NO159016C - Analogifremgangsmaate for fremstilling av terapeutisk aktive fenetanolaminderivater. - Google Patents
Analogifremgangsmaate for fremstilling av terapeutisk aktive fenetanolaminderivater.Info
- Publication number
- NO159016C NO159016C NO841568A NO841568A NO159016C NO 159016 C NO159016 C NO 159016C NO 841568 A NO841568 A NO 841568A NO 841568 A NO841568 A NO 841568A NO 159016 C NO159016 C NO 159016C
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- therapeutically active
- analogue procedure
- phenetanolamine
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/17—Unsaturated ethers containing halogen
- C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/17—Unsaturated ethers containing halogen
- C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
- C07C43/1742—Unsaturated ethers containing halogen containing six-membered aromatic rings with halogen atoms bound to the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1782—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/54—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Epoxy Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838310477A GB8310477D0 (en) | 1983-04-18 | 1983-04-18 | Chemical compounds |
GB838317087A GB8317087D0 (en) | 1983-06-23 | 1983-06-23 | Chemical compounds |
GB838329568A GB8329568D0 (en) | 1983-11-04 | 1983-11-04 | Chemical compounds |
GB848401889A GB8401889D0 (en) | 1984-01-25 | 1984-01-25 | Chemical compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
NO841568L NO841568L (no) | 1984-10-19 |
NO159016B NO159016B (no) | 1988-08-15 |
NO159016C true NO159016C (no) | 1988-11-23 |
Family
ID=27449465
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO841568A NO159016C (no) | 1983-04-18 | 1984-04-18 | Analogifremgangsmaate for fremstilling av terapeutisk aktive fenetanolaminderivater. |
NO1994017C NO1994017I1 (no) | 1983-04-18 | 1994-09-22 | Salmeterol/ (RS)-5-(1-hydroksy-2-(6-(4-fenylbutoksy)heksylamino)-etyl)-salicylalkohol (generisk vavn Salmeterol) og dens salter og solvater innebefattet 1-hydroksy-2-naftalenkarboksylatet (hydroksynaftoat) (xinafoat) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO1994017C NO1994017I1 (no) | 1983-04-18 | 1994-09-22 | Salmeterol/ (RS)-5-(1-hydroksy-2-(6-(4-fenylbutoksy)heksylamino)-etyl)-salicylalkohol (generisk vavn Salmeterol) og dens salter og solvater innebefattet 1-hydroksy-2-naftalenkarboksylatet (hydroksynaftoat) (xinafoat) |
Country Status (37)
Country | Link |
---|---|
US (5) | US4992474A (xx) |
JP (2) | JPS63264443A (xx) |
KR (1) | KR920004186B1 (xx) |
AR (3) | AR244199A1 (xx) |
AT (1) | AT390611B (xx) |
AU (1) | AU573212B2 (xx) |
BE (1) | BE899448A (xx) |
BG (1) | BG61490B2 (xx) |
CA (2) | CA1335999C (xx) |
CH (2) | CH661497A5 (xx) |
CY (1) | CY1482A (xx) |
CZ (1) | CZ285602B6 (xx) |
DE (4) | DE19575029I2 (xx) |
DK (2) | DK167493B1 (xx) |
ES (2) | ES8505641A1 (xx) |
FI (1) | FI85011C (xx) |
FR (1) | FR2545482B1 (xx) |
GB (2) | GB2140800B (xx) |
GR (1) | GR79925B (xx) |
HK (1) | HK36889A (xx) |
HU (1) | HU200160B (xx) |
IE (1) | IE57237B1 (xx) |
IL (1) | IL71569A (xx) |
IT (1) | IT1199112B (xx) |
KE (1) | KE3864A (xx) |
LU (2) | LU88265I2 (xx) |
MX (1) | MX9203226A (xx) |
MY (1) | MY102087A (xx) |
NL (2) | NL188406C (xx) |
NO (2) | NO159016C (xx) |
NZ (2) | NZ207885A (xx) |
PH (1) | PH21574A (xx) |
PT (1) | PT78443B (xx) |
SE (1) | SE462594B (xx) |
SG (1) | SG12289G (xx) |
SK (1) | SK278120B6 (xx) |
ZW (1) | ZW6584A1 (xx) |
Families Citing this family (180)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZW6584A1 (en) * | 1983-04-18 | 1985-04-17 | Glaxo Group Ltd | Phenethanolamine derivatives |
PT80304B (en) * | 1984-04-17 | 1987-03-16 | Glaxo Group Ltd | Process for preparing phenethanolamine compounds |
GB8525321D0 (en) * | 1985-10-15 | 1985-11-20 | Glaxo Group Ltd | Chemical compounds |
US4943591A (en) * | 1984-10-17 | 1990-07-24 | Glaxo Group Limited | Dichloroaniline derivatives |
EP0220054A3 (en) * | 1985-10-16 | 1987-12-02 | Glaxo Group Limited | Ethanolamine derivatives |
