NO20073487L - Valg av pasienter for terapi med en HER-inhibitor - Google Patents
Valg av pasienter for terapi med en HER-inhibitorInfo
- Publication number
- NO20073487L NO20073487L NO20073487A NO20073487A NO20073487L NO 20073487 L NO20073487 L NO 20073487L NO 20073487 A NO20073487 A NO 20073487A NO 20073487 A NO20073487 A NO 20073487A NO 20073487 L NO20073487 L NO 20073487L
- Authority
- NO
- Norway
- Prior art keywords
- therapy
- inhibitor
- selecting patients
- gene expression
- expression analysis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57449—Specifically defined cancers of ovaries
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/485—Epidermal growth factor [EGF] (urogastrone)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
- G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63394104P | 2004-12-07 | 2004-12-07 | |
PCT/US2005/044247 WO2006063042A2 (en) | 2004-12-07 | 2005-12-06 | Selecting patients for therapy with a her inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20073487L true NO20073487L (no) | 2007-09-05 |
Family
ID=36177671
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20073487A NO20073487L (no) | 2004-12-07 | 2007-07-05 | Valg av pasienter for terapi med en HER-inhibitor |
Country Status (14)
Country | Link |
---|---|
US (2) | US20060121044A1 (es) |
EP (1) | EP1825001A2 (es) |
JP (1) | JP2008523073A (es) |
KR (1) | KR20070085855A (es) |
CN (1) | CN101115849A (es) |
AR (1) | AR051524A1 (es) |
AU (1) | AU2005314127A1 (es) |
BR (1) | BRPI0518086A (es) |
CA (1) | CA2587519A1 (es) |
MX (1) | MX2007006529A (es) |
NO (1) | NO20073487L (es) |
RU (1) | RU2007125644A (es) |
WO (1) | WO2006063042A2 (es) |
ZA (1) | ZA200704796B (es) |
Families Citing this family (53)
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KR20140024061A (ko) * | 2000-05-19 | 2014-02-27 | 제넨테크, 인크. | ErbB 길항제에 의한 암 치료요법에 대한 효과적인 반응의 가능성을 개선시키기 위한 유전자 검출 분석 |
US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
AU2002311919B8 (en) | 2001-05-11 | 2007-03-22 | Ludwig Institute For Cancer Research Ltd | Specific binding proteins and uses thereof |
US7767792B2 (en) * | 2004-02-20 | 2010-08-03 | Ludwig Institute For Cancer Research Ltd. | Antibodies to EGF receptor epitope peptides |
GT200500155A (es) * | 2004-06-16 | 2006-05-15 | Terapia del càncer resistente al platino | |
CN101023100B (zh) * | 2004-07-22 | 2012-08-29 | 健泰科生物技术公司 | Her2抗体组合物 |
JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
EP1825001A2 (en) * | 2004-12-07 | 2007-08-29 | Genentech, Inc. | Selecting patients for therapy with a her inhibitor |
WO2006078307A1 (en) | 2005-01-21 | 2006-07-27 | Genentech, Inc. | Fixed dosing of her antibodies |
ES2440481T3 (es) * | 2005-02-23 | 2014-01-29 | Genentech, Inc. | Prolongación del tiempo hasta la progresión de la enfermedad o supervivencia en pacientes de cáncer de ovario usando pertuzumab |
PE20070207A1 (es) | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
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US9090693B2 (en) | 2007-01-25 | 2015-07-28 | Dana-Farber Cancer Institute | Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease |
KR20150039212A (ko) | 2007-03-02 | 2015-04-09 | 제넨테크, 인크. | 낮은 her3 발현을 기초로 한 her 이량체화 억제제에 대한 반응 예측 |
US9551033B2 (en) | 2007-06-08 | 2017-01-24 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
ES2583377T3 (es) * | 2007-06-08 | 2016-09-20 | Genentech, Inc. | Marcadores de expresión génica de la resistencia tumoral al tratamiento con inhibidor de HER2 |
ES2609915T3 (es) | 2007-08-14 | 2017-04-25 | Ludwig Institute For Cancer Research Ltd. | Anticuerpo monoclonal 175 direccionado al receptor de EGF y derivados y usos del mismo |
WO2009026705A1 (en) * | 2007-08-24 | 2009-03-05 | The University Of Western Ontario | Method of diagnosing and treating osteoarthritis |
TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至her2結構域ii之抗體及其酸性變異體的組合物 |
BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
US9086414B2 (en) | 2008-07-08 | 2015-07-21 | George Mason Research Foundation, Inc. | Phosphorylated C-ErbB2 as a superior predictive theranostic marker for the diagnosis and treatment of cancer |
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WO2011084496A1 (en) * | 2009-12-16 | 2011-07-14 | Abbott Biotherapeutics Corp. | Anti-her2 antibodies and their uses |
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WO2011147986A1 (en) | 2010-05-27 | 2011-12-01 | Genmab A/S | Monoclonal antibodies against her2 |
NZ604007A (en) | 2010-05-27 | 2015-03-27 | Genmab As | Monoclonal antibodies against her2 epitope |
TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
EP2635604B1 (en) | 2010-11-01 | 2016-11-30 | Symphogen A/S | Pan-her antibody composition |
JP2014514314A (ja) | 2011-04-20 | 2014-06-19 | ゲンマブ エー/エス | Her2およびcd3に対する二重特異性抗体 |
US9828635B2 (en) * | 2011-10-06 | 2017-11-28 | Aveo Pharmaceuticals, Inc. | Predicting tumor response to anti-ERBB3 antibodies |
CN116808199A (zh) | 2011-10-14 | 2023-09-29 | 霍夫曼-拉罗奇有限公司 | Her2二聚化抑制剂帕妥珠单抗的用途和包含her2二聚化抑制剂帕妥珠单抗的制品 |
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EP4039281A1 (en) | 2013-03-15 | 2022-08-10 | Biomolecular Holdings LLC | Hybrid immunoglobulin containing non-peptidyl linkage |
MX368259B (es) | 2013-04-16 | 2019-09-25 | Genentech Inc | Variantes de pertuzumab y su evaluacion. |
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ES2788973T3 (es) | 2014-03-14 | 2020-10-23 | Biomolecular Holdings Llc | Inmunoglobulina híbrida que contiene una unión distinta de peptidilo |
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EP3304072A4 (en) * | 2015-05-29 | 2018-12-05 | Expression Pathology, Inc. | Quantifying her2 protein for optimal cancer therapy |
EP3302551B1 (en) | 2015-05-30 | 2024-06-26 | F. Hoffmann-La Roche AG | Methods of treating her2-positive previously untreated metastatic breast cancer |
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WO2017087280A1 (en) | 2015-11-16 | 2017-05-26 | Genentech, Inc. | Methods of treating her2-positive cancer |
GB201611580D0 (en) * | 2016-07-01 | 2016-08-17 | Aslan Pharmaceuticals Pte Ltd | Method |
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CA3046092A1 (en) | 2016-12-28 | 2018-07-05 | Genentech, Inc. | Treatment of advanced her2 expressing cancer |
PT3570884T (pt) | 2017-01-17 | 2020-11-24 | Hoffmann La Roche | Formulações subcutâneas de anticorpo do her2 |
KR102417583B1 (ko) | 2017-03-02 | 2022-07-07 | 제넨테크, 인크. | Her2-양성 유방암 어쥬번트 치료 |
EP3615695A1 (en) | 2017-04-24 | 2020-03-04 | Genentech, Inc. | Erbb2/her2 mutations in the transmebrane or juxtamembrane domain |
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ATE540696T1 (de) * | 2004-04-08 | 2012-01-15 | David B Agus | Erbb2-antagonisten für die tumorschmerztherapie |
GT200500155A (es) * | 2004-06-16 | 2006-05-15 | Terapia del càncer resistente al platino | |
CN101023100B (zh) * | 2004-07-22 | 2012-08-29 | 健泰科生物技术公司 | Her2抗体组合物 |
JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
EP1825001A2 (en) * | 2004-12-07 | 2007-08-29 | Genentech, Inc. | Selecting patients for therapy with a her inhibitor |
WO2006078307A1 (en) * | 2005-01-21 | 2006-07-27 | Genentech, Inc. | Fixed dosing of her antibodies |
ES2440481T3 (es) * | 2005-02-23 | 2014-01-29 | Genentech, Inc. | Prolongación del tiempo hasta la progresión de la enfermedad o supervivencia en pacientes de cáncer de ovario usando pertuzumab |
US20060204505A1 (en) * | 2005-03-08 | 2006-09-14 | Sliwkowski Mark X | Methods for identifying tumors responsive to treatment with HER dimerization inhibitors (HDIs) |
JP2006316040A (ja) * | 2005-05-13 | 2006-11-24 | Genentech Inc | Herceptin(登録商標)補助療法 |
PE20070207A1 (es) * | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
US7700299B2 (en) * | 2005-08-12 | 2010-04-20 | Hoffmann-La Roche Inc. | Method for predicting the response to a treatment |
TW200812615A (en) * | 2006-03-22 | 2008-03-16 | Hoffmann La Roche | Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2 |
JP2009539836A (ja) * | 2006-06-05 | 2009-11-19 | ジェネンテック・インコーポレーテッド | EGFまたはTGF−αのレベルの上昇が生じている癌患者の生存の延長 |
US20080050385A1 (en) * | 2006-08-21 | 2008-02-28 | Thomas Friess | Tumor therapy with an anti-vegf antibody |
-
2005
- 2005-12-06 EP EP05853228A patent/EP1825001A2/en not_active Withdrawn
- 2005-12-06 WO PCT/US2005/044247 patent/WO2006063042A2/en active Application Filing
- 2005-12-06 RU RU2007125644/13A patent/RU2007125644A/ru not_active Application Discontinuation
- 2005-12-06 KR KR1020077012834A patent/KR20070085855A/ko not_active Application Discontinuation
- 2005-12-06 US US11/295,229 patent/US20060121044A1/en not_active Abandoned
- 2005-12-06 ZA ZA200704796A patent/ZA200704796B/xx unknown
- 2005-12-06 MX MX2007006529A patent/MX2007006529A/es not_active Application Discontinuation
- 2005-12-06 CA CA002587519A patent/CA2587519A1/en not_active Abandoned
- 2005-12-06 CN CNA2005800478629A patent/CN101115849A/zh active Pending
- 2005-12-06 AU AU2005314127A patent/AU2005314127A1/en not_active Abandoned
- 2005-12-06 BR BRPI0518086-4A patent/BRPI0518086A/pt not_active IP Right Cessation
- 2005-12-06 JP JP2007545584A patent/JP2008523073A/ja active Pending
- 2005-12-07 AR ARP050105126A patent/AR051524A1/es not_active Application Discontinuation
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2007
- 2007-07-05 NO NO20073487A patent/NO20073487L/no not_active Application Discontinuation
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2008
- 2008-05-01 US US12/113,802 patent/US20080317753A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
BRPI0518086A (pt) | 2008-10-28 |
AR051524A1 (es) | 2007-01-17 |
CA2587519A1 (en) | 2006-06-15 |
US20060121044A1 (en) | 2006-06-08 |
CN101115849A (zh) | 2008-01-30 |
AU2005314127A1 (en) | 2006-06-15 |
EP1825001A2 (en) | 2007-08-29 |
WO2006063042A2 (en) | 2006-06-15 |
WO2006063042A3 (en) | 2007-02-08 |
US20080317753A1 (en) | 2008-12-25 |
KR20070085855A (ko) | 2007-08-27 |
JP2008523073A (ja) | 2008-07-03 |
MX2007006529A (es) | 2007-06-22 |
RU2007125644A (ru) | 2009-01-20 |
ZA200704796B (en) | 2008-11-26 |
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