NO984284L - Nye tripeptidforbindelser og anti-AIDS-legemidler - Google Patents
Nye tripeptidforbindelser og anti-AIDS-legemidlerInfo
- Publication number
- NO984284L NO984284L NO984284A NO984284A NO984284L NO 984284 L NO984284 L NO 984284L NO 984284 A NO984284 A NO 984284A NO 984284 A NO984284 A NO 984284A NO 984284 L NO984284 L NO 984284L
- Authority
- NO
- Norway
- Prior art keywords
- aids drugs
- compounds
- tripeptide compounds
- new tripeptide
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Nye tripeptidforbindelser med utmerkede HIV-proteaseinhiberende virkninger, og som har den generelle formel (I) (O farmakologisk akseptable salter derav og anti-AIDS-legemidler som inneholder de samme som den aktive bestanddel. Et eksempel på forbindelsene er (R)-N-(2- metylbenzyl)-3-{(2S,3S)-3-[N-(2-kromon- karbonyl)-L-asparaginyl]amino-2- hydroksy-4-fenylbutanoyl}-5,5-dimetyl- 1,3-tiazolidin-4-karboksamid.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP35922696 | 1996-12-27 | ||
JP15052097 | 1997-05-23 | ||
PCT/JP1997/004734 WO1998029118A1 (fr) | 1996-12-27 | 1997-12-22 | Nouveaux composes de tripeptides et medicaments anti-sida |
Publications (2)
Publication Number | Publication Date |
---|---|
NO984284D0 NO984284D0 (no) | 1998-09-16 |
NO984284L true NO984284L (no) | 1999-08-26 |
Family
ID=26480090
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO984284A NO984284L (no) | 1996-12-27 | 1998-09-16 | Nye tripeptidforbindelser og anti-AIDS-legemidler |
Country Status (5)
Country | Link |
---|---|
US (1) | US6291432B1 (no) |
EP (1) | EP0900566A4 (no) |
CA (1) | CA2249747A1 (no) |
NO (1) | NO984284L (no) |
WO (1) | WO1998029118A1 (no) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6403818B1 (en) | 2000-02-28 | 2002-06-11 | Eisai Co., Ltd. | Process for producing α-hydroxy-carbonyl compound |
US6593455B2 (en) | 2001-08-24 | 2003-07-15 | Tripep Ab | Tripeptide amides that block viral infectivity and methods of use thereof |
US6455670B1 (en) | 2001-09-06 | 2002-09-24 | Tripep Ab | Pentamer peptide amide, ALGPG-NH2, that inhibits viral infectivity and methods of use thereof |
WO2003024995A1 (en) | 2001-09-19 | 2003-03-27 | Tripep Ab | Molecules that block viral infectivity and methods of use thereof |
KR101368988B1 (ko) | 2005-09-16 | 2014-02-28 | 다케다 야쿠힌 고교 가부시키가이샤 | 디펩티딜 펩티다제 억제제 |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0395664A1 (en) | 1987-10-21 | 1990-11-07 | The Upjohn Company | Renin inhibitors containing a (1-amino-2-hydroxy-2-heterocyclic) ethyl moiety |
US4963655A (en) | 1988-05-27 | 1990-10-16 | Mayo Foundation For Medical Education And Research | Boron analogs of amino acid/peptide protease inhibitors |
CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
US5342922A (en) | 1989-03-08 | 1994-08-30 | Washington University | Inhibitors of retroviral protease |
US5086165A (en) | 1989-03-08 | 1992-02-04 | Washington University | Inhibitors of retroviral protease with a ketomethylene isosteric replaced amide bond |
DE3913272A1 (de) | 1989-04-22 | 1990-10-25 | Hoechst Ag | Dipeptid-derivate mit enzym-inhibitorischer wirkung |
US5212157A (en) | 1989-06-06 | 1993-05-18 | Bio-Mega, Inc. | Enzyme inhibitors |
US5126326A (en) | 1989-06-06 | 1992-06-30 | Bio-Mega, Inc. | Enzyme inhibiting peptide derivatives |
DE4001236A1 (de) | 1990-01-18 | 1991-07-25 | Bayer Ag | Neue peptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, insbesondere als arzneimittel gegen retroviren |
EP0438311A3 (en) | 1990-01-19 | 1992-07-01 | Merck & Co. Inc. | Di- and tripeptide renin inhibitors |
EP0546115A1 (en) | 1990-08-24 | 1993-06-16 | The Upjohn Company | Peptides containing amino-polyols as transition-state mimics |
US5188950A (en) | 1990-10-11 | 1993-02-23 | Merck & Co., Inc. | Method of preparing HIV protease inhibitors |
