NL7903029A - 2'DEOXY-5- (2-HALOGENVINYL) -URIDINES. - Google Patents

2'DEOXY-5- (2-HALOGENVINYL) -URIDINES.

Info

Publication number
NL7903029A
NL7903029A NL7903029A NL7903029A NL7903029A NL 7903029 A NL7903029 A NL 7903029A NL 7903029 A NL7903029 A NL 7903029A NL 7903029 A NL7903029 A NL 7903029A NL 7903029 A NL7903029 A NL 7903029A
Authority
NL
Netherlands
Prior art keywords
halogenvinyl
uridines
deoxy
Prior art date
Application number
NL7903029A
Other languages
Dutch (nl)
Other versions
NL192793C (en
NL192793B (en
Original Assignee
Univ Birmingham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Birmingham filed Critical Univ Birmingham
Publication of NL7903029A publication Critical patent/NL7903029A/en
Publication of NL192793B publication Critical patent/NL192793B/en
Application granted granted Critical
Publication of NL192793C publication Critical patent/NL192793C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
NL7903029A 1978-04-24 1979-04-18 Deoxyuridine derivatives with antiviral activity; method for its preparation and anti-viral drug. NL192793C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB16158/78A GB1601020A (en) 1978-04-24 1978-04-24 2'-deoxy-5 (2-halogenovinyl)-uridines
GB1615978 1978-04-24

Publications (3)

Publication Number Publication Date
NL7903029A true NL7903029A (en) 1979-10-26
NL192793B NL192793B (en) 1997-10-01
NL192793C NL192793C (en) 1998-02-03

Family

ID=10072234

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7903029A NL192793C (en) 1978-04-24 1979-04-18 Deoxyuridine derivatives with antiviral activity; method for its preparation and anti-viral drug.

Country Status (11)

