NO20014876L - Lav-molekyl¶re inhibitorer av komplement-proteaser - Google Patents
Lav-molekyl¶re inhibitorer av komplement-proteaserInfo
- Publication number
- NO20014876L NO20014876L NO20014876A NO20014876A NO20014876L NO 20014876 L NO20014876 L NO 20014876L NO 20014876 A NO20014876 A NO 20014876A NO 20014876 A NO20014876 A NO 20014876A NO 20014876 L NO20014876 L NO 20014876L
- Authority
- NO
- Norway
- Prior art keywords
- molecular
- low
- weight inhibitors
- complement proteases
- complement
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19915930 | 1999-04-09 | ||
PCT/EP2000/002710 WO2000061608A2 (de) | 1999-04-09 | 2000-03-28 | Niedermolekulare inhibitoren von komplementproteasen |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20014876D0 NO20014876D0 (no) | 2001-10-08 |
NO20014876L true NO20014876L (no) | 2001-12-04 |
Family
ID=7903946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20014876A NO20014876L (no) | 1999-04-09 | 2001-10-08 | Lav-molekyl¶re inhibitorer av komplement-proteaser |
Country Status (22)
Country | Link |
---|---|
US (1) | US6683055B1 (hu) |
EP (1) | EP1169338B1 (hu) |
JP (1) | JP4489976B2 (hu) |
KR (1) | KR20010108477A (hu) |
CN (1) | CN1351609A (hu) |
AT (1) | ATE281466T1 (hu) |
AU (1) | AU4111700A (hu) |
BG (1) | BG105978A (hu) |
BR (1) | BR0009678A (hu) |
CA (1) | CA2369378A1 (hu) |
CZ (1) | CZ20013577A3 (hu) |
DE (1) | DE50008510D1 (hu) |
HK (1) | HK1045846A1 (hu) |
HU (1) | HUP0203167A3 (hu) |
IL (1) | IL145771A0 (hu) |
MX (1) | MXPA01010114A (hu) |
NO (1) | NO20014876L (hu) |
PL (1) | PL351441A1 (hu) |
SK (1) | SK14232001A3 (hu) |
TR (1) | TR200102913T2 (hu) |
WO (1) | WO2000061608A2 (hu) |
ZA (2) | ZA200107890B (hu) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7144902B1 (en) * | 1999-04-09 | 2006-12-05 | Abbott Gmbh & Co. Kg | Prodrugs of thrombin inhibitors |
NZ547626A (en) * | 2000-08-11 | 2007-10-26 | Wilex Ag | Non-covalent inhibitors of urokinase and blood vessel formation |
EP1182207B1 (en) * | 2000-08-11 | 2007-04-18 | Dendreon Corporation | Non-covalent inhibitors of urokinase and blood vessel formation |
AU2003206945A1 (en) * | 2002-02-22 | 2003-09-09 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Use of proteinase inhibitors in the treatment of autoimmune diseases |
WO2003078448A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
JP4459629B2 (ja) | 2002-04-12 | 2010-04-28 | メルク エンド カムパニー インコーポレーテッド | 二環式アミド |
ES2522525T3 (es) * | 2003-05-15 | 2014-11-14 | Genentech, Inc. | Métodos y composiciones para la prevención y el tratamiento de la sepsis |
TW200519105A (en) * | 2003-10-20 | 2005-06-16 | Lg Life Science Ltd | Novel inhibitors of DPP-IV, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent |
CN1304568C (zh) * | 2004-07-05 | 2007-03-14 | 中国人民解放军第二军医大学 | 新型人补体C1r样丝氨酸蛋白酶类似物,其编码序列及用途 |
US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
US8221804B2 (en) * | 2005-02-03 | 2012-07-17 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
KR20080002832A (ko) * | 2005-03-16 | 2008-01-04 | 얀센 파마슈티카 엔.브이. | 보체 매개성 질병 및 이상을 치료하기 위한 신규한 티오펜설폭시민 |
JP5607025B2 (ja) | 2008-04-21 | 2014-10-15 | シグナム バイオサイエンシーズ, インコーポレイテッド | 化合物、組成物およびそれらを作製する方法 |
CN102464701B (zh) * | 2010-11-08 | 2015-10-21 | 上海医药工业研究院 | 一类新型化合物、其制备方法及用途 |
IN2014CN02805A (hu) | 2011-10-14 | 2015-07-03 | Bristol Myers Squibb Co | |
ES2699226T3 (es) | 2011-10-14 | 2019-02-08 | Bristol Myers Squibb Co | Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor XIa |
TWI633091B (zh) | 2011-10-14 | 2018-08-21 | Bristol-Myers Squibb Company | 作為因子xia抑制劑之經取代四氫異喹啉化合物 |
WO2014059214A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
NZ707990A (en) | 2012-10-12 | 2018-07-27 | Bristol Myers Squibb Co | Crystalline forms of a factor xia inhibitor |
EP2906552B1 (en) | 2012-10-12 | 2017-11-22 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
WO2014160668A1 (en) | 2013-03-25 | 2014-10-02 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors |
NO2760821T3 (hu) | 2014-01-31 | 2018-03-10 | ||
DK3099687T3 (en) | 2014-01-31 | 2018-10-22 | Bristol Myers Squibb Co | MACROCYCLES WITH HETEROCYCLIC P2 'GROUPS AS FACTOR XIA INHIBITORS |
CN107074821B (zh) | 2014-09-04 | 2020-05-22 | 百时美施贵宝公司 | 为fxia抑制剂的二酰胺大环化合物 |
US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
JP2022519924A (ja) * | 2019-03-22 | 2022-03-25 | アキリオン ファーマシューティカルズ, インコーポレーテッド | 補体媒介性障害の治療のための医薬化合物 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3738910A1 (de) | 1987-11-17 | 1989-05-24 | Basf Ag | Tributylammoniumsalz von 1,1-dicyano-2-hydroxy-3-chlorprop-1-en, ein verfahren zu seiner herstellung sowie ein verfahren zur herstellung von 2-amino-4-chlor-3-cyano-5-formylthiophen |
AU675981B2 (en) * | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
DE4421052A1 (de) | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
DE4443390A1 (de) * | 1994-12-06 | 1996-06-13 | Basf Ag | Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten |
KR19980702112A (ko) * | 1995-02-10 | 1998-07-15 | 페라 스타르크,요헨 카르크 | 트롬빈 억제제 |
SI9620037A (sl) | 1995-02-17 | 1998-02-28 | Basf Aktiengesellschaft | Novi trombinski inhibitorji |
TW541316B (en) * | 1995-12-21 | 2003-07-11 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
DE19632772A1 (de) * | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Benzamidine |
DE19632773A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
DE19635674A1 (de) | 1996-09-03 | 1998-03-05 | Basf Ag | Verfahren zur Herstellung von Amidinen |
US6653340B1 (en) * | 1997-06-03 | 2003-11-25 | Biocryst Pharmaceuticals, Inc. | Compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation |
WO1999037668A1 (de) * | 1998-01-26 | 1999-07-29 | Basf Aktiengesellschaft | Thrombininhibitoren |
WO1999037611A1 (de) * | 1998-01-26 | 1999-07-29 | Basf Aktiengesellschaft | Heterocyclische amidine als kallikrein protease inhibitoren |
-
2000
- 2000-03-28 WO PCT/EP2000/002710 patent/WO2000061608A2/de active IP Right Grant
- 2000-03-28 CN CN00807468A patent/CN1351609A/zh active Pending
- 2000-03-28 KR KR1020017012848A patent/KR20010108477A/ko not_active Application Discontinuation
- 2000-03-28 IL IL14577100A patent/IL145771A0/xx unknown
- 2000-03-28 TR TR2001/02913T patent/TR200102913T2/xx unknown
- 2000-03-28 CA CA002369378A patent/CA2369378A1/en not_active Abandoned
- 2000-03-28 AT AT00920597T patent/ATE281466T1/de not_active IP Right Cessation
- 2000-03-28 EP EP00920597A patent/EP1169338B1/de not_active Expired - Lifetime
- 2000-03-28 BR BR0009678-4A patent/BR0009678A/pt not_active IP Right Cessation
- 2000-03-28 AU AU41117/00A patent/AU4111700A/en not_active Abandoned
- 2000-03-28 SK SK1423-2001A patent/SK14232001A3/sk unknown
- 2000-03-28 HU HU0203167A patent/HUP0203167A3/hu unknown
- 2000-03-28 MX MXPA01010114A patent/MXPA01010114A/es unknown
- 2000-03-28 CZ CZ20013577A patent/CZ20013577A3/cs unknown
- 2000-03-28 JP JP2000611550A patent/JP4489976B2/ja not_active Expired - Fee Related
- 2000-03-28 PL PL00351441A patent/PL351441A1/xx not_active Application Discontinuation
- 2000-03-28 DE DE50008510T patent/DE50008510D1/de not_active Expired - Lifetime
- 2000-03-30 US US09/539,811 patent/US6683055B1/en not_active Expired - Lifetime
-
2001
- 2001-09-26 ZA ZA200107890A patent/ZA200107890B/xx unknown
- 2001-09-28 ZA ZA200107978A patent/ZA200107978B/xx unknown
- 2001-10-04 BG BG105978A patent/BG105978A/bg unknown
- 2001-10-08 NO NO20014876A patent/NO20014876L/no unknown
-
2002
- 2002-09-26 HK HK02107037.8A patent/HK1045846A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CA2369378A1 (en) | 2000-10-19 |
CZ20013577A3 (cs) | 2002-07-17 |
ATE281466T1 (de) | 2004-11-15 |
NO20014876D0 (no) | 2001-10-08 |
PL351441A1 (en) | 2003-04-22 |
ZA200107978B (en) | 2003-03-26 |
IL145771A0 (en) | 2002-07-25 |
SK14232001A3 (sk) | 2002-06-04 |
JP4489976B2 (ja) | 2010-06-23 |
EP1169338A2 (de) | 2002-01-09 |
MXPA01010114A (es) | 2002-07-30 |
HUP0203167A3 (en) | 2003-09-29 |
HK1045846A1 (zh) | 2002-12-13 |
DE50008510D1 (de) | 2004-12-09 |
CN1351609A (zh) | 2002-05-29 |
TR200102913T2 (tr) | 2002-01-21 |
AU4111700A (en) | 2000-11-14 |
ZA200107890B (en) | 2003-11-26 |
US6683055B1 (en) | 2004-01-27 |
WO2000061608A2 (de) | 2000-10-19 |
KR20010108477A (ko) | 2001-12-07 |
BG105978A (bg) | 2002-07-31 |
BR0009678A (pt) | 2002-01-22 |
HUP0203167A2 (hu) | 2003-02-28 |
EP1169338B1 (de) | 2004-11-03 |
WO2000061608A3 (de) | 2001-01-11 |
JP2002542164A (ja) | 2002-12-10 |
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