NO910649L - Fremgangsmaate til fremstilling av staurosporin. - Google Patents
Fremgangsmaate til fremstilling av staurosporin.Info
- Publication number
- NO910649L NO910649L NO91910649A NO910649A NO910649L NO 910649 L NO910649 L NO 910649L NO 91910649 A NO91910649 A NO 91910649A NO 910649 A NO910649 A NO 910649A NO 910649 L NO910649 L NO 910649L
- Authority
- NO
- Norway
- Prior art keywords
- staurosporin
- procedure
- manufacturing
- medium
- organism
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/55—Streptomyces hygroscopicus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/898—Streptomyces hygroscopicus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Staurosporin ble fremstilt ved dyrkning av en stauro- sporin-produserende stamme av Streptomyces hygroscopicus i et vandig næringsmedium under submerse aerobe betingelser, inntil en betydelig mengde staurosporin var dannet av organismen i dyrkningsmediet, og deretter ble staurosporin, som i alt det vesentlige var fri for ko-produserede stoffer, utvunnet fra mediet.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/482,390 US4973552A (en) | 1990-02-20 | 1990-02-20 | Staurosporine fermentation process |
Publications (2)
Publication Number | Publication Date |
---|---|
NO910649D0 NO910649D0 (no) | 1991-02-19 |
NO910649L true NO910649L (no) | 1991-08-21 |
Family
ID=23915871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO91910649A NO910649L (no) | 1990-02-20 | 1991-02-19 | Fremgangsmaate til fremstilling av staurosporin. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4973552A (no) |
EP (1) | EP0444503A3 (no) |
JP (1) | JPH0737B2 (no) |
CA (1) | CA2036669A1 (no) |
FI (1) | FI910756A (no) |
HU (1) | HUT60526A (no) |
NO (1) | NO910649L (no) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0575955B1 (en) * | 1992-06-22 | 1999-09-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing staurosporine derivatives |
US6210935B1 (en) | 1995-08-30 | 2001-04-03 | Novartis Ag | Staurosporin biosynthesis gene clusters |
US6964860B2 (en) * | 2001-04-25 | 2005-11-15 | Wyeth Holdings Corporation | Glycopeptide antibiotics |
US7138255B2 (en) | 2002-09-30 | 2006-11-21 | Auburn University | Method of isolation and self-assembly of small protein particles from blood and other biological materials |
WO2004094645A1 (en) * | 2003-04-22 | 2004-11-04 | Lonza Ag | Process for the recovery of staurosporine from a fermentation broth |
CN110642872B (zh) * | 2019-11-18 | 2020-12-22 | 湖北宏中药业股份有限公司 | 一种星孢菌素提取方法 |
CN113122591B (zh) * | 2019-12-30 | 2022-11-22 | 上海医药工业研究院 | 一种发酵生产星孢菌素的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5373501A (en) * | 1976-12-11 | 1978-06-30 | Kitasato Inst | Novel antibiotics amm2282 and process for preparing same |
US5015578A (en) * | 1989-03-23 | 1991-05-14 | Bristol-Myers Squibb Company | BMY-41950 antitumor antibiotic |
-
1990
- 1990-02-20 US US07/482,390 patent/US4973552A/en not_active Expired - Fee Related
- 1990-11-29 JP JP2333494A patent/JPH0737B2/ja not_active Expired - Fee Related
-
1991
- 1991-02-15 FI FI910756A patent/FI910756A/fi not_active Application Discontinuation
- 1991-02-19 CA CA002036669A patent/CA2036669A1/en not_active Abandoned
- 1991-02-19 EP EP19910102374 patent/EP0444503A3/en not_active Ceased
- 1991-02-19 HU HU91550A patent/HUT60526A/hu unknown
- 1991-02-19 NO NO91910649A patent/NO910649L/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO910649D0 (no) | 1991-02-19 |
JPH0737B2 (ja) | 1995-01-11 |
JPH03244387A (ja) | 1991-10-31 |
HU910550D0 (en) | 1991-09-30 |
HUT60526A (en) | 1992-09-28 |
FI910756A (fi) | 1991-08-21 |
CA2036669A1 (en) | 1991-08-21 |
EP0444503A3 (en) | 1992-02-26 |
US4973552A (en) | 1990-11-27 |
FI910756A0 (fi) | 1991-02-15 |
EP0444503A2 (en) | 1991-09-04 |
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