NO180582C - Dietylentriamineddiksyremonoamider (DTPA-monoamider), komplekser og komplekssalter derav, samt anvendelse av forbindelsene til fremstilling av midler for NMR-, röntgen-eller radiodiagnostikk - Google Patents
Dietylentriamineddiksyremonoamider (DTPA-monoamider), komplekser og komplekssalter derav, samt anvendelse av forbindelsene til fremstilling av midler for NMR-, röntgen-eller radiodiagnostikkInfo
- Publication number
- NO180582C NO180582C NO911345A NO911345A NO180582C NO 180582 C NO180582 C NO 180582C NO 911345 A NO911345 A NO 911345A NO 911345 A NO911345 A NO 911345A NO 180582 C NO180582 C NO 180582C
- Authority
- NO
- Norway
- Prior art keywords
- group
- hydrogen atom
- radical
- monoamides
- alkyl
- Prior art date
Links
- -1 Diethylenetriamine acetic acid monoamides Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000006165 cyclic alkyl group Chemical group 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000001174 sulfone group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4011684A DE4011684A1 (de) | 1990-04-06 | 1990-04-06 | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
Publications (4)
Publication Number | Publication Date |
---|---|
NO911345D0 NO911345D0 (no) | 1991-04-05 |
NO911345L NO911345L (no) | 1991-10-07 |
NO180582B NO180582B (no) | 1997-02-03 |
NO180582C true NO180582C (no) | 1997-05-14 |
Family
ID=6404192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO911345A NO180582C (no) | 1990-04-06 | 1991-04-05 | Dietylentriamineddiksyremonoamider (DTPA-monoamider), komplekser og komplekssalter derav, samt anvendelse av forbindelsene til fremstilling av midler for NMR-, röntgen-eller radiodiagnostikk |
Country Status (16)
Country | Link |
---|---|
US (4) | US5859214A (ja) |
EP (1) | EP0450742B1 (ja) |
JP (1) | JP2854159B2 (ja) |
AT (1) | ATE108179T1 (ja) |
AU (1) | AU644639B2 (ja) |
CA (1) | CA2039846A1 (ja) |
DE (2) | DE4011684A1 (ja) |
DK (1) | DK0450742T3 (ja) |
ES (1) | ES2057746T3 (ja) |
FI (1) | FI911646A (ja) |
HU (1) | HUT57180A (ja) |
IE (1) | IE65923B1 (ja) |
NO (1) | NO180582C (ja) |
NZ (1) | NZ237711A (ja) |
PT (1) | PT97263B (ja) |
ZA (1) | ZA912550B (ja) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4011684A1 (de) * | 1990-04-06 | 1991-10-10 | Schering Ag | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
WO1994001393A1 (en) * | 1992-07-03 | 1994-01-20 | The Green Cross Corporation | Novel chelating agent, complex compound composed of said agent and metallic atom, and diagnostic agent containing said compound |
US6875864B2 (en) | 1991-08-01 | 2005-04-05 | Bracco International B.V. | Aminocarboxylate ligands having substituted aromatic amide moieties |
AU5360994A (en) * | 1992-10-13 | 1994-05-09 | Mallinckrodt Medical, Inc. | Novel compositions for magnetic resonance imaging |
DE69312951T2 (de) * | 1992-10-14 | 1997-12-11 | Nycomed Imaging As | Chelatpolymere |
US5817292A (en) * | 1992-10-14 | 1998-10-06 | Nycomed Imaging As | MR imaging compositions and methods |
DE69327659T2 (de) * | 1992-10-14 | 2000-09-21 | Nycomed Imaging As, Oslo | Therapeutische und diagnostische bilderzeugungzusammensetzung und verfahren zur herstellung |
DE4317588C2 (de) * | 1993-05-24 | 1998-04-16 | Schering Ag | Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung |
DE4318369C1 (de) * | 1993-05-28 | 1995-02-09 | Schering Ag | Verwendung von makrocyclischen Metallkomplexen als Temperatursonden |
JP3878208B2 (ja) * | 1994-04-08 | 2007-02-07 | ブラッコ インターナショナル ベスローテン フェンノートシャップ | 芳香族アミド化合物およびそれらのキレート |
US5582814A (en) * | 1994-04-15 | 1996-12-10 | Metasyn, Inc. | 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging |
JPH10509734A (ja) * | 1994-11-30 | 1998-09-22 | シェリング アクチェンゲゼルシャフト | 肝臓及び胆嚢用x線診断薬剤としての金属錯体の使用 |
US5672335A (en) * | 1994-11-30 | 1997-09-30 | Schering Aktiengesellschaft | Use of metal complexes as liver and gallbladder X-ray diagnostic agents |
TW319763B (ja) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
DE19507819A1 (de) * | 1995-02-21 | 1996-08-22 | Schering Ag | DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel |
DE19507822B4 (de) * | 1995-02-21 | 2006-07-20 | Schering Ag | Substituierte DTPA-Monoamide der zentralen Carbonsäure und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel |
IL117200A0 (en) * | 1995-02-21 | 1996-06-18 | Schering Ag | Diethylenetriamine-pentaacetic acid monoamide derivatives pharmaceutical compostions containing the same and processes for the preparation thereof |
DE19507820A1 (de) * | 1995-02-21 | 1996-08-22 | Schering Ag | Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel |
DE19646762B4 (de) * | 1996-11-04 | 2004-05-13 | Schering Ag | Verwendung von Metallverbindungen zur Herstellung von Mitteln zur Strahlentherapie von Tumoren |
EP0953360B1 (en) * | 1998-03-24 | 2004-05-26 | Council of Scientific and Industrial Research | Technetium-99m radiolabelled diethylene triamine pentaacetic acid diester and process for the preparation of technetium-99m diethylene triamine penta-acetic acid diester |
GB9806530D0 (en) | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Inflammatory mediator |
GB9823175D0 (en) * | 1998-10-22 | 1998-12-16 | Nycomed Imaging As | Compound |
AU2005280455A1 (en) * | 2004-08-26 | 2006-03-09 | Mallinckrodt Inc. | Luminescent metal complexes for monitoring renal function |
FI20065030L (fi) * | 2006-01-17 | 2007-07-18 | Wallac Oy | Neutraaliset leimausreagenssit ja niistä johdetut konjugaatit |
CA2660717A1 (en) * | 2006-08-17 | 2008-02-21 | Epix Pharmaceuticals, Inc. | Methods for lymph system imaging |
CN102171384B (zh) * | 2008-05-28 | 2013-12-25 | 乔治洛德方法研究和开发液化空气有限公司 | 碳化硅基抗反射涂层 |
BR112012008381A2 (pt) | 2009-09-24 | 2017-06-13 | Inserm (Institut Nat De La Santé Et De La Rech Médicale) | interação fkbp52-tau como novo alvo terapêutico para tratar os distúrbios neurológicos envolvendo disfunção da tau |
US20140296106A1 (en) | 2011-05-16 | 2014-10-02 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for screening substances capable of modulating the replication of an influenza virus |
WO2014053871A1 (en) | 2012-10-04 | 2014-04-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for screening a compound capable of inhibiting the notch1 transcriptional activity |
EP3108255B1 (en) | 2014-02-18 | 2020-08-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of diseases mediated by the nrp-1/obr complex signaling pathway |
US10189887B2 (en) | 2014-04-17 | 2019-01-29 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Polypeptides and uses thereof for reducing CD95-mediated cell motility |
JP2020517584A (ja) * | 2017-04-27 | 2020-06-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 修飾mri造影剤およびその使用 |
US11008354B2 (en) * | 2018-05-24 | 2021-05-18 | The Texas A&M University System | Chiral solvating agents |
ES2942917T3 (es) | 2019-01-11 | 2023-06-07 | Inst Nat Sante Rech Med | Métodos para cribar inhibidores contra el virus de chikungunya y para determinar si los sujetos tienen predisposición a infección por dicho virus |
CN115043747B (zh) * | 2022-08-15 | 2022-11-25 | 康瑞鑫(天津)药物研究院有限公司 | 卡洛酸三钠的析晶方法及制备的卡洛酸三钠晶体 |
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US4352751A (en) * | 1979-09-10 | 1982-10-05 | Analytical Radiation Corporation | Species-linked diamine triacetic acids and their chelates |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
DE3324235A1 (de) * | 1983-07-01 | 1985-01-10 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue komplexbildner, komplexe und komplexsalze |
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DE3710730A1 (de) * | 1987-03-31 | 1988-10-20 | Schering Ag | Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
US5693309A (en) | 1987-03-31 | 1997-12-02 | Schering Aktiengesellschaft | Substituted complexing agents, complexes, and complex salts, processes for their production, and pharmaceuticals containing same |
US4994259A (en) * | 1987-05-08 | 1991-02-19 | Salutar, Inc. | Improvement in the method of NMR imaging employing a manganese II chelates of N,N'-bis[pyridoxal-alkylene (or cycloalkylene) (or arylene)]-N,N'-diacetic acid derivatives |
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US5399340A (en) * | 1987-09-24 | 1995-03-21 | Schering Aktiengesellschaft | Use of amide complex compounds |
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US5198426A (en) | 1988-12-30 | 1993-03-30 | Warner-Lambert Company | Renin inhibitors containing c-terminal dihydroxy amides |
GB8900719D0 (en) * | 1989-01-13 | 1989-03-08 | Nycomed As | Compounds |
US5011925A (en) * | 1989-03-09 | 1991-04-30 | Mallinckrodt, Inc. | Morpholinoamido EDTA derivatives |
US5384108A (en) * | 1989-04-24 | 1995-01-24 | Mallinckrodt Medical, Inc. | Magnetic resonance imaging agents |
US6039931A (en) | 1989-06-30 | 2000-03-21 | Schering Aktiengesellschaft | Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production |
DE3922005A1 (de) * | 1989-06-30 | 1991-01-10 | Schering Ag | Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
US5087440A (en) * | 1989-07-31 | 1992-02-11 | Salutar, Inc. | Heterocyclic derivatives of DTPA used for magnetic resonance imaging |
GB8923843D0 (en) * | 1989-10-23 | 1989-12-13 | Salutar Inc | Compounds |
DE4011684A1 (de) * | 1990-04-06 | 1991-10-10 | Schering Ag | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
US5843399A (en) * | 1990-04-06 | 1998-12-01 | Schering Aktiengesellschaft | DTPA monoamides for MRI |
US5077037A (en) * | 1990-08-03 | 1991-12-31 | Mallinckrodt Medical, Inc. | Novel compositions for magnetic resonance imaging |
WO1994001393A1 (en) * | 1992-07-03 | 1994-01-20 | The Green Cross Corporation | Novel chelating agent, complex compound composed of said agent and metallic atom, and diagnostic agent containing said compound |
JP3215457B2 (ja) | 1991-08-05 | 2001-10-09 | 株式会社ブリヂストン | 氷雪上性能の改善されたゴム製品およびその製造方法 |
US5330743A (en) * | 1992-11-12 | 1994-07-19 | Magnetic Research, Inc. | Aminosaccharide contrast agents for magnetic resonance images |
-
1990
- 1990-04-06 DE DE4011684A patent/DE4011684A1/de not_active Withdrawn
-
1991
- 1991-04-04 JP JP3097976A patent/JP2854159B2/ja not_active Expired - Lifetime
- 1991-04-05 DE DE59102092T patent/DE59102092D1/de not_active Expired - Lifetime
- 1991-04-05 NO NO911345A patent/NO180582C/no not_active IP Right Cessation
- 1991-04-05 AT AT91250089T patent/ATE108179T1/de active
- 1991-04-05 FI FI911646A patent/FI911646A/fi unknown
- 1991-04-05 ZA ZA912550A patent/ZA912550B/xx unknown
- 1991-04-05 NZ NZ237711A patent/NZ237711A/en unknown
- 1991-04-05 EP EP91250089A patent/EP0450742B1/de not_active Expired - Lifetime
- 1991-04-05 DK DK91250089.9T patent/DK0450742T3/da active
- 1991-04-05 ES ES91250089T patent/ES2057746T3/es not_active Expired - Lifetime
- 1991-04-05 CA CA002039846A patent/CA2039846A1/en not_active Abandoned
- 1991-04-05 PT PT97263A patent/PT97263B/pt not_active IP Right Cessation
- 1991-04-05 HU HU911126A patent/HUT57180A/hu unknown
- 1991-04-08 IE IE115591A patent/IE65923B1/en not_active IP Right Cessation
- 1991-04-08 AU AU74186/91A patent/AU644639B2/en not_active Ceased
-
1994
- 1994-04-15 US US08/228,524 patent/US5859214A/en not_active Expired - Lifetime
-
1998
- 1998-04-28 US US09/066,674 patent/US6287538B1/en not_active Expired - Fee Related
-
2000
- 2000-03-10 US US09/523,310 patent/US6565830B1/en not_active Expired - Fee Related
-
2003
- 2003-03-25 US US10/395,080 patent/US7074387B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FI911646A (fi) | 1991-10-07 |
DE59102092D1 (de) | 1994-08-18 |
NO180582B (no) | 1997-02-03 |
DK0450742T3 (da) | 1994-11-07 |
US5859214A (en) | 1999-01-12 |
ATE108179T1 (de) | 1994-07-15 |
HU911126D0 (en) | 1991-10-28 |
HUT57180A (en) | 1991-11-28 |
NZ237711A (en) | 1993-12-23 |
IE911155A1 (en) | 1991-10-09 |
EP0450742B1 (de) | 1994-07-06 |
NO911345L (no) | 1991-10-07 |
US20030202943A1 (en) | 2003-10-30 |
ES2057746T3 (es) | 1994-10-16 |
EP0450742A1 (de) | 1991-10-09 |
FI911646A0 (fi) | 1991-04-05 |
NO911345D0 (no) | 1991-04-05 |
US6287538B1 (en) | 2001-09-11 |
US7074387B2 (en) | 2006-07-11 |
AU644639B2 (en) | 1993-12-16 |
AU7418691A (en) | 1991-10-10 |
DE4011684A1 (de) | 1991-10-10 |
CA2039846A1 (en) | 1991-10-07 |
PT97263A (pt) | 1992-01-31 |
JP2854159B2 (ja) | 1999-02-03 |
ZA912550B (en) | 1992-01-29 |
IE65923B1 (en) | 1995-11-29 |
JPH0665174A (ja) | 1994-03-08 |
PT97263B (pt) | 1998-08-31 |
US6565830B1 (en) | 2003-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |