NO326114B1 - Diagnotiske avbildningskontrastmidler med forlenget blodretensjon - Google Patents
Diagnotiske avbildningskontrastmidler med forlenget blodretensjon Download PDFInfo
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- NO326114B1 NO326114B1 NO19973510A NO973510A NO326114B1 NO 326114 B1 NO326114 B1 NO 326114B1 NO 19973510 A NO19973510 A NO 19973510A NO 973510 A NO973510 A NO 973510A NO 326114 B1 NO326114 B1 NO 326114B1
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- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
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- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
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- PNYPSKHTTCTAMD-UHFFFAOYSA-K trichlorogadolinium;hexahydrate Chemical compound O.O.O.O.O.O.[Cl-].[Cl-].[Cl-].[Gd+3] PNYPSKHTTCTAMD-UHFFFAOYSA-K 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38231795A | 1995-02-01 | 1995-02-01 | |
| PCT/US1996/000164 WO1996023526A2 (en) | 1995-02-01 | 1996-01-16 | Diagnostic imaging contrast agents with extended blood retention |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO973510L NO973510L (no) | 1997-07-30 |
| NO973510D0 NO973510D0 (no) | 1997-07-30 |
| NO326114B1 true NO326114B1 (no) | 2008-09-29 |
Family
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| NO19973510A NO326114B1 (no) | 1995-02-01 | 1997-07-30 | Diagnotiske avbildningskontrastmidler med forlenget blodretensjon |
| NO20081355A NO20081355L (no) | 1995-02-01 | 2008-03-14 | Kontrastmiddel |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20081355A NO20081355L (no) | 1995-02-01 | 2008-03-14 | Kontrastmiddel |
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| EP (2) | EP0806968B1 (xx) |
| JP (4) | JP4064458B2 (xx) |
| KR (1) | KR100403755B1 (xx) |
| CN (3) | CN101011586A (xx) |
| AR (1) | AR006510A1 (xx) |
| AT (1) | ATE342738T1 (xx) |
| AU (1) | AU689700B2 (xx) |
| BR (1) | BR9607136A (xx) |
| CA (1) | CA2211100C (xx) |
| DE (3) | DE122006000061I1 (xx) |
| DK (1) | DK0806968T3 (xx) |
| ES (1) | ES2274523T3 (xx) |
| FI (1) | FI973183A0 (xx) |
| HK (2) | HK1002551A1 (xx) |
| IL (1) | IL116847A (xx) |
| IS (1) | IS2505B (xx) |
| MY (1) | MY128089A (xx) |
| NL (1) | NL300253I2 (xx) |
| NO (2) | NO326114B1 (xx) |
| NZ (1) | NZ301181A (xx) |
| PT (1) | PT806968E (xx) |
| TW (1) | TW319763B (xx) |
| WO (1) | WO1996023526A2 (xx) |
| ZA (1) | ZA96417B (xx) |
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| TW319763B (xx) * | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| US6713045B1 (en) | 1995-06-02 | 2004-03-30 | Research Corporation Technologies, Inc. | Targeted magnetic resonance imaging agents for the detection of physiological processes |
| US6770261B2 (en) | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| DE19543077C2 (de) * | 1995-11-13 | 1997-10-16 | Schering Ag | Verwendung von gashaltigen Metallkomplexen als Ultraschallkontrastmittel |
| AU726914B2 (en) * | 1996-04-01 | 2000-11-23 | Epix Pharmaceuticals, Inc. | Bioactivated diagnostic imaging contrast agents |
| US5900228A (en) | 1996-07-31 | 1999-05-04 | California Institute Of Technology | Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye |
| US5919967A (en) * | 1997-04-11 | 1999-07-06 | Epix Medical, Inc. | Process for synthesizing phosphodiesters |
| DE19744004C1 (de) * | 1997-09-26 | 1999-07-22 | Schering Ag | Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging |
| US6495118B1 (en) | 1997-09-26 | 2002-12-17 | Schering Aktiengesellschaft | Lipophilic metal complexes for necrosis and infarction imaging |
| BR9812716A (pt) * | 1997-10-02 | 2000-08-22 | Epix Medical Inc | Métodos para formação de imagem para diagnóstico de contraste intensificado para monitorar terapias interventivas |
