NZ206247A - Reducing thrombogenicity by attaching heparin to surface of polymeric articles - Google Patents
Reducing thrombogenicity by attaching heparin to surface of polymeric articlesInfo
- Publication number
- NZ206247A NZ206247A NZ206247A NZ20624783A NZ206247A NZ 206247 A NZ206247 A NZ 206247A NZ 206247 A NZ206247 A NZ 206247A NZ 20624783 A NZ20624783 A NZ 20624783A NZ 206247 A NZ206247 A NZ 206247A
- Authority
- NZ
- New Zealand
- Prior art keywords
- accordance
- substrate
- plasma
- aqueous
- heparin
- Prior art date
Links
- 229920000669 heparin Polymers 0.000 title claims description 52
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims description 45
- 229960002897 heparin Drugs 0.000 title claims description 45
- 238000000034 method Methods 0.000 claims description 59
- 239000000758 substrate Substances 0.000 claims description 53
- -1 polyethylene Polymers 0.000 claims description 29
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 17
- 239000001301 oxygen Substances 0.000 claims description 17
- 229910052760 oxygen Inorganic materials 0.000 claims description 17
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 15
- 239000000243 solution Substances 0.000 claims description 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 14
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000007864 aqueous solution Substances 0.000 claims description 12
- 239000012153 distilled water Substances 0.000 claims description 11
- 150000001875 compounds Chemical class 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 9
- 210000004369 blood Anatomy 0.000 claims description 9
- 238000009832 plasma treatment Methods 0.000 claims description 9
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 8
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000004094 surface-active agent Substances 0.000 claims description 8
- 238000005406 washing Methods 0.000 claims description 8
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 239000007789 gas Substances 0.000 claims description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 239000004698 Polyethylene Substances 0.000 claims description 6
- 229920000573 polyethylene Polymers 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 5
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 5
- 239000006185 dispersion Substances 0.000 claims description 5
- 238000007654 immersion Methods 0.000 claims description 5
- 150000002500 ions Chemical class 0.000 claims description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 4
- 229910021529 ammonia Inorganic materials 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 125000002091 cationic group Chemical group 0.000 claims description 4
- 230000001419 dependent effect Effects 0.000 claims description 3
- 229920002635 polyurethane Polymers 0.000 claims description 3
- 239000004814 polyurethane Substances 0.000 claims description 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims description 2
- 239000005977 Ethylene Substances 0.000 claims description 2
- 239000004952 Polyamide Substances 0.000 claims description 2
- 239000004743 Polypropylene Substances 0.000 claims description 2
- 239000004809 Teflon Substances 0.000 claims description 2
- 229920006362 Teflon® Polymers 0.000 claims description 2
- 229910052786 argon Inorganic materials 0.000 claims description 2
- 229920002301 cellulose acetate Polymers 0.000 claims description 2
- 238000002474 experimental method Methods 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 150000002367 halogens Chemical group 0.000 claims description 2
- 239000001307 helium Substances 0.000 claims description 2
- 229910052734 helium Inorganic materials 0.000 claims description 2
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims description 2
- 229910052743 krypton Inorganic materials 0.000 claims description 2
- DNNSSWSSYDEUBZ-UHFFFAOYSA-N krypton atom Chemical compound [Kr] DNNSSWSSYDEUBZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229920002647 polyamide Polymers 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 229920001155 polypropylene Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims description 2
