NO308738B1 - Bicyklisk kondenserte pyridiner, legemidler inneholdende disse og anvendelse av forbindelsene for fremstilling av legemidler - Google Patents

Bicyklisk kondenserte pyridiner, legemidler inneholdende disse og anvendelse av forbindelsene for fremstilling av legemidler

Info

Publication number
NO308738B1
NO308738B1 NO973144A NO973144A NO308738B1 NO 308738 B1 NO308738 B1 NO 308738B1 NO 973144 A NO973144 A NO 973144A NO 973144 A NO973144 A NO 973144A NO 308738 B1 NO308738 B1 NO 308738B1
Authority
NO
Norway
Prior art keywords
drugs
bicyclically
compounds
preparation
condensed pyridines
Prior art date
Application number
NO973144A
Other languages
English (en)
Norwegian (no)
Other versions
NO973144D0 (no
NO973144L (no
Inventor
Arndt Brandes
Michael Loegers
Gunter Schmidt
Rolf Angerbauer
Carsten Schmeck
Klaus-Dieter Bremm
Hilmar Bischoff
Delf Schmidt
Joachim Schuhmacher
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO973144D0 publication Critical patent/NO973144D0/no
Publication of NO973144L publication Critical patent/NO973144L/no
Publication of NO308738B1 publication Critical patent/NO308738B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NO973144A 1996-07-08 1997-07-07 Bicyklisk kondenserte pyridiner, legemidler inneholdende disse og anvendelse av forbindelsene for fremstilling av legemidler NO308738B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19627430A DE19627430A1 (de) 1996-07-08 1996-07-08 Bicyclisch kondensierte Pyridine

Publications (3)

Publication Number Publication Date
NO973144D0 NO973144D0 (no) 1997-07-07
NO973144L NO973144L (no) 1998-01-09
NO308738B1 true NO308738B1 (no) 2000-10-23

Family

ID=7799218

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973144A NO308738B1 (no) 1996-07-08 1997-07-07 Bicyklisk kondenserte pyridiner, legemidler inneholdende disse og anvendelse av forbindelsene for fremstilling av legemidler

Country Status (30)

Country Link
US (1) US6063788A (sh)
EP (1) EP0825185A1 (sh)
JP (1) JPH1067751A (sh)
KR (1) KR980009247A (sh)
CN (1) CN1172803A (sh)
AR (1) AR007716A1 (sh)
AU (1) AU722365B2 (sh)
BG (1) BG61972B1 (sh)
BR (1) BR9703886A (sh)
CA (1) CA2209609A1 (sh)
CO (1) CO4870759A1 (sh)
CZ (1) CZ214797A3 (sh)
DE (1) DE19627430A1 (sh)
EE (1) EE9700151A (sh)
HN (1) HN1997000082A (sh)
HR (1) HRP970331A2 (sh)
HU (1) HUP9701158A1 (sh)
ID (1) ID17659A (sh)
IL (1) IL121235A0 (sh)
MA (1) MA24261A1 (sh)
NO (1) NO308738B1 (sh)
NZ (1) NZ328260A (sh)
PE (1) PE87798A1 (sh)
PL (1) PL320954A1 (sh)
SG (1) SG46782A1 (sh)
SK (1) SK92697A3 (sh)
TN (1) TNSN97116A1 (sh)
TR (1) TR199700583A2 (sh)
YU (1) YU28897A (sh)
ZA (1) ZA976021B (sh)

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US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
EP1140184B1 (en) 1998-12-23 2003-06-04 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
EA200100707A1 (ru) 1998-12-23 2001-12-24 Джи.Ди.Сирл Ллс Сочетания ингибиторов транспорта желчных кислот в подвздошной кишке и производных фибриновой кислоты для сердечно-сосудистых показаний
AU776664B2 (en) 1998-12-23 2004-09-16 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
IL143943A0 (en) 1998-12-23 2002-04-21 Searle Llc Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications
DE69908644T2 (de) 1998-12-23 2004-05-13 G.D. Searle Llc, Chicago Kombnationen von cholesteryl ester transfer protein inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen
IL143946A0 (en) 1998-12-23 2002-04-21 Searle Llc Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein for cardiovascular indications
US6924313B1 (en) 1999-09-23 2005-08-02 Pfizer Inc. Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US6723752B2 (en) 1999-09-23 2004-04-20 Pharmacia Corporation (R)-chiral halogenated substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
US6586434B2 (en) 2000-03-10 2003-07-01 G.D. Searle, Llc Method for the preparation of tetrahydrobenzothiepines
US20040219619A1 (en) * 2000-07-21 2004-11-04 Ester Fernandez-Salas Methods of identifying compounds that alter toxin persistence and/or protease activity
US6903109B2 (en) * 2001-04-18 2005-06-07 Ortho-Muniel Pharmaceutical, Inc. Arylindenopyridines and related therapeutic and prophylactic methods
US6958328B2 (en) * 2001-04-18 2005-10-25 Ortho-Mcneil Pharmaceutical, Inc Arylindenopyridines and related therapeutic and prophylactic methods
US20050239782A1 (en) * 2001-04-18 2005-10-27 Heintzelman Geoffrey R Arylindenopyridines and related therapeutic and prophylactic methods
EP1404300B1 (en) 2001-06-22 2009-09-30 Pfizer Products Inc. Pharmaceutical compositions of dispersions of drugs and neutral polymers
MXPA03010165A (es) 2001-06-22 2004-03-10 Pfizer Prod Inc Composiciones farmaceuticas de adsorbatos de farmaco amorfo.
US6740663B2 (en) 2001-11-02 2004-05-25 G.D. Searle, Llc Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
JP2005521653A (ja) 2002-01-17 2005-07-21 ファルマシア コーポレイション 先端ナトリウム同時依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取込みの阻害剤としての新規アルキル／アリールヒドロキシまたはケトチエピン化合物
EP1469832B2 (en) 2002-02-01 2016-10-26 Bend Research, Inc. Pharmaceutical compositions of amorphous dispersions of drugs and lipophilic microphase-forming materials
US20040127510A1 (en) 2002-04-16 2004-07-01 Heintzelman Geoffrey R. Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods
CA2532931A1 (en) * 2003-08-04 2005-02-10 Pfizer Products Inc. Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials
CL2004001884A1 (es) 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
EP2319509A1 (en) 2003-09-26 2011-05-11 Japan Tobacco, Inc. Method of Inhibiting remnant lipoprotein production
BRPI0414186A (pt) 2003-10-08 2006-10-31 Lilly Co Eli compostos, métodos de antagonizar a atividade de cetp, de tratar ou prevenir uma doença, de diminuir o colesterol ldl plasmático em um mamìmero, de tratar e/ou prevenir seqüelas patológicas, formulação farmacêutica, e, uso de um composto
CA2557010A1 (en) 2004-03-26 2005-10-20 Eli Lilly And Company Compounds and methods for treating dyslipidemia
JP5132317B2 (ja) * 2004-12-18 2013-01-30 バイエル・ファルマ・アクチェンゲゼルシャフト ４−シクロアルキル置換テトラヒドロキノリン誘導体および医薬としてのそれらの使用
WO2006082518A1 (en) 2005-02-03 2006-08-10 Pfizer Products Inc. Pharmaceutical compositions with enhanced performance
CN101291662A (zh) 2005-10-21 2008-10-22 诺瓦提斯公司 肾素抑制剂和抗血脂异常剂和/或抗肥胖剂的组合
DE102006012548A1 (de) * 2006-03-18 2007-09-20 Bayer Healthcare Ag Substituierte Chromanol-Derivate und ihre Verwendung
PA8801401A1 (es) * 2007-10-25 2009-05-15 Janssen Pharmaceutica Nv Arilindenopirimidinas y su uso como adenosina a2a
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169857A (en) * 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
GB8626344D0 (en) * 1986-11-04 1986-12-03 Zyma Sa Bicyclic compounds
NO177005C (no) * 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
ZA911046B (en) * 1990-02-26 1992-10-28 Squibb & Sons Inc Quinoline and pyridine anchors for hmg-coa reductase inhibitors
JPH059179A (ja) * 1990-09-27 1993-01-19 Takeda Chem Ind Ltd 複素環化合物、その製造法及びａｃａｔ阻害剤

Also Published As

Publication number Publication date
HN1997000082A (es) 1997-12-26
BG61972B1 (bg) 1998-11-30
AR007716A1 (es) 1999-11-10
PL320954A1 (en) 1998-01-19
YU28897A (sh) 2000-03-21
CN1172803A (zh) 1998-02-11
AU2844897A (en) 1998-01-15
BR9703886A (pt) 1998-11-03
CZ214797A3 (cs) 1998-01-14
BG101746A (en) 1998-03-31
KR980009247A (ko) 1998-04-30
US6063788A (en) 2000-05-16
NO973144D0 (no) 1997-07-07
TR199700583A2 (xx) 1998-01-21
HRP970331A2 (en) 1998-08-31
NZ328260A (en) 1998-09-24
AU722365B2 (en) 2000-08-03
SG46782A1 (en) 1998-02-20
NO973144L (no) 1998-01-09
HU9701158D0 (en) 1997-09-29
IL121235A0 (en) 1998-01-04
EP0825185A1 (de) 1998-02-25
DE19627430A1 (de) 1998-01-15
CA2209609A1 (en) 1998-01-08
PE87798A1 (es) 1999-02-13
SK92697A3 (en) 1998-02-04
CO4870759A1 (es) 1999-12-27
HUP9701158A1 (hu) 1999-09-28
TNSN97116A1 (fr) 2005-03-15
ZA976021B (en) 1998-02-02
JPH1067751A (ja) 1998-03-10
ID17659A (id) 1998-01-15
MA24261A1 (fr) 1998-04-01
EE9700151A (et) 1998-02-16

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