| AU750686B2 (en) * | 1997-10-27 | 2002-07-25 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the delivery of therapeutic agents |
| US6713046B1 (en) | 1997-10-27 | 2004-03-30 | Research Corporation Technologies | Magnetic resonance imaging agents for the delivery of therapeutic agents |
| JP4163381B2 (ja) | 1997-11-17 | 2008-10-08 | カリフォルニア・インスティテュート・オブ・テクノロジー | 生理学的薬剤の検出のための磁気共鳴造影剤 |
| GB9912356D0 (en) | 1999-05-26 | 1999-07-28 | Btg Int Ltd | Generation of microfoam |
| JP3848493B2 (ja) * | 1999-06-30 | 2006-11-22 | 英三 盛 | Ｘ線診断システム |
| NZ517017A (en) | 1999-07-29 | 2004-05-28 | Epix Medical Inc | Targeting multimeric imaging agents through multiocus binding and improving the efficacy of in vivo contrast agents |
| DE19964224B4 (de) * | 1999-09-09 | 2005-09-01 | Schering Ag | Pharmazeutische Mittel enthaltend Calcium-Komplex von [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-yl-säure-.kappa.N6,.kappa.N9,.kappa.011]1-oxidato(6-)]-, tetrahydrogen (MS-325) und dessen Salze sowie Verfahren zur Herstellung der Mittel |
| US20030203879A1 (en) * | 1999-09-09 | 2003-10-30 | Schering Ag | Calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.O)methyl]-1-[(4,4-diphenylcyclohexy)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.Kappa.N9,.Kappa 011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents |
| DE19944893C2 (de) * | 1999-09-09 | 2001-09-20 | Schering Ag | Calcium-Komplex von [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-. kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-yl-säure-.kappa.N6, .kappa.N9,.kappa.O11]1-oxidato(6-)]-, hexahydrogen, dessen Salze und diese Komplexe enthaltende pharmazeutische Mittel |
| US6559330B1 (en) | 1999-09-09 | 2003-05-06 | Schering Aktiengesellschaft | Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents |
| ES2157129T3 (es) * | 1999-09-09 | 2001-08-01 | Schering Ag | Complejo con calcio de (((4r)-4-(bis((carboxi-.kappa.0)-metil)amino-.kappa.n)-6,9-bis((carboxi-.kappa-0)metil)-1-((4,4-difenil-ciclohexil)oxi)-1-hidroxi-2-oxa-6,9-diaza-1-fosfaundecan-11-il-acido.kappa.n6,.kappa.n9,.kappa.011)-oxidato(6-))-,hexahidrogeno, sus sales, agentes farma |
| WO2001037630A2 (en) | 1999-11-22 | 2001-05-31 | Epix Medical, Inc. | Imaging sexual response |
| US20030082106A1 (en) * | 2000-01-22 | 2003-05-01 | Aleksandr Nivorozhkin | Magnetic resonance imaging using contrast agents bioactivated by enzymatic cleavage |
| US6673333B1 (en) | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
| US6656450B2 (en) | 2000-07-17 | 2003-12-02 | California Institute Of Technology, Inc. | Macrocyclic magnetic resonance imaging contrast agents |
| US7029655B2 (en) | 2000-10-04 | 2006-04-18 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
| US6549798B2 (en) | 2001-02-07 | 2003-04-15 | Epix Medical, Inc. | Magnetic resonance angiography data |
| TWI221406B (en) | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
| TWI284539B (en) | 2001-07-30 | 2007-08-01 | Epix Pharm Inc | A method for making a magnetic resonance (MR) imaging agent, a MR imaging contrast agent, a method for altering stability of a peptide and a modified peptide |
| US8512680B2 (en) | 2001-08-08 | 2013-08-20 | Btg International Ltd. | Injectables in foam, new pharmaceutical applications |
| US7186797B2 (en) * | 2001-08-10 | 2007-03-06 | Epix Pharmaceuticals, Inc. | Polypeptide conjugates with extended circulating half-lives |
| WO2003029257A1 (de) * | 2001-09-27 | 2003-04-10 | Schering Aktiengesellschaft | (ethylen)-(propylen/butylen)-phosphodiester-triaminpentaessigsäure-derivate |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| CA2477836A1 (en) | 2002-03-01 | 2003-09-12 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| US20050100963A1 (en) | 2002-03-01 | 2005-05-12 | Dyax Corporation | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
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| EP0702677A1 (en) | 1994-04-08 | 1996-03-27 | BRACCO International B.V. | Aromatic amide compounds and metal chelates thereof |
| GB9407435D0 (en) | 1994-04-14 | 1994-06-08 | Nycomed Salutar Inc | Compounds |
| IT1269839B (it) | 1994-05-26 | 1997-04-15 | Bracco Spa | Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi |
| TW319763B (xx) * | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| IT1283650B1 (it) | 1996-08-02 | 1998-04-23 | Bracco Spa | Chelati paramagnetici ad alta relassivita' in siero |
| US6342598B1 (en) | 1998-11-26 | 2002-01-29 | Bracco International B.V. | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents |
| IT1304501B1 (it) | 1998-12-23 | 2001-03-19 | Bracco Spa | Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza |
| NZ517017A (en) | 1999-07-29 | 2004-05-28 | Epix Medical Inc | Targeting multimeric imaging agents through multiocus binding and improving the efficacy of in vivo contrast agents |
| IT1313617B1 (it) | 1999-08-31 | 2002-09-09 | Bracco Spa | Processo per la preparazione di derivati degli acidi biliari. |
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1995
- 1995-12-29 TW TW084114108A patent/TW319763B/zh active
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1996
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- 1996-01-16 JP JP52354396A patent/JP4064458B2/ja not_active Expired - Fee Related
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- 1996-01-16 ES ES96902106T patent/ES2274523T3/es not_active Expired - Lifetime
- 1996-01-16 BR BR9607136A patent/BR9607136A/pt not_active Application Discontinuation
- 1996-01-16 CN CNA2006100957916A patent/CN101011586A/zh active Pending
- 1996-01-16 WO PCT/US1996/000164 patent/WO1996023526A2/en active IP Right Grant
- 1996-01-16 EP EP96902106A patent/EP0806968B1/en not_active Expired - Lifetime
- 1996-01-16 CN CNB961917474A patent/CN1177806C/zh not_active Expired - Lifetime
- 1996-01-16 PT PT96902106T patent/PT806968E/pt unknown
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- 1996-01-16 AT AT96902106T patent/ATE342738T1/de active
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- 1996-01-16 DE DE69636635T patent/DE69636635T2/de not_active Expired - Lifetime
- 1996-01-16 EP EP06016539A patent/EP1716871A3/en not_active Withdrawn
- 1996-01-16 DK DK96902106T patent/DK0806968T3/da active
- 1996-01-16 NZ NZ301181A patent/NZ301181A/xx not_active IP Right Cessation
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1997
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- 1997-07-30 NO NO19973510A patent/NO326114B1/no not_active IP Right Cessation
- 1997-07-31 FI FI973183A patent/FI973183A0/fi not_active Application Discontinuation
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1998
- 1998-02-09 HK HK98100980A patent/HK1002551A1/xx not_active IP Right Cessation
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2001
- 2001-12-20 US US10/034,522 patent/US6676929B2/en not_active Expired - Lifetime
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2002
- 2002-12-19 JP JP2002369062A patent/JP2004026793A/ja not_active Withdrawn
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2003
- 2003-01-30 US US10/354,723 patent/US7011815B2/en not_active Expired - Fee Related
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2004
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2005
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2006
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2007
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2008
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2011
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