NO984205L - Nye substituerte cykliske aminosyrer som farmas°ytiske midler - Google Patents
Nye substituerte cykliske aminosyrer som farmas°ytiske midlerInfo
- Publication number
- NO984205L NO984205L NO984205A NO984205A NO984205L NO 984205 L NO984205 L NO 984205L NO 984205 A NO984205 A NO 984205A NO 984205 A NO984205 A NO 984205A NO 984205 L NO984205 L NO 984205L
- Authority
- NO
- Norway
- Prior art keywords
- pct
- amino acids
- cyclic amino
- pharmaceuticals
- substituted cyclic
- Prior art date
Links
- -1 cyclic amino acids Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000006083 Hypokinesia Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000002173 dizziness Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 230000003483 hypokinetic effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1343296P | 1996-03-14 | 1996-03-14 | |
PCT/US1997/002295 WO1997033858A1 (en) | 1996-03-14 | 1997-02-18 | Novel substituted cyclic amino acids as pharmaceutical agents |
Publications (2)
Publication Number | Publication Date |
---|---|
NO984205D0 NO984205D0 (no) | 1998-09-11 |
NO984205L true NO984205L (no) | 1998-09-14 |
Family
ID=21759938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO984205A NO984205L (no) | 1996-03-14 | 1998-09-11 | Nye substituerte cykliske aminosyrer som farmas°ytiske midler |
Country Status (29)
Country | Link |
---|---|
US (1) | US6103932A (de) |
EP (1) | EP0888286B1 (de) |
JP (1) | JP2000506861A (de) |
KR (1) | KR100512506B1 (de) |
AT (1) | ATE207878T1 (de) |
AU (1) | AU734173B2 (de) |
BG (1) | BG63662B1 (de) |
BR (1) | BR9708200A (de) |
CA (1) | CA2244912C (de) |
CZ (1) | CZ293759B6 (de) |
DE (1) | DE69707842T2 (de) |
DK (2) | DK0888286T3 (de) |
EA (1) | EA002765B1 (de) |
EE (1) | EE9800309A (de) |
ES (1) | ES2167717T3 (de) |
GE (1) | GEP20012413B (de) |
HU (1) | HU224720B1 (de) |
IL (1) | IL125544A (de) |
IS (1) | IS1990B (de) |
MX (1) | MX9806069A (de) |
NO (1) | NO984205L (de) |
NZ (1) | NZ331143A (de) |
PL (1) | PL185991B1 (de) |
PT (1) | PT888286E (de) |
SK (1) | SK283295B6 (de) |
TR (1) | TR199801807T2 (de) |
UA (1) | UA49011C2 (de) |
WO (1) | WO1997033858A1 (de) |
ZA (1) | ZA972200B (de) |
Families Citing this family (62)
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IL126999A (en) | 1996-07-24 | 2002-03-10 | Warner Lambert Co | Pharmaceutical preparations containing isobutylgaba and its history for use in the treatment of pain |
DK1032555T3 (da) * | 1997-10-27 | 2006-07-17 | Warner Lambert Co | Cykliske aminosyrer og derivater deraf, som er anvendelige som lægemidler |
DE19751062A1 (de) * | 1997-11-18 | 1999-07-08 | Univ Ludwigs Albert | An 4-Stellung substituierte 2-Pyrrolidinon-Derivate zur Verringerung des extrazellulären Glutamat-Spiegels |
US6984659B2 (en) | 1997-11-18 | 2006-01-10 | Klinikum Der Albert-Ludwigs Universitaet | 2-pyrrolidinone derivatives substituted at position 4 for reducing the extracellular glutamate level |
PT1047678E (pt) * | 1997-12-16 | 2004-12-31 | Warner Lambert Co | Derivados do 1-aminometil-cicloalcano substituido em 1 (=analogos da gabapentina) sua preparacao e sua utilizacao no tratamento de disturbios neurologicos |
NZ508490A (en) * | 1998-07-09 | 2003-08-29 | Warner Lambert Co | Use of a combination of a GABA analog and caffeine as an analgesic |
EP1031350A1 (de) * | 1999-02-23 | 2000-08-30 | Warner-Lambert Company | Verwendung eines Gabapentin-Analogen zur Herstellung eines Arzneimittels zur Prophylaxe und Behandlung von Eingeweideschmerzen |
US6992109B1 (en) * | 1999-04-08 | 2006-01-31 | Segal Catherine A | Method for the treatment of incontinence |
DZ3141A1 (fr) * | 1999-12-08 | 2001-01-14 | Warner Lambert Co | Inhibiteurs d'aminotransferase acides aminés-dépendante à chaîne ramifiée, et leur utilisation dans le cadre du traitement de la rétinopathie diabétique. |