US5187074A (en) | 1990-10-11 | 1993-02-16 | Merck & Co., Inc. | Method of hydroxylation with ATCC 55086 |
US5192668A (en) | 1990-10-11 | 1993-03-09 | Merck & Co., Inc. | Synthesis of protease inhibitor |
JPH05294993A (ja) | 1990-10-22 | 1993-11-09 | Takeda Chem Ind Ltd | レトロウイルスプロテアーゼ阻害物質 |
US5475013A (en) | 1990-11-19 | 1995-12-12 | Monsanto Company | Retroviral protease inhibitors |
US5438118A (en) | 1990-11-30 | 1995-08-01 | Smithkline Beechman Corp. | HIV protease inhibitors |
CA2056911C (en) | 1990-12-11 | 1998-09-22 | Yuuichi Nagano | Hiv protease inhibitors |
CA2060844A1 (en) * | 1991-02-08 | 1992-08-09 | Yabe Yuichiro | Beta-amino-alpha-hydroxycarboxylic acids and their use |
IE922316A1 (en) | 1991-07-17 | 1993-01-27 | Smithkline Beecham Corp | Retroviral protease inhibitors |
JPH05178824A (ja) | 1991-08-05 | 1993-07-20 | Takeda Chem Ind Ltd | アスパラギン誘導体およびその用途 |
WO1993008184A1 (en) | 1991-10-23 | 1993-04-29 | Merck & Co., Inc. | Hiv protease inhibitors |
ZA929869B (en) | 1991-12-20 | 1994-06-20 | Syntex Inc | Hiv protease inhibitors |
US5644028A (en) | 1992-05-13 | 1997-07-01 | Japan Energy Corporation | Process for producing peptide derivatives and salts therefor |
JPH06100533A (ja) * | 1992-08-07 | 1994-04-12 | Sankyo Co Ltd | Hivプロテアーゼ阻害活性を有するペプチド誘導体 |
FI933472A (fi) | 1992-08-07 | 1994-02-08 | Sankyo Co | Peptider med foermaoga att inhibera effekten av HIV-proteas, deras framstaellning och terapeutiska anvaendning |
DE69329544T2 (de) | 1992-12-22 | 2001-05-31 | Eli Lilly And Co., Indianapolis | HIV Protease hemmende Verbindungen |
MX9308016A (es) | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
US5491166A (en) | 1992-12-22 | 1996-02-13 | Eli Lilly And Company | Inhibitors of HIV protease useful for the treatment of AIDS |
US5434265A (en) | 1992-12-22 | 1995-07-18 | Eli Lilly And Company | Inhibitors of HIV protease |
US5554653A (en) | 1992-12-22 | 1996-09-10 | Eli Lilly And Company | Inhibitors of HIV protease useful for the treatment of AIDS |
JPH06220031A (ja) * | 1993-01-25 | 1994-08-09 | Japan Energy Corp | ペプチド誘導体またはその塩の製造法 |
WO1994018192A1 (en) | 1993-02-12 | 1994-08-18 | Merck & Co., Inc. | Piperazine derivatives as hiv protease inhibitors |
WO1994026749A1 (en) | 1993-05-14 | 1994-11-24 | Merck & Co., Inc. | Hiv protease inhibitors |
US5587514A (en) | 1993-11-08 | 1996-12-24 | Emory University | Diastereoselective synthesis of hydroxyethylene dipeptide isosteres |
US5476874A (en) | 1994-06-22 | 1995-12-19 | Merck & Co., Inc. | New HIV protease inhibitors |
US5492910A (en) | 1994-11-17 | 1996-02-20 | Bristol-Myers Squibb Co. | Retrocarbamate protease inhibitors |
WO1996028423A1 (fr) | 1995-03-15 | 1996-09-19 | Sankyo Company, Limited | Composes dipeptidiques de structure ahpba |
JP3408379B2 (ja) * | 1995-06-30 | 2003-05-19 | 株式会社ジャパンエナジー | 新規なジペプチド化合物又はその薬理的に許容される塩及びその医薬用途 |
-
1997
- 1997-12-22 EP EP97949191A patent/EP0900566A4/en not_active Withdrawn
- 1997-12-22 WO PCT/JP1997/004734 patent/WO1998029118A1/ja not_active Application Discontinuation
- 1997-12-22 US US09/155,773 patent/US6291432B1/en not_active Expired - Fee Related
- 1997-12-22 CA CA002249747A patent/CA2249747A1/en not_active Abandoned
-
1998
- 1998-09-16 NO NO984284A patent/NO984284L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP0900566A4 (en) | 2001-04-25 |
AU721578B2 (en) | 2000-07-06 |
AU7888598A (en) | 1998-07-31 |
CA2249747A1 (en) | 1998-07-09 |
US6291432B1 (en) | 2001-09-18 |
EP0900566A1 (en) | 1999-03-10 |
WO1998029118A1 (fr) | 1998-07-09 |
NO984284D0 (no) | 1998-09-16 |
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Legal Events
Date | Code | Title | Description |
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |