NO331027B1 - Forbindelse som bindes til en mpl-reseptor, dimer, polynukleotid, vektor, vertscelle, fremgangsmate for fremstilling av en forbindelse, anvendelse av en forbindelse for fremstilling av et medikament, samt farmasoytisk preparat. - Google Patents

Forbindelse som bindes til en mpl-reseptor, dimer, polynukleotid, vektor, vertscelle, fremgangsmate for fremstilling av en forbindelse, anvendelse av en forbindelse for fremstilling av et medikament, samt farmasoytisk preparat.

Info

Publication number
NO331027B1
NO331027B1 NO20011962A NO20011962A NO331027B1 NO 331027 B1 NO331027 B1 NO 331027B1 NO 20011962 A NO20011962 A NO 20011962A NO 20011962 A NO20011962 A NO 20011962A NO 331027 B1 NO331027 B1 NO 331027B1
Authority
NO
Norway
Prior art keywords
compound
preparation
dimer
polynucleotide
binds
Prior art date
Application number
NO20011962A
Other languages
English (en)
Norwegian (no)
Other versions
NO20011962D0 (no
NO20011962L (no
Inventor
Chuan-Fa Liu
Ulrich Feige
Janet Cheetham
Original Assignee
Kirin Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Amgen Inc filed Critical Kirin Amgen Inc
Publication of NO20011962D0 publication Critical patent/NO20011962D0/no
Publication of NO20011962L publication Critical patent/NO20011962L/no
Publication of NO331027B1 publication Critical patent/NO331027B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO20011962A 1998-10-23 2001-04-20 Forbindelse som bindes til en mpl-reseptor, dimer, polynukleotid, vektor, vertscelle, fremgangsmate for fremstilling av en forbindelse, anvendelse av en forbindelse for fremstilling av et medikament, samt farmasoytisk preparat. NO331027B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10534898P 1998-10-23 1998-10-23
PCT/US1999/024834 WO2000024770A2 (en) 1998-10-23 1999-10-22 Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity

Publications (3)

Publication Number Publication Date
NO20011962D0 NO20011962D0 (no) 2001-04-20
NO20011962L NO20011962L (no) 2001-06-21
NO331027B1 true NO331027B1 (no) 2011-09-12

Family

ID=22305310

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20011962A NO331027B1 (no) 1998-10-23 2001-04-20 Forbindelse som bindes til en mpl-reseptor, dimer, polynukleotid, vektor, vertscelle, fremgangsmate for fremstilling av en forbindelse, anvendelse av en forbindelse for fremstilling av et medikament, samt farmasoytisk preparat.
NO2012005C NO2012005I2 (no) 1998-10-23 2012-03-12 Romiplostim

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2012005C NO2012005I2 (no) 1998-10-23 2012-03-12 Romiplostim

Country Status (36)

Country Link
US (8) US6835809B1 (sr)
EP (3) EP2319928B9 (sr)
JP (2) JP3820105B2 (sr)
KR (1) KR100719202B1 (sr)
CN (2) CN1250721C (sr)
AR (1) AR020934A1 (sr)
AT (1) ATE348163T1 (sr)
AU (1) AU773891C (sr)
BG (3) BG110221A (sr)
BR (1) BRPI9914698B8 (sr)
CA (1) CA2346996C (sr)
CY (4) CY1107526T1 (sr)
CZ (1) CZ302155B6 (sr)
DE (2) DE69934425T2 (sr)
DK (3) DK1124961T3 (sr)
EA (1) EA003998B1 (sr)
ES (3) ES2279649T3 (sr)
FR (1) FR09C0030I2 (sr)
HK (2) HK1042114B (sr)
HU (1) HU228582B1 (sr)
IL (1) IL142023A0 (sr)
LT (1) LTC1124961I2 (sr)
LU (1) LU91598I2 (sr)
ME (2) MEP42108A (sr)
MY (1) MY126795A (sr)
NL (1) NL300398I2 (sr)
NO (2) NO331027B1 (sr)
NZ (1) NZ510529A (sr)
PL (1) PL219605B1 (sr)
PT (3) PT2319928E (sr)
RS (1) RS51237B (sr)
SI (3) SI2319928T1 (sr)
SK (1) SK287737B6 (sr)
TW (2) TWI250988B (sr)
WO (1) WO2000024770A2 (sr)
ZA (1) ZA200102102B (sr)

Families Citing this family (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091311B2 (en) * 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
MY126795A (en) 1998-10-23 2006-10-31 Amgen K A Inc Dimeric thrombopoietic peptide mimetics binding to mp1 receptor and having thrombopoietic activity.
US6808902B1 (en) * 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
EP1274730A2 (en) * 2000-04-21 2003-01-15 Amgen, Inc. Integrin/adhesion antagonists
US20020090646A1 (en) * 2000-05-03 2002-07-11 Amgen Inc. Calcitonin-related molecules
WO2001095942A2 (en) * 2000-06-09 2001-12-20 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates
ES2258558T3 (es) * 2000-12-05 2006-09-01 Alexion Pharmaceuticals, Inc. Anticuerpos diseñados racionalmente.
US7396917B2 (en) * 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
US20040018203A1 (en) * 2001-06-08 2004-01-29 Ira Pastan Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates
CA2457164A1 (en) 2001-08-17 2003-02-27 Enkam Pharmaceuticals A/S Compounds capable of affecting differentiation, proliferation, regeneration, plasticity and survival of cells
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
BR0314591A (pt) * 2002-09-18 2005-08-09 Ortho Mcneil Pharm Inc Métodos de aumento de plaquetas e produção de célula tronco hematopoiética
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
PL1629007T3 (pl) 2003-05-12 2009-09-30 Affymax Inc Nowe peptydy wiążące się z receptorem erytropoetyny
EP1625156B1 (en) 2003-05-12 2012-09-19 Affymax, Inc. Peptides that bind to the erythropoietin receptor
EA010016B1 (ru) * 2003-05-12 2008-06-30 Афимакс, Инк. Новые модифицированные полиэтиленгликолем соединения и их применение
BRPI0411166A (pt) * 2003-05-12 2006-07-18 Affymax Inc composto compreendendo uma parcela de peptìdeo, uma parcela espaçadora e uma parcela de polìmero solúvel em água e composição farmacêutica compreendendo tal composto
MXPA06015234A (es) * 2004-06-30 2007-11-22 Nektar Therapeutics Al Corp Conjugados de fraccion polimero-factor ix.
EP1773400A2 (en) * 2004-07-08 2007-04-18 Amgen Inc. Therapeutic peptides
US7550433B2 (en) 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
CA2648732A1 (en) * 2005-06-23 2006-12-28 Aplagen Gmbh Supravalent compounds
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
WO2007075899A2 (en) * 2005-12-21 2007-07-05 Maxygen, Inc. Dual agonist compounds and uses thereof
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
EP1986677A2 (en) * 2006-01-25 2008-11-05 Amgen Inc. Thrombopoietic compounds
JO3324B1 (ar) 2006-04-21 2019-03-13 Amgen Inc مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
US8173427B2 (en) 2006-07-24 2012-05-08 The University Of Queensland Method of producing a population of post-mitotic cells of the neutrophil lineage
JP2010520855A (ja) 2007-01-31 2010-06-17 アフィーマックス・インコーポレイテッド 修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー
EP2738257A1 (en) 2007-05-22 2014-06-04 Amgen Inc. Compositions and methods for producing bioactive fusion proteins
WO2008157824A2 (en) * 2007-06-21 2008-12-24 Conjuchem Biotechnologies Inc. Thrombopoietin peptide conjugates
US20110097318A1 (en) * 2007-08-31 2011-04-28 Amgen Inc. Solid-State Protein Formulation
US8383114B2 (en) 2007-09-27 2013-02-26 Amgen Inc. Pharmaceutical formulations
WO2009064838A1 (en) 2007-11-15 2009-05-22 Amgen, Inc. Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration
ES2559634T3 (es) 2007-11-28 2016-02-15 Enkam Pharmaceuticals A/S Péptidos derivados de NCAM (FGLs)
CA2755336C (en) 2009-03-20 2015-07-14 Amgen Inc. Carrier immunoglobulins and uses thereof
KR101431318B1 (ko) 2009-04-02 2014-08-20 로슈 글리카트 아게 전장 항체 및 단일쇄 ｆａｂ 단편을 포함하는 다중특이성 항체
NZ598962A (en) 2009-09-16 2014-12-24 Genentech Inc Coiled coil and/or tether containing protein complexes and uses thereof
US20120253009A1 (en) * 2009-10-16 2012-10-04 Amgen Inc. Thrombopoietic compounds
US9662271B2 (en) 2009-10-23 2017-05-30 Amgen Inc. Vial adapter and system
WO2011098095A1 (en) 2010-02-09 2011-08-18 Aplagen Gmbh Peptides binding the tpo receptor
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
TW201742925A (zh) 2010-04-23 2017-12-16 建南德克公司 異多聚體蛋白質之製造
SI2575935T2 (sl) 2010-06-07 2023-12-29 Amgen Inc. Naprava za dajanje zdravila
BR112013003279A2 (pt) 2010-08-13 2016-06-14 Genentech In “métodos para tratar uma doença, método para neutralizar ou bloquear a atividade de il-1ß e/ou il-18, anticorpo, usos de um anticorpo e usos de um anticorpo monoclonal”
KR101586128B1 (ko) 2010-08-24 2016-01-15 에프. 호프만-라 로슈 아게 디술피드 안정화 ― Ｆｖ 단편을 포함하는 이중특이적 항체
EA201370076A1 (ru) 2010-09-22 2013-08-30 Амген Инк. Иммуноглобулины-переносчики и их применение
EP2655413B1 (en) 2010-12-23 2019-01-16 F.Hoffmann-La Roche Ag Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
EP2670776B1 (en) 2011-02-04 2018-11-21 F. Hoffmann-La Roche AG Fc VARIANTS AND METHODS FOR THEIR PRODUCTION
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
AU2012236573B2 (en) 2011-03-31 2016-06-02 Amgen Inc. Vial adapter and system
HUE042822T2 (hu) 2011-04-20 2019-07-29 Amgen Inc Automata befecskendezõ szerkezet
RU2654567C2 (ru) 2011-10-11 2018-05-21 Дженентек, Инк. Улучшенная сборка биспецифических антител
IL301153B2 (en) 2011-10-14 2024-05-01 Amgen Inc Syringe and assembly method
WO2013119966A2 (en) 2012-02-10 2013-08-15 Genentech, Inc. Single-chain antibodies and other heteromultimers
CN102552184A (zh) * 2012-02-16 2012-07-11 山东泉港药业有限公司 一种血小板生成素拟肽冻干制剂
MX2014014804A (es) 2012-06-27 2015-02-12 Hoffmann La Roche Metodo para la elaboracion de conjugados de la region fc de anticuerpos que comprenden por lo menos una entidad de union que se une especificamente a un objetivo y usos del mismo.
WO2014001324A1 (en) 2012-06-27 2014-01-03 Hoffmann-La Roche Ag Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof
CA3206182A1 (en) 2012-11-21 2014-05-30 Amgen Inc. Drug delivery device including insertion member and reservoir
CN104046642B (zh) * 2013-03-15 2018-07-06 兰州大学 发酵生产二聚体化融合蛋白的方法
CN104045715B (zh) * 2013-03-15 2018-05-01 兰州大学 二聚体化融合蛋白的制备及应用
JP6336564B2 (ja) 2013-03-15 2018-06-06 アムゲン・インコーポレーテッド 薬物カセット、自動注入器、および自動注入器システム
EP2968775B1 (en) 2013-03-15 2019-12-18 Amgen Inc. Drug cassette, autoinjector, and autoinjector system
IL292270B2 (en) 2013-03-22 2024-04-01 Amgen Inc Injector and assembly method
MX2016005312A (es) 2013-10-24 2016-08-11 Amgen Inc Inyector y metodo de montaje.
EP3501575B1 (en) 2013-10-24 2021-12-01 Amgen Inc. Drug delivery system with temperature-sensitive-control
US10994112B2 (en) 2014-02-05 2021-05-04 Amgen Inc. Drug delivery system with electromagnetic field generator
CN105017408B (zh) * 2014-04-30 2019-11-05 重庆派金生物科技有限公司 聚乙二醇化血小板生成素模拟肽同源四聚体及其用途
ES2955736T3 (es) 2014-05-06 2023-12-05 Hoffmann La Roche Producción de proteínas heteromultiméricas usando células de mamífero
EP3785749A1 (en) 2014-05-07 2021-03-03 Amgen Inc. Autoinjector with shock reducing elements
CN106470717B (zh) 2014-06-03 2020-09-11 安姆根有限公司 药物递送系统和使用方法
WO2015199039A1 (ja) * 2014-06-23 2015-12-30 東亞合成株式会社 細胞の多核化を誘導するペプチドおよびその利用
TN2017000109A1 (en) * 2014-09-26 2018-07-04 Bayer Pharma AG Stabilized adrenomedullin derivatives and use thereof
EP3943135A3 (en) 2014-10-14 2022-06-29 Amgen Inc. Drug injection device with visual and audible indicators
CN107001482B (zh) 2014-12-03 2021-06-15 豪夫迈·罗氏有限公司 多特异性抗体
EP3848072A1 (en) 2014-12-19 2021-07-14 Amgen Inc. Drug delivery device with proximity sensor
US11357916B2 (en) 2014-12-19 2022-06-14 Amgen Inc. Drug delivery device with live button or user interface field
JP6730705B2 (ja) * 2015-02-12 2020-07-29 国立大学法人岩手大学 哺乳動物細胞に対する外来遺伝子の導入効率の向上剤
CA2976935C (en) 2015-02-17 2020-03-10 Amgen Inc. Drug delivery device with vacuum assisted securement and/or feedback
JP2018512184A (ja) 2015-02-27 2018-05-17 アムジエン・インコーポレーテツド 針ガードの移動に対する抵抗力の閾値が調整可能な針ガード機構を備えた薬物送達装置
WO2017039786A1 (en) 2015-09-02 2017-03-09 Amgen Inc. Syringe assembly adapter for a syringe
JP7082568B2 (ja) 2015-12-09 2022-06-08 アムジエン・インコーポレーテツド 信号伝達キャップ付き自動注射器
WO2017120178A1 (en) 2016-01-06 2017-07-13 Amgen Inc. Auto-injector with signaling electronics
US11200298B2 (en) 2016-03-15 2021-12-14 Amgen Inc. Reducing probability of glass breakage in drug delivery devices
US11541168B2 (en) 2016-04-29 2023-01-03 Amgen Inc. Drug delivery device with messaging label
WO2017192287A1 (en) 2016-05-02 2017-11-09 Amgen Inc. Syringe adapter and guide for filling an on-body injector
CA3018426A1 (en) 2016-05-13 2017-11-16 Amgen Inc. Vial sleeve assembly
US11238150B2 (en) 2016-05-16 2022-02-01 Amgen Inc. Data encryption in medical devices with limited computational capability
WO2017209899A1 (en) 2016-06-03 2017-12-07 Amgen Inc. Impact testing apparatuses and methods for drug delivery devices
US11285266B2 (en) 2016-07-01 2022-03-29 Amgen Inc. Drug delivery device having minimized risk of component fracture upon impact events
WO2018034784A1 (en) 2016-08-17 2018-02-22 Amgen Inc. Drug delivery device with placement detection
US20200261643A1 (en) 2016-10-25 2020-08-20 Amgen Inc. On-body injector
CN108264547B (zh) * 2016-12-30 2021-09-21 四川科伦博泰生物医药股份有限公司 一种纯化蛋白的方法以及试剂盒
MX2019008432A (es) 2017-01-17 2019-11-18 Amgen Inc Dispositivos de inyeccion y metodos relacionados de uso y ensamblaje.
AU2018221351B2 (en) 2017-02-17 2023-02-23 Amgen Inc. Insertion mechanism for drug delivery device
EP3582825A1 (en) 2017-02-17 2019-12-25 Amgen Inc. Drug delivery device with sterile fluid flowpath and related method of assembly
JP2020508803A (ja) 2017-03-06 2020-03-26 アムジエン・インコーポレーテツド 作動防止特徴部を備える薬物送達デバイス
EP3592402A1 (en) 2017-03-07 2020-01-15 Amgen Inc. Needle insertion by overpressure
AU2018230486B2 (en) 2017-03-09 2023-05-11 Amgen Inc. Insertion mechanism for drug delivery device
KR102517342B1 (ko) 2017-03-28 2023-03-31 암겐 인코포레이티드 플런저 로드 및 주사기 조립 시스템 및 방법
US11590294B2 (en) 2017-06-08 2023-02-28 Amgen Inc. Syringe assembly for a drug delivery device and method of assembly
JP7200134B2 (ja) 2017-06-08 2023-01-06 アムジエン・インコーポレーテツド トルク駆動式薬物送達デバイス
EP3641857A1 (en) 2017-06-22 2020-04-29 Amgen Inc. Device activation impact/shock reduction
US11395880B2 (en) 2017-06-23 2022-07-26 Amgen Inc. Electronic drug delivery device
WO2019014014A1 (en) 2017-07-14 2019-01-17 Amgen Inc. NEEDLE INSERTION-RETRACTING SYSTEM HAVING DOUBLE TORSION SPRING SYSTEM
IL271173B2 (en) 2017-07-21 2024-04-01 Amgen Inc Gas permeable sealing element for drug container and methods of assembly
JP2020528296A (ja) 2017-07-25 2020-09-24 アムジエン・インコーポレーテツド ギヤモジュールを有する薬物送達デバイス及び関連する組立方法
EP3658206A1 (en) 2017-07-25 2020-06-03 Amgen Inc. Drug delivery device with container access system and related method of assembly
WO2019032482A2 (en) 2017-08-09 2019-02-14 Amgen Inc. HYDRAULIC-PNEUMATIC PRESSURE CHAMBER DELIVERY SYSTEM
WO2019036181A1 (en) 2017-08-18 2019-02-21 Amgen Inc. BODY INJECTOR WITH STERILE ADHESIVE PATCH
US11103636B2 (en) 2017-08-22 2021-08-31 Amgen Inc. Needle insertion mechanism for drug delivery device
US11759565B2 (en) 2017-10-04 2023-09-19 Amgen Inc. Flow adapter for drug delivery device
EP3691716B1 (en) 2017-10-06 2023-11-29 Amgen Inc. Drug delivery device with interlock assembly and related method of assembly
EP3694578A1 (en) 2017-10-09 2020-08-19 Amgen Inc. Drug delivery device with drive assembly and related method of assembly
EP3703779A1 (en) 2017-11-03 2020-09-09 Amgen Inc. Systems and approaches for sterilizing a drug delivery device
EP3706830B1 (en) 2017-11-06 2024-08-07 Amgen Inc. Drug delivery device with placement and flow sensing
EP3707075A1 (en) 2017-11-06 2020-09-16 Amgen Inc. Fill-finish assemblies and related methods
JP7247174B2 (ja) 2017-11-10 2023-03-28 アムジエン・インコーポレーテツド 薬物送達デバイスのプランジャ
MA50903A (fr) 2017-11-16 2021-05-12 Amgen Inc Auto-injecteur avec détection de décrochage et de point d'extrémité
CA3079540A1 (en) 2017-11-16 2019-05-23 Amgen Inc. Door latch mechanism for drug delivery device
US10835685B2 (en) 2018-05-30 2020-11-17 Amgen Inc. Thermal spring release mechanism for a drug delivery device
US11083840B2 (en) 2018-06-01 2021-08-10 Amgen Inc. Modular fluid path assemblies for drug delivery devices
EP3586860A1 (en) * 2018-06-22 2020-01-01 Universität Ulm Complement inhibitors and uses thereof
WO2020023336A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Hybrid drug delivery devices with grip portion
MX2021000748A (es) 2018-07-24 2021-03-26 Amgen Inc Dispositivos de suministro para administrar farmacos.
EP3826699A1 (en) 2018-07-24 2021-06-02 Amgen Inc. Delivery devices for administering drugs
WO2020023220A1 (en) 2018-07-24 2020-01-30 Amgen Inc. Hybrid drug delivery devices with tacky skin attachment portion and related method of preparation
MA53320A (fr) 2018-07-31 2021-11-03 Amgen Inc Ensemble de trajet de fluide pour dispositif d'administration de médicament
US20210346601A1 (en) 2018-09-24 2021-11-11 Amgen Inc. Interventional dosing systems and methods
US12042642B2 (en) 2018-09-28 2024-07-23 Amgen Inc. Muscle wire escapement activation assembly for a drug delivery device
TW202027806A (zh) 2018-10-02 2020-08-01 美商安進公司 具有內部力傳遞的用於藥物遞送之注射系統
MX2021003491A (es) 2018-10-05 2021-06-18 Amgen Inc Dispositivo de administracion de farmacos con indicador de dosis.
MX2021004219A (es) 2018-10-15 2021-05-27 Amgen Inc Dispositivo de administracion de farmacos con mecanismo de amortiguacion.
CN112689523A (zh) 2018-10-15 2021-04-20 安进公司 用于药物递送装置的平台组装方法
BR112021007710A2 (pt) 2018-10-26 2021-08-10 Kyowa Kirin Co., Ltd. composição farmacêutica para tratar anemia aplástica
AU2019370159A1 (en) 2018-11-01 2021-04-22 Amgen Inc. Drug delivery devices with partial drug delivery member retraction
TWI831847B (zh) 2018-11-01 2024-02-11 美商安進公司 部分針頭縮回之藥物遞送裝置及其操作方法
US11213620B2 (en) 2018-11-01 2022-01-04 Amgen Inc. Drug delivery devices with partial drug delivery member retraction
JP7510952B2 (ja) 2019-04-24 2024-07-04 アムジエン・インコーポレーテツド シリンジ滅菌確認アセンブリ及び方法
JP2022545227A (ja) 2019-08-23 2022-10-26 アムジエン・インコーポレーテツド 構成可能な針シールド係合構成要素を備えた薬物送達デバイス及び関連方法
WO2022129460A1 (en) 2020-12-18 2022-06-23 Richter Gedeon Nyrt. Methods for the purification of refolded fc-peptide fusion protein
CN113402614A (zh) * 2021-04-22 2021-09-17 山东泉港药业有限公司 血小板生成素拟肽融合蛋白(fc-tmp)编码基因与应用
WO2022246055A1 (en) 2021-05-21 2022-11-24 Amgen Inc. Method of optimizing a filling recipe for a drug container
WO2023044774A1 (en) * 2021-09-24 2023-03-30 Sichuan Clover Biopharmaceuticals, Inc. Tpo mimetic fusion proteins and methods of use submission of sequence listing as ascii text file
AU2023241233A1 (en) 2022-03-24 2024-08-15 Richter Gedeon Nyrt. Method for the manufacture of biopharmaceuticals
WO2024036324A1 (en) 2022-08-11 2024-02-15 Selecta Biosciences, Inc. Compositions and methods related to immunoglobulin proteases and fusions thereof
CN117986346B (zh) * 2024-04-07 2024-07-26 中国人民解放军军事科学院军事医学研究院 一种tpo模拟肽及其应用

Family Cites Families (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7012859A (sr) * 1969-09-01 1971-03-03
US3691016A (en) 1970-04-17 1972-09-12 Monsanto Co Process for the preparation of insoluble enzymes
CA1023287A (en) 1972-12-08 1977-12-27 Boehringer Mannheim G.M.B.H. Process for the preparation of carrier-bound proteins
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US3941763A (en) 1975-03-28 1976-03-02 American Home Products Corporation PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
US4002531A (en) 1976-01-22 1977-01-11 Pierce Chemical Company Modifying enzymes with polyethylene glycol and product produced thereby
US4195128A (en) 1976-05-03 1980-03-25 Bayer Aktiengesellschaft Polymeric carrier bound ligands
US4330440A (en) 1977-02-08 1982-05-18 Development Finance Corporation Of New Zealand Activated matrix and method of activation
CA1093991A (en) 1977-02-17 1981-01-20 Hideo Hirohara Enzyme immobilization with pullulan gel
US4229537A (en) 1978-02-09 1980-10-21 New York University Preparation of trichloro-s-triazine activated supports for coupling ligands
US4289872A (en) 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4503235A (en) 1983-03-11 1985-03-05 Warner-Lambert Company Process for producing 4-carbamoyl-1H-imidazolium-5-olate
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
EP0154316B1 (en) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Chemically modified lymphokine and production thereof
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
US5017691A (en) * 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US5985599A (en) 1986-05-29 1999-11-16 The Austin Research Institute FC receptor for immunoglobulin
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
AU610083B2 (en) 1986-08-18 1991-05-16 Clinical Technologies Associates, Inc. Delivery systems for pharmacological agents
US5229490A (en) 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
US5336603A (en) 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
ATE106249T1 (de) 1987-11-05 1994-06-15 Hybritech Inc Polysaccharidmodifizierte immunglobuline mit reduziertem immunogenem potential oder verbesserter pharmakokinetik.
US4904584A (en) 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
DE68926888T2 (de) 1988-01-22 1997-01-09 Zymogenetics Inc Verfahren zur Herstellung von sekretierten Rezeptoranalogen
CA1340810C (en) 1988-03-31 1999-11-02 Motoo Yamasaki Polypeptide derivatives of human granulocyte colony stimulating factor
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8824591D0 (en) 1988-10-20 1988-11-23 Royal Free Hosp School Med Fractionation process
CA2006596C (en) 1988-12-22 2000-09-05 Rika Ishikawa Chemically-modified g-csf
EP0452364B1 (en) 1988-12-22 2002-05-22 Genentech, Inc. Method for preparing water soluble polypeptides
US4902502A (en) 1989-01-23 1990-02-20 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
US5089261A (en) 1989-01-23 1992-02-18 Cetus Corporation Preparation of a polymer/interleukin-2 conjugate
US5098833A (en) 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5216131A (en) 1989-02-23 1993-06-01 Genentech, Inc. Lymphocyte homing receptors
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
US5627262A (en) 1989-07-05 1997-05-06 The Board Of Regents Of The University Of Oklahoma Method and composition for the treatment of septic shock
EP0417563B1 (de) 1989-09-12 2000-07-05 F. Hoffmann-La Roche Ag TNF-bindende Proteine
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
JPH04218000A (ja) 1990-02-13 1992-08-07 Kirin Amgen Inc 修飾ポリペプチド
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
CA2109602C (en) 1990-07-10 2002-10-01 Gregory P. Winter Methods for producing members of specific binding pairs
ATE224911T1 (de) 1990-07-17 2002-10-15 Univ Oklahoma Gmp-140 ligand
IE912365A1 (en) 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
NZ241954A (en) 1991-03-15 1994-01-26 Amgen Inc Compositions of g-csf for pulmonary administration.
CA2106079C (en) 1991-03-15 2000-04-25 Robert C. Thompson Pegylation of polypeptides
US5595732A (en) 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
US6139843A (en) 1991-04-02 2000-10-31 Albert Einstein College Of Medicine Of Yeshiva University Peptide compositions for the treatment of HIV
US5281698A (en) 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
US5362852A (en) 1991-09-27 1994-11-08 Pfizer Inc. Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5733731A (en) 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
NZ244778A (en) 1991-10-21 1994-03-25 Ortho Pharma Corp Peg imidates and protein derivatives thereof
DK0667901T4 (da) * 1991-10-25 2008-11-10 Immunex Corp Hidtil ukendt cytokin
US5376367A (en) 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
WO1993021259A1 (en) 1992-04-14 1993-10-28 Cornell Research Foundation Inc. Dendritic based macromolecules and method of production
WO1993024135A1 (en) 1992-05-26 1993-12-09 Immunex Corporation Novel cytokine that binds cd30
US5792451A (en) 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
EP0671926B1 (en) 1992-08-11 2002-11-13 President And Fellows Of Harvard College Immunomodulatory peptides
US5844094A (en) * 1992-09-25 1998-12-01 Commonwealth Scientific And Industrial Research Organization Target binding polypeptide
GB9225448D0 (en) 1992-12-04 1993-01-27 Erba Carlo Spa Improved synthesis of polymer bioactive conjugates
NZ247231A (en) * 1993-03-23 1994-10-26 Holyoake Ind Ltd Diffuser for air conditioning system; outlet air direction thermostatically controlled
WO1995009917A1 (en) 1993-10-07 1995-04-13 The Regents Of The University Of California Genetically engineered bispecific tetravalent antibodies
US5922545A (en) 1993-10-29 1999-07-13 Affymax Technologies N.V. In vitro peptide and antibody display libraries
US5773569A (en) 1993-11-19 1998-06-30 Affymax Technologies N.V. Compounds and peptides that bind to the erythropoietin receptor
US5981478A (en) 1993-11-24 1999-11-09 La Jolla Cancer Research Foundation Integrin-binding peptides
GB2285446B (en) 1994-01-03 1999-07-28 Genentech Inc Thrombopoietin
US5608035A (en) 1994-02-02 1997-03-04 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5880096A (en) 1994-02-02 1999-03-09 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
US5786331A (en) 1994-02-02 1998-07-28 Affymax Technologies N.V. Peptides and compounds that bind to the IL-1 receptor
EP0695355A1 (en) * 1994-02-14 1996-02-07 Kirin Brewery Company, Ltd. Protein having tpo activity
CA2183266A1 (en) 1994-02-14 1995-08-17 Richard D. Holly Hematopoietic protein and materials and methods for making it
WO1995021919A2 (en) 1994-02-14 1995-08-17 Kirin Brewery Company, Limited Protein having tpo activity
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
DK0690127T3 (da) 1994-03-31 1999-05-03 Amgen Inc Sammensætninger og fremgangsmåder til stimulering af megakaryocytvækst og -differentiering
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
IL111196A0 (en) 1994-10-07 1994-12-29 Yeda Res & Dev Peptides and pharmaceutical compositions comprising them
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
AU693478B2 (en) 1994-11-10 1998-07-02 Metabolic Pharmaceuticals Limited Treatment of obesity
IL116026A (en) 1994-11-22 2005-08-31 Rhone Poulenc Rorer Sa Peptides capable of linking to the sh3 domain of gap, nucleotide sequences encoding the same, their preparation and uses
JP3511321B2 (ja) * 1994-11-29 2004-03-29 出光興産株式会社 スチレン系重合体の分子量制御方法
US5641655A (en) * 1994-11-30 1997-06-24 Zymogenetics, Inc. Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide
CA2206848A1 (en) 1994-12-07 1996-06-13 Bionebraska, Inc. Production of peptides using recombinant fusion protein constructs
JPH11501506A (ja) 1994-12-12 1999-02-09 ベス イスラエル デアコネス メディカル センター キメラ型サイトカインおよびその利用
US5888763A (en) 1994-12-30 1999-03-30 The Rockefeller University Peptides specific for the first Crk-SH3 domain
WO1996023899A1 (en) 1995-02-01 1996-08-08 University Of Massachusetts Medical Center Methods of selecting a random peptide that binds to a target protein
IL113159A0 (en) 1995-03-28 1995-06-29 Yeda Res & Dev Synthetic peptides and pharmaceutical compositions comprising them
US5739277A (en) 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
US6096871A (en) 1995-04-14 2000-08-01 Genentech, Inc. Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
YU34196A (sh) * 1995-06-07 1999-03-04 Glaxo Group Limited Peptidi i jedinjenja koja se vezuju za receptor
US5767078A (en) 1995-06-07 1998-06-16 Johnson; Dana L. Agonist peptide dimers
EP0885242B1 (en) 1995-06-07 2008-03-26 Glaxo Group Limited Peptides and compounds that bind to a thrombopoietin receptor
US6251864B1 (en) * 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
IL118524A (en) 1995-06-19 2004-02-19 Akzo Nobel Nv Peptides and pharmaceutical preparations containing them useful in the treatment of peptide tolerance
CN102416176A (zh) 1995-07-27 2012-04-18 基因技术股份有限公司 稳定等渗的冻干蛋白质制剂
US5746516A (en) 1995-08-11 1998-05-05 Hitachi Powdered Metals Co., Ltd. Porous bearing system having internal grooves and electric motor provided with the same
WO1997008553A1 (en) 1995-08-22 1997-03-06 The Regents Of The University Of California Targeting of proteins to the cell wall of gram-positive bacteria
US5817750A (en) 1995-08-28 1998-10-06 La Jolla Cancer Research Foundation Structural mimics of RGD-binding sites
JPH09151200A (ja) 1995-09-29 1997-06-10 Ajinomoto Co Inc ヒト胃癌に対する免疫応答を誘導できるペプチド及び該ペプチドを含むヒト胃癌治療、予防剤
US5670110A (en) 1995-12-21 1997-09-23 The Procter & Gamble Company Method for making three-dimensional macroscopically-expanded webs having improved functional surfaces
US6369027B1 (en) 1995-12-22 2002-04-09 Amgen Inc. Osteoprotegerin
CN1154971A (zh) * 1996-01-19 1997-07-23 北京医科大学 血小板生长因子(tpo)及其制备方法和用途
US5714577A (en) 1996-01-26 1998-02-03 University Of Pittsburgh Antimicrobial peptides
ES2334726T3 (es) 1996-02-09 2010-03-15 Amgen Inc. Composicion que comprende il-1ra como inhibidor de interleucina 1 e hialuronano como polimero de liberacion controlada.
IL117223A0 (en) 1996-02-22 1996-06-18 Yeda Res & Dev Antipathogenic polypeptides and compositions comprising them
ATE279947T1 (de) 1996-03-18 2004-11-15 Univ Texas Immunglobulinähnliche domäne mit erhöhten halbwertszeiten
EP0906419A2 (en) 1996-03-28 1999-04-07 Chiron Corporation Peptide ligands of the urokinase receptor
IL118003A0 (en) 1996-04-23 1996-08-04 Yeda Res & Dev Novel vip fragments and pharmaceutical compositions comprising them
FR2748028B1 (fr) 1996-04-30 1998-08-14 Lab Francais Du Fractionnement Peptides derives du facteur von willebrand et leur utilisation comme anticoagulant
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
CA2257108A1 (en) 1996-06-07 1997-12-11 Takeda Chemical Industries, Ltd. Novel peptides and production and use thereof
US6126939A (en) 1996-09-03 2000-10-03 Yeda Research And Development Co. Ltd. Anti-inflammatory dipeptide and pharmaceutical composition thereof
WO1998010795A2 (en) 1996-09-10 1998-03-19 The Burnham Institute Tumor homing molecules, conjugates derived therefrom, and methods of using same
US5932546A (en) 1996-10-04 1999-08-03 Glaxo Wellcome Inc. Peptides and compounds that bind to the thrombopoietin receptor
ATE230850T1 (de) 1996-10-08 2003-01-15 Bisys B V U Verfahren und mittel zur auswahl von peptiden und proteinen mit spezifischer affinität zu einem zielmolekül
JP4771563B2 (ja) 1996-12-06 2011-09-14 アムジエン・インコーポレーテツド Ｉｌ−１媒介疾患を処置するためにｉｌ−１インヒビターを使用する組合せ療法
EA004790B1 (ru) 1996-12-20 2004-08-26 Амген Инк. Композиции на основе слитого белка ов и способы их применения
KR19980066046A (ko) 1997-01-18 1998-10-15 정용훈 고역가의 CTLA4-Ig 융합단백질
WO1998033812A1 (en) 1997-02-05 1998-08-06 Brigham And Women's Hospital, Inc. Mast cell protease peptide inhibitors
US5863735A (en) 1997-02-24 1999-01-26 Incyte Pharmaceuticals, Inc. Human transmembrane 4 superfamily protein
EP0975754B2 (en) 1997-04-16 2016-01-06 Amgen Inc., Osteoprotegerin binding proteins and their receptors
CN1202862C (zh) 1997-04-17 2005-05-25 安姆根有限公司 包含具有抗体Fc链的稳定、有活性人OB蛋白的结合物的组合物及方法
US6265535B1 (en) 1997-05-30 2001-07-24 The Trustees Of The University Of Pennsylvania Peptides and peptide analogues designed from binding sites of tumor necrosis factor receptor superfamily and their uses
AU743490B2 (en) 1997-06-06 2002-01-24 Regeneron Pharmaceuticals, Inc. NTN-2 member of TNF ligand family
WO1999005302A1 (en) 1997-07-24 1999-02-04 The Perkin-Elmer Corporation Conjugates of transporter peptides and nucleic acid analogs, and their use
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
US6238667B1 (en) 1997-09-19 2001-05-29 Heinz Kohler Method of affinity cross-linking biologically active immunogenic peptides to antibodies
AU9790798A (en) 1997-10-06 1999-04-27 Millennium Pharmaceuticals, Inc. Signal peptide containing proteins and uses therefor
JP4439111B2 (ja) 1997-10-10 2010-03-24 サイトビア インコーポレイテッド ジペプチドのアポトーシスインヒビターおよびそれらの使用
DE69812727D1 (de) 1997-11-07 2003-04-30 Conjuchem Inc Opioid-konjugate mit endogenen Trägerproteinen
WO1999038526A1 (en) 1998-01-29 1999-08-05 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Variant peptide ligands that selectively induce apoptosis
US6162613A (en) 1998-02-18 2000-12-19 Vertex Pharmaceuticals, Inc. Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases
JP2002505338A (ja) 1998-03-05 2002-02-19 カイロン コーポレイション 生物学的に活性な分子の血清半減期を増加するための方法
US6235872B1 (en) 1998-03-12 2001-05-22 The Burnham Institute Proapoptotic peptides dependence polypeptides and methods of use
AU3189299A (en) 1998-03-20 1999-10-11 Chugai Pharmaceutical Co., Ltd. Peptide ligands for the erythropoietin receptor
EP0947524A1 (en) 1998-03-30 1999-10-06 Upither B.V. Novel peptides for the treatment of autoimmune diseases
AU744044B2 (en) 1998-04-06 2002-02-14 Advanced Immunit, Inc. Short peptides for treatment of neurological degenerative diseases
JP2002512982A (ja) 1998-04-28 2002-05-08 アプライド・リサーチ・システムズ・エイアールエス・ホールディング・ナムローゼ・フェンノートシャップ Ｐｅｇ−ｌｈｒｈアナログ複合体
EP0972780A1 (en) 1998-05-18 2000-01-19 Applied Research Systems ARS Holding N.V. Il-6 antagonist peptides
ATE267018T1 (de) 1998-05-21 2004-06-15 Tecnogen Scpa Verwendung von peptidverbindungen zur behandlung von sle
AU764277B2 (en) 1998-05-22 2003-08-14 Abbvie Inc. Peptide antiangiogenic drugs
US5932548A (en) 1998-06-03 1999-08-03 Deghenghi; Romano Lysine containing peptides for treatment of heart disease
WO2000001402A1 (en) 1998-07-02 2000-01-13 Envision Biomedical Consulting Antiproliferative and antiviral proteins and peptides
US6168785B1 (en) 1998-07-16 2001-01-02 Institut Pasteur Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents
US20020142374A1 (en) 1998-08-17 2002-10-03 Michael Gallo Generation of modified molecules with increased serum half-lives
WO2000011028A2 (en) 1998-08-21 2000-03-02 Yeda Research And Development Co. Ltd. Anti-inflammatory peptides derived from il-2 and analogues thereof
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
MY126795A (en) 1998-10-23 2006-10-31 Amgen K A Inc Dimeric thrombopoietic peptide mimetics binding to mp1 receptor and having thrombopoietic activity.
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
WO2000047740A2 (en) 1999-02-12 2000-08-17 Amgen Inc. Tnf-related proteins
US6635646B1 (en) 1999-05-04 2003-10-21 Schering Corporation Pegylated interferon alfa-CCR5 antagonist combination HIV therapy
JP2003505020A (ja) 1999-07-02 2003-02-12 ジェネンテック・インコーポレーテッド ペプチドリガンドドメイン及び多量体化ドメインを含む融合ペプチド
US6586398B1 (en) 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
CA2407956A1 (en) 2000-05-03 2001-11-08 Amgen Inc. Modified peptides as therapeutic agents
US7396917B2 (en) 2000-12-05 2008-07-08 Alexion Pharmaceuticals, Inc. Rationally designed antibodies
ES2258558T3 (es) 2000-12-05 2006-09-01 Alexion Pharmaceuticals, Inc. Anticuerpos diseñados racionalmente.
AU2002307062A1 (en) 2001-04-02 2002-10-15 Purdue Pharma L.P. Thrombopoietin (tpo) synthebody for stimulation of platelet production
US7205275B2 (en) 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
WO2004002417A2 (en) 2002-06-28 2004-01-08 Centocor, Inc. Mammalian ch1 deleted mimetibodies, compositions, methods and uses
US7241733B2 (en) 2002-06-28 2007-07-10 Centocor, Inc. Mammalian EPO mimetic CH1 deleted mimetibodies, compositions, methods and uses
US6919426B2 (en) 2002-09-19 2005-07-19 Amgen Inc. Peptides and related molecules that modulate nerve growth factor activity
AU2003291689A1 (en) 2002-10-31 2004-05-25 Protein Design Labs, Inc. Stable liquid pharmaceutical formulation of antibodies that are prone to isomerization
EA009056B1 (ru) 2002-12-20 2007-10-26 Амген, Инк. Связывающие агенты, ингибирующие миостатин
CN1871022B (zh) 2003-08-28 2011-07-06 奥索-麦克尼尔药品公司 结合血小板生成素受体的肽和化合物
EP1773400A2 (en) 2004-07-08 2007-04-18 Amgen Inc. Therapeutic peptides
BRPI0516011A (pt) 2004-09-24 2008-08-19 Amgen Inc moléculas fc modificadas
US8258258B2 (en) 2005-03-10 2012-09-04 Biontech Ag Dimeric or multimeric microproteins
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
EP1986677A2 (en) 2006-01-25 2008-11-05 Amgen Inc. Thrombopoietic compounds
JO3324B1 (ar) 2006-04-21 2019-03-13 Amgen Inc مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
US8197642B2 (en) * 2007-07-26 2012-06-12 Nichiha Corporation Inorganic board and method for manufacturing the same
US10534898B2 (en) 2017-01-18 2020-01-14 International Business Machines Corporation Code identification

Also Published As

Publication number Publication date
ES2279649T3 (es) 2007-08-16
LTPA2009006I1 (lt) 2022-03-10
MY126795A (en) 2006-10-31
EP2319928A1 (en) 2011-05-11
EP1124961A2 (en) 2001-08-22
US7994117B2 (en) 2011-08-09
KR20010099695A (ko) 2001-11-09
NL300398I1 (nl) 2009-10-01
NO2012005I2 (no) 2015-02-02
PT2319928E (pt) 2013-06-28
US20090186822A1 (en) 2009-07-23
FR09C0030I1 (fr) 2009-09-25
BR9914698B1 (pt) 2014-04-29
NO2012005I1 (no) 2012-04-02
ZA200102102B (en) 2001-11-15
CN1810832A (zh) 2006-08-02
NO20011962D0 (no) 2001-04-20
FR09C0030I2 (fr) 2010-12-31
PL219605B1 (pl) 2015-06-30
DK1124961T3 (da) 2007-04-10
SI1124961T1 (sl) 2007-06-30
AU1223900A (en) 2000-05-15
AU773891C (en) 2005-02-17
LU91598I2 (fr) 2009-09-30
BRPI9914698B8 (pt) 2021-05-25
KR100719202B1 (ko) 2007-05-16
ATE348163T1 (de) 2007-01-15
US8618044B2 (en) 2013-12-31
PL348041A1 (en) 2002-05-06
DE69934425D1 (en) 2007-01-25
TW200606175A (en) 2006-02-16
AU773891B2 (en) 2004-06-10
US20050080014A1 (en) 2005-04-14
JP2002536960A (ja) 2002-11-05
MEP42108A (en) 2011-02-10
TWI257394B (en) 2006-07-01
US20070142295A1 (en) 2007-06-21
US20150024431A1 (en) 2015-01-22
RS51237B (sr) 2010-12-31
HUP0104327A2 (hu) 2002-02-28
US20060189531A1 (en) 2006-08-24
AR020934A1 (es) 2002-06-05
LU91598I9 (sr) 2019-01-03
US9534032B2 (en) 2017-01-03
ME00238B (me) 2011-02-10
EP1124961B9 (en) 2010-07-21
BG65663B1 (bg) 2009-05-29
NZ510529A (en) 2003-10-31
HU228582B1 (en) 2013-04-29
US20120208760A1 (en) 2012-08-16
SK287737B6 (sk) 2011-08-04
CZ20011287A3 (cs) 2001-10-17
US6835809B1 (en) 2004-12-28
EP2319928B1 (en) 2013-03-27
CZ302155B6 (cs) 2010-11-18
HK1093075A1 (en) 2007-02-23
CA2346996A1 (en) 2000-05-04
EP1783222B1 (en) 2012-06-06
ES2388341T3 (es) 2012-10-11
BG105401A (en) 2003-02-28
DE122009000039I1 (de) 2009-11-05
DK1783222T3 (da) 2012-07-09
EA200100465A1 (ru) 2001-10-22
CN1325447A (zh) 2001-12-05
YU24301A (sh) 2005-07-19
HK1042114B (zh) 2006-09-29
EP1783222A1 (en) 2007-05-09
DK2319928T3 (da) 2013-06-24
CY1107526T1 (el) 2010-07-28
JP4332163B2 (ja) 2009-09-16
JP3820105B2 (ja) 2006-09-13
WO2000024770A3 (en) 2000-09-14
SI1783222T1 (en) 2012-09-28
CA2346996C (en) 2013-11-19
PT1783222E (pt) 2012-07-26
EA003998B1 (ru) 2003-12-25
US8044174B2 (en) 2011-10-25
JP2006230413A (ja) 2006-09-07
IL142023A0 (en) 2002-03-10
CN1250721C (zh) 2006-04-12
EP1124961B1 (en) 2006-12-13
EP2319928B9 (en) 2014-04-16
CN1810832B (zh) 2012-12-12
ES2422231T3 (es) 2013-09-09
TWI250988B (en) 2006-03-11
BG110221A (en) 2009-06-30
US20120034657A1 (en) 2012-02-09
WO2000024770A9 (en) 2000-10-26
NO20011962L (no) 2001-06-21
BG66190B1 (bg) 2011-12-30
CY1113107T1 (el) 2016-04-13
US9145450B2 (en) 2015-09-29
HK1042114A1 (en) 2002-08-02
BR9914698A (pt) 2003-01-07
DE69934425T2 (de) 2007-09-27
SI2319928T1 (sl) 2013-08-30
LTC1124961I2 (lt) 2022-03-25
SK4962001A3 (en) 2001-12-03
CY2009012I2 (el) 2010-07-28
WO2000024770A2 (en) 2000-05-04
HUP0104327A3 (en) 2003-09-29
CY1114940T1 (el) 2016-12-14
PT1124961E (pt) 2007-02-28
US8748571B2 (en) 2014-06-10
CY2009012I1 (el) 2010-07-28
NL300398I2 (nl) 2009-12-01

Similar Documents

Publication Publication Date Title
NO331027B1 (no) Forbindelse som bindes til en mpl-reseptor, dimer, polynukleotid, vektor, vertscelle, fremgangsmate for fremstilling av en forbindelse, anvendelse av en forbindelse for fremstilling av et medikament, samt farmasoytisk preparat.
DK0807111T3 (da) Substituerede heterocykliske forbindelser, fremgangsmåde til fremstillingen heraf samt farmaceutiske sammensætninger indeholdende disse
NO305907B1 (no) Forbindelser, forbindelser for bekjempelse av sykdommer, legemidler som endotelinreseptorantagonist, farmasöytiske preparater samt anvendelse av slike forbindelser til fremstilling av legemidler
DZ3191A1 (fr) Composés d'indazole et compositions pharmaceutiques inhibant les protéines kinases, et procédés d'utilisation de ceux-ci.
NO973923D0 (no) Nye taxoider, deres fremstilling samt farmasöytiske preparater inneholdende forbindelsene
BR9810802B1 (pt) composto, composição farmacêutica, e, processo para a preparação de um composto.
DK1042355T3 (da) 11beta-halogen-7alfa-substituerede estratriener, fremgangsmåde til fremstilling af farmaceutiske præparater, der indeholder disse 11beta-halogen-7alfa-substituerede estratriener, samt deres anvendelse til fremstilling af lægemidler
DK0920441T3 (da) 7alfa-(epsilon-aminoalkyl)-estratriener, fremgangsmåde til deres fremstilling, farmaceutiske præparater, som indeholder disse 7-alfa-(epsilon-aminoalkyl)-estratriener, samt deres anvendelse til fremstilling af lægemidler
IT1289160B1 (it) Compressa farmaceutica completamente rivestita per il rilascio controllato di principi attivi che presentano problemi di
NO986023L (no) Vannbasert, farmas°ytisk preparat
TR199800631A3 (tr) Ecza formülasyonu.
NO980273L (no) Femleddede heterocykluser med bifenylsulfonylsubstitusjon fremgangsmÕte for deres fremstilling, deres anvendelse som medikament eller diagnostikum samt medikament inneholdende forbindelsen
AR028162A1 (es) Disponibilidad controlada de compuestos de formulacion, composiciones y metodos para el lavado que utilizan los mismos.
DK1222163T3 (da) 2'-Substituerede 1,1'-biphenyl-2-carboxamider, fremgangsmåder til fremstilling deraf, deres anvendelse som medikament samt farmaceutiske præparater, som indeholder dem
PT1112266E (pt) 4-amino-2-aril-pirimidinas substituidas, sua preparacao, sua utilizacao e composicoes farmaceuticas que as contem.
NO20003496D0 (no) Nye aromatiske amider, fremgangsmÕte for fremstilling av disse, samt deres anvendelse som medisiner
BR9906373B1 (pt) compostos pirimidinona, composições farmacêuticas contendo os compostos e processos para a preparação dos mesmos.
HK1015789A1 (en) Propanolamine derivatives, processes for their preparation, pharmaceuticals comprising these compounds, and their use.
HK1040249A1 (en) Propanolamine derivatives substituted with heterocyclic compounds, methods for their production, pharmaceutical composition containing said compounds and the use thereof.
DK1140031T3 (da) Farmaceutisk sammensætning til kontrolleret frigivelse med tilidinmesylat som aktivt stof
IT1311921B1 (it) Composti farmaceutici.
NO960364D0 (no) Basisk-substituerte benzolguanidiner, fremgangsmåte for fremstilling derav, deres anvendelse som medikament eller diagnostikum samt medikament inneholdende forbindelsen
NO20022801D0 (no) Substituerte norbornylaminoderivater, fremgangsmåte for deres fremstilling, deres anvendelse som medikament eller diagnostikumsåvel som medikamenter inneholdende disse
NO972433L (no) Substituerte 2-naftoylguanidiner, fremgangsmåter for deres fremstilling, deres anvendelse som medikament eller diagnostikum samt medikamenter inneholdende forbindelsene
HK1045684A1 (en) Biphenyl derivatives as antagonists of the neurokinine-1 receptor.

Legal Events

Date Code Title Description
SPCF Filing of supplementary protection certificate

Free format text: PRODUCT NAME: NPLATE (2 FORSKJELLIGE PREPARATVARIANTER); NAT. REG. NO/DATE: EU/1/08/497/001/NO 20090204; FIRST REG. NO/DATE: EU/1/08/497/001/NO 20090204

Spc suppl protection certif: 2012005

Filing date: 20120312

SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: NPLATE (2 FORSKJELLIGE PREPARATVARIANTER); NAT. REG. NO/DATE: EU/1/08/497/001/NO 20090204; FIRST REG. NO/DATE: EU/1/08/497/001/NO 20090204

Spc suppl protection certif: 2012005

Filing date: 20120312

Extension date: 20240204

MK1K Patent expired
SPCX Expiry of an spc

Spc suppl protection certif: 2012015