NO329756B1 - Imidazo[1,2-a]pyrimidonderivat, anvendelser derav,legemiddel og GSK3beta-inhibitor - Google Patents
Imidazo[1,2-a]pyrimidonderivat, anvendelser derav,legemiddel og GSK3beta-inhibitor Download PDFInfo
- Publication number
- NO329756B1 NO329756B1 NO20043567A NO20043567A NO329756B1 NO 329756 B1 NO329756 B1 NO 329756B1 NO 20043567 A NO20043567 A NO 20043567A NO 20043567 A NO20043567 A NO 20043567A NO 329756 B1 NO329756 B1 NO 329756B1
- Authority
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- Norway
- Prior art keywords
- pyrimidin
- imidazo
- group
- ethyl
- stated
- Prior art date
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- 229940079593 drug Drugs 0.000 title claims description 22
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02290487A EP1340759A1 (en) | 2002-02-28 | 2002-02-28 | 1-[alkyl], 1-[(heteroaryl)alkyl] and 1-[(aryl)alkyl]-7-(pyrimidin-4-yl)-imidazo[1,2-a]pyrimidin-5(1H)-one derivatives |
| PCT/EP2003/002652 WO2003072580A1 (en) | 2002-02-28 | 2003-02-26 | 1-[ALKYL], 1-[HETEROARYL)ALKYL] AND 1-[ARYL)ALKYL]-7-(PYRIMIDIN-4-YL)-IMADAZO[1,2-a]PYRIMIDIN-5(1H)-ONE DERIVATIVES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20043567L NO20043567L (no) | 2004-11-26 |
| NO329756B1 true NO329756B1 (no) | 2010-12-13 |
Family
ID=27675771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20043567A NO329756B1 (no) | 2002-02-28 | 2004-08-26 | Imidazo[1,2-a]pyrimidonderivat, anvendelser derav,legemiddel og GSK3beta-inhibitor |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7429663B2 (da) |
| EP (2) | EP1340759A1 (da) |
| JP (1) | JP4484524B2 (da) |
| KR (1) | KR100935262B1 (da) |
| CN (1) | CN100441581C (da) |
| AR (1) | AR038620A1 (da) |
| AT (1) | ATE309246T1 (da) |
| AU (1) | AU2003214127C1 (da) |
| BR (1) | BR0308106A (da) |
| CA (1) | CA2474875C (da) |
| DE (1) | DE60302220T2 (da) |
| DK (1) | DK1480981T3 (da) |
| EA (1) | EA007459B1 (da) |
| ES (1) | ES2250876T3 (da) |
| IL (1) | IL163288A (da) |
| MX (1) | MXPA04008365A (da) |
| NO (1) | NO329756B1 (da) |
| NZ (1) | NZ534467A (da) |
| PL (1) | PL372664A1 (da) |
| SI (1) | SI1480981T1 (da) |
| TW (1) | TWI305534B (da) |
| WO (1) | WO2003072580A1 (da) |
| ZA (1) | ZA200406154B (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06004043A (es) * | 2003-10-10 | 2006-06-28 | Pfizer Prod Inc | 2h-[1,2,4]triazolo[4,3-a]pirazinas sustituidas como inhibidores de la glucogeno sintetasa cinasa 3. |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| EP2275096A3 (en) | 2005-08-26 | 2011-07-13 | Braincells, Inc. | Neurogenesis via modulation of the muscarinic receptors |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | アンジオテンシン調節による神経新生 |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2009155024A1 (en) * | 2008-05-30 | 2009-12-23 | Merck & Co., Inc. | Novel substituted indoles |
| EP2138494A1 (en) * | 2008-06-26 | 2009-12-30 | Sanofi-Aventis | Substituted alkyl pyrimidin-4-one derivatives |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US8828997B2 (en) * | 2009-07-02 | 2014-09-09 | Sanofi | 2,3-dihydro-1H-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof |
| WO2015173225A1 (en) | 2014-05-13 | 2015-11-19 | F. Hoffmann-La Roche Ag | Deuterated heterocyclic compounds and their use as imaging agents |
| CN112574219A (zh) * | 2021-01-31 | 2021-03-30 | 湖北大学 | 一种苯并咪唑并嘧啶酮衍生物的合成方法 |
| CN115448921B (zh) * | 2021-06-08 | 2023-08-01 | 四川大学 | 一类咪唑烷并嘧啶酮化合物及在治疗HsClpP介导的疾病中的用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3571974D1 (en) * | 1984-12-06 | 1989-09-07 | Pfizer | Substituted dihydroquinolone carboxylic acids, anti-bacterial compositions containing them |
| BR9713850A (pt) * | 1996-12-05 | 2000-02-29 | Amgen Inc | Composto, composição farmacêutica, processos para profilaxia ou tratamento de infecção e de doenças, para diminuir concentrações no plasma de qualquer um ou de ambos tnf-. e o;-1 de qualquer um ou de ambos il-6 e il-8, para profilaxia ou tratamento da doença diabetes e de um distúrbio da dor em um mamìfero, para dimunuir a produção de prostaglandinas em um mamìfero, e, para dimuir a atividade da enzima ciclooxigenase em um mamìfero. |
| AR023052A1 (es) * | 1998-09-25 | 2002-09-04 | Mitsuharu Yoshimura Milton | Derivados de pirimidona |
| EP1184384A1 (en) * | 2000-09-01 | 2002-03-06 | Sanofi-Synthelabo | 1-(Alkyl), 1-((heteroaryl)alkyl) and 1-((aryl)alkyl)-7-pyridin-4-ylimidazo(1,2a)pyrimidin-5(1H)-one derivatives |
| EP1295884A1 (en) * | 2001-09-21 | 2003-03-26 | Sanofi-Synthelabo | 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]Pyrimidin-4-one and 7-Pyrimidinyl-2,3-Dihydroimidazo[1,2-a]Pyrimidin-5(1H)one derivatives |
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2002
- 2002-02-28 EP EP02290487A patent/EP1340759A1/en not_active Withdrawn
-
2003
- 2003-02-26 DE DE60302220T patent/DE60302220T2/de not_active Expired - Lifetime
- 2003-02-26 CA CA2474875A patent/CA2474875C/en not_active Expired - Fee Related
- 2003-02-26 CN CNB038079380A patent/CN100441581C/zh not_active Expired - Fee Related
- 2003-02-26 NZ NZ534467A patent/NZ534467A/en not_active IP Right Cessation
- 2003-02-26 SI SI200330137T patent/SI1480981T1/sl unknown
- 2003-02-26 WO PCT/EP2003/002652 patent/WO2003072580A1/en active IP Right Grant
- 2003-02-26 MX MXPA04008365A patent/MXPA04008365A/es active IP Right Grant
- 2003-02-26 BR BR0308106-0A patent/BR0308106A/pt active Search and Examination
- 2003-02-26 EA EA200400937A patent/EA007459B1/ru not_active IP Right Cessation
- 2003-02-26 JP JP2003571286A patent/JP4484524B2/ja not_active Expired - Fee Related
- 2003-02-26 AT AT03709786T patent/ATE309246T1/de active
- 2003-02-26 ES ES03709786T patent/ES2250876T3/es not_active Expired - Lifetime
- 2003-02-26 KR KR1020047013439A patent/KR100935262B1/ko not_active IP Right Cessation
- 2003-02-26 PL PL03372664A patent/PL372664A1/xx not_active IP Right Cessation
- 2003-02-26 US US10/504,679 patent/US7429663B2/en not_active Expired - Fee Related
- 2003-02-26 DK DK03709786T patent/DK1480981T3/da active
- 2003-02-26 EP EP03709786A patent/EP1480981B1/en not_active Expired - Lifetime
- 2003-02-26 AU AU2003214127A patent/AU2003214127C1/en not_active Ceased
- 2003-02-27 TW TW092104221A patent/TWI305534B/zh not_active IP Right Cessation
- 2003-02-28 AR ARP030100658A patent/AR038620A1/es unknown
-
2004
- 2004-07-29 IL IL163288A patent/IL163288A/en not_active IP Right Cessation
- 2004-08-02 ZA ZA200406154A patent/ZA200406154B/en unknown
- 2004-08-26 NO NO20043567A patent/NO329756B1/no not_active IP Right Cessation
-
2008
- 2008-08-20 US US12/194,899 patent/US20080318980A1/en not_active Abandoned
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| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |