NO20085331L - Pyrazolo[1,5-A]pyrimidiner som CDK-inhibitorer - Google Patents
Pyrazolo[1,5-A]pyrimidiner som CDK-inhibitorerInfo
- Publication number
- NO20085331L NO20085331L NO20085331A NO20085331A NO20085331L NO 20085331 L NO20085331 L NO 20085331L NO 20085331 A NO20085331 A NO 20085331A NO 20085331 A NO20085331 A NO 20085331A NO 20085331 L NO20085331 L NO 20085331L
- Authority
- NO
- Norway
- Prior art keywords
- pyrazolo
- pyrimidines
- cdk inhibitors
- compounds
- cdk
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
I sine mange utførelser tilveiebringer foreliggende oppfinnelse visse pyrazolo[l,5-a]pyrimidinforbindelser med formel (I) som kan anvendes som inhibitorer av syklinavhengige kinaser ("CDK"), så vel som fremgangsmåter for fremstilling av slike forbindelser. Forbindelsene har en mulig anvendelse for behandling, forebyggelse, inhibering eller lindring av én eller flere sykdommer som er forbundet med CDK.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80257706P | 2006-05-22 | 2006-05-22 | |
PCT/US2007/011991 WO2007139732A1 (en) | 2006-05-22 | 2007-05-21 | Pyrazolo [1, 5-a] pyrimidines as cdk inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20085331L true NO20085331L (no) | 2009-02-19 |
Family
ID=38544151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20085331A NO20085331L (no) | 2006-05-22 | 2008-12-19 | Pyrazolo[1,5-A]pyrimidiner som CDK-inhibitorer |
Country Status (18)
Country | Link |
---|---|
US (1) | US20070275963A1 (no) |
EP (1) | EP2027127A1 (no) |
JP (1) | JP2009538304A (no) |
KR (1) | KR20090019796A (no) |
CN (1) | CN101495481A (no) |
AR (1) | AR061072A1 (no) |
AU (1) | AU2007268083A1 (no) |
BR (1) | BRPI0712016A2 (no) |
CA (1) | CA2653076A1 (no) |
EC (1) | ECSP088906A (no) |
IL (1) | IL195238A0 (no) |
MX (1) | MX2008014824A (no) |
NO (1) | NO20085331L (no) |
PE (1) | PE20080071A1 (no) |
RU (1) | RU2008150419A (no) |
TW (1) | TW200817404A (no) |
WO (1) | WO2007139732A1 (no) |
ZA (1) | ZA200809796B (no) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011503084A (ja) * | 2007-11-07 | 2011-01-27 | シェーリング コーポレイション | 新規の細胞周期チェックポイント調節剤およびこれらの調節剤とチェックポイント阻害剤との併用 |
BR112012005550A2 (pt) * | 2009-09-11 | 2015-09-08 | Cylene Pharmaceuticals Inc | lactamas heterociclo-substituídas farmaceuticamente úteis |
AU2010343102B2 (en) | 2009-12-29 | 2016-03-24 | Dana-Farber Cancer Institute, Inc. | Type II Raf kinase inhibitors |
US8916557B2 (en) * | 2011-04-19 | 2014-12-23 | Bayer Intellectual Property Gmbh | Substituted 4-Aryl-N-phenyl-1,3,5-triazin-2-amines |
JP2014517079A (ja) | 2011-06-22 | 2014-07-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Atrキナーゼ阻害剤として有用な化合物 |
WO2013059634A1 (en) | 2011-10-20 | 2013-04-25 | The Regents Of The University Of California | Use of cdk9 inhibitors to reduce cartilage degradation |
WO2013074986A1 (en) | 2011-11-17 | 2013-05-23 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-jun-n-terminal kinase (jnk) |
EP2909194A1 (en) | 2012-10-18 | 2015-08-26 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
USRE48175E1 (en) | 2012-10-19 | 2020-08-25 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
HUE037371T2 (hu) | 2012-12-07 | 2018-08-28 | Vertex Pharma | 2-Amino-6-fluor-N-(5-fluor-4-(4-(4-(oxetan-3-il)piperazin-1-karbonil)piperidin-1-il)piridin-3-il) pirazolo[1,5alfa]pirimidin-3-karboxamid mint ATR kináz inhibitor |
JP2016512815A (ja) | 2013-03-15 | 2016-05-09 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Atrキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体 |
WO2014143242A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
US8957078B2 (en) | 2013-03-15 | 2015-02-17 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
US20160264551A1 (en) | 2013-10-18 | 2016-09-15 | Syros Pharmaceuticals, Inc. | Heteroaromatic compounds useful for the treatment of prolferative diseases |
JP6491202B2 (ja) | 2013-10-18 | 2019-03-27 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | サイクリン依存性キナーゼ7(cdk7)の多環阻害剤 |
SG11201604519PA (en) | 2013-12-06 | 2016-07-28 | Vertex Pharma | 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof |
WO2015092707A2 (en) | 2013-12-17 | 2015-06-25 | Csir | A method for identification of anti-hiv human mirna mimics and mirna inhibitors and anti-hiv pharmaceutical compounds |
