index finger and the middle finger pressing the capsule and rest on the fins of the mount (Figure 36 where it is represented only mount in action), while the thumb passes behind the forearm to form clamping jaw in response to the pressure force.

With the flexible tube 31 the action is similar in that the practitioner holds the frictionally engaged tube in the mount (broken lines, Fig. 31) and presses the device against the skin while pressing the tube. If the practitioner uses the graduated syringe 32, he will hold the syringe-vaccinator together with one hand while pressing it on the skin and will actuate the piston 32c of the other to deliver a quantity. dose of vaccine.

The benefits are apparent Link of the description, in particular it is emphasized: 5 - the easy handling of the vaccine-vaccine container assembly, as well as removable elements of the vaccinator by fins, glue-holders or different colors, - the precise dosing of the vaccine, avoiding a significant waste of the vaccine when introduced into the vaccinator simultaneously with penetration, In some places, spikes, sleeves and frames may be divided into: - the sterile packaging of the vaccinator device and possibly the vaccine container, - the penetration first of the central tips then of the extreme tips, of different lengths, or the different length of the frame and sleeves, ensuring a better vaccination effect since the vaccine is introduced in the central part "15

Claims (10)

11 SUMMARY.
1.- multi-penetrating vaccine device with adaptable effects according vaccinated subjects, acting under a single pressure through the skin, ca-characterized in that it comprises a frame having on one side a portion of apprehension and thrust, while are formed on the other side of this rim, one or more staggered spans or equivalent arrangements for the insertion or removable mounting of one end of concentric sleeves or of hollow supports engaged one inside the other, the free end of the said sleeves or supports and the central bearing having a plurality of points, teeth or other penetrating asperities, 2o-The sleeves or hollow supports engaged in abutment on the abutments or equivalent provisions are at the same level or on the same plane of the side of points or penetration teeth. 3o-The sleeves or hollow supports engaged in abutment on the abutments or equivalent provisions and the central reach do not reach the same at their end bearing the penetrating members, the highest level being on the central and progressive range away from the center. 4 · - The tips, teeth or other asperities of the sleeves and the central door are of the same length. 5 <> - According to 2, the tips, teeth or other asperities of the sleeves and the central bearing, are of different lengths, that is to say that the points of the central span are the shortest, while the points of the dumanchon of larger dimension are the longest, the points of the intermediate sleeves being of intermediate lengths. 6, - The carrying elements of the penetrating members are constituted ', firstly of the last scope of smaller dimension of the frame, and, secondly, the sleeve or hollow supports force-engaged by an end on the intermediate bearing (s) of the mount. 7 · - The carrying elements of the penetrating members are constituted firstly of a central span made on the mount or attached to it by force engagement in a central recess of the mount, and, secondly, the sleeve or sleeves hollow supports forcibly engaged by Life end in one or concentric grooves in the central recess of the frame.
80- According to 1 and 6, the sleeves or hollow supports are tapered externally, their thinnest wall being on the side of the fitting onla or scopes of the frame, to facilitate disassembly. 12 0544a 9, - According to 1, 6, 7 and 8, the dimensioning of the staggered spans waves the recess and concentric grooves of the frame, combined with the dimensions of the central span and the sleeves, are such that a narrow space between the central bearing and the first sleeve and between the sleeves, space holding the vaccine to be inoculated,
10 · - According to 1, 6 and 7j the mount has a shelf extended on one side to fordo the pallet-shaped gripping part, while on the other side a dimension smaller than the tray, receives enpression and sealingly a protective cap preferably conical, covering all the bearings and sleeves and forming in the bottom tank vaccine, 11e- The concentric surfaces or grooves and lining recesses, and the sleeve or sleeves, have a sectional profile ensuring a good concentration of penetration asperities, that is to say offering maximum inoculation on a minimum skin area; this profile being circular or encoresous polygon-shaped (square, hexagonal, ····) which can be inscribed in a circle, 12, - the sleeves or hollow supports present near their extremi-tee bearing points, teeth or other asperities penetration , the inflexed parts or shoulders, while the cap if used, and the last worn or central reach provided with penetration asperities, also have chamfered shoulders,
13 - According to 12, the shoulders, bulging parts or bevels of the caps of the cap and of the central seat, have conical or other contact surfaces which, during the assembly of the sleeves and the cap, constitute, by the pressures exerted and transmitted, a closure sealing the vaccine deposited in the bottom of the cap and bathing the asperities of penetration,
14, - According to 12, the sleeves or hollow supports have at their periphery asperities such as grooves, grooves, grid, striage or equivalent, constituting points or gripping surfaces facilitating handling "
15, - Vaccinator device comprising a portion or surface ofprehension or thrust and a frame carrying a plurality of points, teeth or other .aspérités penetration into the skin, characterized in that the dots or teeth are circular section beveled at their end free for facilitate penetration and constitute a reservoir retaining face. The beveled end of the tips has one or more cavities or cuvettes retaining a more safely inoculated amount of vaccine. 17. - Vaccinator device comprisinga part or surfaceprejection or thrust and a mount carrying a plurality of points, dentsou other asperities penetration into the skin, characterized oe that the tips, teeth or roughness of penetration have a sectional profile with plu - several radial branches.
18. - Vaccinator device comprising a part or surface ofdehension or thrust and a frame carrying a plurality of points, teeth or other asperities penetration into the skin, characterized in that the tips, teeth or asperities penetration have a profile in cruciform section. -Position 19e- Device according to 17 and 18, characterized in that between the branches whose top is preferably an acute edge of penetration, arerouvent formed angles, shapes or internal cavities retention of the vaccine. 20e- Device according to 1, 2, 3, 4, 5, 7, 9, 10, 11, 15, 1c, 17, 18 and 19, characterized in that the frame has a single piece central unit whose free end carries at least one and generally several points, around this range being adapted and retained, in a manner amenable, by friction fit, at least one sleeve having spikes at its free end; the central scope of the frame being open axially-through to receive a body containing vaccine that ondépose on the skin of the subject to be vaccinated at the same time that, by pressure, the tips perforate the skin and inoculate the vaccine *
21, - Device according to 20, characterized in that the ends of the spikes of the central scope of the frame and the sleeves are located in a fictitious convex surface with respect to the axis and the direction of penetration of the spikes, the longest points and the first in contact with the skin being the tips of the central scope of the mount.
22, - Device according to 20, characterized in that a tip protection cap is adapted and retained by friction, or screw thread, removably nnemaniere around the sleeve of larger diameter.
23, - Device according to 20, 21 and 22, characterized e 'that, for the convenience of gripping, movements and manipulations of the practitioner, the mount has fins or equivalent provisions partially déavantordant with respect to the circular collars or gripping partsdu or reported sleeves that can be grasped for or separatelycompositely from the central port of the mount.
24 "- Device according to 20 to 23, characterized in that the vaccine containing member is a flexible capsule with a conical tip terminated by a step which can be broken when it is desired to allow the flow of the vaccine, this tip being adapted, at the time of inoculating the vaccine, in the corresponding regional opening of the scope, the center of the mount. 25 - Device according to 20 to 23, characterized in that the body containing vaccine is a flexible tube with a conical tip terminated by a pellet which can be broken when it is desired to allow the flow of the vaccine, this tip being adapted, at the moment to inoculate the vaccine into the corresponding axial opening of the center span of the frame which has extensions and a crown to hold the flexible tube while leaving the possibility of pressing the said flexible tube when we want to deposit the vaccine. 26-- Device according to 20 to 23, characterized in that the contant organ of the vaccine is a syringe allowing a controlled distribution and dosage at will of the vaccine, case by case, by the practitioner. 27-- Device according to 20 to 26, characterized in that the frame, the lid and cap, and possibly the organ containing vaccine, are protected until the moment of vaccination, in a packaging, such as for example a case flexible sealed, or thermo-shaped plastic cell, the assembly being sterilized 28th- Device according to 20 to 23, characterized in that the sleeves are different colors totally or according to their upper flange orleurs fins, to facilitate identification by the practitioner when he has to remove one. or several sleeves following the vaccinated subject.
OA55949A 1975-10-16 1976-10-08 Multipenetrating vaccinating device OA5448A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR7532385A FR2327754B1 (en) 1975-10-16 1975-10-16
FR7535241A FR2330372B2 (en) 1975-11-10 1975-11-10