Country Link
US (1) US4424211A (en)
JP (1) JPS554364A (en)
BE (1) BE875773A (en)
CA (1) CA1117108A (en)
CH (1) CH643273A5 (en)
DE (1) DE2915254A1 (en)
FR (1) FR2432526A1 (en)
GB (1) GB1601020A (en)
IT (1) IT1165954B (en)
NL (1) NL192793C (en)
SE (1) SE445832B (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5687599A (en) * 1979-12-19 1981-07-16 Yamasa Shoyu Co Ltd E 55 22halogenovinyl arabinofuranosyluracil and its preparation
US4383990A (en) * 1980-10-01 1983-05-17 Beecham Group Limited Antiviral agents, their preparation and use
EP0060099A1 (en) * 1981-03-11 1982-09-15 Beecham Group Plc Antiviral agents, their preparation and use
NZ199764A (en) * 1981-03-20 1984-08-24 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives and pharmaceutical compositions
EP0072137A1 (en) * 1981-08-01 1983-02-16 Beecham Group Plc Antiviral deoxyuridine compounds
HU183567B (en) * 1981-09-07 1984-05-28 Mta Koezponti Kemiai Kutato In Process for preparing /e/-5-/2-bromo-vinyl/-uridine and derivatives thereof
EP0082667A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc Pharmaceutical compositions
EP0088501B1 (en) * 1982-02-12 1986-04-16 United Kingdom Atomic Energy Authority Laser pipe welder/cutter
EP0095294A1 (en) * 1982-05-22 1983-11-30 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
EP0095292A1 (en) * 1982-05-22 1983-11-30 Beecham Group Plc 5-(2-halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections"
EP0097039A1 (en) * 1982-06-16 1983-12-28 Beecham Group Plc 5-(E-2-halovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them, and their use in treating viral infections
HU187736B (en) * 1982-08-04 1986-02-28 Mta Koezponti Kemiai Kutato Intezet,Hu Process for producing /e/ -5-/2-bromovinyl/-2-comma above-deoxyuridine and o-acyl derivatives
FI832884A (en) * 1982-08-17 1984-02-18 Sandoz Ag DESOXYURIDINDERIVAT, DERAS FRAMSTAELLNINGSFOERFARANDEN OCH ANVAENDNING SOM PHARMACEUTISKA MEDEL
JPS5980620A (en) * 1982-09-17 1984-05-10 グラクソ・グル−プ・リミテツド 5-halovinyl-2'-deoxyuridine derivative
EP0104857A1 (en) * 1982-09-28 1984-04-04 Beecham Group Plc Deoxyuridine compounds, methods for preparing them and their use in medicine
US4658044A (en) * 1983-09-16 1987-04-14 Glaxo Group Limited Intermediates for uracil derivatives
JPS62500239A (en) * 1984-09-24 1987-01-29 ピイシーアール，インコーポレイテッド Method for producing 2-deoxyuridine
GB8517402D0 (en) 1985-07-10 1985-08-14 Wellcome Found Treatment of viral infections
GB8629892D0 (en) * 1986-12-15 1987-01-28 Wellcome Found Antiviral compounds
US5215971A (en) * 1986-12-19 1993-06-01 Medivir Ab Antiviral pharmaceutical composition comprising 5-substituted pyrimidine nucleosides
SE8605503D0 (en) * 1986-12-19 1986-12-19 Astra Laekemedel Ab NOVEL MEDICINAL USE
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
JPH0217198A (en) * 1988-07-05 1990-01-22 Japan Tobacco Inc Production of 2'-deoxy-beta-cytidine derivative and salt thereof
JPH0217199A (en) * 1988-07-05 1990-01-22 Japan Tobacco Inc Production of 2'-deoxy-beta-adenosine
EP0428623A4 (en) * 1988-08-10 1993-12-08 Stephen Leslie Sacks Production of radioiodinated 1--g(b)-d-arabinofuranosyl)-5(e)-(2-iodovinyl)uracil, and uses thereof, and related analogues incorporating alternative halogen radionuclides, the general radiohalogenation precursors, 1-(2,3,5-tri-o-acetyl--g(b)-d-arabinofuranosyl)-5(z and e)-(2-trimethylsilylvinyl)urac
EA005497B1 (en) * 2001-01-03 2005-02-24 Берлин Хеми Аг One-day pharmaceutical composition containing brivudine
DE10109657A1 (en) * 2001-02-28 2002-09-05 Menarini Ricerche Spa Process for the preparation of (E) -5- (2-bromovinyl) -2`-deoxyuridine
AU2002360697B2 (en) 2001-12-20 2009-04-23 Beth Israel Deaconess Medical Center Treatment of EBV and KHSV infection and associated abnormal cellular proliferation
CN102432655A (en) * 2011-10-28 2012-05-02 河南师范大学 Method for synthesizing 5-((E)-2-bromovinyl)-2'-deoxyuridine (brivudine)
EP3792271A1 (en) 2019-09-13 2021-03-17 Aurobindo Pharma Limited A process for the preparation of brivudine
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU452961A3 (en) 1969-04-11 1974-12-05 Шеринг Аг. (Фирма) The method of producing pyrimidine nucleosides
DE2012888C3 (en) 1970-03-14 1981-04-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Process for the preparation of 5-azapyrimidine nucleosides
DE2122991C2 (en) 1971-05-04 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Process for the preparation of cytosine and 6-azacytosine nucleosides
US4093715A (en) 1977-04-28 1978-06-06 Research Corporation 5-Iodo-5'-amino-2',5'-dideoxycytidine and the pharmaceutically acceptable salts thereof
US4093716A (en) 1977-04-28 1978-06-06 Research Corporation Compositions containing 5-amino-5-deoxythymidine and pharmaceutically acceptable salts thereof
DE2721466A1 (en) 1977-05-12 1978-11-16 Robugen Gmbh PROCESS FOR THE PREPARATION OF 2'-DESOXYRIBOFURANOSYL NUCLEOSIDES

Also Published As

Publication number Publication date
JPS642599B2 (en) 1989-01-18
CH643273A5 (en) 1984-05-30
SE7903541L (en) 1979-10-25
IT1165954B (en) 1987-04-29
NL192793C (en) 1998-02-03
FR2432526B1 (en) 1982-10-08
NL192793B (en) 1997-10-01
DE2915254A1 (en) 1979-11-15
JPS554364A (en) 1980-01-12
US4424211A (en) 1984-01-03
BE875773A (en) 1979-10-23
IT7909403A0 (en) 1979-04-23
GB1601020A (en) 1981-10-21
FR2432526A1 (en) 1980-02-29
SE445832B (en) 1986-07-21
DE2915254C2 (en) 1990-07-12
CA1117108A (en) 1982-01-26

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Legal Events

Date Code Title Description
A85 Still pending on 85-01-01
BA A request for search or an international-type search has been filed
BB A search report has been drawn up
BC A request for examination has been filed
V4 Discontinued because of reaching the maximum lifetime of a patent

Free format text: 19990418