NO322240B1 - Substituerte bisindolylmaleimider, deres fremstilling, farmasoytiske preparater inneholdende slike, samt anvendelse av slike forbindelser for fremstilling av medikamenter for inhibering av celleproliferasjon - Google Patents

Substituerte bisindolylmaleimider, deres fremstilling, farmasoytiske preparater inneholdende slike, samt anvendelse av slike forbindelser for fremstilling av medikamenter for inhibering av celleproliferasjon Download PDF

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Publication number
NO322240B1
NO322240B1 NO20022776A NO20022776A NO322240B1 NO 322240 B1 NO322240 B1 NO 322240B1 NO 20022776 A NO20022776 A NO 20022776A NO 20022776 A NO20022776 A NO 20022776A NO 322240 B1 NO322240 B1 NO 322240B1
Authority
NO
Norway
Prior art keywords
indol
methyl
nitro
dihydro
dioxo
Prior art date
Application number
NO20022776A
Other languages
English (en)
Norwegian (no)
Other versions
NO20022776L (no
NO20022776D0 (no
Inventor
Jr John Guilfoyle Mullin
Allen John Lovey
Nader Fotouhi
Emily Aijun Liu
Guiseppe Federico Weber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20022776L publication Critical patent/NO20022776L/no
Publication of NO20022776D0 publication Critical patent/NO20022776D0/no
Publication of NO322240B1 publication Critical patent/NO322240B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572Five-membered rings
    • C07F9/5728Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO20022776A 1999-12-16 2002-06-11 Substituerte bisindolylmaleimider, deres fremstilling, farmasoytiske preparater inneholdende slike, samt anvendelse av slike forbindelser for fremstilling av medikamenter for inhibering av celleproliferasjon NO322240B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17105199P 1999-12-16 1999-12-16
PCT/EP2000/012559 WO2001044234A1 (fr) 1999-12-16 2000-12-12 Bisindolylmaleimides substitues destines a inhiber la proliferation cellulaire

Publications (3)

Publication Number Publication Date
NO20022776L NO20022776L (no) 2002-06-11
NO20022776D0 NO20022776D0 (no) 2002-06-11
NO322240B1 true NO322240B1 (no) 2006-09-04

Family

ID=22622296

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20022776A NO322240B1 (no) 1999-12-16 2002-06-11 Substituerte bisindolylmaleimider, deres fremstilling, farmasoytiske preparater inneholdende slike, samt anvendelse av slike forbindelser for fremstilling av medikamenter for inhibering av celleproliferasjon

Country Status (33)

Country Link
US (1) US6313143B1 (fr)
EP (1) EP1242408B1 (fr)
JP (2) JP2003516986A (fr)
KR (1) KR100507422B1 (fr)
CN (1) CN1229374C (fr)
AR (1) AR029415A1 (fr)
AT (1) ATE306484T1 (fr)
AU (1) AU783616B2 (fr)
BR (1) BRPI0016329B8 (fr)
CA (1) CA2392902C (fr)
CO (1) CO5050293A1 (fr)
CZ (1) CZ304130B6 (fr)
DE (1) DE60023182T2 (fr)
ES (1) ES2249314T3 (fr)
GC (1) GC0000265A (fr)
HK (1) HK1054385B (fr)
HR (1) HRP20020513B1 (fr)
HU (1) HU230003B1 (fr)
IL (2) IL150128A0 (fr)
JO (1) JO2296B1 (fr)
MA (1) MA26856A1 (fr)
MX (1) MXPA02005560A (fr)
MY (1) MY126998A (fr)
NO (1) NO322240B1 (fr)
NZ (1) NZ519173A (fr)
PE (1) PE20011034A1 (fr)
PL (1) PL200243B1 (fr)
RS (1) RS50449B (fr)
RU (1) RU2264398C2 (fr)
TW (1) TWI274752B (fr)
UY (1) UY26485A1 (fr)
WO (1) WO2001044234A1 (fr)
ZA (1) ZA200204258B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002102373A1 (fr) * 2001-06-15 2002-12-27 F. Hoffmann-La Roche Ag Procede d'administration d'un agent destine a la therapie du cancer
WO2003037384A2 (fr) * 2001-10-29 2003-05-08 Nektar Therapeutics Al, Corporation Conjugues polymeres d'inhibiteurs de proteine kinease c
JP6106437B2 (ja) * 2010-01-07 2017-03-29 アルカーメス ファーマ アイルランド リミテッド 複素芳香族化合物のプロドラッグ
EP2474541A1 (fr) * 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Composés conjugués de 3-(indolyl)- et 3-(azaindolyl)-4-arylmaléimide et leur utilisation dans le traitement de tumeurs