Publications (1)

Publication Number Publication Date
OA5448A true OA5448A (en) 1981-03-31

Family

ID=26219115

Family Applications (1)

Application Number Title Priority Date Filing Date
OA55949A OA5448A (en) 1975-10-16 1976-10-08 Multipenetrating vaccinating device

Country Status (2)

Country Link
US (1) US4109655A (en)
OA (1) OA5448A (en)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2474856B1 (en) * 1980-01-31 1983-10-07 Merieux Inst
NZ239274A (en) * 1991-08-05 1995-12-21 Zenith Technology Corp Ltd Scratch fluid medicament applicator for applying a vaccine to an animal
DE69719761D1 (en) * 1996-06-18 2003-04-17 Alza Corp Apparatus for improving transdermal administration of medicaments or the acceptance of body fluids
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US7344499B1 (en) 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
JP2002517300A (en) * 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション Microneedle device and a manufacturing method and use thereof
US6132449A (en) * 1999-03-08 2000-10-17 Agilent Technologies, Inc. Extraction and transportation of blood for analysis
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
GB2354446A (en) * 1999-09-21 2001-03-28 John Arthur Lunn Multiple puncture device
US6659982B2 (en) * 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
PT1341452E (en) * 2000-10-13 2009-03-18 Alza Corp Microprotrusion member retainer for impact applicator
AU2001297823B2 (en) 2000-10-26 2005-05-12 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
US8641644B2 (en) 2000-11-21 2014-02-04 Sanofi-Aventis Deutschland Gmbh Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
US7027478B2 (en) * 2000-12-21 2006-04-11 Biovalve Technologies, Inc. Microneedle array systems
US7892183B2 (en) 2002-04-19 2011-02-22 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
US8372016B2 (en) 2002-04-19 2013-02-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling and analyte sensing
WO2002074173A1 (en) * 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
EP1752189A3 (en) 2001-04-20 2007-02-21 Alza Corporation Microprojection array having a beneficial agent containing coating
MXPA03009603A (en) * 2001-04-20 2004-12-06 Johnson & Johnson Microprojection array having a beneficial agent containing coating.
US7041068B2 (en) 2001-06-12 2006-05-09 Pelikan Technologies, Inc. Sampling module device and method
WO2002100460A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Electric lancet actuator
US8267870B2 (en) 2002-04-19 2012-09-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for body fluid sampling with hybrid actuation
US7909778B2 (en) 2002-04-19 2011-03-22 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
EP1404233B1 (en) 2001-06-12 2009-12-02 Pelikan Technologies Inc. Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
US7297122B2 (en) 2002-04-19 2007-11-20 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7674232B2 (en) 2002-04-19 2010-03-09 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7229458B2 (en) 2002-04-19 2007-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7232451B2 (en) 2002-04-19 2007-06-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9248267B2 (en) 2002-04-19 2016-02-02 Sanofi-Aventis Deustchland Gmbh Tissue penetration device
US7226461B2 (en) 2002-04-19 2007-06-05 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
US7491178B2 (en) 2002-04-19 2009-02-17 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8360992B2 (en) 2002-04-19 2013-01-29 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
WO2002100254A2 (en) 2001-06-12 2002-12-19 Pelikan Technologies, Inc. Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge
US7547287B2 (en) 2002-04-19 2009-06-16 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7981056B2 (en) 2002-04-19 2011-07-19 Pelikan Technologies, Inc. Methods and apparatus for lancet actuation
US7331931B2 (en) 2002-04-19 2008-02-19 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US7901362B2 (en) 2002-04-19 2011-03-08 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US9427532B2 (en) 2001-06-12 2016-08-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795334B2 (en) 2002-04-19 2017-10-24 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US7976476B2 (en) 2002-04-19 2011-07-12 Pelikan Technologies, Inc. Device and method for variable speed lancet
US8579831B2 (en) 2002-04-19 2013-11-12 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8337419B2 (en) 2002-04-19 2012-12-25 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US7344507B2 (en) 2002-04-19 2008-03-18 Pelikan Technologies, Inc. Method and apparatus for lancet actuation
US8221334B2 (en) 2002-04-19 2012-07-17 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US9226699B2 (en) 2002-04-19 2016-01-05 Sanofi-Aventis Deutschland Gmbh Body fluid sampling module with a continuous compression tissue interface surface
US8784335B2 (en) 2002-04-19 2014-07-22 Sanofi-Aventis Deutschland Gmbh Body fluid sampling device with a capacitive sensor
AU2002327675A1 (en) * 2001-09-19 2003-04-01 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
EP1471953B1 (en) * 2001-09-21 2011-02-16 Valeritas, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
AU2002343457A1 (en) * 2001-09-28 2003-04-07 Biovalve Technologies, Inc. Switchable microneedle arrays and systems and methods relating to same
WO2003026733A2 (en) * 2001-09-28 2003-04-03 Biovalve Technologies, Inc. Microneedle with membrane
DE10152030A1 (en) * 2001-10-23 2003-06-05 Medium Tech Medizingeraete Gmb Needle to be used in tattooing or for application of permanent make up, comprising tip with triangular cross section
CA2464994A1 (en) * 2001-10-29 2003-06-26 Becton, Dickinson And Company Method and device for the delivery of a substance
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US8702624B2 (en) 2006-09-29 2014-04-22 Sanofi-Aventis Deutschland Gmbh Analyte measurement device with a single shot actuator
US6719734B1 (en) * 2002-05-28 2004-04-13 Willie E. Harkless Anesthetic delivery tool and method of using
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
WO2004024224A1 (en) * 2002-09-16 2004-03-25 Sung-Yun Kwon Solid micro-perforators and methods of use
AU2003279641B2 (en) * 2002-06-28 2009-06-18 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
AR040819A1 (en) * 2002-08-08 2005-04-20 Alza Corp Transdermal delivery device having coated vaccine microprojections
AU2003275301A1 (en) 2002-09-30 2004-04-23 Alza Corporation Drug delivery device having coated microprojections incorporating vasoconstrictors
US7695486B2 (en) * 2002-10-02 2010-04-13 Linda Dixon Intradermal color introducing needle device, and apparatus and method involving the same
IL152912D0 (en) * 2002-11-18 2003-06-24 Nanopass Ltd Micro needle systems
AR042815A1 (en) * 2002-12-26 2005-07-06 Alza Corp Delivery device active agent having composite members
US8574895B2 (en) 2002-12-30 2013-11-05 Sanofi-Aventis Deutschland Gmbh Method and apparatus using optical techniques to measure analyte levels
US7052652B2 (en) 2003-03-24 2006-05-30 Rosedale Medical, Inc. Analyte concentration detection devices and methods
US20050070819A1 (en) * 2003-03-31 2005-03-31 Rosedale Medical, Inc. Body fluid sampling constructions and techniques
AT476137T (en) 2003-05-30 2010-08-15 Pelikan Technologies Inc Method and device for injecting liquid
US7850621B2 (en) 2003-06-06 2010-12-14 Pelikan Technologies, Inc. Method and apparatus for body fluid sampling and analyte sensing
KR20060029162A (en) * 2003-06-30 2006-04-04 알자 코포레이션 Method for coating skin piercing microprojections
BRPI0412029A (en) 2003-06-30 2006-09-05 Alza Corp microprojections coated formulations containing non-volatile counter-ion
US20050123507A1 (en) * 2003-06-30 2005-06-09 Mahmoud Ameri Formulations for coated microprojections having controlled solubility
KR20060037320A (en) * 2003-07-02 2006-05-03 알자 코포레이션 Microprojection array immunization patch and method
WO2005033659A2 (en) 2003-09-29 2005-04-14 Pelikan Technologies, Inc. Method and apparatus for an improved sample capture device
WO2005037095A1 (en) 2003-10-14 2005-04-28 Pelikan Technologies, Inc. Method and apparatus for a variable user interface
CN101415443A (en) * 2003-10-23 2009-04-22 阿尔扎公司 Compositions of stabilized DNA for coating microprojctions
EP1680057A4 (en) * 2003-10-24 2007-10-31 Alza Corp Apparatus and method for enhancing transdermal drug delivery
CA2543154A1 (en) * 2003-10-28 2005-05-19 Alza Corporation Method and apparatus for reducing the incidence of tobacco use
AU2004287059A1 (en) * 2003-10-28 2005-05-19 Alza Corporation Delivery of polymer conjugates of therapeutic peptides and proteins via coated microporjections
CA2543641A1 (en) * 2003-10-31 2005-05-19 Alza Corporation Self-actuating applicator for microprojection array
AU2004292954A1 (en) * 2003-11-13 2005-06-09 Alza Corporation Composition and apparatus for transdermal delivery
