NO20001465L - Acid addition salt of morphine alkaloids and their use - Google Patents
Acid addition salt of morphine alkaloids and their useInfo
- Publication number
- NO20001465L NO20001465L NO20001465A NO20001465A NO20001465L NO 20001465 L NO20001465 L NO 20001465L NO 20001465 A NO20001465 A NO 20001465A NO 20001465 A NO20001465 A NO 20001465A NO 20001465 L NO20001465 L NO 20001465L
- Authority
- NO
- Norway
- Prior art keywords
- acids
- substituted
- addition salt
- acid addition
- hydroxy
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 229930013053 morphinan alkaloid Natural products 0.000 title 1
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical class O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 amino-substituted benzoic acids Chemical class 0.000 abstract 2
- 235000010233 benzoic acid Nutrition 0.000 abstract 2
- 150000001559 benzoic acids Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 150000003797 alkaloid derivatives Chemical class 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 150000003460 sulfonic acids Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C07D489/04—Salts; Organic complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Det blir fremskaffet et stoff bestående av syreaddisjonssaltet av et morfmalkaloid og en organisk syre. Den organiske syren er valgt blant monoestere av C3- til C|6- dikarboksylsyrer med enverdige Cr til C4-aIkoholer, C2- til C^-sulfonsyrer, substituerte bensosyrer utvalgt blant gruppen halogen-, hydroksy-, alkyl-, hydroksy-, alkyl-, alkoksyalkyl- og/eller alkoksysubstituerte bensosyrer så vel som eventuelt på N-atomet alkylerte aminosubstituerte bensosyrer, 5- eller 6- ring heterocyckluser med minst ett N- atom eller S-atom og med en karboksyfunksjon, mettede eller umettede, eventuelt substituerte okso-karboksylsyrer med 5 til 10 C-atomer, fenyl- eller fenoksysubstituerte mettede C2-C4-karboksylsyrer, alifatiske, aromatiske eller heterocycliske C2-C]2- aminosyrer, hvor en aminogruppe er substituert med en eventuelt substituert C2-C6- alkanoylgruppe eller en eventuelt substituert benzoylgruppe.A substance consisting of the acid addition salt of a morphal alkaloid and an organic acid is obtained. The organic acid is selected from mono esters of C3 to C6 dicarboxylic acids with monovalent Cr to C4 alcohols, C2 to C4 sulfonic acids, substituted benzoic acids selected from the group of halogenated, hydroxy, alkyl, hydroxy, alkyl -, alkoxyalkyl and / or alkoxy-substituted benzoic acids as well as optionally alkylated amino-substituted benzoic acids, 5- or 6-ring heterocycles having at least one N atom or S atom and having a carboxy function, saturated or unsaturated, optionally substituted oxo carboxylic acids having 5 to 10 C atoms, phenyl or phenoxy-substituted saturated C 2 -C 4 carboxylic acids, aliphatic, aromatic or heterocyclic C 2 -C 1- optionally substituted benzoyl group.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742296 | 1997-09-25 | ||
| DE19834005A DE19834005A1 (en) | 1997-09-25 | 1998-07-29 | Acid addition salts of morphine alkaloids and their use |
| PCT/EP1998/005652 WO1999015528A1 (en) | 1997-09-25 | 1998-09-05 | Acidic addition salts of morphine alkaloids and the application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20001465D0 NO20001465D0 (en) | 2000-03-21 |
| NO20001465L true NO20001465L (en) | 2000-03-21 |
Family
ID=26040297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20001465A NO20001465L (en) | 1997-09-25 | 2000-03-21 | Acid addition salt of morphine alkaloids and their use |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1017696B1 (en) |
| JP (1) | JP2001517669A (en) |
| AT (1) | ATE214702T1 (en) |
| AU (1) | AU741434B2 (en) |
| CA (1) | CA2304722C (en) |
| CZ (1) | CZ300532B6 (en) |
| DK (1) | DK1017696T3 (en) |
| ES (1) | ES2174490T3 (en) |
| HU (1) | HUP0003686A3 (en) |
| ID (1) | ID26296A (en) |
| IL (1) | IL134787A (en) |
| MX (1) | MXPA00002658A (en) |
| NO (1) | NO20001465L (en) |
| NZ (1) | NZ503459A (en) |
| PL (1) | PL193321B1 (en) |
| PT (1) | PT1017696E (en) |
| SK (1) | SK4322000A3 (en) |
| TR (1) | TR200000653T2 (en) |
| TW (1) | TW576836B (en) |
| WO (1) | WO1999015528A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9924797D0 (en) | 1999-10-20 | 1999-12-22 | West Pharm Serv Drug Res Ltd | Compound |
| GB0218811D0 (en) * | 2002-08-14 | 2002-09-18 | Cenes Ltd | Salts of morphine-6-glucuronide |
| DE102006054732B4 (en) | 2006-11-21 | 2010-12-30 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with ion-pair microreservoirs |
| EP2311498A4 (en) * | 2008-08-05 | 2013-07-24 | Medrx Co Ltd | External preparation comprising fatty acid salt or benzoic acid salt of basic pharmacologically active component, and method for production thereof |
| WO2013019825A1 (en) * | 2011-08-02 | 2013-02-07 | Mallinckrodt Llc | Stepwise process for the production of alkaloid salts |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE524639C (en) * | 1929-05-25 | 1931-05-09 | Chem Fab Vorm Sandoz | Process for the preparation of easily soluble salts of benzylmorphone |
| DE728804C (en) * | 1935-04-02 | 1942-12-03 | Jean Lucien Regnier | Process for the preparation of salts of morphine with aralkylcarboxylic acids |
| DE1172267B (en) * | 1961-09-19 | 1964-06-18 | Dausse S A Lab | Process for the preparation of the bis-guaiacol-sulfonic acid salt of morphine-ª ‰ -morpholyl-ethyl-ether |
| FR6598M (en) * | 1967-07-28 | 1969-01-06 | ||
| US4626539A (en) * | 1984-08-10 | 1986-12-02 | E. I. Dupont De Nemours And Company | Trandermal delivery of opioids |
| US4908389A (en) * | 1986-08-27 | 1990-03-13 | Warner-Lambert Company | Penetration enhancement system |
| US4879297A (en) * | 1987-06-01 | 1989-11-07 | Warner-Lambert Company | Fatty acids and their small chain esters as penetration enhancers in aqueous systems |
| US5374645A (en) * | 1990-01-22 | 1994-12-20 | Ciba-Geigy Corporation | Transdermal administation of ionic pharmaceutically active agents via aqueous isopropanol |
| TW225536B (en) * | 1990-08-23 | 1994-06-21 | Ciba Geigy Ag | |
| FR2708611B1 (en) * | 1993-07-29 | 1995-10-27 | Meram Lab | Codeine salt of 2- (3-benzoylphenyl) propionic acid, process for obtaining it and pharmaceutical compositions containing it. |
| DE19607395C2 (en) * | 1996-02-28 | 2002-11-21 | Lohmann Therapie Syst Lts | Salts from a cationic narcotic analgesic with an anionic non-narcotic analgesic, process for their preparation and the pharmaceutical preparations containing these salts |
-
1998
- 1998-09-05 CA CA002304722A patent/CA2304722C/en not_active Expired - Fee Related
- 1998-09-05 DK DK98945312T patent/DK1017696T3/en active
- 1998-09-05 ID IDW20000549A patent/ID26296A/en unknown
- 1998-09-05 JP JP2000512833A patent/JP2001517669A/en active Pending
- 1998-09-05 AT AT98945312T patent/ATE214702T1/en active
- 1998-09-05 AU AU92666/98A patent/AU741434B2/en not_active Ceased
- 1998-09-05 HU HU0003686A patent/HUP0003686A3/en unknown
- 1998-09-05 MX MXPA00002658A patent/MXPA00002658A/en active IP Right Grant
- 1998-09-05 SK SK432-2000A patent/SK4322000A3/en unknown
- 1998-09-05 PT PT98945312T patent/PT1017696E/en unknown
- 1998-09-05 CZ CZ20001048A patent/CZ300532B6/en not_active IP Right Cessation
- 1998-09-05 ES ES98945312T patent/ES2174490T3/en not_active Expired - Lifetime
- 1998-09-05 EP EP98945312A patent/EP1017696B1/en not_active Expired - Lifetime
- 1998-09-05 PL PL339516A patent/PL193321B1/en not_active IP Right Cessation
- 1998-09-05 WO PCT/EP1998/005652 patent/WO1999015528A1/en active IP Right Grant
- 1998-09-05 TR TR2000/00653T patent/TR200000653T2/en unknown
- 1998-09-05 NZ NZ503459A patent/NZ503459A/en not_active IP Right Cessation
- 1998-09-05 IL IL134787A patent/IL134787A/en not_active IP Right Cessation
- 1998-09-23 TW TW087115805A patent/TW576836B/en not_active IP Right Cessation
-
2000
- 2000-03-21 NO NO20001465A patent/NO20001465L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL134787A (en) | 2007-05-15 |
| IL134787A0 (en) | 2001-04-30 |
| NZ503459A (en) | 2001-12-21 |
| PL339516A1 (en) | 2000-12-18 |
| CZ300532B6 (en) | 2009-06-10 |
| HUP0003686A3 (en) | 2003-04-28 |
| NO20001465D0 (en) | 2000-03-21 |
| TR200000653T2 (en) | 2000-07-21 |
| CZ20001048A3 (en) | 2000-08-16 |
| WO1999015528A1 (en) | 1999-04-01 |
| JP2001517669A (en) | 2001-10-09 |
| EP1017696B1 (en) | 2002-03-20 |
| MXPA00002658A (en) | 2004-03-10 |
| AU9266698A (en) | 1999-04-12 |
| CA2304722C (en) | 2005-11-22 |
| PT1017696E (en) | 2002-09-30 |
| EP1017696A1 (en) | 2000-07-12 |
| ES2174490T3 (en) | 2002-11-01 |
| PL193321B1 (en) | 2007-01-31 |
| AU741434B2 (en) | 2001-11-29 |
| DK1017696T3 (en) | 2002-07-08 |
| TW576836B (en) | 2004-02-21 |
| CA2304722A1 (en) | 1999-04-01 |
| ID26296A (en) | 2000-12-14 |
| ATE214702T1 (en) | 2002-04-15 |
| HUP0003686A2 (en) | 2001-09-28 |
| SK4322000A3 (en) | 2000-10-09 |
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