LT3152212T (lt) | 2014-06-05 | 2020-05-11 | Vertex Pharmaceuticals Inc. | Radioaktyviai žymėti 2-amino-6-fluor-n-[5-fluor-piridin-il]- pirazolo[1,5-a]pirimidin-3-karboksamido junginio dariniai, naudingi kaip atr kinazės inhibitoriai, minėto junginio gamybos būdas ir jo skirtingos kietos formos |
SI3157566T1 (sl) | 2014-06-17 | 2019-08-30 | Vertex Pharmaceuticals Incorporated | Postopek za zdravljenje raka z uporabo kombinacije inhibitorjev CHK1 in ATR |
EP3206749B1 (en) | 2014-10-14 | 2021-09-08 | The Regents of the University of California | The cdk9 and brd4 inhibitors flavopiridol and jq1 to inhibit cartilage inflammation |
US10870651B2 (en) | 2014-12-23 | 2020-12-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
AU2016243529B2 (en) * | 2015-03-27 | 2021-03-25 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
US10702527B2 (en) | 2015-06-12 | 2020-07-07 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
US11142507B2 (en) | 2015-09-09 | 2021-10-12 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
MX2018003657A (es) | 2015-09-30 | 2018-04-30 | Vertex Pharma | Metodo para tratar cancer usando una combinacion de agentes que dañan el adn e inhibidores de proteina relacionada con ataxia telangiectasia y rad3 (atr). |
RU2633032C1 (ru) * | 2016-05-23 | 2017-10-12 | Общество с ограниченной ответственностью "Новые научные технологии" | Новые ингибиторы серин-треониновых киназ, в том числе для лечения онкологических заболеваний и туберкулеза |
WO2019154177A1 (zh) * | 2018-02-12 | 2019-08-15 | 恩瑞生物医药科技(上海)有限公司 | 嘧啶类化合物、其制备方法及其医药用途 |
CN112996790B (zh) | 2018-10-30 | 2023-11-03 | 克洛诺斯生物公司 | 用于调节cdk9活性的化合物、组合物和方法 |
CN111393447B (zh) * | 2020-05-14 | 2021-01-15 | 苏州信诺维医药科技有限公司 | 一种嘧啶并吡唑类化合物、其制备方法及应用 |
CN117567460A (zh) * | 2022-08-08 | 2024-02-20 | 明慧医药(杭州)有限公司 | 一种前药化合物及其制备方法和用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003298571B2 (en) * | 2002-09-04 | 2006-10-19 | Merck Sharp & Dohme Corp. | Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors |
NZ539165A (en) * | 2002-09-04 | 2008-03-28 | Schering Corp | Pyrazolopyrimidines as cyclin-dependent kinase inhibitors |
US7119200B2 (en) * | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
US7605155B2 (en) * | 2002-09-04 | 2009-10-20 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
BRPI0616985B1 (pt) * | 2005-10-06 | 2021-10-26 | Merck Sharp & Dohme Corp. | Composto de pirazolo[1,5-a]pirimidina, e, uso de um composto |
TW200745123A (en) * | 2005-10-06 | 2007-12-16 | Schering Corp | Pyrazolopyrimidines as protein kinase inhibitors |
-
2007
- 2007-05-21 JP JP2009512064A patent/JP2009538304A/ja active Pending
- 2007-05-21 CN CNA2007800280091A patent/CN101495481A/zh active Pending
- 2007-05-21 MX MX2008014824A patent/MX2008014824A/es unknown
- 2007-05-21 WO PCT/US2007/011991 patent/WO2007139732A1/en active Application Filing
- 2007-05-21 KR KR1020087028392A patent/KR20090019796A/ko not_active Application Discontinuation
- 2007-05-21 EP EP07795066A patent/EP2027127A1/en not_active Withdrawn
- 2007-05-21 RU RU2008150419/04A patent/RU2008150419A/ru not_active Application Discontinuation
- 2007-05-21 PE PE2007000617A patent/PE20080071A1/es not_active Application Discontinuation
- 2007-05-21 BR BRPI0712016-8A patent/BRPI0712016A2/pt not_active IP Right Cessation
- 2007-05-21 AU AU2007268083A patent/AU2007268083A1/en not_active Abandoned
- 2007-05-21 CA CA002653076A patent/CA2653076A1/en not_active Abandoned
- 2007-05-21 US US11/751,282 patent/US20070275963A1/en not_active Abandoned
- 2007-05-22 AR ARP070102207A patent/AR061072A1/es not_active Application Discontinuation
- 2007-05-22 TW TW096118244A patent/TW200817404A/zh unknown
-
2008
- 2008-11-11 IL IL195238A patent/IL195238A0/en unknown
- 2008-11-17 ZA ZA200809796A patent/ZA200809796B/xx unknown
- 2008-11-21 EC EC2008008906A patent/ECSP088906A/es unknown
- 2008-12-19 NO NO20085331A patent/NO20085331L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2009538304A (ja) | 2009-11-05 |
IL195238A0 (en) | 2009-08-03 |
RU2008150419A (ru) | 2010-09-20 |
CA2653076A1 (en) | 2007-12-06 |
US20070275963A1 (en) | 2007-11-29 |
CN101495481A (zh) | 2009-07-29 |
ECSP088906A (es) | 2008-12-30 |
KR20090019796A (ko) | 2009-02-25 |
MX2008014824A (es) | 2008-12-01 |
PE20080071A1 (es) | 2008-02-11 |
EP2027127A1 (en) | 2009-02-25 |
BRPI0712016A2 (pt) | 2011-12-27 |
WO2007139732A1 (en) | 2007-12-06 |
ZA200809796B (en) | 2009-11-25 |
AR061072A1 (es) | 2008-07-30 |
TW200817404A (en) | 2008-04-16 |
AU2007268083A1 (en) | 2007-12-06 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |