NO991838D0 - Procedure for selective derivatization of taxanes - Google Patents

Procedure for selective derivatization of taxanes

Info

Publication number
NO991838D0
NO991838D0 NO991838A NO991838A NO991838D0 NO 991838 D0 NO991838 D0 NO 991838D0 NO 991838 A NO991838 A NO 991838A NO 991838 A NO991838 A NO 991838A NO 991838 D0 NO991838 D0 NO 991838D0
Authority
NO
Norway
Prior art keywords
sup
taxanes
hydroxytaxane
acyloxy
procedure
Prior art date
Application number
NO991838A
Other languages
Norwegian (no)
Other versions
NO325139B1 (en
NO991838L (en
Inventor
Robert A Holton
Zhuming Zhang
Paul A Clark
Original Assignee
Univ Florida State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27368950&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO991838(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Florida State filed Critical Univ Florida State
Publication of NO991838D0 publication Critical patent/NO991838D0/en
Publication of NO991838L publication Critical patent/NO991838L/en
Publication of NO325139B1 publication Critical patent/NO325139B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888

Abstract

A process is described for converting the C(7) hydroxy group of a 10-acyloxy-7-hydroxytaxane to an acetal or ketal, the process comprising treating the 10-acyloxy-7-hydroxytaxane with a ketalizing agent in the presence of an acid catalyst to form a C(7) ketalized taxane of the formula or wherein either X<sup>31</sup> or X<sup>32</sup> represents the 10-acyloxy-7-hydroxytaxane moiety and the other of X<sup>31</sup> and X<sup>32</sup> as well as X<sup>33</sup> and X<sup>34</sup> are independently hydrocarbyl, substituted hydrocarbyl or heteroaryl moieties. Taxanes having a ketalized C(7) hydroxy group are also described.
NO19991838A 1997-08-18 1999-04-16 Process for acylating a C (10) hydroxy group in a taxane having C (7) and C (10) hydroxy groups NO325139B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5600097P 1997-08-18 1997-08-18
US8126598P 1998-04-09 1998-04-09
US09/063,477 US7288665B1 (en) 1997-08-18 1998-04-20 Process for selective derivatization of taxanes
PCT/US1998/017016 WO1999009021A1 (en) 1997-08-18 1998-08-17 Process for selective derivatization of taxanes

Publications (3)

Publication Number Publication Date
NO991838D0 true NO991838D0 (en) 1999-04-16
NO991838L NO991838L (en) 1999-06-18
NO325139B1 NO325139B1 (en) 2008-02-11

Family

ID=27368950

Family Applications (4)

Application Number Title Priority Date Filing Date
NO19991838A NO325139B1 (en) 1997-08-18 1999-04-16 Process for acylating a C (10) hydroxy group in a taxane having C (7) and C (10) hydroxy groups
NO20054513A NO20054513L (en) 1997-08-18 2005-09-29 taxanes
NO20054514A NO20054514L (en) 1997-08-18 2005-09-29 taxanes
NO20054512A NO20054512L (en) 1997-08-18 2005-09-29 taxanes

Family Applications After (3)

Application Number Title Priority Date Filing Date
NO20054513A NO20054513L (en) 1997-08-18 2005-09-29 taxanes
NO20054514A NO20054514L (en) 1997-08-18 2005-09-29 taxanes
NO20054512A NO20054512L (en) 1997-08-18 2005-09-29 taxanes

Country Status (25)

Country Link
US (5) US7288665B1 (en)
EP (6) EP1795528A1 (en)
JP (1) JP2001504864A (en)
KR (1) KR100596989B1 (en)
CN (3) CN100351246C (en)
AT (3) ATE326455T1 (en)
AU (1) AU744987B2 (en)
BR (1) BR9806145A (en)
CA (2) CA2268662A1 (en)
CY (1) CY1105399T1 (en)
CZ (1) CZ296580B6 (en)
DE (3) DE69834584T2 (en)
DK (3) DK0956284T3 (en)
ES (3) ES2274579T3 (en)
HU (1) HUP0300425A3 (en)
ID (1) ID21654A (en)
IL (3) IL129386A0 (en)
NO (4) NO325139B1 (en)
NZ (1) NZ335156A (en)
PL (3) PL332723A1 (en)
PT (3) PT956284E (en)
RU (1) RU2225402C2 (en)
SG (1) SG97986A1 (en)
WO (1) WO1999009021A1 (en)
ZA (1) ZA987394B (en)

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