NO333468B1 - Anvendelse av en sammensetning for behandling eller forebygging av rosacea samt topisk sammensetning - Google Patents
Anvendelse av en sammensetning for behandling eller forebygging av rosacea samt topisk sammensetning Download PDFInfo
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- NO333468B1 NO333468B1 NO20056104A NO20056104A NO333468B1 NO 333468 B1 NO333468 B1 NO 333468B1 NO 20056104 A NO20056104 A NO 20056104A NO 20056104 A NO20056104 A NO 20056104A NO 333468 B1 NO333468 B1 NO 333468B1
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- Prior art keywords
- topical
- pharmaceutically acceptable
- topical composition
- skin
- composition according
- Prior art date
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- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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US10/853,585 US7439241B2 (en) | 2003-05-27 | 2004-05-25 | Compounds, formulations, and methods for treating or preventing rosacea |
PCT/US2004/016799 WO2004105703A2 (en) | 2003-05-27 | 2004-05-26 | Compounds, formulations, and methods for treating or preventing rosacea |
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NO333468B1 true NO333468B1 (no) | 2013-06-17 |
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US (13) | US7439241B2 (xx) |
EP (3) | EP2815748B1 (xx) |
CN (4) | CN1829518B (xx) |
AT (1) | ATE530185T1 (xx) |
AU (1) | AU2004242967C1 (xx) |
CA (1) | CA2530938C (xx) |
CY (3) | CY1112242T1 (xx) |
DK (3) | DK1631293T4 (xx) |
ES (3) | ES2376172T5 (xx) |
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HR (1) | HRP20150957T1 (xx) |
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NZ (1) | NZ544300A (xx) |
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PT (3) | PT1631293E (xx) |
SI (3) | SI2815748T1 (xx) |
WO (1) | WO2004105703A2 (xx) |
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US20040266776A1 (en) * | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
US8410102B2 (en) * | 2003-05-27 | 2013-04-02 | Galderma Laboratories Inc. | Methods and compositions for treating or preventing erythema |
US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
US20050020600A1 (en) * | 2003-07-23 | 2005-01-27 | Scherer Warren J. | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
US7812049B2 (en) * | 2004-01-22 | 2010-10-12 | Vicept Therapeutics, Inc. | Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists |
NZ552325A (en) * | 2004-05-25 | 2010-11-26 | Sansrosa Pharmaceutical Dev Inc | The use of alpha 2 andrenoceptor agonists such as brimonidine for treating inflammatory skin disorders |
US20080095735A1 (en) * | 2005-01-31 | 2008-04-24 | Kross Robert D | Skin-Protective Polymer For Use In Teat Care Compositions |
DE202005002183U1 (de) | 2005-02-04 | 2005-04-14 | Beiersdorf Ag | Hautverwöhnende Cremelotion |
US8580317B2 (en) * | 2005-03-30 | 2013-11-12 | Revance Therapeutics, Inc. | Compositions and methods for treating acne |
DK1890732T3 (en) | 2005-06-17 | 2018-07-02 | Wisconsin Alumni Res Found | TOPICAL VASO CONSTRUCTOR PREPARATIONS AND METHODS FOR PROTECTING CELLS UNDER CANCER THERAPY AND RADIATION THERAPY |
WO2007002447A2 (en) * | 2005-06-23 | 2007-01-04 | Bioform Medical, Inc. | Compositions for treating rosacea |
FR2894474B1 (fr) * | 2005-12-12 | 2008-04-11 | Galderma Res & Dev | Gel depigmentant hydroalcoolique |
WO2008144399A1 (en) * | 2007-05-18 | 2008-11-27 | Bausch & Lomb Incorporated | COMPLEXES COMPRISING α2-ADRENERGIC RECEPTOR AGONISTS AND COMPOSITIONS |
