NO331787B1 - Fysiologisk aktive PEG-GCSF-konjugater, sammensetning omfattende konjugatene og fremgangsmate for fremstilling av konjugatene - Google Patents
Fysiologisk aktive PEG-GCSF-konjugater, sammensetning omfattende konjugatene og fremgangsmate for fremstilling av konjugatene Download PDFInfo
- Publication number
- NO331787B1 NO331787B1 NO20013700A NO20013700A NO331787B1 NO 331787 B1 NO331787 B1 NO 331787B1 NO 20013700 A NO20013700 A NO 20013700A NO 20013700 A NO20013700 A NO 20013700A NO 331787 B1 NO331787 B1 NO 331787B1
- Authority
- NO
- Norway
- Prior art keywords
- conjugates
- peg
- gcsf
- conjugate
- mutein
- Prior art date
Links
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- 125000004042 4-aminobutyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyethers (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11791799P | 1999-01-29 | 1999-01-29 | |
| PCT/US2000/001264 WO2000044785A1 (en) | 1999-01-29 | 2000-01-19 | Gcsf conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20013700D0 NO20013700D0 (no) | 2001-07-27 |
| NO20013700L NO20013700L (no) | 2001-09-25 |
| NO331787B1 true NO331787B1 (no) | 2012-04-02 |
Family
ID=22375505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20013700A NO331787B1 (no) | 1999-01-29 | 2001-07-27 | Fysiologisk aktive PEG-GCSF-konjugater, sammensetning omfattende konjugatene og fremgangsmate for fremstilling av konjugatene |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US20030130193A1 (es) |
| EP (1) | EP1157037B1 (es) |
| JP (1) | JP2002540065A (es) |
| KR (1) | KR100689212B1 (es) |
| CN (1) | CN1376164A (es) |
| AT (1) | ATE246202T1 (es) |
| AU (1) | AU2618500A (es) |
| BG (1) | BG65213B1 (es) |
| BR (1) | BR0007781A (es) |
| CA (1) | CA2361766C (es) |
| CZ (1) | CZ300546B6 (es) |
| DE (1) | DE60004172T2 (es) |
| DK (1) | DK1157037T3 (es) |
| EA (2) | EA200400067A1 (es) |
| ES (1) | ES2204509T3 (es) |
| HK (1) | HK1049673A1 (es) |
| HU (1) | HU228488B1 (es) |
| IL (1) | IL144361A0 (es) |
| MX (1) | MXPA01007609A (es) |
| NO (1) | NO331787B1 (es) |
| NZ (1) | NZ513113A (es) |
| PT (1) | PT1157037E (es) |
| RS (1) | RS50928B (es) |
| SK (1) | SK286898B6 (es) |
| WO (1) | WO2000044785A1 (es) |
| ZA (1) | ZA200105932B (es) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002540065A (ja) * | 1999-01-29 | 2002-11-26 | アムジェン インコーポレーテッド | Ｇｃｓｆコンジュゲート |
| US6646110B2 (en) | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
| US6555660B2 (en) | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
| US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
| ES2320101T3 (es) | 2000-10-16 | 2009-05-19 | Chugai Seiyaku Kabushiki Kaisha | Eritropoyetina conjugada con mono-peg. |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| WO2004099231A2 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| US7416858B2 (en) * | 2001-10-10 | 2008-08-26 | Neose Technologies, Inc. | Pharmaceutical compositions of glycoconjugates |
| EP2322229B1 (en) * | 2001-10-10 | 2016-12-21 | Novo Nordisk A/S | Remodeling and glycoconjugation of Factor IX |
| GEP20063860B (en) * | 2001-11-20 | 2006-06-26 | Pharmacia Corp | Chemically-modified human growth hormone conjugates |
| EP1526872A1 (en) * | 2002-07-24 | 2005-05-04 | F. Hoffmann-La Roche Ag | Polyalkylene glycol acid additives |
| US7695723B2 (en) | 2002-12-31 | 2010-04-13 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
| US7785601B2 (en) | 2002-12-31 | 2010-08-31 | Sygnis Bioscience Gmbh & Co. Kg | Methods of treating neurological conditions with hematopoietic growth factors |
| US9005625B2 (en) | 2003-07-25 | 2015-04-14 | Novo Nordisk A/S | Antibody toxin conjugates |
| WO2005018663A1 (en) * | 2003-08-22 | 2005-03-03 | The Council Of The Queensland Institute Of Medical Research | G-csf derivative for inducing immunological tolerance |
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