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 2
- 239000004800 polyvinyl chloride Substances 0.000 claims description 2
- 229910052724 xenon Inorganic materials 0.000 claims description 2
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- SVBAPZTYWZGPKN-UHFFFAOYSA-N n-methyldodecan-1-amine;hydrochloride Chemical compound Cl.CCCCCCCCCCCCNC SVBAPZTYWZGPKN-UHFFFAOYSA-N 0.000 claims 2
- MUXFZBHBYYYLTH-UHFFFAOYSA-N Zaltoprofen Chemical compound O=C1CC2=CC(C(C(O)=O)C)=CC=C2SC2=CC=CC=C21 MUXFZBHBYYYLTH-UHFFFAOYSA-N 0.000 claims 1
- 210000001691 amnion Anatomy 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000052 comparative effect Effects 0.000 claims 1
- QYCBIOKOKSULOM-UHFFFAOYSA-N decyl(methyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCC[NH2+]C QYCBIOKOKSULOM-UHFFFAOYSA-N 0.000 claims 1
- 229920001971 elastomer Polymers 0.000 claims 1
- NNKSAZWMTWKXLD-UHFFFAOYSA-N n-methyloctadecan-1-amine;hydrochloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[NH2+]C NNKSAZWMTWKXLD-UHFFFAOYSA-N 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000005060 rubber Substances 0.000 claims 1
- 239000002952 polymeric resin Substances 0.000 description 15
- 229920003002 synthetic resin Polymers 0.000 description 15
- 239000000463 material Substances 0.000 description 12
- 229920003023 plastic Polymers 0.000 description 12
- 239000004033 plastic Substances 0.000 description 12
- 229920005989 resin Polymers 0.000 description 9
- 239000011347 resin Substances 0.000 description 9
- 238000000576 coating method Methods 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 description 4
- 230000001453 nonthrombogenic effect Effects 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- 238000003795 desorption Methods 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 229910015900 BF3 Inorganic materials 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 238000013030 3-step procedure Methods 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 206010016334 Feeling hot Diseases 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000002473 artificial blood Substances 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical group FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 229910052754 neon Inorganic materials 0.000 description 1
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000002885 thrombogenetic effect Effects 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 229940032912 zephiran Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/12—Chemical modification
- C08J7/123—Treatment by wave energy or particle radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0017—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using a surface active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0094—Physical treatment, e.g. plasma treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Physics & Mathematics (AREA)
- Plasma & Fusion (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Materials For Medical Uses (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48891183A | 1983-04-27 | 1983-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ206247A true NZ206247A (en) | 1987-05-29 |
Family
ID=23941629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ206247A NZ206247A (en) | 1983-04-27 | 1983-11-14 | Reducing thrombogenicity by attaching heparin to surface of polymeric articles |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0124200B1 (https=) |
| JP (1) | JPS59200656A (https=) |
| AU (1) | AU557989B2 (https=) |
| CA (1) | CA1215676A (https=) |
| DE (1) | DE3482446D1 (https=) |
| DK (1) | DK171139B1 (https=) |
| ES (2) | ES8601688A1 (https=) |
| NZ (1) | NZ206247A (https=) |
| ZA (1) | ZA838545B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61230058A (ja) * | 1985-04-04 | 1986-10-14 | Susumu Kogyo Kk | アルブミンの定量法 |
| JP2504087B2 (ja) * | 1987-12-16 | 1996-06-05 | エヌオーケー株式会社 | 生理活性物質固定化用担体の製造法 |
| US5338770A (en) * | 1988-06-08 | 1994-08-16 | Cardiopulmonics, Inc. | Gas permeable thrombo-resistant coatings and methods of manufacture |
| NZ229354A (en) * | 1988-07-01 | 1990-09-26 | Becton Dickinson Co | Treating polymer surfaces with a gas plasma and then applying a layer of endothelial cells to the surface |
| US4865870A (en) * | 1988-07-07 | 1989-09-12 | Becton, Dickinson And Company | Method for rendering a substrate surface antithrombogenic |
| US4967763A (en) * | 1989-03-13 | 1990-11-06 | Becton, Dickinson And Company | Platelet stable blood collection assembly |
| US5244654A (en) * | 1990-11-08 | 1993-09-14 | Cordis Corporation | Radiofrequency plasma biocompatibility treatment of inside surfaces of medical tubing and the like |
| DE69125828T2 (de) * | 1991-05-21 | 1997-07-31 | Hewlett Packard Gmbh | Verfahren zur Vorbehandlung der Oberfläche eines medizinischen Artikels |
| EP0588895B1 (en) * | 1991-05-31 | 1995-01-11 | Baxter International Inc. | Thromboresistant coating for defoaming applications |
| UA35578C2 (uk) * | 1991-08-16 | 2001-04-16 | Майлс Е. Гелін | Передньокамерний очний імплантат, спосіб його одержання та спосіб лікування короткозорості |
| WO1993005825A1 (en) * | 1991-09-20 | 1993-04-01 | Baxter International Inc. | Processes for reducing the thrombogenicity of biomaterials |
| JP3363282B2 (ja) * | 1995-03-20 | 2003-01-08 | 株式会社クリニカル・サプライ | 潤滑化された表面を有する医療用具及びその製造方法 |
| CA2197375C (en) * | 1996-02-15 | 2003-05-06 | Yasuhiro Okuda | Artificial blood vessel |
| JP2000510720A (ja) * | 1996-05-03 | 2000-08-22 | ユーロス コーポレイション | 医療装置用のペントサンポリスルフェート被膜 |
| AU6140299A (en) | 1998-09-10 | 2000-04-03 | Percardia, Inc. | Tmr shunt |
| US6632470B2 (en) * | 2001-01-31 | 2003-10-14 | Percardia | Methods for surface modification |
| GB0225197D0 (en) * | 2002-10-30 | 2002-12-11 | Univ Sheffield | Surface |
| US8288118B2 (en) | 2007-09-19 | 2012-10-16 | Becton, Dickinson And Company | Method of analyzing various surface chemistries for culturing a given cell line |
| JP5723767B2 (ja) * | 2008-05-27 | 2015-05-27 | エーオー テクノロジー アーゲー | ポリマーの表面改質 |
| JP5956074B2 (ja) | 2012-08-29 | 2016-07-20 | カーディアック ペースメイカーズ， インコーポレイテッド | 医療用リードのための向上した低摩擦コーティングおよび製造方法 |
| EP2922594B1 (en) | 2012-11-21 | 2018-02-14 | Cardiac Pacemakers, Inc. | Medical electrodes with layered coatings |
| GB201416593D0 (en) * | 2014-09-19 | 2014-11-05 | Jozef Stefan Inst And University Of Maribor | Method for immobilization of heparin on a polymeric material |
| CN114106493B (zh) * | 2022-01-24 | 2022-04-29 | 山东大学 | 一种肝素化pvc材料、其制备方法及作为医疗器械的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE757386A (fr) * | 1969-10-13 | 1971-04-13 | Du Pont | Procede de transfert double pour images photodurcissables |
| DE2148011C3 (de) * | 1970-10-05 | 1978-11-09 | Aminkemi Ab | Verfahren zum Herstellen nichtthrombogener Kunststoffoberflächen |
| GB1357011A (en) * | 1970-10-05 | 1974-06-19 | Aminkemi Ab | Method of stabilizing heparinized non-thrombogenic plastic surfaces |
| US4326532A (en) * | 1980-10-06 | 1982-04-27 | Minnesota Mining And Manufacturing Company | Antithrombogenic articles |
-
1983
- 1983-11-07 CA CA000440532A patent/CA1215676A/en not_active Expired
- 1983-11-14 NZ NZ206247A patent/NZ206247A/en unknown
- 1983-11-15 AU AU21371/83A patent/AU557989B2/en not_active Ceased
- 1983-11-16 ZA ZA838545A patent/ZA838545B/xx unknown
- 1983-12-14 ES ES528034A patent/ES8601688A1/es not_active Expired
-
1984
- 1984-01-09 JP JP59001798A patent/JPS59200656A/ja active Granted
- 1984-02-08 EP EP84300805A patent/EP0124200B1/en not_active Expired - Lifetime
- 1984-02-08 DE DE8484300805T patent/DE3482446D1/de not_active Expired - Fee Related
- 1984-02-15 DK DK069484A patent/DK171139B1/da not_active IP Right Cessation
-
1985
- 1985-06-17 ES ES544285A patent/ES8702150A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EP0124200B1 (en) | 1990-06-13 |
| EP0124200A3 (en) | 1987-01-07 |
| AU557989B2 (en) | 1987-01-15 |
| DK69484A (da) | 1984-10-28 |
| EP0124200A2 (en) | 1984-11-07 |
| ES8702150A1 (es) | 1986-12-16 |
| ZA838545B (en) | 1984-07-25 |
| ES544285A0 (es) | 1986-12-16 |
| AU2137183A (en) | 1984-11-01 |
| ES528034A0 (es) | 1985-11-16 |
| DK69484D0 (da) | 1984-02-15 |
| CA1215676A (en) | 1986-12-23 |
| JPS6128348B2 (https=) | 1986-06-30 |
| JPS59200656A (ja) | 1984-11-14 |
| DE3482446D1 (de) | 1990-07-19 |
| DK171139B1 (da) | 1996-07-01 |
| ES8601688A1 (es) | 1985-11-16 |
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