NO169483C - Fremgangsmaate ved fremstilling av et daunomycinon-derivat - Google Patents
Fremgangsmaate ved fremstilling av et daunomycinon-derivatInfo
- Publication number
- NO169483C NO169483C NO890566A NO890566A NO169483C NO 169483 C NO169483 C NO 169483C NO 890566 A NO890566 A NO 890566A NO 890566 A NO890566 A NO 890566A NO 169483 C NO169483 C NO 169483C
- Authority
- NO
- Norway
- Prior art keywords
- daunomycinone
- group
- daunomycinon
- derivative
- preparing
- Prior art date
Links
- YOFDHOWPGULAQF-MQJDWESPSA-N (7s,9s)-9-acetyl-6,7,9,11-tetrahydroxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical class C1[C@@](O)(C(C)=O)C[C@H](O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O YOFDHOWPGULAQF-MQJDWESPSA-N 0.000 title 1
- XYDJGVROLWFENK-YBTHPKLGSA-N (7s,9s)-9-acetyl-4,6,7,9,11-pentahydroxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound O=C1C2=C(O)C=CC=C2C(=O)C2=C1C(O)=C1[C@@H](O)C[C@@](C(=O)C)(O)CC1=C2O XYDJGVROLWFENK-YBTHPKLGSA-N 0.000 abstract 1
- ZUFQFGSMHXKORU-UHFFFAOYSA-N 9-acetyl-6,7,9,11-tetrahydroxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(O)=C1C(O)CC(C(=O)C)(O)CC1=C2O ZUFQFGSMHXKORU-UHFFFAOYSA-N 0.000 abstract 1
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 1
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 1
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 abstract 1
- XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000001989 diazonium salts Chemical class 0.000 abstract 1
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 1
- 229960000908 idarubicin Drugs 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/38—Quinones containing —CHO or non—quinoid keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888803301A GB8803301D0 (en) | 1988-02-12 | 1988-02-12 | Process for preparation of 4-demethoxy-daunomycinone aglycone of 4-demethoxy-daunorubicin |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO890566D0 NO890566D0 (no) | 1989-02-09 |
| NO890566L NO890566L (no) | 1989-08-11 |
| NO169483B NO169483B (no) | 1992-03-23 |
| NO169483C true NO169483C (no) | 1992-07-01 |
Family
ID=10631620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO890566A NO169483C (no) | 1988-02-12 | 1989-02-09 | Fremgangsmaate ved fremstilling av et daunomycinon-derivat |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5015745A (cs) |
| EP (1) | EP0328399B1 (cs) |
| JP (1) | JP2784202B2 (cs) |
| KR (1) | KR970000484B1 (cs) |
| CN (1) | CN1020592C (cs) |
| AT (1) | ATE92457T1 (cs) |
| AU (1) | AU605960B2 (cs) |
| CA (1) | CA1339634C (cs) |
| CS (1) | CS273198B2 (cs) |
| DE (1) | DE68907934T2 (cs) |
| DK (1) | DK170248B1 (cs) |
| ES (1) | ES2059718T3 (cs) |
| FI (1) | FI92186C (cs) |
| GB (1) | GB8803301D0 (cs) |
| HU (1) | HU200979B (cs) |
| IE (1) | IE62954B1 (cs) |
| IL (1) | IL89198A (cs) |
| MY (1) | MY104941A (cs) |
| NO (1) | NO169483C (cs) |
| NZ (1) | NZ227873A (cs) |
| PH (1) | PH27328A (cs) |
| PT (1) | PT89663B (cs) |
| RU (1) | RU1819256C (cs) |
| UA (1) | UA19151A (cs) |
| YU (1) | YU47206B (cs) |
| ZA (1) | ZA891018B (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ224252A (en) * | 1987-04-21 | 1991-09-25 | Erba Carlo Spa | An anthracycline glycoside and its preparation |
| GB8808475D0 (en) * | 1988-04-11 | 1988-05-11 | Erba Carlo Spa | Process for preparing 4-demethoxydauno-mycinone |
| IT1275953B1 (it) * | 1995-03-22 | 1997-10-24 | Sicor Spa | Procedimento per la preparazione di antibiotici della classe delle antracicline |
| AUPQ319799A0 (en) * | 1999-10-01 | 1999-10-28 | Institute Of Drug Technology Australia Limited | Chemical methods |
| US7053191B2 (en) | 2003-05-21 | 2006-05-30 | Solux Corporation | Method of preparing 4-R-substituted 4-demethoxydaunorubicin |
| DE602005020636D1 (en) * | 2004-08-23 | 2010-05-27 | Sicor Inc | Synthese von idarubin-aglycon |
| RU2450013C2 (ru) | 2005-12-13 | 2012-05-10 | Солюкс Корпорейшен | Способ получения 4-деметилдаунорубицина |
| US8802830B2 (en) | 2005-12-20 | 2014-08-12 | Solux Corporation | Synthesis of epirubicin from 13-dihydrodaunorubicine |
| US8357785B2 (en) | 2008-01-08 | 2013-01-22 | Solux Corporation | Method of aralkylation of 4′-hydroxyl group of anthracylins |
| US8846882B2 (en) * | 2011-04-29 | 2014-09-30 | Synbias Pharma Ag | Method of producing 4-demethoxydaunorubicin |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862225A (en) * | 1961-08-18 | 1975-01-21 | Pfizer | D-ring substituted tetracyclines |
| US4020270A (en) * | 1974-05-02 | 1977-04-26 | Societa' Farmaceutici Italia S.P.A. | L-lyxohex-1-enopyranose derivative |
| GB1467383A (en) * | 1974-06-12 | 1977-03-16 | Farmaceutici Italia | Daunomycin analogues |
| GB1500421A (en) * | 1975-01-22 | 1978-02-08 | Farmaceutici Italia | Optically active anthracyclinones |
| GB1509875A (en) * | 1976-06-14 | 1978-05-04 | Farmaceutici Italia | Optically active anthracyclinones and anthracycline glycosides |
| GB1527050A (en) * | 1976-06-19 | 1978-10-04 | Farmaceutici Italia | Optically active anthracyclinones |
| GB8317037D0 (en) * | 1983-06-23 | 1983-07-27 | Erba Farmitalia | 6-deoxyanthracyclines |
| US4495103A (en) * | 1982-07-30 | 1985-01-22 | Sumitomo Chemical Company, Ltd. | Preparation of optically active 4-demethoxydaunomycinone |
| IT1177014B (it) * | 1983-10-19 | 1987-08-26 | Univ Melbourne | Composti organici che comprendono antracicline e antraciclinoni |
| NZ224252A (en) * | 1987-04-21 | 1991-09-25 | Erba Carlo Spa | An anthracycline glycoside and its preparation |
| GB8808475D0 (en) * | 1988-04-11 | 1988-05-11 | Erba Carlo Spa | Process for preparing 4-demethoxydauno-mycinone |
| GB8824947D0 (en) * | 1988-10-25 | 1988-11-30 | Erba Carlo Spa | New 4-substituted anthracyclinones & process for preparing them |
-
1988
- 1988-02-12 GB GB888803301A patent/GB8803301D0/en active Pending
-
1989
- 1989-02-06 US US07/306,559 patent/US5015745A/en not_active Expired - Lifetime
- 1989-02-06 PH PH38165A patent/PH27328A/en unknown
- 1989-02-07 CS CS80789A patent/CS273198B2/cs unknown
- 1989-02-07 NZ NZ227873A patent/NZ227873A/xx unknown
- 1989-02-07 IL IL8919889A patent/IL89198A/en not_active IP Right Cessation
- 1989-02-07 IE IE38389A patent/IE62954B1/en not_active IP Right Cessation
- 1989-02-08 AU AU29745/89A patent/AU605960B2/en not_active Ceased
- 1989-02-08 KR KR1019890001402A patent/KR970000484B1/ko not_active Expired - Fee Related
- 1989-02-08 YU YU31089A patent/YU47206B/sh unknown
- 1989-02-09 FI FI890612A patent/FI92186C/fi active IP Right Grant
- 1989-02-09 ZA ZA891018A patent/ZA891018B/xx unknown
- 1989-02-09 UA UA4613419A patent/UA19151A/uk unknown
- 1989-02-09 NO NO890566A patent/NO169483C/no unknown
- 1989-02-09 RU SU894613419A patent/RU1819256C/ru not_active IP Right Cessation
- 1989-02-09 JP JP1030929A patent/JP2784202B2/ja not_active Expired - Fee Related
- 1989-02-09 PT PT89663A patent/PT89663B/pt not_active IP Right Cessation
- 1989-02-10 ES ES89301282T patent/ES2059718T3/es not_active Expired - Lifetime
- 1989-02-10 MY MYPI89000165A patent/MY104941A/en unknown
- 1989-02-10 EP EP89301282A patent/EP0328399B1/en not_active Expired - Lifetime
- 1989-02-10 DE DE89301282T patent/DE68907934T2/de not_active Expired - Fee Related
- 1989-02-10 DK DK063889A patent/DK170248B1/da not_active IP Right Cessation
- 1989-02-10 CN CN89100740A patent/CN1020592C/zh not_active Expired - Fee Related
- 1989-02-10 HU HU89630A patent/HU200979B/hu unknown
- 1989-02-10 AT AT89301282T patent/ATE92457T1/de not_active IP Right Cessation
- 1989-02-10 CA CA000590705A patent/CA1339634C/en not_active Expired - Fee Related
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