US20090060852A1 (en) * | 2007-07-27 | 2009-03-05 | Jack Dejovin | Compounds, Formulations and Methods for Reducing Skin Wrinkles, Creasing and Sagging |
US20090061020A1 (en) * | 2007-08-31 | 2009-03-05 | Theobald Klaus P | Brimonidine Compositions for Treating Erythema |
SI2818184T1 (sl) * | 2007-11-16 | 2019-03-29 | Aclaris Therapeutics, Inc. | Sestava in postopki za zdravljenje purpure |
IE20070935A1 (en) * | 2007-12-21 | 2009-06-24 | Trinity College Dublin | Guanidine based compounds and their use in the treatment of mental and neurological disorders. |
EP2230910A4 (en) * | 2007-12-21 | 2011-04-13 | Galderma Lab Inc | PRE-SURGICAL TREATMENT |
US8283350B2 (en) | 2008-08-01 | 2012-10-09 | Alpha Synergy Development, Inc. | Compositions and methods for reducing capillary permeability |
US20100197694A1 (en) * | 2008-08-01 | 2010-08-05 | Gerald Horn | Compositions and methods for treatment of diseases and conditions with increased vascular permeability |
CA2750636C (en) * | 2009-01-23 | 2017-07-25 | Jr Chem, Llc | Rosacea treatments and kits for performing them |
FR2942138A1 (fr) | 2009-02-16 | 2010-08-20 | Galderma Res & Dev | Association de composes pour le traitement ou la prevention des affections dermatologiques |
KR101859486B1 (ko) * | 2009-05-15 | 2018-06-28 | 레크로파마, 인코포레이티드 | 설하용 덱스메데토미딘 조성물과 그의 사용 방법 |
US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
WO2010136585A2 (en) * | 2009-05-29 | 2010-12-02 | Galderma Research & Development | Combination of adrenergic receptor agonist -1 or -2, preferably brimonidine with fillers, preferablyhyaluronic acid |
BR112012009891A2 (pt) * | 2009-10-26 | 2015-09-29 | Galderma Pharma Sa | métodos para tratar eritema agudo e para prevenir o eritema agudo e uma inflamação secundária em um humano em necessidade do mesmo |
EP2329849B1 (en) | 2009-11-18 | 2015-04-29 | Galderma Research & Development | Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder |
US8394800B2 (en) | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
US9114188B2 (en) | 2010-01-13 | 2015-08-25 | Allergan, Industrie, S.A.S. | Stable hydrogel compositions including additives |
HUE033143T2 (en) * | 2010-03-26 | 2017-11-28 | Galderma Res & Dev | Preparations containing brimonidine for the treatment of erythema |
JP5747392B2 (ja) * | 2010-03-26 | 2015-07-15 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 毛細血管拡張症の安全かつ有効な治療のための改善された方法および組成物 |
CN104288768A (zh) | 2010-06-30 | 2015-01-21 | 盖尔德马研究及发展公司 | α2-肾上腺素能受体激动剂的用途 |
EP2595616B1 (en) | 2010-06-30 | 2016-04-13 | Galderma Research & Development | Use of alpha-adrenergic receptor agonist for preventing or treating skin tumor |
KR20130128375A (ko) * | 2010-08-06 | 2013-11-26 | 갈데르마 리서치 & 디벨로프먼트 | 피부 질환을 치료 또는 예방하기 위한 화합물들의 배합물 |
US8492557B2 (en) * | 2010-09-16 | 2013-07-23 | Allergan, Inc. | Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol |
US20120076738A1 (en) * | 2010-09-28 | 2012-03-29 | Michael Graeber | Combination treatment for dermatological conditions |
US20120082625A1 (en) * | 2010-09-28 | 2012-04-05 | Michael Graeber | Combination treatment for rosacea |
FR2966366B1 (fr) * | 2010-10-21 | 2012-11-09 | Galderma Sa | Composition de gel de brimonidine |
CN103313700A (zh) * | 2010-10-21 | 2013-09-18 | 高德美国际公司 | 外用凝胶剂组合物 |
US8053427B1 (en) | 2010-10-21 | 2011-11-08 | Galderma R&D SNC | Brimonidine gel composition |
RU2571277C2 (ru) | 2010-10-21 | 2015-12-20 | Галдерма С.А. | Композиции геля с бримонидином и способы применения |
FR2966365B1 (fr) * | 2010-10-21 | 2012-11-09 | Galderma Sa | Composition de gel topique |
