NO20023953A - Pyridinylimidazoler - Google Patents

Pyridinylimidazoler

Info

Publication number
NO20023953A
NO20023953A NO20023953A NO20023953A NO20023953A NO 20023953 A NO20023953 A NO 20023953A NO 20023953 A NO20023953 A NO 20023953A NO 20023953 A NO20023953 A NO 20023953A NO 20023953 A NO20023953 A NO 20023953A
Authority
NO
Norway
Prior art keywords
pyridinylimidazoler
Prior art date
Application number
NO20023953A
Other languages
English (en)
Other versions
NO20023953D0 (no
Inventor
Laramie Mary Gaster
Michael Stewart Hadley
John David Harling
Frank Peter Harrington
Jag Paul Heer
Tom Daniel Heightman
Andrew Hele Payne
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB0004053A priority Critical patent/GB0004053D0/en
Priority to GB0015902A priority patent/GB0015902D0/en
Priority to PCT/GB2001/000736 priority patent/WO2001062756A1/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of NO20023953D0 publication Critical patent/NO20023953D0/no
Publication of NO20023953A publication Critical patent/NO20023953A/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
NO20023953A 2000-02-21 2002-08-20 Pyridinylimidazoler NO20023953A (no)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB0004053A GB0004053D0 (en) 2000-02-21 2000-02-21 Compounds
GB0015902A GB0015902D0 (en) 2000-06-28 2000-06-28 Compounds
PCT/GB2001/000736 WO2001062756A1 (en) 2000-02-21 2001-02-21 Pyridinylimidazoles

Publications (2)

Publication Number Publication Date
NO20023953D0 NO20023953D0 (no) 2002-08-20
NO20023953A true NO20023953A (no) 2002-10-21

Family

ID=26243690

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20023953A NO20023953A (no) 2000-02-21 2002-08-20 Pyridinylimidazoler

Country Status (17)

Country Link
US (2) US20030166633A1 (no)
EP (1) EP1257543A1 (no)
JP (1) JP2003524010A (no)
CN (1) CN1404478A (no)
AR (1) AR029803A1 (no)
AU (2) AU2001233918B2 (no)
BR (1) BR0108437A (no)
CA (1) CA2401036A1 (no)
CO (1) CO5271680A1 (no)
CZ (1) CZ20022852A3 (no)
HU (1) HU0204514A3 (no)
IL (1) IL151319D0 (no)
MX (1) MXPA02008082A (no)
NO (1) NO20023953A (no)
NZ (1) NZ520753A (no)
PL (1) PL357420A1 (no)
WO (1) WO2001062756A1 (no)

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WO2002040468A1 (en) * 2000-11-16 2002-05-23 Smithkline Beecham Corporation Compounds
GB0127433D0 (en) * 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
GB0127430D0 (en) * 2001-11-15 2002-01-09 Smithkline Beecham Corp Compounds
AU2003224335A1 (en) * 2002-05-15 2003-12-02 Smithkline Beecham Corporation Benzoxazine and benzoxazinone substituted triazoles
US20040146509A1 (en) * 2002-07-25 2004-07-29 Zhihe Li Methods for improvement of lung function using TGF-beta inhibitors
WO2004010929A2 (en) * 2002-07-25 2004-02-05 Scios, Inc. METHODS FOR IMPROVEMENT OF LUNG FUNCTION USING TGF-β INHIBITORS
AU2003268447B2 (en) 2002-09-06 2008-07-24 Biogen Idec Ma Inc. Pyrazolopyridines and method of making and using the same
KR20050035296A (ko) * 2002-09-06 2005-04-15 바이오겐 아이덱 엠에이 인코포레이티드 이미다졸로피리딘과 그것의 제조 및 사용 방법
KR20050057441A (ko) 2002-09-18 2005-06-16 화이자 프로덕츠 인코포레이티드 전환 성장 인자 억제제로서의 신규한 아이소티아졸 및아이속사졸 화합물
CN1681502A (zh) 2002-09-18 2005-10-12 辉瑞产品公司 作为转化生长因子(tgf)抑制剂的三唑类衍生物
BR0314383A (pt) 2002-09-18 2005-07-19 Pfizer Prod Inc Compostos de oxazol e tiazol como inibidores do fator de crescimento transformante(tgf)
ES2325687T3 (es) * 2002-09-18 2009-09-14 Pfizer Products Inc. Compuestos de imidazol novedosos como inhibidores del factor de crecimiento transformante (tgf).
EP2165708A3 (en) 2002-09-18 2010-07-28 Pfizer Products Inc. New pyrazole derivatives as transforming growth factor (TGF) inhibitors
PA8595001A1 (es) 2003-03-04 2004-09-28 Pfizer Prod Inc Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transforante (tgf)
US7368445B2 (en) 2004-03-01 2008-05-06 Eli Lilly And Company Fused pyrazole derivatives as TGF-β signal transduction inhibitors for the treatment of fibrosis and neoplasms
US7678810B2 (en) * 2004-03-05 2010-03-16 Taisho Pharmaceutical Co., Ltd Thiazole derivative
US20080319012A1 (en) 2004-04-21 2008-12-25 In2Gen Co., Ltd. 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
KR100749566B1 (ko) * 2004-04-21 2007-08-16 에스케이케미칼주식회사 Alk5 및/또는 alk4 억제제로 유효한 2-피리딜이치환된 이미다졸 유도체
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
WO2006028029A1 (ja) * 2004-09-07 2006-03-16 Sankyo Company, Limited 置換ビフェニル誘導体
WO2006138744A2 (en) * 2005-06-24 2006-12-28 Genelabs Technologies, Inc. Heteroaryl derivatives for treating viruses
KR100694181B1 (ko) * 2005-11-25 2007-03-06 연세대학교 산학협력단 근원세포 또는 근섬유로부터 신경세포 분화를 유도하는화합물, 이를 포함하는 약학적 조성물, 신경세포 분화를유도하는 방법 및 신경세포 분화를 유도하는 화합물을검색하는 스크리닝 방법
WO2008071605A2 (en) * 2006-12-15 2008-06-19 F. Hoffmann-La Roche Ag Methods of treating inflammatory diseases
GB0715087D0 (en) 2007-08-03 2007-09-12 Summit Corp Plc Drug combinations for the treatment of duchenne muscular dystrophy
RS55735B1 (sr) 2007-08-03 2017-07-31 Summit (Oxford) Ltd Kombinacije lekova za lečenje dišenove mišićne distrofije
WO2009047163A1 (en) * 2007-10-10 2009-04-16 F. Hoffmann-La Roche Ag Methods of treating inflammatory diseases
JP5384611B2 (ja) * 2008-03-21 2014-01-08 ノバルティス アーゲー 新規ヘテロ環式化合物およびそれらの使用
US8865732B2 (en) 2008-03-21 2014-10-21 Novartis Ag Heterocyclic compounds and uses thereof
US8586581B2 (en) * 2009-12-17 2013-11-19 Hoffmann-La Roche Inc Ethynyl compounds useful for treatment of CNS disorders
US8080568B1 (en) 2010-06-29 2011-12-20 Ewha University - Industry Collaboration Foundation 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors
US8513222B2 (en) 2010-06-29 2013-08-20 EWHA University—Industry Collaboration Foundation Methods of treating fibrosis, cancer and vascular injuries
USRE47141E1 (en) 2010-06-29 2018-11-27 EWHA University—Industry Collaboration Foundation Methods of treating fibrosis, cancer and vascular injuries
TWI410425B (en) * 2010-12-03 2013-10-01 Lilly Co Eli Oxazolo[5,4-b]pyridin-5-yl compounds
CN103764655B (zh) 2011-07-13 2017-04-12 Sk化学公司 作为alk5和/或alk4抑制剂的经2‑吡啶基取代的咪唑
MX350442B (es) * 2011-07-29 2017-09-06 Karyopharm Therapeutics Inc Moduladores del transporte nuclear y usos de los mismos.
PL2736887T3 (pl) 2011-07-29 2018-03-30 Karyopharm Therapeutics, Inc. Modulatory transportu jądrowego zawierające ugrupowanie hydrazydu i ich zastosowania
ES2702279T3 (es) 2012-05-09 2019-02-28 Biogen Ma Inc Moduladores del transporte nuclear y usos de los mismos
SG11201407635XA (en) 2012-05-30 2014-12-30 Univ Cornell Generation of functional and durable endothelial cells from human amniotic fluid-derived cells
WO2014039189A1 (en) 2012-08-01 2014-03-13 Mcnally Elizabeth Mitigating tissue damage and fibrosis via latent transforming growth factor beta binding protein (ltbp4)
EP2958992A1 (en) 2013-02-22 2015-12-30 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
EP2968278B1 (en) 2013-03-15 2018-12-12 Karyopharm Therapeutics, Inc. Methods of promoting wound healing using crm1 inhibitors
CN105339358A (zh) 2013-06-21 2016-02-17 卡尔约药物治疗公司 核转运调节剂及其用途
WO2015164228A1 (en) 2014-04-21 2015-10-29 Cellular Dynamics International, Inc. Hepatocyte production via forward programming by combined genetic and chemical engineering
AU2015250994B2 (en) 2014-04-22 2018-12-20 Piqur Therapeutics Ag Novel manufacturing process for triazine, pyrimidine and pyridine derivatives
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
WO2018132279A1 (en) * 2017-01-05 2018-07-19 Bristol-Myers Squibb Company Tgf beta receptor antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH561716A5 (no) * 1971-05-10 1975-05-15 Ciba Geigy Ag
AP9300477A0 (en) * 1992-01-13 1993-01-31 Smithkline Beecham Corp Novel compounds
ZA9405363B (en) * 1993-07-21 1995-03-14 Smithkline Beecham Corp Novel compounds
US5656644A (en) * 1994-07-20 1997-08-12 Smithkline Beecham Corporation Pyridyl imidazoles
JPH09124640A (ja) * 1995-08-25 1997-05-13 Nippon Soda Co Ltd ピリジルイミダゾール化合物、製法および農園芸用殺菌剤
CA2295021A1 (en) * 1997-06-30 1999-01-28 Ortho-Mcneil Pharmaceutical, Inc. 2-substituted imidazoles useful in the treatment of inflammatory diseases
US6207687B1 (en) * 1998-07-31 2001-03-27 Merck & Co., Inc. Substituted imidazoles having cytokine inhibitory activity

Also Published As

Publication number Publication date
MXPA02008082A (es) 2003-02-27
US20030166633A1 (en) 2003-09-04
AU3391801A (en) 2001-09-03
US20040220230A1 (en) 2004-11-04
AU2001233918B2 (en) 2004-06-24
IL151319D0 (en) 2003-04-10
HU0204514A3 (en) 2004-07-28
CA2401036A1 (en) 2001-08-30
HU0204514A2 (en) 2003-05-28
CZ20022852A3 (cs) 2003-04-16
WO2001062756A1 (en) 2001-08-30
NZ520753A (en) 2004-08-27
AR029803A1 (es) 2003-07-16
EP1257543A1 (en) 2002-11-20
NO20023953D0 (no) 2002-08-20
BR0108437A (pt) 2005-06-28
CN1404478A (zh) 2003-03-19
PL357420A1 (xx) 2004-07-26
JP2003524010A (ja) 2003-08-12
CO5271680A1 (es) 2003-04-30

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Legal Events

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FC2A Rejection of laid open patent application