GB8525484D0 (en) * | 1985-10-16 | 1985-11-20 | Glaxo Group Ltd | Chemical compounds |
EP0223410A3 (en) * | 1985-10-16 | 1987-11-19 | Glaxo Group Limited | Ethanolamine derivatives |
GB8525483D0 (en) * | 1985-10-16 | 1985-11-20 | Glaxo Group Ltd | Chemical compounds |
JPS63290852A (ja) * | 1987-02-10 | 1988-11-28 | グラクソ、グループ、リミテッド | 化合物 |
US4937268A (en) * | 1987-03-12 | 1990-06-26 | Glaxo Group Limited | Chemical compounds |
GB8718940D0 (en) * | 1987-08-11 | 1987-09-16 | Glaxo Group Ltd | Chemical compounds |
GB8718938D0 (en) * | 1987-08-11 | 1987-09-16 | Glaxo Group Ltd | Chemical compounds |
ES2039646T3 (es) * | 1987-11-13 | 1993-10-01 | Glaxo Group Limited | Derivados de fenetanolamina. |
NZ227365A (en) * | 1987-12-18 | 1990-10-26 | Glaxo Group Ltd | Aromatic amino ethers and pharmaceutical compositions |
ZA889405B (en) * | 1987-12-18 | 1989-12-27 | Glaxo Group Ltd | Ethanolamine derivatives |
GB8909273D0 (en) * | 1989-04-24 | 1989-06-07 | Glaxo Group Ltd | Chemical compounds |
GB2230775A (en) * | 1989-04-24 | 1990-10-31 | Glaxo Group Ltd | Phenethanolamine compounds |
US5290815A (en) * | 1989-09-07 | 1994-03-01 | Glaxo Group Limited | Treatment of inflammation and allergy |
JPH03178929A (ja) * | 1989-09-07 | 1991-08-02 | Glaxo Group Ltd | 炎症及びアレルギー治療用化合物 |
US5270305A (en) * | 1989-09-08 | 1993-12-14 | Glaxo Group Limited | Medicaments |
US5208226A (en) * | 1989-09-08 | 1993-05-04 | Glaxo Group Limited | Medicaments |
IL95590A (en) * | 1989-09-08 | 1996-06-18 | Glaxo Group Ltd | Medicinal preparations containing Salmetrol and Pluticasone Propionate |
DK0416950T3 (da) * | 1989-09-08 | 1993-10-11 | Glaxo Group Ltd | Medikamenter |
TW209832B (xx) * | 1989-10-10 | 1993-07-21 | Glaxo Group Ltd | |
US6536427B2 (en) | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
MY105368A (en) | 1990-03-02 | 1994-09-30 | Glaxo Group Ltd | Inhalation device. |
HU213221B (en) | 1990-03-02 | 1997-03-28 | Glaxo Group Ltd | Inhalation device and medicine packet for device |
US5919827A (en) * | 1990-07-11 | 1999-07-06 | Sepracor Inc. | Method for treating asthma using optically pure R(-) salmeterol |
GB9026005D0 (en) * | 1990-11-29 | 1991-01-16 | Glaxo Group Ltd | Drug material suitable for micronisation |
CN1056974C (zh) * | 1992-02-11 | 2000-10-04 | 格拉克索公司 | 适宜于微粒化的药物材料的制备方法 |
AU1229892A (en) * | 1992-02-11 | 1993-09-03 | Glaxo Group Limited | Benzenedimethanol derivative suitable for micronisation |
AP323A (en) * | 1992-05-08 | 1994-03-07 | Glaxo Group Ltd | Drug material suitable for micronisation. |
GB9215274D0 (en) * | 1992-07-17 | 1992-09-02 | Scras | Derivatives of(phenylethyl-beta-ol)amine |
ES2065269B1 (es) * | 1993-05-11 | 1995-10-01 | S A L V A T Lab Sa | 6-(4-(fenilbutoxi) hexilaminometil-4-hidroxi-a1,a3-bencenodimetanol. procedimiento para la obtencion del mismo y nuevos intermedios utilizados en su preparacion. |
EP0733047B1 (en) * | 1993-12-10 | 1998-09-16 | Novartis AG | Substituted oxazolidines with stimulating effect of beta-adrenergig receptor |
GB9507768D0 (en) | 1995-04-13 | 1995-05-31 | Glaxo Group Ltd | Method of apparatus |
BR9604978A (pt) | 1995-04-14 | 1998-06-09 | Glaxo Wellcome Inc | Inalador com dose medida |
AP979A (en) * | 1995-04-14 | 2001-06-28 | Glaxo Wellcome Inc | Metered dose imhaler for salmeterol. |
CN1186473A (zh) | 1995-04-14 | 1998-07-01 | 葛兰素惠尔康公司 | 二丙酸氯地米松计定剂量吸入器 |
EP1157749B1 (en) | 1995-04-14 | 2007-09-19 | SmithKline Beecham Corporation | Proces for preparing a metered dose inhaler |
AU4967997A (en) | 1996-12-02 | 1998-06-29 | Chisso Corporation | Optically active nitro alcohol derivatives, optically active amino alcohol derivates, and process for preparing the same |
US6254882B1 (en) | 1997-09-16 | 2001-07-03 | Sepracor Inc. | Methods and compositions for treating pulmonary disorders using optically pure (S)—salmeterol |
WO1999062451A1 (en) * | 1998-06-01 | 1999-12-09 | Verbiscar Anthony J | Topical transdermal treatments |
ES2142771B1 (es) * | 1998-09-28 | 2001-01-01 | Vita Invest Sa | Nuevos derivados de la 6-(4-fenil-butoxi) hexilamina y procedimiento para la obtencion de salmeterol. |
DE60001492T2 (de) | 1999-04-14 | 2003-12-18 | Glaxo Group Ltd., Greenford | Pharmazeutische aerosolformulierung |
PT1212089E (pt) * | 1999-08-21 | 2006-08-31 | Altana Pharma Ag | Combinacao sinergica de roflumilast e salmeterol |
GB0009613D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Pharmaceutical compositions |
GB0009609D0 (en) * | 2000-04-18 | 2000-06-07 | Glaxo Group Ltd | Therapeutic compositions |
GB0014546D0 (en) * | 2000-06-14 | 2000-08-09 | Glaxo Group Ltd | A novel process |
GB0015043D0 (en) | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Medicament dispenser |
US6759398B2 (en) | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
US6858596B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
US6777400B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6777399B2 (en) * | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
US6858593B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
GB0019172D0 (en) | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
AU2001276497B2 (en) * | 2000-08-05 | 2005-04-07 | Glaxo Group Limited | 17.beta.-carbothioate 17.alpha.-arylcarbonyloxyloxy androstane derivative as anti-inflammatory agents |
US6787532B2 (en) | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
US6750210B2 (en) | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
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- 1984-04-18 PH PH30586A patent/PH21574A/en unknown
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- 1984-04-18 LU LU85329A patent/LU85329A1/fr active Protection Beyond IP Right Term
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- 1984-04-18 DK DK201784A patent/DK167493B1/da not_active IP Right Cessation
- 1984-04-18 GR GR74450A patent/GR79925B/el unknown
- 1984-04-18 SE SE8402188A patent/SE462594B/sv not_active IP Right Cessation
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- 1984-04-18 CA CA000452288A patent/CA1335999C/en not_active Expired - Lifetime
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1985
- 1985-01-16 ES ES539625A patent/ES8609209A1/es not_active Expired
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1986
- 1986-05-21 GB GB08612357A patent/GB2176476B/en not_active Expired
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1987
- 1987-02-25 AR AR87306841A patent/AR245687A1/es active
- 1987-09-29 MY MYPI87002277A patent/MY102087A/en unknown
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1988
- 1988-02-25 JP JP63043277A patent/JPS63264443A/ja active Granted
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1989
- 1989-02-08 AR AR89313169A patent/AR247721A1/es active
- 1989-02-17 KE KE3864A patent/KE3864A/xx unknown
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- 1989-05-04 HK HK368/89A patent/HK36889A/xx not_active IP Right Cessation
- 1989-08-23 US US07/397,664 patent/US4992474A/en not_active Expired - Lifetime
- 1989-12-08 CY CY1482A patent/CY1482A/xx unknown
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1990
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- 1990-11-29 US US07/619,899 patent/US5126375A/en not_active Expired - Lifetime
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1991
- 1991-12-19 US US07/810,183 patent/US5243076A/en not_active Expired - Lifetime
- 1991-12-23 CZ CS914028A patent/CZ285602B6/cs unknown
- 1991-12-23 SK SK4028-91A patent/SK278120B6/sk unknown
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1992
- 1992-02-19 US US07/837,783 patent/US5225445A/en not_active Expired - Lifetime
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- 1992-08-18 JP JP4219484A patent/JPH0729997B2/ja not_active Expired - Lifetime
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1993
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- 1993-08-20 BG BG098059A patent/BG61490B2/bg unknown
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1994
- 1994-09-22 NO NO1994017C patent/NO1994017I1/no unknown
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