NO20003344L - Topical eye preparations containing immunosuppressants - Google Patents

Topical eye preparations containing immunosuppressants

Info

Publication number
NO20003344L
NO20003344L NO20003344A NO20003344A NO20003344L NO 20003344 L NO20003344 L NO 20003344L NO 20003344 A NO20003344 A NO 20003344A NO 20003344 A NO20003344 A NO 20003344A NO 20003344 L NO20003344 L NO 20003344L
Authority
NO
Norway
Prior art keywords
weight
hydroxy
ethanediyl
oxy
poly
Prior art date
Application number
NO20003344A
Other languages
Norwegian (no)
Other versions
NO20003344D0 (en
Inventor
Milan Stuchlik
Alexandr Jegorov
Vladimir Matha
Josef Stuchlik
Original Assignee
Galena As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galena As filed Critical Galena As
Publication of NO20003344L publication Critical patent/NO20003344L/en
Publication of NO20003344D0 publication Critical patent/NO20003344D0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Det beskrives terapeutiske preparater for topisk oftalmisk påføring, inne- holdende fra 0,02 til 5,0 vekt% immunsuppressive midler tilhørende gruppen av monocykliske undekapeptider, makrolid-laktoner eller kortikosteroider, i en bærer omfattende opp til 10 vekt% polyalkylenglykol-polyuretan-kopolymerer. Nevnte kopolymerer består fortrinnsvis av poly(oksy-1,2-etandiyl)-a-hydro-o>- hydroksypolymerer med 1,1'-metylen-bis-(4-isocyanatcykloheksan) som har en gjennomsnittlig molekylvekt på fra 1000 til 3000 i en hydrofil bærer og fortrinnsvis av poly[oksy-(metyl-1,2-etandiyl)]-a-hydro-co-hydroksypolymerer med 1,1 '-metylen-bis- (4-isocyanatcykloheksan) som har en gjennomsnittlig molekylvekt på'fra 1600 til ¿ 18000 i en lipofil bærer. Nevnte terapeutiske midler kan dessuten inneholde hjelpestoffer som er vanlige i topiske administrasjonsformer.Therapeutic preparations for topical ophthalmic application containing from 0.02 to 5.0% by weight immunosuppressants of the group of monocyclic undecapeptides, macrolide lactones or corticosteroids are disclosed in a carrier comprising up to 10% by weight of polyalkylene glycol polyurethane copolymers. . Said copolymers preferably consist of poly (oxy-1,2-ethanediyl) -α-hydroxy-hydroxy polymers with 1,1'-methylene bis- (4-isocyanate cyclohexane) having an average molecular weight of from 1000 to 3000 a hydrophilic support and preferably of poly [oxy (methyl-1,2-ethanediyl)] - α-hydro-co-hydroxy polymers with 1,1 '-methylene bis- (4-isocyanate cyclohexane) having an average molecular weight of from 1600 to ¿18000 in a lipophilic carrier. Said therapeutic agents may additionally contain adjuvants which are common in topical forms of administration.

NO20003344A 1997-12-30 2000-06-27 Topical eye preparations containing immunosuppressants NO20003344D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ19974237A CZ287497B6 (en) 1997-12-30 1997-12-30 Topic eye preparations containing immunosuppressive substances
PCT/CZ1998/000054 WO1999034830A1 (en) 1997-12-30 1998-12-17 Topical ophthalmic preparations containing immunosuppressive agents

Publications (2)

Publication Number Publication Date
NO20003344L true NO20003344L (en) 2000-06-27
NO20003344D0 NO20003344D0 (en) 2000-06-27

Family

ID=5467853

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20003344A NO20003344D0 (en) 1997-12-30 2000-06-27 Topical eye preparations containing immunosuppressants

Country Status (12)

