NO974744D0 - Oksygenert-heterocykelinneholdende sulfonamidhemmere av aspartylprotease - Google Patents

Oksygenert-heterocykelinneholdende sulfonamidhemmere av aspartylprotease

Info

Publication number
NO974744D0
NO974744D0 NO974744A NO974744A NO974744D0 NO 974744 D0 NO974744 D0 NO 974744D0 NO 974744 A NO974744 A NO 974744A NO 974744 A NO974744 A NO 974744A NO 974744 D0 NO974744 D0 NO 974744D0
Authority
NO
Norway
Prior art keywords
heterocycle
oxygen
aspartyl protease
containing sulfonamide
sulfonamide inhibitors
Prior art date
Application number
NO974744A
Other languages
English (en)
Norwegian (no)
Other versions
NO974744L (no
Inventor
Roger D Tung
Govinda Rao Bhisetti
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NO974744L publication Critical patent/NO974744L/no
Publication of NO974744D0 publication Critical patent/NO974744D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D317/34—Oxygen atoms
    • C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
NO974744A 1995-04-19 1997-10-14 Oksygenert-heterocykelinneholdende sulfonamidhemmere av aspartylprotease NO974744D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/424,810 US5691372A (en) 1995-04-19 1995-04-19 Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
PCT/US1996/005473 WO1996033187A1 (fr) 1995-04-19 1996-04-18 Sulfamides contenant des heterocycles oxygenes et agissant comme inhibiteurs de l'aspartyle protease

Publications (2)

Publication Number Publication Date
NO974744L NO974744L (no) 1997-10-14
NO974744D0 true NO974744D0 (no) 1997-10-14

Family

ID=23683966

Family Applications (1)

Application Number Title Priority Date Filing Date
NO974744A NO974744D0 (no) 1995-04-19 1997-10-14 Oksygenert-heterocykelinneholdende sulfonamidhemmere av aspartylprotease

Country Status (35)

Country Link
US (2) US5691372A (fr)
EP (3) EP0833826B1 (fr)
JP (1) JP4240532B2 (fr)
KR (1) KR100485237B1 (fr)
CN (1) CN1110491C (fr)
AP (2) AP9600827A0 (fr)
AR (1) AR004663A1 (fr)
AT (3) ATE314360T1 (fr)
AU (1) AU712913B2 (fr)
BG (1) BG102041A (fr)
BR (1) BR9608033A (fr)
CA (1) CA2217745C (fr)
CO (1) CO4700433A1 (fr)
CZ (1) CZ329497A3 (fr)
DE (3) DE69638252D1 (fr)
DK (1) DK0833826T3 (fr)
EA (1) EA000906B1 (fr)
EE (1) EE9700254A (fr)
ES (3) ES2256117T3 (fr)
GE (1) GEP20001915B (fr)
HK (2) HK1009811A1 (fr)
HU (1) HUP9801948A3 (fr)
IL (1) IL117962A0 (fr)
IS (1) IS4575A (fr)
MY (1) MY115797A (fr)
NO (1) NO974744D0 (fr)
NZ (1) NZ307342A (fr)
PE (1) PE43697A1 (fr)
PL (1) PL322904A1 (fr)
PT (1) PT833826E (fr)
SK (1) SK143097A3 (fr)
TR (1) TR199701194T1 (fr)
TW (1) TW404945B (fr)
WO (1) WO1996033187A1 (fr)
ZA (1) ZA962891B (fr)

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US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
OA11573A (en) 1998-06-19 2004-07-01 Vertex Pharma Sulfonamide inhibitors of aspartyl protease.
PT1088098E (pt) * 1998-06-23 2011-05-25 Univ Illinois Medicamento para tratar mam?feros infectados com hiv
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US6337340B1 (en) 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
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WO2000047551A2 (fr) * 1999-02-12 2000-08-17 Vertex Pharmaceuticals Incorporated Inhibiteurs d'aspartyle protease
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CN1187052C (zh) 2000-03-30 2005-02-02 布里斯托尔-迈尔斯斯奎布公司 含有司他夫定(stavudine)的持续释放微球
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Also Published As

Publication number Publication date
BG102041A (en) 1998-09-30
JP4240532B2 (ja) 2009-03-18
DE69635679T2 (de) 2006-08-31
EP1637528B1 (fr) 2010-09-01
HK1092791A1 (en) 2007-02-16
GEP20001915B (en) 2000-01-05
BR9608033A (pt) 1999-01-12
CA2217745C (fr) 2011-07-05
AR004663A1 (es) 1999-03-10
KR100485237B1 (ko) 2005-09-30
SK143097A3 (en) 1998-03-04
US5990155A (en) 1999-11-23
ATE314360T1 (de) 2006-01-15
KR19990007823A (ko) 1999-01-25
PT833826E (pt) 2002-06-28
CZ329497A3 (cs) 1998-03-18
ES2171670T3 (es) 2002-09-16
ATE479674T1 (de) 2010-09-15
AU712913B2 (en) 1999-11-18
US5691372A (en) 1997-11-25
CA2217745A1 (fr) 1996-10-24
DE69618779D1 (de) 2002-03-14
MY115797A (en) 2003-09-30
HUP9801948A2 (hu) 1999-09-28
EP1637528A1 (fr) 2006-03-22
EA199700330A1 (ru) 1998-04-30
DK0833826T3 (da) 2002-05-06
AU5665596A (en) 1996-11-07
HK1009811A1 (en) 1999-06-11
NO974744L (no) 1997-10-14
EE9700254A (et) 1998-04-15
EP0833826B1 (fr) 2002-01-23
EP1136479B1 (fr) 2005-12-28
JPH11504628A (ja) 1999-04-27
CN1184474A (zh) 1998-06-10
CO4700433A1 (es) 1998-12-29
EP1136479A1 (fr) 2001-09-26
ES2256117T3 (es) 2006-07-16
IL117962A0 (en) 1996-08-04
TR199701194T1 (xx) 1998-03-21
AP862A (en) 2000-08-04
ZA962891B (en) 1996-10-15
DE69638252D1 (de) 2010-10-14
IS4575A (is) 1997-10-02
AP9600827A0 (en) 1997-10-17
CN1110491C (zh) 2003-06-04
EA000906B1 (ru) 2000-06-26
PE43697A1 (es) 1997-10-11
DE69635679D1 (de) 2006-02-02
EP0833826A1 (fr) 1998-04-08
AP9701104A0 (en) 1997-10-31
PL322904A1 (en) 1998-03-02
ATE212344T1 (de) 2002-02-15
ES2351970T3 (es) 2011-02-14
WO1996033187A1 (fr) 1996-10-24
HUP9801948A3 (en) 2002-04-29
NZ307342A (en) 1999-04-29
DE69618779T2 (de) 2002-08-29
TW404945B (en) 2000-09-11

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