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
GB9416467D0 (en) * 1994-08-13 1994-10-05 Wellcome Found Compounds for use in medicine
WO1997033552A1 (fr) * 1996-03-12 1997-09-18 Pg-Txl Company, L.P. Bioprecurseurs de paclitaxel solubles dans l'eau
TW517067B (en) * 1996-05-31 2003-01-11 Hoffmann La Roche Interferon conjugates
PE91698A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
PE91498A1 (es) * 1996-07-29 1998-12-22 Hoffmann La Roche Pirroles sustituidos
PE91598A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
JP2002500184A (ja) * 1998-01-09 2002-01-08 アリゾナ ボード オブ リーゼンツ フェンスタチンとそのプロドラッグの合成
KR100659411B1 (ko) 1998-03-17 2006-12-18 에프. 호프만-라 로슈 아게 세포 증식 억제를 위한 치환된 비스인돌리말레이미드
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
MXPA02003667A (es) * 1999-10-12 2002-08-30 Hoffmann La Roche Pirroles sustituidos como agentes antiproliferativos para tratamiento del cancer.

Also Published As

Publication number Publication date
IL150128A (en) 2006-06-11
MA26856A1 (fr) 2004-12-20
JP2007153905A (ja) 2007-06-21
HU230003B1 (en) 2015-04-28
US6313143B1 (en) 2001-11-06
AU783616B2 (en) 2005-11-17
KR20020063215A (ko) 2002-08-01
GC0000265A (en) 2006-11-01
CN1409709A (zh) 2003-04-09
HUP0203696A3 (en) 2004-01-28
HK1054385A1 (en) 2003-11-28
ATE306484T1 (de) 2005-10-15
BR0016329A (pt) 2002-08-27
YU43302A (sh) 2005-03-15
HUP0203696A2 (hu) 2003-03-28
JP4763623B2 (ja) 2011-08-31
BR0016329B1 (pt) 2013-03-19
PE20011034A1 (es) 2001-10-12
TWI274752B (en) 2007-03-01
KR100507422B1 (ko) 2005-08-10
MY126998A (en) 2006-11-30
CZ20022447A3 (cs) 2003-06-18
ZA200204258B (en) 2003-08-28
MXPA02005560A (es) 2002-09-02
RU2264398C2 (ru) 2005-11-20
HK1054385B (zh) 2006-02-17
CO5050293A1 (es) 2001-06-27
CN1229374C (zh) 2005-11-30
EP1242408B1 (fr) 2005-10-12
DE60023182T2 (de) 2006-07-06
IL150128A0 (en) 2002-12-01
BRPI0016329B8 (pt) 2021-05-25
NO20022776L (no) 2002-06-11
PL355856A1 (en) 2004-05-31
HRP20020513A2 (en) 2004-08-31
PL200243B1 (pl) 2008-12-31
AR029415A1 (es) 2003-06-25
RU2002119209A (ru) 2004-01-10
WO2001044234A1 (fr) 2001-06-21
DE60023182D1 (de) 2006-02-23
JP2003516986A (ja) 2003-05-20
NZ519173A (en) 2004-06-25
CA2392902C (fr) 2009-01-13
RS50449B (sr) 2010-03-02
JO2296B1 (en) 2005-09-12
CZ304130B6 (cs) 2013-11-13
EP1242408A1 (fr) 2002-09-25
UY26485A1 (es) 2001-06-29
HRP20020513B1 (en) 2006-10-31
NO20022776D0 (no) 2002-06-11
AU2008201A (en) 2001-06-25
ES2249314T3 (es) 2006-04-01
CA2392902A1 (fr) 2001-06-21

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