Country Link
EP (1) EP1058560A1 (en)
JP (1) JP2002500200A (en)
AU (1) AU1481399A (en)
BG (1) BG104558A (en)
CA (1) CA2317010A1 (en)
CZ (1) CZ287497B6 (en)
HR (1) HRP20000258A2 (en)
HU (1) HUP0004173A2 (en)
NO (1) NO20003344D0 (en)
PL (1) PL341604A1 (en)
SK (1) SK284246B6 (en)
WO (1) WO1999034830A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2356382A1 (en) * 1998-12-24 2000-07-06 R-Tech Ueno, Ltd. Agent for treating visual cell function disorder
US6864232B1 (en) 1998-12-24 2005-03-08 Sucampo Ag Agent for treating visual cell function disorder
TWI324925B (en) * 2001-08-23 2010-05-21 Novartis Ag Ophthalmic composition
EP2514420B1 (en) 2002-09-18 2014-08-13 Trustees Of The University Of Pennsylvania Use of rapamycin for the treatment or prevention of age-related macular degeneration
US7354574B2 (en) 2002-11-07 2008-04-08 Advanced Ocular Systems Limited Treatment of ocular disease
US7083802B2 (en) 2003-07-31 2006-08-01 Advanced Ocular Systems Limited Treatment of ocular disease
US7083803B2 (en) 2003-09-19 2006-08-01 Advanced Ocular Systems Limited Ocular solutions
US7087237B2 (en) 2003-09-19 2006-08-08 Advanced Ocular Systems Limited Ocular solutions
KR20070104931A (en) 2005-02-09 2007-10-29 마커사이트, 인코포레이티드 Formulations for ocular treatment
PL1904056T3 (en) 2005-07-18 2009-09-30 Minu Llc Use of a macrolide to restore corneal sensation
JP5528708B2 (en) 2006-02-09 2014-06-25 参天製薬株式会社 Stable formulations and methods for preparing and using them
BRPI0709016A2 (en) 2006-03-23 2011-06-21 Macusight Inc formulations and methods for diseases or conditions related to vascular permeability
DK2948134T3 (en) 2013-01-24 2020-06-02 Palvella Therapeutics Inc COMPOSITIONS FOR TRANSDERMAL ADMINISTRATION OF MTOR INHIBITORS
CN105431138B (en) * 2013-03-27 2019-01-11 全球药物科技有限公司 Eye medicine combination, preparation method and the usage
CA3016464A1 (en) 2016-03-08 2017-09-14 Soo-Young Kang Long lasting cosmetic compositions
IL267869B2 (en) 2017-01-06 2023-10-01 Palvella Therapeutics Inc Anhydrous compositions of mtor inhibitors and methods of use
CA3074843A1 (en) 2017-09-13 2019-03-21 Living Proof, Inc. Long lasting cosmetic compositions
EP3681921A2 (en) 2017-09-13 2020-07-22 Living Proof, Inc. Color protectant compositions
WO2019099966A1 (en) 2017-11-20 2019-05-23 Living Proof, Inc. Properties for achieving long-lasting cosmetic performance
CN112041365A (en) 2018-04-27 2020-12-04 生活实验公司 Long-lasting cosmetic composition
WO2020010073A1 (en) 2018-07-02 2020-01-09 Palvella Therapeutics, Inc. ANHYDROUS COMPOSITIONS OF mTOR INHIBITORS AND METHODS OF USE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5051260A (en) * 1987-07-16 1991-09-24 The Regents Of The University Of California Method and composition for enhancing the cutaneous penetration of pharmacologically active agents
US5045317A (en) * 1987-07-16 1991-09-03 The Regents Of The University Of California Enhancing the cutaneous penetration of pharmacologically active agents
US4971800A (en) * 1988-07-08 1990-11-20 The Regents Of The University Of California Method and compositions for enhancing the cutaneous penetration of pharmacologically active agents

Also Published As

Publication number Publication date
HUP0004173A2 (en) 2001-08-28
EP1058560A1 (en) 2000-12-13
NO20003344D0 (en) 2000-06-27
BG104558A (en) 2001-02-28
CZ287497B6 (en) 2000-12-13
CA2317010A1 (en) 1999-07-15
AU1481399A (en) 1999-07-26
PL341604A1 (en) 2001-04-23
JP2002500200A (en) 2002-01-08
SK284246B6 (en) 2004-12-01
WO1999034830A1 (en) 1999-07-15
HRP20000258A2 (en) 2001-04-30
SK171798A3 (en) 1999-10-08
CZ423797A3 (en) 1999-07-14

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Legal Events

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FC2A Withdrawal, rejection or dismissal of laid open patent application