BRPI0416822A (en) * 2003-11-21 2007-03-06 Alza Corp method and transdermal vaccine delivery system with ultrasound
CA2552385C (en) * 2003-12-29 2013-07-23 3M Innovative Properties Company Medical devices and kits including same
WO2005065414A2 (en) 2003-12-31 2005-07-21 Pelikan Technologies, Inc. Method and apparatus for improving fluidic flow and sample capture
US20050171567A1 (en) * 2004-01-29 2005-08-04 Dehart Damon H. Lancet and method of manufacturing the same
CN101120101A (en) * 2004-04-13 2008-02-06 阿尔扎公司 Apparatus and method for transdermal delivery of multiple vaccines
EP1751546A2 (en) 2004-05-20 2007-02-14 Albatros Technologies GmbH &amp; Co. KG Printable hydrogel for biosensors
US9775553B2 (en) 2004-06-03 2017-10-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a fluid sampling device
EP1765194A4 (en) 2004-06-03 2010-09-29 Pelikan Technologies Inc Method and apparatus for a fluid sampling device
EP3329960A1 (en) * 2004-06-10 2018-06-06 3M Innovative Properties Company Patch application device and kit
WO2006001797A1 (en) 2004-06-14 2006-01-05 Pelikan Technologies, Inc. Low pain penetrating
MX2007005813A (en) 2004-11-18 2007-07-18 3M Innovative Properties Co Low-profile microneedle array applicator.
AU2005306429B2 (en) 2004-11-18 2011-04-14 3M Innovative Properties Company Microneedle array applicator and retainer
US8652831B2 (en) 2004-12-30 2014-02-18 Sanofi-Aventis Deutschland Gmbh Method and apparatus for analyte measurement test time
US7822454B1 (en) 2005-01-03 2010-10-26 Pelikan Technologies, Inc. Fluid sampling device with improved analyte detecting member configuration
US20100049021A1 (en) * 2006-03-28 2010-02-25 Jina Arvind N Devices, systems, methods and tools for continuous analyte monitoring
US20090131778A1 (en) * 2006-03-28 2009-05-21 Jina Arvind N Devices, systems, methods and tools for continuous glucose monitoring
US10035008B2 (en) 2005-04-07 2018-07-31 3M Innovative Properties Company System and method for tool feedback sensing
US20060281187A1 (en) 2005-06-13 2006-12-14 Rosedale Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
EP1904158B1 (en) 2005-06-24 2013-07-24 3M Innovative Properties Company Collapsible patch with microneedle array
CN101208130B (en) 2005-06-27 2012-05-16 3M创新有限公司 Microneedle array applicator device
CA2629393C (en) * 2005-09-06 2014-06-10 Theraject, Inc. Solid solution perforator containing drug particle and/or drug-adsorbed particles
CN101267896A (en) * 2005-09-12 2008-09-17 阿尔扎公司 Coatable transdermal delivery microprojection assembly
CA2624059C (en) 2005-09-30 2019-04-02 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
WO2007124411A1 (en) * 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
US20080234562A1 (en) * 2007-03-19 2008-09-25 Jina Arvind N Continuous analyte monitor with multi-point self-calibration
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
WO2009126900A1 (en) 2008-04-11 2009-10-15 Pelikan Technologies, Inc. Method and apparatus for analyte detecting device
CN102105108B (en) * 2008-05-21 2013-12-04 谢拉杰克特股份有限公司 Method of manufacturing solid solution peforator patches and uses thereof
EP2293719B1 (en) 2008-05-30 2015-09-09 Intuity Medical, Inc. Body fluid sampling device -- sampling site interface
CA2726067A1 (en) 2008-06-06 2009-12-10 Intuity Medical, Inc. Detection meter and mode of operation
DE102008030894B4 (en) * 2008-06-30 2016-03-03 Edelgard Liebl Hautpunktierungsstempel and its use
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
CA2782047A1 (en) 2009-11-30 2011-06-03 Intuity Medical, Inc. Calibration material delivery devices and methods
US8965476B2 (en) 2010-04-16 2015-02-24 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9795747B2 (en) 2010-06-02 2017-10-24 Sanofi-Aventis Deutschland Gmbh Methods and apparatus for lancet actuation
WO2011162823A1 (en) 2010-06-25 2011-12-29 Intuity Medical, Inc. Analyte monitoring methods and systems
US8597199B2 (en) 2010-10-11 2013-12-03 Ziv Harish Reduced-pain allergy skin test device
WO2013020103A1 (en) 2011-08-03 2013-02-07 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis
US9011350B2 (en) 2011-11-30 2015-04-21 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
US8469900B2 (en) 2011-11-30 2013-06-25 Lincoln Diagnostics, Inc. Allergy testing device and method of testing for allergies
CN103157178B (en) * 2013-02-05 2014-12-31 北京化工大学 Seal type tool capable of accurately controlling microneedle insertion length

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3221739A (en) * 1962-03-26 1965-12-07 Rosenthal Sol Roy Injection device
US3221740A (en) * 1962-08-31 1965-12-07 Rosenthal Sol Roy Injection device
US3322121A (en) * 1965-11-26 1967-05-30 Oscar H Banker Skin-puncturing unit with a collapsible protective cover

Also Published As

Publication number Publication date
US4109655A (en) 1978-08-29

Similar Documents

Publication Publication Date Title
US3500829A (en) Earhole piercing and treating apparatus
AU622602B2 (en) Syringe assembly
US4840619A (en) Syringe
CN1268287C (en) Blood lancet with bygienic tip protection
DE60207498T2 (en) Packaging for blood collection set with button-actuated protective cover
US9895493B2 (en) Injection device
CA1333982C (en) Device for the administration of implants
US3221739A (en) Injection device
US4659330A (en) Hypodermic syringe needle guard
US4986818A (en) Syringe assembly
US4915701A (en) Protective device and syringe
ES2329762T3 (en) Impression coping.
EP0585391B1 (en) Hypodermic needle guard and method to prevent needle stick injuries
ES2347917T3 (en) Cap for an injection device.
US20040167475A1 (en) Venipuncture site protector and method of using same
US5456265A (en) Endocervical brush assembly and method for obtaining tissue samples
US5630803A (en) Safety cap assembly for needles
US5469964A (en) Multiple syringe unsheathing and resheathing device
EP0051288A1 (en) A blood sampling set
EP0189118B1 (en) Blood collection assembly
US5554128A (en) Syringe and vial connector
EP0343438A1 (en) Needle shield
EP0227890A2 (en) Hypodermic syringe having a protective sheath cover
US2696212A (en) Hypodermic syringe
EP0485345B1 (en) A single-use syringe incorporating a sliding protection cap for the needle