NO961405L - Kondenserte heksacykliske forbindelser og fremgangsmåter for fremstilling derav - Google Patents

Kondenserte heksacykliske forbindelser og fremgangsmåter for fremstilling derav

Info

Publication number
NO961405L
NO961405L NO961405A NO961405A NO961405L NO 961405 L NO961405 L NO 961405L NO 961405 A NO961405 A NO 961405A NO 961405 A NO961405 A NO 961405A NO 961405 L NO961405 L NO 961405L
Authority
NO
Norway
Prior art keywords
preparation
compound
processes
hexacyclic compounds
formula
Prior art date
Application number
NO961405A
Other languages
English (en)
Other versions
NO314085B1 (no
NO961405D0 (no
Inventor
Shinji Kamihara
Kazuaki Kanai
Shigeru Noguchi
Hirofumi Terasawa
Hiroaki Kitaoka
Original Assignee
Daiichi Seiyaku Co
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co, Yakult Honsha Kk filed Critical Daiichi Seiyaku Co
Publication of NO961405D0 publication Critical patent/NO961405D0/no
Publication of NO961405L publication Critical patent/NO961405L/no
Publication of NO314085B1 publication Critical patent/NO314085B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
NO19961405A 1995-04-10 1996-04-09 Kondenserte heksacykliske forbindelser og fremgangsmåter for fremstilling derav, samt farmasöytiske preparater inneholdende dem NO314085B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8371795 1995-04-10

Publications (3)

Publication Number Publication Date
NO961405D0 NO961405D0 (no) 1996-04-09
NO961405L true NO961405L (no) 1996-10-11
NO314085B1 NO314085B1 (no) 2003-01-27

Family

ID=13810270

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19961405A NO314085B1 (no) 1995-04-10 1996-04-09 Kondenserte heksacykliske forbindelser og fremgangsmåter for fremstilling derav, samt farmasöytiske preparater inneholdende dem

Country Status (13)

Country Link
US (2) US6504029B1 (no)
EP (1) EP0737686B1 (no)
KR (1) KR100400941B1 (no)
CN (1) CN1050131C (no)
AT (1) ATE181919T1 (no)
CA (1) CA2173671A1 (no)
DE (1) DE69603117T2 (no)
DK (1) DK0737686T3 (no)
EA (1) EA000036B1 (no)
ES (1) ES2136338T3 (no)
GR (1) GR3031400T3 (no)
NO (1) NO314085B1 (no)
TW (1) TW382630B (no)