AU2011329209B8 (en) * | 2010-11-16 | 2017-03-09 | Allergan, Inc. | Pharmaceutical compositions comprising (3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl) methanol |
DK2645993T3 (en) * | 2010-12-03 | 2017-02-13 | Allergan Inc | Pharmaceutical cream compositions comprising oxymetazoline |
JP2013545800A (ja) | 2010-12-20 | 2013-12-26 | コルゲート・パーモリブ・カンパニー | 親水性活性剤、疎水性構造化剤および油担体を含有するゼラチンカプセル化された口腔ケア組成物 |
WO2012083397A1 (en) | 2010-12-22 | 2012-06-28 | Silvestre Labs Químia E Farmaceutica Ltda. | Guanabenz-containing compound for the treatment of primary cutaneous amyloidosis |
CA2827373C (en) * | 2011-02-15 | 2019-05-14 | Stuart D. Shanler | Pharmaceutical cream compositions of oxymetazoline for treating symptoms of rosacea |
CN102260608B (zh) * | 2011-06-23 | 2012-07-04 | 江苏安惠生物科技有限公司 | 灵芝肥皂及其制备方法 |
CN103796652A (zh) * | 2011-07-14 | 2014-05-14 | 阿勒根公司 | 羟甲唑啉的凝胶组合物及使用方法 |
WO2013016072A1 (en) * | 2011-07-22 | 2013-01-31 | Allergan, Inc. | Pharmaceutical compositions comprising 4-bromo-n-(imidazolidin-2-ylidene)-1h-benzimidazol-5-amine for treating skin diseases |
WO2013052770A1 (en) | 2011-10-05 | 2013-04-11 | Sanders Jennifer L | Methods and compositions for treating foot or hand pain |
EP2768501A1 (en) | 2011-10-19 | 2014-08-27 | Galderma S.A. | Method for treating capillary hemangiomas |
EP2768502A2 (en) | 2011-10-19 | 2014-08-27 | Galderma S.A. | Method of reducing facial flushing associated with systemic use of phosphodiesterase type 5 inhibitors |
US9283217B2 (en) | 2011-11-10 | 2016-03-15 | Allergan, Inc. | Pharmaceutical compositions comprising 7-(1 H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions |
UA109359C2 (xx) * | 2011-11-10 | 2015-08-10 | Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном | |
EP2782569A1 (en) | 2011-11-21 | 2014-10-01 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases |
AU2012352528B9 (en) | 2011-12-11 | 2017-11-02 | Baudax Bio, Inc. | Intranasal dexmedetomidine compositions and methods of use thereof |
WO2013115844A1 (en) * | 2012-02-02 | 2013-08-08 | Alpha Synergy Development, Inc. | Compositions and methods for treatment of glaucoma |
FR3000398A1 (fr) * | 2012-12-31 | 2014-07-04 | Galderma Res & Dev | Combinaison de laropiprant et de brimonidine pour le traitement de la rosacee |
FR3000397A1 (fr) | 2012-12-31 | 2014-07-04 | Galderma Res & Dev | Combinaison de laropiprant et d'ivermectine pour le traitement de la rosacee |
AU2013201465B2 (en) | 2012-10-24 | 2016-03-03 | Rayner Surgical (Ireland) Limited | Stable preservative-free mydriatic and anti-inflammatory solutions for injection |
EA201500699A1 (ru) * | 2012-12-24 | 2015-12-30 | Рамот Эт Тель-Авив Юниверсити Лтд. | Агенты для лечения генетических заболеваний, возникающих в результате нонсенс-мутаций, и способы идентификации этих агентов |
US9861645B2 (en) | 2012-12-28 | 2018-01-09 | Rak Holdings Llc | Anti-itch scalp treatment compositions and combinations |
CN105188691A (zh) | 2013-05-06 | 2015-12-23 | 阿勒根公司 | 用于治疗组织创伤的α-肾上腺素能激动剂 |
KR20160055794A (ko) * | 2013-07-26 | 2016-05-18 | 갈데르마 리서치 & 디벨로프먼트 | 피부 비후의 치료용 조성물 |
EP3054930B1 (en) | 2013-10-07 | 2020-12-02 | Teikoku Pharma USA, Inc. | Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine |
US10772871B2 (en) | 2013-10-07 | 2020-09-15 | Teikoku Pharma Usa, Inc. | Dexmedetomidine transdermal delivery devices and methods for using the same |
TWI709417B (zh) | 2013-10-07 | 2020-11-11 | 美商帝國製藥美國股份有限公司 | 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物 |
FR3015288B1 (fr) | 2013-12-19 | 2016-02-12 | Galderma Res & Dev | Utilsation du naratriptan dans le traitement de la rosacee |
CA2951725C (en) | 2014-06-11 | 2022-06-07 | Allergan, Inc. | Stabilized oxymetazoline formulations and their uses |
US20150374686A1 (en) | 2014-06-30 | 2015-12-31 | Galderma S.A. | Methods of Treating Flushing Associated with Carcinoid Tumors and Carcinoid Syndrome |
RU2560698C1 (ru) * | 2014-08-15 | 2015-08-20 | Общество с ограниченной ответственностью "Уральский медико-химический центр" (ООО "УМХЦ") | Средство наружной терапии больных акне |
US9351945B1 (en) * | 2015-02-27 | 2016-05-31 | John Daniel Dobak, III | Reduction of adipose tissue |
JP6659819B2 (ja) | 2015-07-09 | 2020-03-04 | ガルデルマ・ソシエテ・アノニム | 化学療法に関連する脱毛の軽減方法 |
FR3041537B1 (fr) * | 2015-09-29 | 2018-11-30 | Galderma Research & Development | Mousse chimique non rincee contenant de la brimonidine et son utilisation dans le traitement de la rosacee. |
US11213539B2 (en) | 2015-11-17 | 2022-01-04 | Galderma Holding SA | Use of ivermectin and brimonidine in the treatment and/or prevention of moderate to severe rosacea |
WO2017161432A1 (pt) * | 2016-03-22 | 2017-09-28 | Doris Maria Hexsel | Uso de uma composição farmacêutica destinada ao tratamento do eritema cutâneo das poiquilodermias |
US10744135B2 (en) * | 2016-06-28 | 2020-08-18 | Doris Maria HEXSEL | Use of an active substance in the treatment of melasma |
CN109265448B (zh) * | 2018-11-15 | 2020-09-15 | 三峡大学 | 一类含叔丁基的n-咪唑乙酰基二氢喹喔啉类衍生物,合成方法及其作为杀菌剂上的应用 |
CA3130362A1 (en) | 2019-02-19 | 2020-08-27 | Sol-Gel Technologies Ltd. | Method for providing early onset of action in the treatment of rosacea |
US20220211672A1 (en) | 2019-05-01 | 2022-07-07 | Clexio Biosciences Ltd. | Methods of treating pruritus |
US11185532B2 (en) | 2019-05-01 | 2021-11-30 | Clexio Biosciences Ltd. | Methods of treating pruritus |
WO2022047042A1 (en) * | 2020-08-26 | 2022-03-03 | Oticara, Inc. | Compositions devices and methods for treating nasal, otic and other tissue infection and/or inflammation |
RU2766973C1 (ru) * | 2021-10-05 | 2022-03-16 | Татьяна Сергеевна Русина | Способ сочетанной терапии розацеа эритематозно-телеангэктатического подтипа |
WO2023130086A1 (en) * | 2021-12-31 | 2023-07-06 | Jss Research, Llc | Compositions and methods for topical treatment of vascular conditions |
Family Cites Families (92)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3278447A (en) | 1963-12-02 | 1966-10-11 | Cloro Bac Products Inc | Process for stabilizing chlorine dioxide solution |
US3560501A (en) * | 1966-09-15 | 1971-02-02 | Ciba Geigy Corp | Process for making dihydroquinazolines |
US3723432A (en) * | 1968-11-12 | 1973-03-27 | Sandoz Ag | 1-substituted-4-aryl-2(1h)-quinazolinones and their preparation |
US3594380A (en) * | 1969-02-18 | 1971-07-20 | American Home Prod | Isoquinolin-1(2h)-ones |
BE766039A (fr) * | 1971-04-21 | 1971-09-16 | Labofina Sa | Nouveaux polymeres contenant des unites de pyrazole et procede de preparation de ces polymeres. |
US3740442A (en) * | 1972-01-14 | 1973-06-19 | Sandoz Ag | 2-isopropylaminobenzophenones in treating inflammation |
BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
US4029792A (en) * | 1972-02-29 | 1977-06-14 | Pfizer Inc. | (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents |
US4164570A (en) * | 1973-09-24 | 1979-08-14 | David Clough | Stabilized aqueous catecholamine solutions |
US4201211A (en) * | 1977-07-12 | 1980-05-06 | Alza Corporation | Therapeutic system for administering clonidine transdermally |