WO2001072311A1 (en) * | 2000-03-28 | 2001-10-04 | Delorenzo Robert J | Inhibition of a novel calcium injury current that forms in neurons during injury prevents neuronal cell death |
GB2362646A (en) * | 2000-05-26 | 2001-11-28 | Warner Lambert Co | Cyclic amino acid derivatives useful as pharmaceutical agents |
DE10048715A1 (de) * | 2000-09-30 | 2004-05-19 | Grünenthal GmbH | Verwendung von Aminosäure zur Behandlung von Schmerz |
WO2002032376A2 (en) | 2000-10-06 | 2002-04-25 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
EP1343805A4 (de) | 2000-10-06 | 2005-07-20 | Xenoport Inc | Von gallensäuren abgeleitete verbindungen für die bereitstellung anhaltender systemischer konzentrationen von arzneimitteln nach oraler verabreichung |
US6683112B2 (en) * | 2000-10-24 | 2004-01-27 | Andrx Corporation | Gabapentin prodrugs and formulations |
GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
JP2004530637A (ja) * | 2000-11-02 | 2004-10-07 | テバ ファーマシューティカル インダストリーズ リミティド | ガバペンチン中間体の製造のための改善方法 |
EP1373186A1 (de) * | 2001-03-16 | 2004-01-02 | Solchem Italiana S.p.A | Verfahren zur herstellung von zyklischen aminosäuren |
US7186855B2 (en) * | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US7232924B2 (en) * | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
WO2002100344A2 (en) | 2001-06-11 | 2002-12-19 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
MXPA03011565A (es) | 2001-06-11 | 2004-10-28 | Xenoport Inc | Profarmacos de analogos de gaba, composiciones y usos de las mismas. |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US8048917B2 (en) * | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
CN1642547A (zh) * | 2002-01-16 | 2005-07-20 | 恩多制药公司 | 治疗中枢神经系统障碍的药物组合物和方法 |
EP1485082A4 (de) | 2002-02-19 | 2009-12-30 | Xenoport Inc | Syntheseverfahren für prodrugs von 1-acyl-alkyl derivaten und ihre zusammensetzungen |
WO2003080588A1 (en) | 2002-03-20 | 2003-10-02 | Xenoport | Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof |
EP1549323A2 (de) * | 2002-05-07 | 2005-07-06 | A & D Bioscience, Inc. | Konjugate mit einem wirkstoff für das zentrale nervensystem |
WO2003099338A2 (en) | 2002-05-17 | 2003-12-04 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
AU2003297927A1 (en) | 2002-12-11 | 2004-06-30 | Xenoport, Inc. | Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof |
WO2004053192A1 (en) * | 2002-12-11 | 2004-06-24 | Xenoport, Inc. | Orally administered dosage forms of fused gaba analog prodrugs having reduced toxicity |
CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
WO2004054560A1 (en) | 2002-12-13 | 2004-07-01 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
GB0301143D0 (en) * | 2003-01-17 | 2003-02-19 | Amedis Pharm Ltd | Compounds and their use |
AU2004227995B2 (en) * | 2003-03-31 | 2010-06-03 | Xenoport, Inc. | Treating or preventing hot flashes using prodrugs of GABA analogs |
EP1670451A4 (de) * | 2003-09-11 | 2009-10-21 | Xenoport Inc | Behandlung und/oder prävention von harninkontinenz mit prodrugs von gaba-analoga |
ATE449633T1 (de) | 2003-09-12 | 2009-12-15 | Pfizer | Kombinationen aus alpha-2-delta liganden und serotonin / noradrenalin-wiederaufnahmehemmern |
WO2005027850A2 (en) | 2003-09-17 | 2005-03-31 | Xenoport, Inc. | Treating or preventing restless legs syndrome using prodrugs of gaba analogs |
JP4308263B2 (ja) | 2003-10-14 | 2009-08-05 | ゼノポート,インコーポレイティド | γ−アミノ酪酸アナログの結晶形 |
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WO2005087709A1 (en) * | 2004-03-17 | 2005-09-22 | Hikal Limited | 4-t-butylgabapentin and its synthesis |
US20050209332A1 (en) * | 2004-03-17 | 2005-09-22 | Hikal Limited | Gabapentin analogues and process thereof |
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JP2008518971A (ja) | 2004-11-04 | 2008-06-05 | ゼノポート,インコーポレイティド | ガバペンチンプロドラッグ持続放出経口薬剤 |
JP2010512314A (ja) * | 2006-12-08 | 2010-04-22 | ゼノポート,インコーポレーテッド | 疾患を治療するためのgabaアナログのプロドラッグの使用 |
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US8828665B2 (en) | 2007-02-16 | 2014-09-09 | Ark Diagnostics, Inc. | Compounds and methods for use in detecting gabapentin |
WO2008157408A2 (en) * | 2007-06-15 | 2008-12-24 | Xenoport, Inc. | Use of prodrugs of gaba analogs, antispasticity agents, and prodrugs of gaba b receptor agonists for treating spasticity |
WO2009061934A1 (en) * | 2007-11-06 | 2009-05-14 | Xenoport, Inc. | Use of prodrugs of gaba b agonists for treating neuropathic and musculoskeletal pain |
EP2250148B1 (de) | 2008-01-25 | 2016-08-17 | XenoPort, Inc. | Kristalline form von kalziumsalzen von (3s)-aminomethyl-5-methylhexansäuren und anwendungsverfahren |
US8062870B2 (en) * | 2008-01-25 | 2011-11-22 | Xenoport, Inc. | Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs |
US7868043B2 (en) | 2008-01-25 | 2011-01-11 | Xenoport, Inc. | Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
CN102216257B (zh) | 2008-10-08 | 2015-11-25 | 凯飞药业公司 | Gaba偶联物及其使用方法 |
EP2349335B1 (de) | 2008-10-24 | 2013-08-07 | ARK Diagnostics, Inc. | Levetiracetam-immunoassays |
EP2400989B1 (de) * | 2009-02-24 | 2016-08-10 | Nektar Therapeutics | Gabapentin-peg konjugate |
US20110130454A1 (en) * | 2009-11-24 | 2011-06-02 | Xenoport, Inc. | Prodrugs of gamma-amino acid, alpha-2-delta ligands, pharmaceutical compositions and uses thereof |
US20110124705A1 (en) * | 2009-11-24 | 2011-05-26 | Xenoport, Inc. | Prodrugs of alpha-2-delta ligands, pharmaceutical compositions and uses thereof |
US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
US9970929B2 (en) | 2013-01-18 | 2018-05-15 | Ark Diagnostics, Inc. | Voriconazole immunoassays |
EP2948139B1 (de) | 2013-01-28 | 2019-06-12 | Lopez, Hector, L. | Verfahren zur verbesserung der verträglichkeit, pharmakodynamik und wirksamkeit von b-alanin und verwendung davon |
US9920136B2 (en) | 2013-02-13 | 2018-03-20 | Ark Diagnostics, Inc. | Posaconazole immunoassays |
JP7441181B2 (ja) | 2018-05-14 | 2024-02-29 | エックスジーン ファーマシューティカル インク. | ナプロキセンとプレガバリンの1-(アシルオキシ)-アルキルカルバメート薬品複合体の結晶形態 |
Family Cites Families (24)
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---|---|---|---|---|
US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
DE2543821C2 (de) * | 1974-12-21 | 1984-10-18 | Gödecke AG, 1000 Berlin | Bestimmte Salze und Ester von 1-Aminomethyl-1-cycloalkanessigsäuren und diese Verbindungen enthaltende Arzneimittel |
DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
DE2611690A1 (de) * | 1976-03-19 | 1977-09-22 | Goedecke Ag | Cyclische sulfonyloxyimide |
DE2626467C2 (de) * | 1976-06-12 | 1984-11-22 | Gödecke AG, 1000 Berlin | 1-(N-Isopropylaminomethyl)-cyclohexanessigsäure, Verfahren zu deren Herstellung und diese Verbindung enthaltende Arzneimittel |
US4894476A (en) * | 1988-05-02 | 1990-01-16 | Warner-Lambert Company | Gabapentin monohydrate and a process for producing the same |
US4960931A (en) * | 1988-05-02 | 1990-10-02 | Warner-Lambert Company | Gabapentin mohohydrate and a process for producing the same |
YU162789A (en) * | 1988-09-01 | 1990-12-31 | Lonza Ag | 2-aza-4-(alcoxycarbonyl) spiro/4,5/decan-3-ones |
US5132451A (en) * | 1989-08-25 | 1992-07-21 | Warner-Lambert Company | Process for cyclic amino acid anticonvulsant compounds |
DE3928182A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von gabapentin |
US5319135A (en) * | 1989-08-25 | 1994-06-07 | Warner-Lambert Company | Process for cyclic amino acid anticonvulsant compounds |
DE3928184A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte |
DE3928183A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Lactamfreie cyclische aminosaeuren |
US5098931A (en) * | 1989-08-31 | 1992-03-24 | Merck & Co., Inc. | 7-substituted HMG-CoA reductase inhibitors |
US5149870A (en) * | 1989-11-16 | 1992-09-22 | Lonza Ltd. | Process for the production of 1-(aminomethyl)cyclohexane acetic acid |
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FI905584A (fi) * | 1989-11-16 | 1991-05-17 | Lonza Ag | Foerfarande foer framstaellning av 1-(aminometyl)cyklohexanaettikssyra. |
US5084479A (en) * | 1990-01-02 | 1992-01-28 | Warner-Lambert Company | Novel methods for treating neurodegenerative diseases |
PT97078B (pt) * | 1990-03-20 | 1997-07-31 | Sanofi Sa | Processo para a preparacao de derivados heterociclicos n-substituidos e de composicoes farmaceuticas que os contem |
EP0458751A1 (de) * | 1990-05-25 | 1991-11-27 | Warner-Lambert Company | System zur Freisetzung von cyclischen Aminosäuren mit verbessertem Geschmack, Struktur und Komprimierbarkeit |
US5025035A (en) * | 1990-10-12 | 1991-06-18 | Warner-Lambert Company | Method of treating depression |
FR2691146B1 (fr) * | 1992-05-15 | 1998-01-02 | Adir | Nouveaux derives d'acides alcenecarboxyliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
AU6226494A (en) * | 1993-03-04 | 1994-09-26 | Pfizer Inc. | Spiroazacyclic derivatives as substance p antagonists |
US5792796A (en) * | 1994-07-27 | 1998-08-11 | Warner-Lambert Company | Methods for treating anxiety and panic |
-
1997
- 1997-02-18 EE EE9800309A patent/EE9800309A/xx unknown
- 1997-02-18 KR KR10-1998-0707229A patent/KR100512506B1/ko not_active IP Right Cessation
- 1997-02-18 WO PCT/US1997/002295 patent/WO1997033858A1/en active IP Right Grant
- 1997-02-18 GE GEAP19974526A patent/GEP20012413B/en unknown
- 1997-02-18 AU AU20511/97A patent/AU734173B2/en not_active Ceased
- 1997-02-18 EA EA199800798A patent/EA002765B1/ru unknown
- 1997-02-18 EP EP97908655A patent/EP0888286B1/de not_active Expired - Lifetime
- 1997-02-18 JP JP9532601A patent/JP2000506861A/ja not_active Ceased
- 1997-02-18 ES ES97908655T patent/ES2167717T3/es not_active Expired - Lifetime
- 1997-02-18 PL PL97328816A patent/PL185991B1/pl not_active IP Right Cessation
- 1997-02-18 UA UA98105386A patent/UA49011C2/uk unknown
- 1997-02-18 IL IL12554497A patent/IL125544A/en not_active IP Right Cessation
- 1997-02-18 DK DK97908655T patent/DK0888286T3/da active
- 1997-02-18 TR TR1998/01807T patent/TR199801807T2/xx unknown
- 1997-02-18 DE DE69707842T patent/DE69707842T2/de not_active Expired - Fee Related
- 1997-02-18 NZ NZ331143A patent/NZ331143A/en unknown
- 1997-02-18 BR BR9708200A patent/BR9708200A/pt not_active Application Discontinuation
- 1997-02-18 AT AT97908655T patent/ATE207878T1/de not_active IP Right Cessation
- 1997-02-18 CZ CZ19982863A patent/CZ293759B6/cs not_active IP Right Cessation
- 1997-02-18 DK DK97906630T patent/DK0888285T3/da active
- 1997-02-18 SK SK1238-98A patent/SK283295B6/sk unknown
- 1997-02-18 US US09/068,874 patent/US6103932A/en not_active Expired - Fee Related
- 1997-02-18 PT PT97908655T patent/PT888286E/pt unknown
- 1997-02-18 HU HU9902136A patent/HU224720B1/hu not_active IP Right Cessation
- 1997-02-18 CA CA002244912A patent/CA2244912C/en not_active Expired - Fee Related
- 1997-03-13 ZA ZA9702200A patent/ZA972200B/xx unknown
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1998
- 1998-07-28 MX MX9806069A patent/MX9806069A/es active IP Right Grant
- 1998-08-10 IS IS4819A patent/IS1990B/is unknown
- 1998-08-28 BG BG102733A patent/BG63662B1/bg unknown
- 1998-09-11 NO NO984205A patent/NO984205L/no not_active Application Discontinuation
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