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CZ298259B6 (cs) 2000-02-28 2007-08-08 Aventis Pharma S. A. Farmaceutická kombinace k lécení rakoviny obsahující CPT-11 a capecitabin
US6548488B2 (en) 2000-03-17 2003-04-15 Aventis Pharma S.A. Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer
US6545010B2 (en) 2000-03-17 2003-04-08 Aventis Pharma S.A. Composition comprising camptothecin or a camptothecin derivative and a platin derivative for the treatment of cancer
AR030207A1 (es) * 2000-04-07 2003-08-13 Daiichi Seiyaku Co Composicion farmaceutica que contiene un derivado de camptotecina y procedimiento de preparacion de la misma
US6486320B2 (en) 2000-09-15 2002-11-26 Aventis Pharma S.A. Preparation of camptothecin and of its derivatives
PL365685A1 (en) 2000-10-27 2005-01-10 Aventis Pharma S.A. A combination comprising camptothecin and a stilbene derivative for the treatment of cancer
WO2006069344A2 (en) 2004-12-22 2006-06-29 Rutgers, The State University Of New Jersey Controlled release hydrogels
WO2012050591A1 (en) 2010-10-15 2012-04-19 Rutgers, The State University Of New Jersey Hydrogel formulation for dermal and ocular delivery
AU2007232206B2 (en) 2006-03-30 2013-04-04 Drais Pharmaceuticals, Inc. Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2671888A1 (en) 2008-12-23 2013-12-11 Gilead Pharmasset LLC 3',5'-cyclic nucleoside phosphate analogues
US8716262B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Nucleoside phosphoramidates
NZ617066A (en) 2008-12-23 2015-02-27 Gilead Pharmasset Llc Nucleoside analogs
PT2752422T (pt) 2010-03-31 2017-11-07 Gilead Pharmasset Llc Síntese estereosseletiva de princípios ativos contendo fósforo
KR102237639B1 (ko) 2012-10-11 2021-04-07 다이이찌 산쿄 가부시키가이샤 항체-약물 콘주게이트
US9872924B2 (en) 2012-10-19 2018-01-23 Daiichi Sankyo Company, Limited Antibody-drug conjugate produced by binding through linker having hydrophilic structure
CN116987193A (zh) 2013-12-25 2023-11-03 第一三共株式会社 抗trop2抗体－药物偶联物
IL278891B2 (en) 2014-01-31 2024-06-01 Daiichi Sankyo Co Ltd Anti-HER2 drug-antibody conjugates, preparations containing them and their uses
KR101937549B1 (ko) 2014-04-10 2019-01-10 다이이찌 산쿄 가부시키가이샤 항her3 항체-약물 콘주게이트
US11185594B2 (en) 2014-04-10 2021-11-30 Daiichi Sankyo Company, Limited (Anti-HER2 antibody)-drug conjugate
EP4180455A1 (en) 2015-06-29 2023-05-17 Daiichi Sankyo Company, Limited Method for selectively manufacturing antibody-drug conjugate
SG10201912575RA (en) 2016-12-12 2020-02-27 Daiichi Sankyo Co Ltd Combination of antibody-drug conjugate and immune checkpoint inhibitor
SG11201906554RA (en) 2017-01-17 2019-08-27 Daiichi Sankyo Co Ltd Anti-gpr20 antibody and anti-gpr20 antibody-drug conjugate
TWI794230B (zh) 2017-05-15 2023-03-01 日商第一三共股份有限公司 抗ｃｄｈ６抗體及抗ｃｄｈ６抗體-藥物結合物、以及其製造方法
KR20240018674A (ko) * 2017-08-31 2024-02-13 다이이찌 산쿄 가부시키가이샤 항체-약물 콘주게이트의 신규 제조 방법
EP3677589A4 (en) 2017-08-31 2021-04-21 Daiichi Sankyo Company, Limited IMPROVED PROCESS FOR PREPARING ANTIBODY-ACTIVE CONJUGATE
PT3794042T (pt) 2018-05-18 2024-06-14 Daiichi Sankyo Co Ltd Conjugado anticorpo-fármaco anti-muc1-exatecano
US20210353764A1 (en) 2018-09-26 2021-11-18 Jiangsu Hengrui Medicine Co., Ltd. Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof
US20210347894A1 (en) 2018-09-30 2021-11-11 Jiangsu Hengrui Medicine Co., Ltd. Anti-b7h3 antibody-exatecan analog conjugate and medicinal use thereof
CN113631196B (zh) 2019-03-29 2024-03-15 免疫医疗有限公司 化合物及其缀合物
EP3996749A1 (en) 2019-07-10 2022-05-18 Cybrexa 3, Inc. Peptide conjugates of microtubule-targeting agents as therapeutics
KR20220052918A (ko) 2019-07-10 2022-04-28 싸이브렉사 2, 인크. 치료제로서의 사이토톡신의 펩티드 접합체
JP2023505708A (ja) 2019-12-12 2023-02-10 江蘇恒瑞医薬股▲ふん▼有限公司 抗クローディン抗体薬物複合体及びその医薬用途
WO2021147993A1 (zh) 2020-01-22 2021-07-29 江苏恒瑞医药股份有限公司 抗trop-2抗体-依喜替康类似物偶联物及其医药用途
CA3177279A1 (en) 2020-03-25 2021-09-30 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Anti-psma antibody-exatecan analogue conjugate and medical use thereof
CA3175733A1 (en) 2020-03-25 2021-09-30 Shanghai Hengrui Pharmaceutical Co., Ltd. Pharmaceutical composition comprising antibody drug conjugate and use thereof
CN115103858A (zh) 2020-03-25 2022-09-23 江苏恒瑞医药股份有限公司 一种抗体药物偶联物的制备方法
CN117940432A (zh) * 2021-09-01 2024-04-26 上海弼领生物技术有限公司 一种喜树碱类化合物、其制备方法和用途
WO2024149193A1 (zh) * 2023-01-09 2024-07-18 四川科伦博泰生物医药股份有限公司 含氮稠环化合物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6087746A (ja) * 1983-10-17 1985-05-17 Hakubakumai Kk 即席麺ないしは焼そば用蒸し麺の製造方法
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
US5637770A (en) * 1991-01-16 1997-06-10 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic compound
JP3008226B2 (ja) * 1991-01-16 2000-02-14 第一製薬株式会社 六環性化合物
JP3359955B2 (ja) * 1992-07-16 2002-12-24 第一製薬株式会社 抗腫瘍剤
IS4152A (is) * 1993-04-29 1994-10-30 Glaxo Inc. Vatnsuppleysanlegar Camptothecin afleiður og aðferð til framleiðslu þeirra
GB9319944D0 (en) * 1993-09-28 1993-11-17 Erba Carlo Spa Process for the preparation of 9-amino camptothecin

Also Published As

Publication number Publication date
NO314085B1 (no) 2003-01-27
US6504029B1 (en) 2003-01-07
US20010034446A1 (en) 2001-10-25
AU692078B2 (en) 1998-05-28
CN1133290A (zh) 1996-10-16
US6552197B2 (en) 2003-04-22
CN1050131C (zh) 2000-03-08
AU5056696A (en) 1996-10-24
DE69603117T2 (de) 1999-10-28
KR100400941B1 (ko) 2003-12-24
GR3031400T3 (en) 2000-01-31
EA199600018A3 (ru) 1997-03-31
DK0737686T3 (da) 1999-11-22
ES2136338T3 (es) 1999-11-16
ATE181919T1 (de) 1999-07-15
NO961405D0 (no) 1996-04-09
DE69603117D1 (de) 1999-08-12
TW382630B (en) 2000-02-21
EA199600018A2 (ru) 1996-10-01
EP0737686B1 (en) 1999-07-07
EP0737686A1 (en) 1996-10-16
EA000036B1 (ru) 1998-02-26
CA2173671A1 (en) 1996-10-11
KR960037682A (ko) 1996-11-19

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