US4285967A (en) * | 1978-06-30 | 1981-08-25 | Estee Lauder Inc. | Cosmetic preparation for reducing redness of blemishes |
US4254145A (en) * | 1978-08-16 | 1981-03-03 | American Cyanamid Company | Topical application of prostaglandin hypotensive agents |
US4256763A (en) * | 1978-09-19 | 1981-03-17 | Mchugh John E | Treatment of herpes simplex infections and acne |
DE2924005C2 (de) * | 1979-06-13 | 1984-07-05 | Sanol Schwarz-Monheim Gmbh, 4019 Monheim | Isosorbiddinitrat enthaltendes Mittel |
US5166331A (en) * | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
US4908387A (en) | 1988-06-06 | 1990-03-13 | The Regents Of The University Of California | Use of beta2 antagonists in the treatment of inflammatory diseases, in particular, rheumatoid arthritis |
CA2003198C (en) * | 1988-11-29 | 1995-03-21 | Anthony J. Dziabo, Jr. | Aqueous ophthalmic solutions and method for preserving same |
US5198442A (en) * | 1989-10-12 | 1993-03-30 | Allergan, Inc. | (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same |
US5077292A (en) * | 1989-10-12 | 1991-12-31 | Allergan, Inc. | (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same |
US5326763A (en) * | 1989-10-12 | 1994-07-05 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
US5204347A (en) * | 1989-10-12 | 1993-04-20 | Allergan, Inc. | Methods for using (2-imidazolin-2-ylamino) tetrahydroquinoxalines |
US5112822A (en) * | 1989-10-12 | 1992-05-12 | Allergan, Inc. | (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same |
US5021416A (en) * | 1989-10-31 | 1991-06-04 | Allergan, Inc. | Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure |
US5237072A (en) * | 1990-02-06 | 1993-08-17 | Allergan, Inc. | Method for producing amino-2-imidazoline derivatives |
US5130441A (en) * | 1990-02-06 | 1992-07-14 | Allergan, Inc. | Method for producing amino-2-imidazoline derivatives |
US5721237A (en) * | 1991-05-10 | 1998-02-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties |
US5326566A (en) * | 1991-05-17 | 1994-07-05 | Bristol-Myers Squibb Company | Use of dibutyl adipate and isopropyl myristate in topical and transdermal products |
IT1248014B (it) * | 1991-06-07 | 1995-01-05 | Inverni Della Beffa Spa | Preparazioni oftalmiche a rilascio protratto |
US5292517A (en) * | 1992-02-25 | 1994-03-08 | Allergan, Inc. | pH sensitive, reversible gelling, copolymeric erodible drug delivery system |
US5736165A (en) * | 1993-05-25 | 1998-04-07 | Allergan | In-the-eye use of chlorine dioxide-containing compositions |
JP3683908B2 (ja) * | 1993-10-13 | 2005-08-17 | アラーガン、インコーポレイテッド | (2−イミダゾリン−2−イルアミノ)キノキサリン誘導体の使用方法 |
US6323204B1 (en) * | 1993-10-13 | 2001-11-27 | Allergan | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives |
US6117871A (en) * | 1993-12-17 | 2000-09-12 | The Procter & Gamble Company | 6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists |
US6350781B1 (en) * | 1994-01-14 | 2002-02-26 | Lee Shahinia, Jr. | Method and analgesic preparations for sustained and extended corneal analgesia with subanesthetic concentrations of lidocaine |
WO1996013267A2 (en) | 1994-10-27 | 1996-05-09 | Allergan | Combinations of prostaglandins and brimonidine or derivatives thereof for the treatment of glaucoma |
US5688810A (en) * | 1994-12-22 | 1997-11-18 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
WO1996025163A1 (en) | 1995-02-14 | 1996-08-22 | Board Of Supervisors Or Louisiana State Universityof Agricultural And Mechanical College Through Itsmedical Center | Treatment of herpes simplex viruses |
US5620416A (en) * | 1995-06-07 | 1997-04-15 | North Carolina State University | Methods of using topical agents with systemically administered active agents |
US6194415B1 (en) * | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
US5720962A (en) * | 1995-10-04 | 1998-02-24 | Au Pharmaceuticals, Inc. | Analgesic lotion for hemorrhoids and method of making such lotion |
US6441047B2 (en) * | 1995-11-17 | 2002-08-27 | Alcon Manufacturing Ltd.. | Combination therapy for treating glaucoma |
US5910312A (en) | 1996-10-09 | 1999-06-08 | Ideal Ideas, Inc. | Acne treatment composition with vasoconstrictor |
US5753637A (en) * | 1996-10-09 | 1998-05-19 | Ideal Ideas, Inc. | Method of treating acne conditions |
US5916574A (en) * | 1996-10-09 | 1999-06-29 | Ideal Ideas, Inc. | Method of treating natural poison skin conditions |
EP0969790A2 (de) | 1997-02-21 | 2000-01-12 | Beiersdorf Aktiengesellschaft | Zubereitungen für die behandlung von rosacea |
ES2245028T3 (es) * | 1997-04-10 | 2005-12-16 | Agennix, Inc. | Uso de lactoferrina en el tratamiento de trastornos inducidos por alergenos. |
JPH1129482A (ja) | 1997-05-14 | 1999-02-02 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
US6513247B1 (en) * | 1997-05-29 | 2003-02-04 | Ariel Krasik-Geiger | Calibrated angle and depth scissors |
US6159944A (en) * | 1998-02-27 | 2000-12-12 | Synchroneuron, Llc | Method for treating painful conditions of the anal region and compositions therefor |
US6432934B1 (en) * | 1998-08-06 | 2002-08-13 | Advanced Vision Research | Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease |
AR020660A1 (es) | 1998-09-30 | 2002-05-22 | Alcon Lab Inc | Composiciones antibioticas para el tratamiento de ojos, oidos y nariz |
US20030087962A1 (en) | 1998-10-20 | 2003-05-08 | Omeros Corporation | Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation |
WO2004073708A1 (en) * | 1998-12-17 | 2004-09-02 | Dean Thomas R | Brinzolamide and brimonidine for treating ocular conditions |
US6258350B1 (en) * | 1999-01-20 | 2001-07-10 | Alcon Manufacturing, Ltd. | Sustained release ophthalmic formulation |
IN185228B (xx) | 1999-02-03 | 2000-12-09 | Bakulesh Mafatlal Dr Khamar | |
US20020197300A1 (en) | 1999-02-22 | 2002-12-26 | Schultz Clyde L. | Drug delivery system for anti-glaucomatous medication |
AU5331200A (en) | 1999-06-11 | 2001-01-02 | Ohio State University Research Foundation, The | Methods and compositions for treating raynaud's phenomenon and scleroderma |
US6340681B1 (en) | 1999-07-16 | 2002-01-22 | Pfizer Inc | 2-benzimidazolylamine compounds as ORL-1-receptor agonists |
US6147102A (en) * | 1999-10-26 | 2000-11-14 | Curatek Pharmaceuticals Holding, Inc. | Clonidine preparations |
US20030077301A1 (en) * | 1999-12-16 | 2003-04-24 | Maibach Howard I. | Topical pharmaceutical composition for the treatment of inflammatory dermatoses |
US6740655B2 (en) * | 2000-01-31 | 2004-05-25 | Pfizer Inc | Pyrimidine carboxamides useful as inhibitors of PDE4 isozymes |
US6294553B1 (en) * | 2000-02-15 | 2001-09-25 | Allergan Sales, Inc. | Method for treating ocular pain |
US6284765B1 (en) * | 2000-04-27 | 2001-09-04 | The University Of North Texas Health Science Center At Fort Worth | (+) naloxone and epinephrine combination therapy |
US6444681B1 (en) * | 2000-06-09 | 2002-09-03 | The Ohio State University Research Foundation | Methods and compositions for treating Raynaud's Phenomenon and scleroderma |
US6468989B1 (en) | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
RU2311928C2 (ru) | 2000-07-14 | 2007-12-10 | Аллерган Инк. | Композиции, содержащие альфа-2-адренергические агонисты |
US6387383B1 (en) | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
BR0115067A (pt) | 2000-10-30 | 2004-04-06 | Univ Zuerich | Análogos de gnrh para tratamento de incontinência urinária |
US7211267B2 (en) | 2001-04-05 | 2007-05-01 | Collagenex Pharmaceuticals, Inc. | Methods of treating acne |
CA2446356C (en) * | 2001-05-09 | 2012-07-10 | The Regents Of The University Of Michigan | Use of compositions for treating rosacea |
TNSN02063A1 (en) * | 2001-07-07 | 2005-12-23 | Egyptian Natural Oil Co Natoil | The medical effect of jojoba oil |
US7115724B2 (en) * | 2001-08-22 | 2006-10-03 | Wyeth | Murine genomic polynucleotide sequence encoding a G-protein coupled receptor and methods of use therefor |
US7704530B2 (en) | 2001-09-14 | 2010-04-27 | Kenji Nakamura | Antimicrobially treated material and methods of preventing coloring thereof |
US6680062B2 (en) * | 2001-10-05 | 2004-01-20 | Color Access, Inc. | Anti-irritating rosacea treatment |
US20040266776A1 (en) | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
US7345065B2 (en) * | 2002-05-21 | 2008-03-18 | Allergan, Inc. | Methods and compositions for alleviating pain |
US20040092482A1 (en) * | 2002-11-07 | 2004-05-13 | Gupta Shyam K. | Hydroxy acids based delivery systems for skin resurfacing and anti-aging compositions |
US20040156873A1 (en) * | 2003-02-10 | 2004-08-12 | Gupta Shyam K. | Topically Bioavailable Acne and Rosacea Treatment Compositions |
US20040220259A1 (en) * | 2003-04-04 | 2004-11-04 | Yu Ruey J. | Topical treatment of dermatological disorders associated with reactive or dilated blood vessels |
WO2004103233A1 (en) * | 2003-05-15 | 2004-12-02 | Cutanix Corporation | Compositions containing a combination of a pharmaceutical agent or a cosmetic agent and an oxy group-bearing aromatic aldehyde |
US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
US8410102B2 (en) * | 2003-05-27 | 2013-04-02 | Galderma Laboratories Inc. | Methods and compositions for treating or preventing erythema |
US20050020600A1 (en) * | 2003-07-23 | 2005-01-27 | Scherer Warren J. | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
FR2862537B1 (fr) * | 2003-11-21 | 2006-03-03 | Galderma Res & Dev | Utilisation du fepradinol pour la preparation d'une composition pharmaceutique pour le traitement de la rosacee |
US7812049B2 (en) * | 2004-01-22 | 2010-10-12 | Vicept Therapeutics, Inc. | Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists |
NZ552325A (en) * | 2004-05-25 | 2010-11-26 | Sansrosa Pharmaceutical Dev Inc | The use of alpha 2 andrenoceptor agonists such as brimonidine for treating inflammatory skin disorders |
WO2007095670A1 (en) * | 2006-02-20 | 2007-08-30 | Commonwealth Scientific And Industrial Research Organisation | Method and composition for priming wood and natural fibres |
WO2008140781A1 (en) * | 2007-05-09 | 2008-11-20 | Atherogenics, Inc. | Spiro compounds for treatment of inflammatory disorders |
US20090061020A1 (en) * | 2007-08-31 | 2009-03-05 | Theobald Klaus P | Brimonidine Compositions for Treating Erythema |
US8394800B2 (en) * | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
HUE033143T2 (en) * | 2010-03-26 | 2017-11-28 | Galderma Res & Dev | Preparations containing brimonidine for the treatment of erythema |
US8053427B1 (en) * | 2010-10-21 | 2011-11-08 | Galderma R&D SNC | Brimonidine gel composition |
-
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Owner name: GALDERMA PHARMA SA, CH |